Cancer CRCdb

TF information

TF name:	BACH1
TF family:	TF_bZIP
Ensembl gene ID:	ENSG00000156273
Ensembl protein ID:	ENSP00000416569, ENSP00000286800, ENSP00000400576, ENSP00000470673, ENSP00000408605, ENSP00000392202, ENSP00000382805
Entrez gene ID:	100379661

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of BACH1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.054794520547945
Sample_02_079	Cell line	Mammary Gland	T-47D_1	1
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.054054054054054
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.26923076923077
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	0.21590909090909

BACH1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_079	Mammary Gland	Cell line	T-47D_1

BACH1 distribution in all CRCs

Genomic distribution of SEs associated with BACH1

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Mutation of BACH1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of BACH1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr21	30699668	30699668	C	T	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30699652	30699652	G	A	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30714912	30714912	A	-	exonic	BACH1	frameshift	THCA\|1\|504\|0.00198
-	chr21	30699058	30699058	G	A	exonic	BACH1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr21	30698572	30698572	A	C	exonic	BACH1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	30699067	30699067	C	-	exonic	BACH1	frameshift	LUAD\|1\|543\|0.00184
rs756562023	chr21	30698948	30698948	C	T	exonic	BACH1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30701994	30701994	G	A	exonic	BACH1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr21	30699682	30699682	G	A	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30699117	30699117	T	G	exonic	BACH1	synonymous	BLCA\|1\|396\|0.00253
rs368476331	chr21	30698863	30698863	C	T	exonic	BACH1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr21	30715097	30715097	T	C	exonic	BACH1	synonymous	LUAD\|1\|543\|0.00184
-	chr21	30714989	30714989	C	T	exonic	BACH1	synonymous	ESCA\|1\|185\|0.00541
-	chr21	30699562	30699562	T	A	exonic	BACH1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	30701962	30701962	G	A	exonic	BACH1	nonsynonymous	LUAD\|1\|543\|0.00184,UCEC\|1\|248\|0.00403
-	chr21	30699416	30699416	G	A	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30699083	30699083	C	A	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30698685	30698685	G	T	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30699050	30699050	A	-	exonic	BACH1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30714991	30714991	G	T	exonic	BACH1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	30714963	30714963	G	T	exonic	BACH1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr21	30715062	30715062	G	T	exonic	BACH1	stopgain	OV\|1\|469\|0.00213
-	chr21	30699077	30699077	A	G	exonic	BACH1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30699198	30699198	G	T	exonic	BACH1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	30698621	30698621	T	G	exonic	BACH1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr21	30699365	30699365	G	A	exonic	BACH1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	30698591	30698591	A	G	exonic	BACH1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr21	30714787	30714787	A	G	exonic	BACH1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	30699094	30699114	CCTCATGGACTTTATTCTTTG	-	exonic	BACH1	nonframeshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs553355487	chr21	30698864	30698864	G	A	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30701856	30701856	G	T	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30701833	30701833	G	A	exonic	BACH1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	30699100	30699100	G	T	exonic	BACH1	stopgain	LUAD\|1\|543\|0.00184
-	chr21	30699670	30699670	G	A	exonic	BACH1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr21	30698986	30698986	G	A	exonic	BACH1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCEC\|2\|248\|0.00806
-	chr21	30699119	30699119	T	-	exonic	BACH1	frameshift	LIHC\|1\|373\|0.00268
-	chr21	30714928	30714928	G	T	exonic	BACH1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr21	30698924	30698924	A	-	exonic	BACH1	frameshift	ESCA\|1\|185\|0.00541
-	chr21	30698598	30698598	G	T	exonic	BACH1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr21	30699208	30699208	G	A	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30693606	30693606	C	G	exonic	BACH1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr21	30699613	30699613	G	C	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30715070	30715070	T	C	exonic	BACH1	synonymous	UCEC\|1\|248\|0.00403
-	chr21	30714868	30714868	C	T	exonic	BACH1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	30693720	30693720	T	C	exonic	BACH1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr21	30699037	30699037	C	T	exonic	BACH1	stopgain	HNSC\|1\|512\|0.00195
-	chr21	30693704	30693704	G	T	exonic	BACH1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr21	30698862	30698862	C	T	exonic	BACH1	synonymous	SKCM\|1\|368\|0.00272
-	chr21	30701924	30701925	AA	-	exonic	BACH1	frameshift	ACC\|1\|90\|0.01111,UCEC\|1\|248\|0.00403
-	chr21	30693790	30693790	C	G	exonic	BACH1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	30699589	30699589	G	C	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30698548	30698548	G	A	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30699086	30699086	C	T	exonic	BACH1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr21	30693685	30693685	G	A	exonic	BACH1	synonymous	SKCM\|1\|368\|0.00272
-	chr21	30698828	30698828	G	T	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30699407	30699407	C	T	exonic	BACH1	nonsynonymous	BRCA\|1\|982\|0.00102
rs778585049	chr21	30715063	30715063	A	G	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30715103	30715103	G	T	exonic	BACH1	synonymous	ESCA\|1\|185\|0.00541
rs753679298	chr21	30693751	30693751	C	T	exonic	BACH1	synonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30701862	30701862	C	G	exonic	BACH1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	30698823	30698823	A	G	exonic	BACH1	synonymous	LIHC\|1\|373\|0.00268
-	chr21	30699316	30699316	C	T	exonic	BACH1	stopgain	BRCA\|1\|982\|0.00102
-	chr21	30698920	30698920	T	C	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
rs748491382	chr21	30699443	30699443	C	G	exonic	BACH1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr21	30693778	30693778	C	T	exonic	BACH1	synonymous	SKCM\|1\|368\|0.00272
-	chr21	30714831	30714831	C	G	exonic	BACH1	nonsynonymous	CESC\|1\|194\|0.00515
rs149732438	chr21	30693752	30693752	G	A	exonic	BACH1	nonsynonymous	THCA\|1\|504\|0.00198
-	chr21	30701998	30701998	C	A	exonic	BACH1	stopgain	LIHC\|1\|373\|0.00268
-	chr21	30699587	30699588	AT	-	exonic	BACH1	frameshift	UCEC\|1\|248\|0.00403
-	chr21	30698866	30698866	A	-	exonic	BACH1	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr21	30693729	30693729	A	G	exonic	BACH1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,UCEC\|1\|248\|0.00403
rs35766001	chr21	30699557	30699557	G	C	exonic	BACH1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr21	30699110	30699110	C	G	exonic	BACH1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr21	30699649	30699649	G	A	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30698954	30698954	G	A	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30693795	30693795	G	T	exonic	BACH1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr21	30698503	30698503	G	T	exonic	BACH1	stopgain	LUAD\|1\|543\|0.00184
-	chr21	30693736	30693736	C	T	exonic	BACH1	synonymous	HNSC\|1\|512\|0.00195,SKCM\|1\|368\|0.00272
-	chr21	30699664	30699664	G	C	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30693761	30693761	G	A	exonic	BACH1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr21	30698939	30698939	G	A	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs575274878	chr21	30715020	30715020	G	A	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30699513	30699513	A	-	exonic	BACH1	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	30699370	30699370	G	A	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30693789	30693789	T	A	exonic	BACH1	nonsynonymous	SKCM\|1\|368\|0.00272
rs748639705	chr21	30698571	30698571	A	-	exonic	BACH1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs773339742	chr21	30715090	30715090	G	A	exonic	BACH1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30699241	30699241	G	A	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
rs111499444	chr21	30698587	30698587	T	C	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30701858	30701858	T	-	exonic	BACH1	frameshift	LIHC\|1\|373\|0.00268
rs377002114	chr21	30715024	30715024	G	A	exonic	BACH1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355,SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr21	30701983	30701983	T	C	exonic	BACH1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30698633	30698633	G	T	exonic	BACH1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	30699099	30699099	T	G	exonic	BACH1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	30699008	30699008	C	A	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	30699435	30699435	G	T	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs763385315	chr21	30693632	30693632	T	C	exonic	BACH1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr21	30714967	30714967	G	A	exonic	BACH1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30714889	30714889	C	T	exonic	BACH1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr21	30699390	30699390	G	T	exonic	BACH1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	30714966	30714966	C	A	exonic	BACH1	synonymous	LAML\|1\|197\|0.00508
-	chr21	30699274	30699274	G	T	exonic	BACH1	stopgain	THYM\|1\|123\|0.00813
-	chr21	30699014	30699014	A	-	exonic	BACH1	frameshift	THCA\|1\|504\|0.00198
-	chr21	30693734	30693734	T	C	exonic	BACH1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	30699313	30699313	G	C	exonic	BACH1	nonsynonymous	THYM\|1\|123\|0.00813
-	chr21	30701851	30701851	G	A	exonic	BACH1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820,UCEC\|1\|248\|0.00403
-	chr21	30701893	30701893	C	A	exonic	BACH1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	30698588	30698588	C	T	exonic	BACH1	nonsynonymous	CESC\|1\|194\|0.00515

Disease information of BACH1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with BACH1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000267	BARD1 signaling events	pid	29	239
pathway0001236	Kaposi sarcoma-associated herpesvirus	mirtarbase	13	2
pathway0002751	Hs_Integrated_Cancer_Pathway_WP1971_82939	wikipathways	33	206

Go term information of BACH1

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GO_term_name	GO_term_type	TF_name
GO_CELL_CYCLE_G1_S_PHASE_TRANSITION	BP	BACH1
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA	BP	BACH1
GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE	BP	BACH1
GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY	MF	BACH1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	BACH1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	BACH1
GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	MF	BACH1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	BACH1
GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	BACH1

Survival analysis of BACH1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of BACH1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)