Pathway name:

p53 signaling pathway

Aging Type:

Accelerate

Aging characteristic:

cellular senescence

Category:

pathway

Phenotype:

Systemic lupus erythematosus

Experimental category:

L

Tissue type:

Bone Marrow

Cell name:

BM-MSC

PMID:

24151513

Experiment:

Western blot//SA-β-gal activity assay//Colony formation assay

Description:

We found that the expressions of p53 and p21 were increased in the BM-MSCs from SLE patients.MSCs declined by about a quarter in SLE patients compared to normal group , P < 0.05) indicating that the capability of replicating and forming colonies of BM-MSCs from SLE patients were decreased. Furthermore, we have found that the number of SA-β-gal-positive cells was notably increased in BM-MSCs from SLE patients, which was used to examine MSCs senescence.

Pathway Network

Pathway name	Pathway source	Gene number	Edge number	Geneset
p53 signaling pathway	kegg	66	297	SESN2;RFWD2;MDM4;CASP9;GADD45A;SFN;TP73;RPRM;STEAP3;TP53I3;RRM2;CASP8;SHISA5;ATR;ZMAT3;CCNG2;RCHY1;CASP3;CCNG1;CCNB1;CCND3;PERP;CDKN1A;SESN1;CYCS;SERPINE1;IGFBP3;CDK6;BAI1;CCNE2;RRM2B;GADD45G;CDKN2A;FAS;CDK1;PTEN;CCNB3;EI24;LRDD;ATM;TP53AIP1;DDB2;CHEK1;SESN3;CD82;CCND1;CCND2;CDK4;IGF1;CDK2;APAF1;MDM2;CCNB2;SIAH1;TSC2;PPM1D;TP53;SERPINB5;PMAIP1;GADD45B;CCNE1;BAX;BBC3;CHEK2;GTSE1;BID