TF information

TF name: CREB3L1
TF family: TF_bZIP
Ensembl gene ID: ENSG00000157613
Ensembl protein ID: ENSP00000481956, ENSP00000436574
Entrez gene ID: 90993
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of CREB3L1 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_069Cell lineBrainSF2680.053435114503817
Sample_02_205TissueStomachGastric_Primary_Sample_T0.12592592592593
Sample_02_219Cell lineMammary GlandMDA-MB-2310.26470588235294
Sample_02_280Cell lineMammary GlandSUM159_DMSO_24h0.066666666666667
Sample_02_317Cell lineNeuroblastomaGICAN0.067567567567568
Sample_02_361Cell lineColonHT29_DMSO0.1858407079646

CREB3L1 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

CREB3L1 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with CREB3L1
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Mutation of CREB3L1
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of CREB3L1

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr114634191046341910GAexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114633394846333948CAexonicCREB3L1nonsynonymous PRAD|1|499|0.00200
-chr114633268146332681AGexonicCREB3L1nonsynonymous HNSC|1|512|0.00195
-chr114633269046332690GCexonicCREB3L1nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
rs745959450chr114634204546342045GAexonicCREB3L1nonsynonymous PAAD|1|185|0.00541
-chr114634192846341928CTexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114633421946334219GCexonicCREB3L1nonsynonymous BRCA|2|982|0.00204
rs774678396chr114634187146341871CTexonicCREB3L1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr114633259346332593GAexonicCREB3L1synonymous PAAD|1|185|0.00541
-chr114634229446342294TCexonicCREB3L1stoploss UCEC|1|248|0.00403
-chr114633891546338915GAexonicCREB3L1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs181804070chr114632151546321515GAexonicCREB3L1synonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr114633902846339028GAexonicCREB3L1synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr114632943846329438GCexonicCREB3L1nonsynonymous CESC|1|194|0.00515
-chr114633392446333924CTexonicCREB3L1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr114633268746332687AGexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114634192346341923GTexonicCREB3L1nonsynonymous LUAD|1|543|0.00184
rs766233746chr114632948846329488CTexonicCREB3L1synonymous BLCA|1|396|0.00253
-chr114633155446331554GCexonicCREB3L1nonsynonymous ESCA|1|185|0.00541
-chr114633897146338971CAexonicCREB3L1nonsynonymous UCEC|1|248|0.00403
rs376081099chr114633263946332639GAexonicCREB3L1nonsynonymous HNSC|1|512|0.00195
-chr114632150746321507CTexonicCREB3L1nonsynonymous ACC|1|90|0.01111
-chr114629967646299676TCexonicCREB3L1nonsynonymous UCEC|1|248|0.00403
-chr114634207446342074CAexonicCREB3L1nonsynonymous ESCA|1|185|0.00541
-chr114633266846332668CAexonicCREB3L1synonymous UCEC|1|248|0.00403
-chr114632155746321557CAexonicCREB3L1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs368441030chr114634203346342033GAexonicCREB3L1nonsynonymous LUAD|1|543|0.00184
rs559259997chr114633902046339020GAexonicCREB3L1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr114632940046329400ATexonicCREB3L1nonsynonymous LIHC|1|373|0.00268
-chr114633387546333875GTsplicingCREB3L1splicing COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr114633392646333926GAexonicCREB3L1synonymous SARC|1|247|0.00405
-chr114633400746334007GAexonicCREB3L1synonymous SKCM|2|368|0.00543
-chr114634229246342292CTexonicCREB3L1nonsynonymous SKCM|2|368|0.00543
-chr114633397146333971CAexonicCREB3L1synonymous BLCA|1|396|0.00253
-chr114633446846334468CAexonicCREB3L1nonsynonymous LIHC|1|373|0.00268
-chr114633900546339005CAexonicCREB3L1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs748283344chr114633418446334184CTexonicCREB3L1nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr114633401046334010GAexonicCREB3L1synonymous SKCM|2|368|0.00543
-chr114633265446332654CAexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114634225946342259AGsplicingCREB3L1splicing COAD|1|367|0.00272,COADREAD|1|489|0.00204,KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr114632158446321584GCexonicCREB3L1nonsynonymous HNSC|1|512|0.00195
-chr114632948046329480-CexonicCREB3L1frameshift COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr114634185946341859TCexonicCREB3L1nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
rs771754544chr114633265546332655GAexonicCREB3L1nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr114634198446341984CTexonicCREB3L1synonymous PAAD|1|185|0.00541
-chr114632150446321504GTexonicCREB3L1nonsynonymous LUAD|1|543|0.00184
-chr114632950146329501AGexonicCREB3L1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr114632163646321636GAexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114632167846321678CAexonicCREB3L1nonsynonymous CHOL|1|35|0.02857
-chr114634193246341932CTexonicCREB3L1nonsynonymous BRCA|1|982|0.00102
-chr114634183146341831CGexonicCREB3L1synonymous HNSC|1|512|0.00195
rs545047399chr114633269246332692GAexonicCREB3L1synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,OV|1|469|0.00213
-chr114633793746337937GTsplicingCREB3L1splicing OV|1|469|0.00213
rs776390325chr114633260846332608-CexonicCREB3L1frameshift BRCA|1|982|0.00102
-chr114634186246341862GAexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
rs201046043chr114633791046337910GAexonicCREB3L1nonsynonymous HNSC|1|512|0.00195
rs201288428chr114633154646331546GAexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114634187546341875GAexonicCREB3L1nonsynonymous SKCM|1|368|0.00272
-chr114632154946321549AGexonicCREB3L1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs777788054chr114633400546334005CTexonicCREB3L1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs755740355chr114632165646321656CTexonicCREB3L1synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122

Disease information of CREB3L1
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
CREB3L1 Osteogenesis Imperfecta C05;C16;C17 Congenital Abnormality; Disease or Syndrome GENOMICS_ENGLAND
CREB3L1 Osteogenesis imperfecta type III (disorder) C05;C16;C17 Disease or Syndrome ORPHANET
CREB3L1 Fibromyxosarcoma Neoplastic Process ORPHANET

Pathway associated with CREB3L1
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001005 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway panther 126 1529
pathway0002297 Transcription regulation by bZIP transcription factor panther 42 653
pathway0002633 Vasopressin-regulated water reabsorption kegg 35 126
pathway0002797 Hs_Lung_fibrosis_WP3624_91475 wikipathways 23 45

Go term information of CREB3L1
GO_term_name GO_term_type TF_name
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CREB3L1
GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3L1
GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3L1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS BP CREB3L1
GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY BP CREB3L1
GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3L1
GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY BP CREB3L1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS BP CREB3L1
GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY BP CREB3L1
GO_CAMP_RESPONSE_ELEMENT_BINDING MF CREB3L1

Survival analysis of CREB3L1



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of CREB3L1