Cancer CRCdb

TF information

TF name:	ESR1
TF family:	ESR-like
Ensembl gene ID:	ENSG00000091831
Ensembl protein ID:	ENSP00000384064, ENSP00000401995, ENSP00000342630, ENSP00000394721, ENSP00000206249, ENSP00000405330, ENSP00000387500
Entrez gene ID:	2099

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ESR1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.087167070217918
Sample_01_046	Cell line	Mammary Gland	MCF-7	1
Sample_02_079	Cell line	Mammary Gland	T-47D_1	1
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.46739130434783
Sample_02_115	Cell line	Mammary Gland	MCF-7	1
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.69230769230769
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	0.78409090909091

ESR1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_046	Mammary Gland	Cell line	MCF-7
Sample_02_079	Mammary Gland	Cell line	T-47D_1
Sample_02_115	Mammary Gland	Cell line	MCF-7
Sample_02_394	Mammary Gland	Cell line	T-47D_2
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat

ESR1 distribution in all CRCs

Genomic distribution of SEs associated with ESR1

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Mutation of ESR1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ESR1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs752794477	chr6	152129139	152129139	T	C	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152382169	152382169	A	G	exonic	ESR1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	152201851	152201851	G	C	exonic	ESR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	152265369	152265369	G	A	exonic	ESR1	synonymous	BRCA\|1\|982\|0.00102
rs104893956	chr6	152163748	152163748	C	T	exonic	ESR1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152265351	152265351	G	T	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152201857	152201857	C	A	exonic	ESR1	stopgain	LUAD\|1\|543\|0.00184
-	chr6	152129053	152129053	C	A	exonic	ESR1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	152265570	152265570	G	A	exonic	ESR1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152415668	152415668	G	A	exonic	ESR1	synonymous	THCA\|1\|504\|0.00198
-	chr6	152265497	152265497	G	T	exonic	ESR1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	152163896	152163896	A	G	exonic	ESR1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	152201827	152201827	C	A	exonic	ESR1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152265629	152265629	C	T	exonic	ESR1	nonsynonymous	BLCA\|1\|396\|0.00253,ESCA\|1\|185\|0.00541
-	chr6	152129212	152129212	C	T	exonic	ESR1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	152129201	152129201	T	C	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152332890	152332890	C	G	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152419965	152419965	C	A	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152420091	152420091	C	A	exonic	ESR1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	152129166	152129166	G	T	exonic	ESR1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	152129446	152129446	G	A	exonic	ESR1	synonymous	HNSC\|1\|512\|0.00195
rs771540162	chr6	152129249	152129249	G	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152201893	152201893	A	G	exonic	ESR1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	152332875	152332875	G	A	exonic	ESR1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	152163866	152163866	A	G	exonic	ESR1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	152419926	152419926	A	G	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152332811	152332811	C	A	exonic	ESR1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	152163850	152163850	T	C	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
rs781741770	chr6	152265314	152265314	G	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152201884	152201884	C	T	exonic	ESR1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152382208	152382208	C	T	exonic	ESR1	synonymous	HNSC\|1\|512\|0.00195
rs185775221	chr6	152420041	152420041	G	A	exonic	ESR1	synonymous	PAAD\|1\|185\|0.00541
rs571716552	chr6	152265535	152265535	G	A	exonic	ESR1	nonsynonymous	ESCA\|1\|185\|0.00541
rs762742833	chr6	152415579	152415579	C	T	exonic	ESR1	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152415601	152415601	A	G	exonic	ESR1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	152382138	152382138	A	C	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152332832	152332832	G	C	exonic	ESR1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	152129472	152129472	G	C	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152163847	152163847	G	A	exonic	ESR1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	152382191	152382191	G	A	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152332878	152332878	C	T	exonic	ESR1	nonsynonymous	UVM\|1\|80\|0.01250
-	chr6	152201863	152201863	C	T	exonic	ESR1	synonymous	DLBC\|1\|48\|0.02083
rs778449608	chr6	152201885	152201885	G	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr6	152129072	152129072	G	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs201562714	chr6	152419948	152419948	C	T	exonic	ESR1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs755020320	chr6	152332874	152332874	C	A	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152332821	152332821	T	C	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778116774	chr6	152419910	152419910	G	A	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152415668	152415668	G	T	exonic	ESR1	nonsynonymous	ESCA\|1\|185\|0.00541
rs138891155	chr6	152420094	152420094	C	T	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152382133	152382133	G	A	exonic	ESR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	152419935	152419935	T	A	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152332924	152332924	G	A	exonic	ESR1	synonymous	SKCM\|1\|368\|0.00272
rs766779326	chr6	152265479	152265479	C	T	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152332842	152332842	G	A	exonic	ESR1	stopgain	THCA\|1\|504\|0.00198
rs866869178	chr6	152265323	152265323	G	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152382259	152382259	G	T	exonic	ESR1	stopgain	LUAD\|1\|543\|0.00184
-	chr6	152419880	152419880	G	C	exonic	ESR1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	152415692	152415692	C	A	exonic	ESR1	synonymous	LUSC\|1\|178\|0.00562
-	chr6	152332851	152332851	T	A	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152265434	152265434	T	C	exonic	ESR1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	152382165	152382165	C	T	exonic	ESR1	synonymous	BLCA\|1\|396\|0.00253
rs775806382	chr6	152419956	152419956	G	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152163816	152163816	C	A	exonic	ESR1	synonymous	HNSC\|1\|512\|0.00195
rs149800668	chr6	152382210	152382210	G	A	exonic	ESR1	synonymous	UCEC\|1\|248\|0.00403
-	chr6	152265629	152265629	C	A	exonic	ESR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	152265339	152265339	G	T	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152265421	152265421	T	C	exonic	ESR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	152163838	152163838	G	T	exonic	ESR1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	152163775	152163775	G	T	exonic	ESR1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	152265432	152265432	G	T	exonic	ESR1	synonymous	LUSC\|1\|178\|0.00562
rs368367164	chr6	152265432	152265432	G	A	exonic	ESR1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152129129	152129131	CGT	-	exonic	ESR1	nonframeshift	BRCA\|1\|982\|0.00102
rs763337967	chr6	152420001	152420001	C	T	exonic	ESR1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr6	152129337	152129337	-	C	exonic	ESR1	frameshift	HNSC\|1\|512\|0.00195
rs141662120	chr6	152420067	152420067	C	T	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152420037	152420037	C	T	exonic	ESR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	152419922	152419922	T	A	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152129170	152129170	G	T	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152265375	152265375	C	A	exonic	ESR1	synonymous	LUAD\|6\|543\|0.01105
-	chr6	152382174	152382174	G	T	exonic	ESR1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	152419923	152419923	A	C	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152265601	152265601	A	C	exonic	ESR1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	152129107	152129107	G	C	exonic	ESR1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	152265534	152265534	C	A	exonic	ESR1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152332867	152332867	C	T	exonic	ESR1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	152129287	152129287	C	-	exonic	ESR1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152419923	152419923	A	G	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152419869	152419869	A	G	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152265313	152265313	C	T	exonic	ESR1	stopgain	PRAD\|1\|499\|0.00200
rs147982903	chr6	152420002	152420002	G	A	exonic	ESR1	synonymous	PRAD\|1\|499\|0.00200
-	chr6	152265522	152265522	G	-	exonic	ESR1	frameshift	LUSC\|1\|178\|0.00562
rs779180038	chr6	152201873	152201873	C	T	exonic	ESR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	152265482	152265482	C	T	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs761420991	chr6	152129084	152129084	G	A	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs745723014	chr6	152332868	152332868	G	A	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
rs756693212	chr6	152129382	152129382	A	C	exonic	ESR1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr6	152201810	152201810	C	T	exonic	ESR1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	152332911	152332911	C	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152382219	152382219	G	T	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152420078	152420078	G	C	exonic	ESR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	152382234	152382234	C	G	exonic	ESR1	synonymous	BRCA\|1\|982\|0.00102,UCEC\|1\|248\|0.00403
-	chr6	152265569	152265569	C	A	exonic	ESR1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152201872	152201872	C	G	exonic	ESR1	synonymous	ACC\|1\|90\|0.01111
-	chr6	152265466	152265466	G	T	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541
-	chr6	152265553	152265553	C	A	exonic	ESR1	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	152265379	152265379	G	T	exonic	ESR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	152129176	152129176	C	A	exonic	ESR1	stopgain	LIHC\|1\|373\|0.00268
-	chr6	152415519	152415519	G	A	splicing	ESR1	splicing	LIHC\|1\|373\|0.00268
-	chr6	152201865	152201865	G	A	exonic	ESR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152415538	152415538	C	T	exonic	ESR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	152129213	152129213	G	A	exonic	ESR1	nonsynonymous	ESCA\|1\|185\|0.00541
rs761613029	chr6	152201798	152201798	G	A	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152415580	152415580	G	T	exonic	ESR1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	152382134	152382141	GAAAATGT	-	exonic	ESR1	frameshift	UCEC\|1\|248\|0.00403
rs779939957	chr6	152129401	152129401	G	A	exonic	ESR1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	152332874	152332874	C	T	exonic	ESR1	nonsynonymous	LIHC\|1\|373\|0.00268
rs746807379	chr6	152265418	152265418	C	A	exonic	ESR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	152163869	152163869	A	G	exonic	ESR1	nonsynonymous	HNSC\|1\|512\|0.00195
rs375030142	chr6	152265483	152265483	C	T	exonic	ESR1	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs182943916	chr6	152419955	152419955	C	T	exonic	ESR1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs778554662	chr6	152419977	152419977	G	A	exonic	ESR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	152332804	152332804	G	T	exonic	ESR1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	152332850	152332850	A	G	exonic	ESR1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	152382153	152382154	GG	-	exonic	ESR1	frameshift	UCEC\|1\|248\|0.00403
rs777783665	chr6	152382190	152382190	C	T	exonic	ESR1	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of ESR1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ESR1	Adenocarcinoma	C04	Neoplastic Process	CTD_human
ESR1	Alzheimer's Disease	C10;F03	Disease or Syndrome	CTD_human
ESR1	Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Atherosclerosis	C14	Disease or Syndrome	CTD_human
ESR1	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Malignant neoplasm of urinary bladder	C04;C12;C13	Neoplastic Process	CTD_human
ESR1	Bladder Neoplasm	C04;C12;C13	Neoplastic Process	CTD_human
ESR1	Bone Diseases	C05	Disease or Syndrome	CTD_human
ESR1	Metabolic Bone Disorder	C05;C18	Disease or Syndrome	CTD_human
ESR1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CGI;CTD_human;UNIPROT
ESR1	Malignant Neoplasms	C04	Neoplastic Process	CGI
ESR1	Carcinoma	C04	Neoplastic Process	CTD_human
ESR1	Neoplastic Cell Transformation	C04;C23	Neoplastic Process	CTD_human
ESR1	Cervical Migraine Syndrome	C10	Disease or Syndrome	CTD_human
ESR1	Coronary Arteriosclerosis	C14	Disease or Syndrome	CTD_human
ESR1	Presenile dementia	C10;F03	Mental or Behavioral Dysfunction	CTD_human
ESR1	Mental Depression	F01	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Depressive disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Endometrial Neoplasms	C04;C13	Neoplastic Process	CTD_human
ESR1	Feminization	C23	Pathologic Function	CTD_human
ESR1	Glomerulonephritis	C12;C13	Disease or Syndrome	CTD_human
ESR1	Hemicrania migraine	C10	Disease or Syndrome	CTD_human
ESR1	Hypercholesterolemia, Familial	C16;C18	Disease or Syndrome	GENOMICS_ENGLAND
ESR1	Female infertility	C13	Pathologic Function	CTD_human
ESR1	Male infertility	C12	Disease or Syndrome	CTD_human
ESR1	Fibroid Tumor	C04	Neoplastic Process	CTD_human
ESR1	leukemia	C04	Neoplastic Process	CTD_human
ESR1	Liver neoplasms	C04;C06	Neoplastic Process	CTD_human
ESR1	Lung Neoplasms	C04;C08	Neoplastic Process	CTD_human
ESR1	Animal Mammary Neoplasms	C04;C22	Neoplastic Process	CTD_human
ESR1	Mammary Neoplasms, Experimental	C04	Experimental Model of Disease; Neoplastic Process	CTD_human
ESR1	Marijuana Abuse	C25;F03	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Mesothelioma	C04	Neoplastic Process	CTD_human
ESR1	Musculoskeletal Pain	C05;C23	Finding	CTD_human
ESR1	Myocardial Infarction	C14	Disease or Syndrome	CTD_human
ESR1	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
ESR1	Neoplasm Metastasis	C04;C23	Neoplastic Process	CTD_human
ESR1	Neoplasm Recurrence, Local	C04;C23	Neoplastic Process	CTD_human
ESR1	Neuroblastoma	C04	Neoplastic Process	CTD_human
ESR1	Obesity	C18;C23	Disease or Syndrome	CTD_human
ESR1	Oligospermia	C12	Disease or Syndrome	CTD_human
ESR1	Osteogenesis Imperfecta	C05;C16;C17	Congenital Abnormality; Disease or Syndrome	GENOMICS_ENGLAND
ESR1	Osteopenia	C05;C18	Disease or Syndrome	CTD_human
ESR1	Ovarian Carcinoma		Neoplastic Process	CGI
ESR1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
ESR1	Psychoses, Drug	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ESR1	Psychoses, Substance-Induced	C25;F03	Mental or Behavioral Dysfunction	CTD_human
ESR1	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Shared Paranoid Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Sterility, Postpartum	C13	Pathologic Function	CTD_human
ESR1	Uterine Fibroids	C04	Neoplastic Process	CTD_human
ESR1	Migraine Variant	C10	Disease or Syndrome	CTD_human
ESR1	Migraine Disorders	C10	Disease or Syndrome	CTD_human
ESR1	Adenocarcinoma, Basal Cell	C04	Neoplastic Process	CTD_human
ESR1	Adenocarcinoma, Oxyphilic	C04	Neoplastic Process	CTD_human
ESR1	Carcinoma, Cribriform	C04	Neoplastic Process	CTD_human
ESR1	Carcinoma, Granular Cell	C04	Neoplastic Process	CTD_human
ESR1	Adenocarcinoma, Tubular	C04	Neoplastic Process	CTD_human
ESR1	Anaplastic carcinoma	C04	Neoplastic Process	CTD_human
ESR1	Carcinoma, Spindle-Cell	C04	Neoplastic Process	CTD_human
ESR1	Undifferentiated carcinoma	C04	Neoplastic Process	CTD_human
ESR1	Carcinomatosis	C04	Neoplastic Process	CTD_human
ESR1	Subependymal Giant Cell Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Disease Exacerbation	C23	Finding	CTD_human
ESR1	Malignant neoplasm of lung	C04;C08	Neoplastic Process	CTD_human
ESR1	Abdominal Migraine	C10	Disease or Syndrome	CTD_human
ESR1	Familial Alzheimer Disease (FAD)	C10;F03	Disease or Syndrome	CTD_human
ESR1	Juvenile Pilocytic Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Diffuse Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Prostatic Intraepithelial Neoplasias	C04	Neoplastic Process	CTD_human
ESR1	Anaplastic astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Protoplasmic astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Gemistocytic astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Fibrillary Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Pilocytic Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Childhood Cerebral Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Status Migrainosus	C10	Disease or Syndrome	CTD_human
ESR1	Subfertility, Female	C13	Disease or Syndrome	CTD_human
ESR1	Malignant neoplasm of liver	C04;C06	Neoplastic Process	CTD_human
ESR1	Breast Cancer, Familial	C04;C17	Neoplastic Process	GENOMICS_ENGLAND
ESR1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
ESR1	Endometrial Carcinoma	C04;C13	Neoplastic Process	CGI;CTD_human
ESR1	Alzheimer Disease, Late Onset	C10;F03	Mental or Behavioral Dysfunction	CTD_human
ESR1	Neoplasm of uncertain or unknown behavior of ovary		Neoplastic Process	CGI
ESR1	Neoplasm of uncertain or unknown behavior of breast		Neoplastic Process	CGI
ESR1	Acute Confusional Migraine	C10	Disease or Syndrome	CTD_human
ESR1	Mood Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
ESR1	Acute Confusional Senile Dementia	C10;F03	Mental or Behavioral Dysfunction	CTD_human
ESR1	Mixed oligoastrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Breast Carcinoma	C04;C17	Neoplastic Process	CGI;CTD_human
ESR1	Sick Headaches	C10	Disease or Syndrome	CTD_human
ESR1	Alzheimer's Disease, Focal Onset	C10;F03	Mental or Behavioral Dysfunction	CTD_human
ESR1	Alzheimer Disease, Early Onset	C10;F03	Disease or Syndrome	CTD_human
ESR1	Cerebral Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Intracranial Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Subfertility, Male	C12	Sign or Symptom	CTD_human
ESR1	Breast adenocarcinoma		Neoplastic Process	CGI
ESR1	Female sterility	C13	Finding	CTD_human
ESR1	Male sterility	C12	Finding	CTD_human
ESR1	ovarian neoplasm	C04;C13;C19	Neoplastic Process	CGI
ESR1	Malignant neoplasm of ovary	C04;C13;C19	Neoplastic Process	CGI
ESR1	Mammary Carcinoma, Animal	C04;C22	Neoplastic Process	CTD_human
ESR1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
ESR1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
ESR1	Atherogenesis	C14	Pathologic Function	CTD_human
ESR1	Grade I Astrocytoma	C04	Neoplastic Process	CTD_human
ESR1	Bright Disease	C12;C13	Disease or Syndrome	CTD_human
ESR1	Female Urogenital Diseases	C13	Disease or Syndrome	CTD_human
ESR1	Coronary Artery Disease	C14	Disease or Syndrome	CTD_human
ESR1	Liver carcinoma	C04;C06	Neoplastic Process	CTD_human
ESR1	ESTROGEN RESISTANCE		Disease or Syndrome	ORPHANET;UNIPROT
ESR1	MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1		Finding	CTD_human
ESR1	Familial M?ni?re disease		Disease or Syndrome	GENOMICS_ENGLAND

Pathway associated with ESR1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000176	AndrogenReceptor	netpath	167	2267
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0000229	ATF-2 transcription factor network	pid	59	451
pathway0000401	Cellular roles of Anthrax toxin	pid	25	73
pathway0000824	FOXA1 transcription factor network	pid	45	204
pathway0000826	FOXM1 transcription factor network	pid	43	294
pathway0001264	Leptin	netpath	98	1355
pathway0001287	LKB1 signaling events	pid	43	314
pathway0001534	Nuclear Receptor transcription pathway	reactome	51	284
pathway0001535	Nuclear signaling by ERBB4	reactome	25	74
pathway0001674	Plasma membrane estrogen receptor signaling	pid	42	384
pathway0001727	Prolactin	netpath	105	1733
pathway0001849	Regulation of nuclear SMAD2/3 signaling	pid	82	1072
pathway0001861	Regulation of Telomerase	pid	70	708
pathway0002034	Signaling events mediated by HDAC Class II	pid	58	627
pathway0002044	Signaling mediated by p38-alpha and p38-beta	pid	35	174
pathway0002190	Tamoxifen Action Pathway	smpdb	10	30
pathway0002191	Tamoxifen Metabolism Pathway	smpdb	10	30
pathway0002388	Validated nuclear estrogen receptor alpha network	pid	65	386
pathway0002691	Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974	wikipathways	36	219
pathway0002712	Hs_Leptin_signaling_pathway_WP2034_89856	wikipathways	37	264
pathway0002731	Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941	wikipathways	122	1333
pathway0002804	Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687	wikipathways	16	60
pathway0002811	Hs_Estrogen_signaling_pathway_WP712_78491	wikipathways	13	57

Go term information of ESR1

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GO_term_name	GO_term_type	TF_name
GO_MAMMARY_GLAND_MORPHOGENESIS	BP	ESR1
GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY	BP	ESR1
GO_REGULATION_OF_GLUCOSE_IMPORT	BP	ESR1
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	ESR1
GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY	BP	ESR1
GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	ESR1
GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS	BP	ESR1
GO_PROSTATE_GLAND_MORPHOGENESIS	BP	ESR1
GO_CELLULAR_RESPONSE_TO_LIPID	BP	ESR1
GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	ESR1
GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY	BP	ESR1
GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY	BP	ESR1
GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM	BP	ESR1
GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS	BP	ESR1
GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION	BP	ESR1
GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT	BP	ESR1
GO_SERTOLI_CELL_DEVELOPMENT	BP	ESR1
GO_REGULATION_OF_HORMONE_LEVELS	BP	ESR1
GO_OSTEOBLAST_DIFFERENTIATION	BP	ESR1
GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY	BP	ESR1
GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY	BP	ESR1
GO_OVULATION_CYCLE	BP	ESR1
GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS	BP	ESR1
GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION	BP	ESR1
GO_DECIDUALIZATION	BP	ESR1
GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY	BP	ESR1
GO_REGULATION_OF_LIPID_METABOLIC_PROCESS	BP	ESR1
GO_OVARIAN_FOLLICLE_DEVELOPMENT	BP	ESR1
GO_CELLULAR_HORMONE_METABOLIC_PROCESS	BP	ESR1
GO_OVULATION_CYCLE_PROCESS	BP	ESR1
GO_PROTEIN_LOCALIZATION_TO_CHROMATIN	BP	ESR1
GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY	BP	ESR1
GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY	BP	ESR1
GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	ESR1
GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME	BP	ESR1
GO_ORGAN_GROWTH	BP	ESR1
GO_FEMALE_SEX_DIFFERENTIATION	BP	ESR1
GO_MAMMARY_GLAND_DEVELOPMENT	BP	ESR1
GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	ESR1
GO_ANDROGEN_METABOLIC_PROCESS	BP	ESR1
GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING	BP	ESR1
GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY	BP	ESR1
GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT	BP	ESR1
GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY	BP	ESR1
GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY	BP	ESR1
GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS	BP	ESR1
GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT	BP	ESR1
GO_PROSTATE_GLAND_GROWTH	BP	ESR1
GO_OSTEOBLAST_DEVELOPMENT	BP	ESR1
GO_TUBE_MORPHOGENESIS	BP	ESR1
GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS	BP	ESR1
GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS	BP	ESR1
GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY	BP	ESR1
GO_PROSTATE_GLAND_DEVELOPMENT	BP	ESR1
GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY	BP	ESR1
GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING	BP	ESR1
GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION	BP	ESR1
GO_GENITALIA_DEVELOPMENT	BP	ESR1
GO_MATERNAL_PLACENTA_DEVELOPMENT	BP	ESR1
GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT	BP	ESR1
GO_SERTOLI_CELL_DIFFERENTIATION	BP	ESR1
GO_FEMALE_GENITALIA_DEVELOPMENT	BP	ESR1
GO_RESPONSE_TO_ALCOHOL	BP	ESR1
GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS	BP	ESR1
GO_NEGATIVE_REGULATION_OF_GENE_SILENCING	BP	ESR1
GO_AXIS_ELONGATION	BP	ESR1
GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY	BP	ESR1
GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS	BP	ESR1
GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT	BP	ESR1
GO_REGULATION_OF_ORGAN_MORPHOGENESIS	BP	ESR1
GO_REGULATION_OF_CELL_PROLIFERATION	BP	ESR1
GO_UTERUS_DEVELOPMENT	BP	ESR1
GO_REGULATION_OF_GENE_SILENCING	BP	ESR1
GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS	BP	ESR1
GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY	BP	ESR1
GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN	CC	ESR1
GO_PERIKARYON	CC	ESR1
GO_AXON_PART	CC	ESR1
GO_TERMINAL_BOUTON	CC	ESR1
GO_BETA_CATENIN_BINDING	MF	ESR1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	ESR1
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	ESR1
GO_TRANSCRIPTION_COFACTOR_BINDING	MF	ESR1
GO_ATPASE_BINDING	MF	ESR1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	ESR1
GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING	MF	ESR1
GO_TRANSCRIPTION_COACTIVATOR_BINDING	MF	ESR1
GO_CHROMATIN_BINDING	MF	ESR1
GO_GLUTAMATE_RECEPTOR_BINDING	MF	ESR1
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	ESR1

Survival analysis of ESR1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ESR1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)