Cancer CRCdb

TF information

TF name:	ETV5
TF family:	ETS
Ensembl gene ID:	ENSG00000244405
Ensembl protein ID:	ENSP00000413755, ENSP00000306894
Entrez gene ID:	2119

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ETV5 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_181	Cell line	Human melanoma	COLO679	0.0656
Sample_02_183	Cell line	Skin	SKMEL2	0.1025641025641
Sample_02_184	Cell line	Skin	SKMEL30	0.15112540192926

ETV5 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

ETV5 distribution in all CRCs

Genomic distribution of SEs associated with ETV5

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Mutation of ETV5

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ETV5

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	185766484	185766484	G	A	exonic	ETV5	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	185766626	185766626	G	A	exonic	ETV5	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr3	185798962	185798962	C	T	exonic	ETV5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs769924564	chr3	185775242	185775242	C	T	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185798929	185798929	G	A	exonic	ETV5	nonsynonymous	CHOL\|1\|35\|0.02857,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185774946	185774946	G	A	exonic	ETV5	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr3	185783686	185783686	G	C	exonic	ETV5	nonsynonymous	PAAD\|1\|185\|0.00541
rs777358489	chr3	185774898	185774898	C	T	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102
rs185636057	chr3	185797727	185797727	C	T	exonic	ETV5	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	185797613	185797613	C	A	exonic	ETV5	stopgain	BLCA\|1\|396\|0.00253
-	chr3	185769818	185769818	C	G	splicing	ETV5	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185766510	185766510	G	A	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs767971453	chr3	185798928	185798928	C	T	exonic	ETV5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	185797835	185797835	G	C	exonic	ETV5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	185823093	185823093	C	T	splicing	ETV5	splicing	BRCA\|1\|982\|0.00102
-	chr3	185774980	185774980	G	A	exonic	ETV5	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185774898	185774898	C	A	exonic	ETV5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr3	185797720	185797720	-	G	exonic	ETV5	frameshift	HNSC\|1\|512\|0.00195
-	chr3	185823486	185823486	C	A	exonic	ETV5	stopgain	SARC\|1\|247\|0.00405
-	chr3	185783621	185783621	C	T	exonic	ETV5	synonymous	SKCM\|1\|368\|0.00272
rs767684440	chr3	185783793	185783793	C	T	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185798884	185798884	C	T	exonic	ETV5	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	185823718	185823718	G	A	UTR5	ETV5	unknown	SKCM\|1\|368\|0.00272
-	chr3	185823280	185823280	A	G	exonic	ETV5	nonsynonymous	SARC\|1\|247\|0.00405
-	chr3	185783693	185783693	A	T	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	185797806	185797806	A	G	exonic	ETV5	synonymous	LIHC\|1\|373\|0.00268
-	chr3	185783730	185783730	C	T	exonic	ETV5	nonsynonymous	UCEC\|1\|248\|0.00403
rs745805257	chr3	185774947	185774947	T	G	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102
rs779639231	chr3	185797681	185797681	G	A	exonic	ETV5	nonsynonymous	PRAD\|1\|499\|0.00200,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185797717	185797717	G	A	exonic	ETV5	nonsynonymous	SKCM\|1\|368\|0.00272
rs151057501	chr3	185766491	185766491	G	A	exonic	ETV5	synonymous	BLCA\|1\|396\|0.00253
-	chr3	185774902	185774902	C	A	exonic	ETV5	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr3	185823434	185823434	T	C	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185797825	185797825	G	A	exonic	ETV5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	185823619	185823619	G	A	exonic	ETV5	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	185766605	185766605	A	G	exonic	ETV5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185798877	185798877	G	A	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185766628	185766628	A	G	exonic	ETV5	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	185823732	185823732	C	A	splicing	ETV5	splicing	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs201212469	chr3	185766571	185766571	G	A	exonic	ETV5	nonsynonymous	THCA\|1\|504\|0.00198
-	chr3	185774866	185774866	C	T	exonic	ETV5	nonsynonymous	CESC\|1\|194\|0.00515
rs761631963	chr3	185766533	185766533	G	A	exonic	ETV5	synonymous	CESC\|1\|194\|0.00515
-	chr3	185797649	185797649	T	C	exonic	ETV5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	185823281	185823281	T	A	exonic	ETV5	synonymous	OV\|1\|469\|0.00213
rs139774137	chr3	185783693	185783693	A	G	exonic	ETV5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185798944	185798944	G	C	exonic	ETV5	nonsynonymous	BLCA\|1\|396\|0.00253
rs865886165	chr3	185797768	185797768	G	A	exonic	ETV5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr3	185797643	185797643	T	G	exonic	ETV5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	185766447	185766447	G	A	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185823096	185823096	T	C	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185797732	185797732	G	A	exonic	ETV5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	185823275	185823275	C	T	exonic	ETV5	synonymous	SKCM\|1\|368\|0.00272
-	chr3	185775021	185775021	T	C	exonic	ETV5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	185797673	185797673	G	A	exonic	ETV5	stopgain	DLBC\|1\|48\|0.02083
-	chr3	185766603	185766603	G	A	exonic	ETV5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr3	185775224	185775224	C	G	exonic	ETV5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	185823132	185823132	T	A	exonic	ETV5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	185783822	185783822	A	G	exonic	ETV5	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr3	185769859	185769859	C	T	exonic	ETV5	nonsynonymous	PRAD\|1\|499\|0.00200
rs745384970	chr3	185766576	185766576	T	C	exonic	ETV5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	185769835	185769835	T	-	exonic	ETV5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs772183700	chr3	185797720	185797720	T	G	exonic	ETV5	nonsynonymous	ACC\|1\|90\|0.01111
-	chr3	185782253	185782253	C	T	exonic	ETV5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185766624	185766624	T	G	exonic	ETV5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185797641	185797641	C	T	exonic	ETV5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185823714	185823714	G	-	UTR5	ETV5	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185783743	185783743	G	C	exonic	ETV5	nonsynonymous	LUAD\|1\|543\|0.00184
rs138683352	chr3	185766547	185766547	C	T	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185823136	185823136	G	A	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272
rs76963399	chr3	185798861	185798861	A	G	exonic	ETV5	synonymous	BLCA\|1\|396\|0.00253
-	chr3	185769904	185769904	C	A	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185797835	185797835	G	-	exonic	ETV5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185769853	185769853	A	-	exonic	ETV5	frameshift	UCEC\|1\|248\|0.00403
-	chr3	185774871	185774871	G	A	exonic	ETV5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	185769871	185769871	T	C	exonic	ETV5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs370362112	chr3	185783741	185783741	C	T	exonic	ETV5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	185775019	185775019	C	G	exonic	ETV5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	185823423	185823423	C	T	exonic	ETV5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	185766568	185766568	G	A	exonic	ETV5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	185798879	185798879	C	A	exonic	ETV5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	185802069	185802069	G	-	intronic	ETV5	unknown	BRCA\|1\|982\|0.00102
-	chr3	185769827	185769827	T	C	exonic	ETV5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs185636057	chr3	185797727	185797727	C	G	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	185769850	185769850	C	T	exonic	ETV5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185766536	185766536	G	A	exonic	ETV5	synonymous	LUSC\|1\|178\|0.00562
-	chr3	185823650	185823650	C	T	exonic	ETV5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	185769884	185769884	C	A	exonic	ETV5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	185769839	185769839	C	T	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	185798911	185798911	A	G	exonic	ETV5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	185766567	185766567	G	A	exonic	ETV5	nonsynonymous	ACC\|1\|90\|0.01111,SKCM\|1\|368\|0.00272
-	chr3	185766542	185766542	G	A	exonic	ETV5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	185783821	185783821	G	A	exonic	ETV5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	185797801	185797801	G	-	exonic	ETV5	frameshift	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	185797866	185797866	C	T	exonic	ETV5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs763950262	chr3	185783746	185783746	G	A	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102
rs773704999	chr3	185766490	185766490	C	T	exonic	ETV5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	185797767	185797767	G	A	exonic	ETV5	synonymous	SARC\|1\|247\|0.00405
-	chr3	185823642	185823642	C	G	exonic	ETV5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	185823097	185823097	T	G	exonic	ETV5	nonsynonymous	OV\|1\|469\|0.00213

Disease information of ETV5

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ETV5	Neoplastic Processes	C04;C23	Neoplastic Process	CTD_human
ETV5	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
ETV5	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human

Pathway associated with ETV5

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000176	AndrogenReceptor	netpath	167	2267
pathway0000702	ERK cascade ( FGF8 signaling (Mouse) )	inoh	17	71
pathway0000703	ERK cascade ( FGF8 signaling (Xenopus) )	inoh	17	71
pathway0000781	FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) )	inoh	20	66
pathway0000782	FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) )	inoh	18	53
pathway0000826	FOXM1 transcription factor network	pid	43	294
pathway0001117	IL12 signaling mediated by STAT4	pid	33	229
pathway0001799	RANKL	netpath	84	1002
pathway0001903	RhoA signaling pathway	pid	46	233
pathway0002863	Hs_Androgen_receptor_signaling_pathway_WP138_79958	wikipathways	27	107

Go term information of ETV5

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GO_term_name	GO_term_type	TF_name
GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT	BP	ETV5
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	ETV5
GO_SYNAPSE_ORGANIZATION	BP	ETV5
GO_ASYMMETRIC_CELL_DIVISION	BP	ETV5
GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	ETV5
GO_STEM_CELL_DIVISION	BP	ETV5
GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION	BP	ETV5
GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION	BP	ETV5
GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION	BP	ETV5
GO_REGULATION_OF_GLIOGENESIS	BP	ETV5
GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS	BP	ETV5
GO_POSITIVE_REGULATION_OF_GLIOGENESIS	BP	ETV5
GO_RECEPTOR_CLUSTERING	BP	ETV5
GO_SEQUENCE_SPECIFIC_DNA_BINDING	MF	ETV5

Survival analysis of ETV5

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ETV5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)