Pathway name: | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 |
Aging Type: | Inhibit |
Aging characteristic: | cellular senescence |
Category: | pathway |
Phenotype: | Breast cancer |
Experiment: | SA-β-gal activity assay |
Description: | Interestingly, constitutive activation of Akt-1 in the drug resistant cells [MCF7/△Akt-1(CA)DoxR] resulted in the complete abrogation of drug-induced senescence at all doses examined (Panel D), suggesting an interplay between active Akt-1 and other resistance mechanisms acquired by the MCF7/DoxR cells. |
Pathway name | Pathway source | Gene number | Edge number | Geneset |
---|---|---|---|---|
Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 | 14 | RAF1;ELAVL1;HIF1A;GSK3B;MAPK1;PRKCB;RUNX2;CRK |