Pathway name:

EPHB forward signaling

Aging Type:

Prevent

Aging characteristic:

delay aging

Category:

pathway

Phenotype:

Aging

Experimental category:

L

Tissue type:

--

Cell name:

UCB-MSC

PMID:

28687409

Experiment:

SA-β-gal activity assay//Western blot

Description:

Compared to the IgG-Fc-treated control group, the EphrinB2-Fc treatments notably decreased the level of SA-β-gal activity,known to be a senescence marker . Consistent with this,EphrinB2-Fc reduced the expression of senescence markers p16 and p21 in a time-dependent manner (0–24 h) , whereas IgG-Fc had no effect on the expression levels of p16 and p21.

Pathway Network

Pathway name	Pathway source	Gene number	Edge number	Geneset
EPHB forward signaling	pid	40	399	CDC42;CRK;DNM1;EFNA5;EFNB1;EFNB2;EFNB3;EPHB1;EPHB2;EPHB3;EPHB4;GRB2;GRB7;HRAS;ITSN1;KALRN;KRAS;MAP2K1;MAP4K4;MAPK1;MAPK3;NCK1;NRAS;PAK1;PIK3CA;PIK3R1;PTK2;PXN;RAC1;RAP1A;RAP1B;RASA1;ROCK1;RRAS;SH3GL2;SHC1;SRC;SYNJ1;TF;WASL