TF information

TF name: ZBTB16
TF family: ZBTB
Ensembl gene ID: ENSG00000109906
Ensembl protein ID: ENSP00000376721, ENSP00000376721, ENSP00000338157, ENSP00000338157
Entrez gene ID: 7704
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of ZBTB16 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_022Cell lineProstateC4-2B0.76190476190476
Sample_01_068Cell lineProstate: derived from metastatic site: vertebral metastasisVCaP0.52054794520548
Sample_02_168Cell lineProstateLNCaP0.34980988593156
Sample_02_285Cell lineLiverHuH7_untreat0.25087108013937
Sample_02_413TissueBrainGBM_24930.70879120879121

ZBTB16 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_01_022ProstateCell lineC4-2B
Sample_02_413BrainTissueGBM_2493

ZBTB16 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with ZBTB16
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Mutation of ZBTB16
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ZBTB16

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr11114112945114112945GAexonicZBTB16nonsynonymous PRAD|1|499|0.00200
rs767860341chr11114121138114121138CTexonicZBTB16nonsynonymous LUSC|1|178|0.00562
-chr11113934436113934436CAexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11114112918114112918TGexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs370480903chr11113934420113934420CTexonicZBTB16nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr11114121139114121139GTexonicZBTB16synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs778496413chr11114118068114118068GAexonicZBTB16synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11114121265114121265GTexonicZBTB16synonymous LUSC|1|178|0.00562
-chr11114121101114121101GTexonicZBTB16nonsynonymous TGCT|1|155|0.00645
-chr11114027098114027098CTexonicZBTB16synonymous SKCM|1|368|0.00272
rs757004570chr11114121229114121229GAexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11113934754113934754GCexonicZBTB16nonsynonymous LUAD|1|543|0.00184
-chr11114112895114112895AGexonicZBTB16nonsynonymous LIHC|1|373|0.00268
-chr11114121125114121125CTexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11113934830113934830GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113935017113935017GTexonicZBTB16nonsynonymous CESC|1|194|0.00515
-chr11113934819113934819GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934211113934211CTexonicZBTB16synonymous BLCA|1|396|0.00253
-chr11114121090114121090GTexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934493113934493CTexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11114118080114118080GAexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11113935031113935031TGexonicZBTB16nonsynonymous BRCA|1|982|0.00102
-chr11114112908114112908CTexonicZBTB16synonymous SKCM|2|368|0.00543
-chr11113934839113934839GAexonicZBTB16nonsynonymous CESC|1|194|0.00515
-chr11114112974114112974GAexonicZBTB16synonymous ESCA|1|185|0.00541
rs751396403chr11113934707113934707CTexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11114113047114113047CTexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934100113934100GCexonicZBTB16nonsynonymous BLCA|1|396|0.00253
-chr11114121049114121049TGexonicZBTB16synonymous BRCA|1|982|0.00102
-chr11114113048114113048GTexonicZBTB16nonsynonymous LUAD|2|543|0.00368
-chr11113934179113934179GAexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114112919114112919-TexonicZBTB16frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11114121244114121244ATexonicZBTB16synonymous CHOL|1|35|0.02857
-chr11114027126114027126CTexonicZBTB16nonsynonymous PAAD|1|185|0.00541
-chr11113934218113934218AGexonicZBTB16nonsynonymous LUSC|1|178|0.00562
-chr11114121062114121062GCexonicZBTB16nonsynonymous HNSC|1|512|0.00195
-chr11114057740114057740CGexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114112981114112981CTexonicZBTB16nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189,STAD|1|395|0.00253,STES|1|395|0.00253
rs753894958chr11114112956114112956GAexonicZBTB16synonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr11113934272113934272CGexonicZBTB16nonsynonymous LUAD|1|543|0.00184
rs779712380chr11113935256113935256GAexonicZBTB16nonsynonymous BRCA|1|982|0.00102
-chr11114057674114057674CTexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11113934508113934508CTexonicZBTB16synonymous SKCM|1|368|0.00272
rs753220958chr11113934474113934474GAexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934258113934258CGexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs750494052chr11113935103113935103GTexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs764601942chr11113934214113934214CTexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11114118040114118040AGexonicZBTB16nonsynonymous ESCA|2|185|0.01081
-chr11114113012114113012CAexonicZBTB16nonsynonymous LUSC|1|178|0.00562
-chr11114121118114121118GTexonicZBTB16synonymous LUAD|1|543|0.00184
-chr11113934279113934279AGexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11114112921114112921G-exonicZBTB16frameshift LUSC|1|178|0.00562
-chr11113934884113934884GAexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs771820953chr11113934498113934498CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934368113934368GAexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11113934832113934832CAexonicZBTB16nonsynonymous OV|1|469|0.00213
-chr11113934295113934295GTexonicZBTB16synonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr11113934741113934741AGexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11113934217113934217CTexonicZBTB16synonymous OV|1|469|0.00213
rs772815592chr11113934978113934978GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934373113934373GAexonicZBTB16synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114113007114113007CTexonicZBTB16synonymous LIHC|1|373|0.00268
-chr11113935271113935271GAexonicZBTB16nonsynonymous HNSC|1|512|0.00195,SKCM|1|368|0.00272
-chr11114113009114113009GCexonicZBTB16nonsynonymous LUAD|1|543|0.00184
-chr11113934832113934832CTexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11113934923113934923GAexonicZBTB16nonsynonymous CESC|1|194|0.00515
-chr11113934320113934320GCexonicZBTB16nonsynonymous BLCA|1|396|0.00253
-chr11114121168114121168AGexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934842113934842GTexonicZBTB16stopgain COADREAD|1|489|0.00204,READ|1|122|0.00820
rs148436647chr11114027086114027086CTexonicZBTB16synonymous DLBC|1|48|0.02083
rs765990632chr11114121187114121187CTexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11113935219113935219CTexonicZBTB16synonymous BRCA|1|982|0.00102
-chr11114118040114118040ACexonicZBTB16nonsynonymous ESCA|1|185|0.00541,STAD|2|395|0.00506,STES|2|395|0.00506
-chr11113935191113935191ATexonicZBTB16nonsynonymous LUAD|1|543|0.00184
-chr11113934462113934462AGexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113935122113935122ACexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11114113010114113010CTexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11114121133114121133CTexonicZBTB16synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11113934449113934449GTexonicZBTB16stopgain LUAD|1|543|0.00184
-chr11113934445113934445GTexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11113934591113934591CAexonicZBTB16stopgain UCEC|1|248|0.00403
-chr11114117961114117961CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
rs762592730chr11114113009114113009GAexonicZBTB16nonsynonymous HNSC|1|512|0.00195,STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114118002114118002GAexonicZBTB16synonymous ESCA|1|185|0.00541
-chr11113934918113934918GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113935071113935071CTexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934854113934854GCexonicZBTB16nonsynonymous BLCA|1|396|0.00253
-chr11113935159113935159CTexonicZBTB16synonymous BLCA|1|396|0.00253
rs200705288chr11113935069113935069GAexonicZBTB16synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,UCEC|1|248|0.00403
rs368971745chr11113934559113934559CTexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11114057690114057690TCexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11113934619113934619CAexonicZBTB16synonymous ESCA|1|185|0.00541,LUAD|1|543|0.00184
-chr11114113039114113039GAexonicZBTB16nonsynonymous PRAD|1|499|0.00200
-chr11114121132114121132GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272
rs758738597chr11114112978114112978GAexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs538741723chr11114027087114027087GAexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11114121089114121089CTexonicZBTB16nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
rs866604032chr11113934591113934591CTexonicZBTB16nonsynonymous LUSC|1|178|0.00562
-chr11113935185113935185-GexonicZBTB16frameshift LUAD|1|543|0.00184
-chr11114118019114118019AGexonicZBTB16nonsynonymous DLBC|1|48|0.02083
-chr11113935103113935103GAexonicZBTB16nonsynonymous ESCA|1|185|0.00541
rs116547293chr11114057705114057705CTexonicZBTB16synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11113934034113934034A-exonicZBTB16frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11114121233114121233GAexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934842113934842GAexonicZBTB16nonsynonymous SKCM|2|368|0.00543
-chr11114121253114121253GAexonicZBTB16synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253
rs755612134chr11113934410113934410GAexonicZBTB16nonsynonymous BLCA|2|396|0.00505
rs748787166chr11114113008114113008CTexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs753518284chr11114118017114118017CTexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11113934981113934981CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934732113934732GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272
rs776974563chr11114027138114027138CTexonicZBTB16nonsynonymous HNSC|1|512|0.00195
-chr11114117978114117978CAexonicZBTB16synonymous HNSC|1|512|0.00195
-chr11113934823113934823GAexonicZBTB16synonymous SKCM|1|368|0.00272
rs754172517chr11113934215113934215CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934475113934475GAexonicZBTB16synonymous BLCA|1|396|0.00253
-chr11113934891113934891CTexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934564113934564TGexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11114117945114117945CAexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr11113934125113934125GAexonicZBTB16nonsynonymous SKCM|1|368|0.00272,STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114112927114112927CTexonicZBTB16nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr11114121182114121182TAexonicZBTB16nonsynonymous DLBC|1|48|0.02083
-chr11113934249113934249CTexonicZBTB16nonsynonymous SARC|1|247|0.00405
-chr11113934865113934865GTexonicZBTB16synonymous HNSC|1|512|0.00195
-chr11113934906113934906TAexonicZBTB16nonsynonymous HNSC|1|512|0.00195
rs201532309chr11114121232114121232CTexonicZBTB16synonymous UCEC|1|248|0.00403
-chr11113935030113935030GCexonicZBTB16synonymous LUAD|1|543|0.00184
-chr11114027082114027082CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934393113934393CAexonicZBTB16nonsynonymous LIHC|1|373|0.00268
-chr11114027108114027108CAexonicZBTB16synonymous HNSC|1|512|0.00195
rs761753131chr11114057719114057719CTexonicZBTB16nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820,UCEC|1|248|0.00403
-chr11113934294113934294CTexonicZBTB16nonsynonymous BRCA|1|982|0.00102,COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs774040543chr11114112937114112937CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934870113934870CTexonicZBTB16nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs200027612chr11113934355113934355CAexonicZBTB16synonymous HNSC|1|512|0.00195
-chr11114112944114112944CGexonicZBTB16nonsynonymous LUAD|1|543|0.00184
-chr11113934758113934758AGexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934573113934573GAexonicZBTB16nonsynonymous PAAD|1|185|0.00541
-chr11113934379113934379GAexonicZBTB16synonymous LUAD|1|543|0.00184
-chr11113934829113934829GAexonicZBTB16synonymous SKCM|1|368|0.00272
-chr11113934299113934299-AexonicZBTB16frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114118039114118039AGexonicZBTB16nonsynonymous PRAD|1|499|0.00200
-chr11113934732113934732GTexonicZBTB16nonsynonymous LUAD|1|543|0.00184
-chr11114118013114118013CTexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934796113934796GAexonicZBTB16synonymous SKCM|2|368|0.00543
rs797011179chr11114027109114027109GAexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11114121202114121202GAexonicZBTB16nonsynonymous HNSC|1|512|0.00195
-chr11114113003114113003GCexonicZBTB16nonsynonymous CESC|1|194|0.00515
-chr11113934110113934110GAexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11113935245113935245TAexonicZBTB16nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr11113934657113934657CTexonicZBTB16nonsynonymous SKCM|1|368|0.00272
-chr11113934930113934930CTexonicZBTB16nonsynonymous UCEC|1|248|0.00403
-chr11113934661113934661CGexonicZBTB16synonymous HNSC|1|512|0.00195
-chr11114027093114027093GAexonicZBTB16nonsynonymous ESCA|1|185|0.00541
-chr11114121046114121046AGsplicingZBTB16splicing UCEC|1|248|0.00403
-chr11114121088114121088CAexonicZBTB16synonymous HNSC|1|512|0.00195

Disease information of ZBTB16
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
ZBTB16 Acute Promyelocytic Leukemia C04 Neoplastic Process CTD_human;ORPHANET
ZBTB16 Neoplasm Invasiveness C04;C23 Pathologic Function CTD_human
ZBTB16 Prostatic Neoplasms C04;C12 Neoplastic Process CTD_human
ZBTB16 Unipolar Depression F03 Mental or Behavioral Dysfunction PSYGENET
ZBTB16 Malignant neoplasm of prostate C04;C12 Neoplastic Process CTD_human
ZBTB16 Major Depressive Disorder F03 Mental or Behavioral Dysfunction PSYGENET
ZBTB16 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma C04;C15;C20 Neoplastic Process ORPHANET
ZBTB16 Skeletal Defects, Genital Hypoplasia, And Mental Retardation C05;C10;C12;C16;C19;C23;F01;F03 Disease or Syndrome CTD_human;UNIPROT
ZBTB16 Intellectual Disability C10;C23;F01;F03 Mental or Behavioral Dysfunction GENOMICS_ENGLAND

Pathway associated with ZBTB16
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0002668 Acute myeloid leukemia kegg 53 562
pathway0002841 Hs_Ectoderm_Differentiation_WP2858_89329 wikipathways 56 137

Go term information of ZBTB16
GO_term_name GO_term_type TF_name
GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION BP ZBTB16
GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION BP ZBTB16
GO_CARTILAGE_DEVELOPMENT BP ZBTB16
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT BP ZBTB16
GO_HINDLIMB_MORPHOGENESIS BP ZBTB16
GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION BP ZBTB16
GO_FORELIMB_MORPHOGENESIS BP ZBTB16
GO_ASYMMETRIC_CELL_DIVISION BP ZBTB16
GO_STEM_CELL_DIVISION BP ZBTB16
GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS BP ZBTB16
GO_APPENDAGE_DEVELOPMENT BP ZBTB16
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION BP ZBTB16
GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION BP ZBTB16
GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS BP ZBTB16
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT BP ZBTB16
GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS BP ZBTB16
GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION BP ZBTB16
GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION BP ZBTB16
GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION BP ZBTB16
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION BP ZBTB16
GO_MESONEPHROS_DEVELOPMENT BP ZBTB16
GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION BP ZBTB16
GO_REGULATION_OF_OSSIFICATION BP ZBTB16
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING MF ZBTB16
GO_PROTEIN_C_TERMINUS_BINDING MF ZBTB16
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING MF ZBTB16
GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING MF ZBTB16

Survival analysis of ZBTB16



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of ZBTB16