Cancer CRCdb

TF information

TF name:	POU3F2
TF family:	Pou
Ensembl gene ID:	ENSG00000184486
Ensembl protein ID:	ENSP00000329170
Entrez gene ID:	5454

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of POU3F2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_069	Cell line	Brain	SF268	0.87022900763359
Sample_02_250	Tissue	Brain	tumormodel3691	0.875
Sample_02_413	Tissue	Brain	GBM_2493	0.8021978021978

POU3F2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_069	Brain	Cell line	SF268
Sample_02_250	Brain	Tissue	tumormodel3691
Sample_02_413	Brain	Tissue	GBM_2493

POU3F2 distribution in all CRCs

Genomic distribution of SEs associated with POU3F2

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Mutation of POU3F2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of POU3F2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs773452318	chr6	99283509	99283509	G	A	exonic	POU3F2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	99283725	99283725	C	T	exonic	POU3F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	99283090	99283090	G	A	exonic	POU3F2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	99283794	99283794	G	A	exonic	POU3F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	99284028	99284028	G	-	exonic	POU3F2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	99283807	99283807	G	A	exonic	POU3F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283695	99283695	C	A	exonic	POU3F2	nonsynonymous	LUAD\|1\|543\|0.00184
rs195860	chr6	99283376	99283376	T	G	exonic	POU3F2	synonymous	ACC\|19\|90\|0.21111
-	chr6	99283172	99283172	-	AG	exonic	POU3F2	frameshift	PAAD\|1\|185\|0.00541
-	chr6	99283906	99283906	C	-	exonic	POU3F2	frameshift	LIHC\|1\|373\|0.00268
-	chr6	99282842	99282842	G	-	exonic	POU3F2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	99283256	99283256	G	C	exonic	POU3F2	synonymous	BRCA\|1\|982\|0.00102
-	chr6	99283696	99283696	T	A	exonic	POU3F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	99283560	99283560	G	A	exonic	POU3F2	nonsynonymous	BLCA\|1\|396\|0.00253,SARC\|1\|247\|0.00405
-	chr6	99283761	99283761	T	A	exonic	POU3F2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	99283474	99283474	C	T	exonic	POU3F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99282855	99282855	G	C	exonic	POU3F2	nonsynonymous	LUSC\|1\|178\|0.00562
rs751058060	chr6	99283616	99283616	G	A	exonic	POU3F2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|2\|512\|0.00391
-	chr6	99283482	99283482	C	T	exonic	POU3F2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	99283793	99283793	C	T	exonic	POU3F2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	99283537	99283537	A	G	exonic	POU3F2	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	99282904	99282904	G	T	exonic	POU3F2	nonsynonymous	LUAD\|1\|543\|0.00184
rs749593813	chr6	99283832	99283832	C	A	exonic	POU3F2	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	99283822	99283822	G	A	exonic	POU3F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	99283457	99283457	C	A	exonic	POU3F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	99282803	99282803	C	A	exonic	POU3F2	synonymous	ESCA\|2\|185\|0.01081
-	chr6	99283871	99283871	C	G	exonic	POU3F2	synonymous	HNSC\|1\|512\|0.00195
-	chr6	99283852	99283852	C	T	exonic	POU3F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	99283812	99283812	C	T	exonic	POU3F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	99283859	99283859	G	T	exonic	POU3F2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	99282792	99282792	A	G	exonic	POU3F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283810	99283810	A	C	exonic	POU3F2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr6	99283635	99283635	G	A	exonic	POU3F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283224	99283224	G	A	exonic	POU3F2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	99282855	99282855	G	A	exonic	POU3F2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	99283557	99283557	C	T	exonic	POU3F2	synonymous	SKCM\|1\|368\|0.00272
rs779168236	chr6	99284012	99284012	C	T	exonic	POU3F2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99282855	99282855	G	T	exonic	POU3F2	stopgain	HNSC\|1\|512\|0.00195
-	chr6	99283682	99283682	T	A	exonic	POU3F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283976	99283976	G	T	exonic	POU3F2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	99283990	99283990	C	T	exonic	POU3F2	nonsynonymous	BLCA\|1\|396\|0.00253,LIHC\|1\|373\|0.00268
-	chr6	99283608	99283608	A	G	exonic	POU3F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	99282917	99282917	C	A	exonic	POU3F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	99283888	99283888	C	A	exonic	POU3F2	stopgain	CESC\|1\|194\|0.00515
-	chr6	99283174	99283175	AG	-	exonic	POU3F2	frameshift	THYM\|1\|123\|0.00813
-	chr6	99283622	99283622	G	-	exonic	POU3F2	frameshift	HNSC\|1\|512\|0.00195
-	chr6	99283514	99283514	C	A	exonic	POU3F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	99283620	99283620	G	A	exonic	POU3F2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	99283719	99283719	C	T	exonic	POU3F2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCS\|1\|57\|0.01754
-	chr6	99283523	99283523	G	A	exonic	POU3F2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283814	99283814	G	A	exonic	POU3F2	synonymous	SARC\|1\|247\|0.00405
-	chr6	99283591	99283591	G	A	exonic	POU3F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283464	99283465	CC	-	exonic	POU3F2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283169	99283169	-	C	exonic	POU3F2	frameshift	UCEC\|1\|248\|0.00403
-	chr6	99283815	99283815	A	-	exonic	POU3F2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283427	99283427	C	-	exonic	POU3F2	frameshift	HNSC\|1\|512\|0.00195
-	chr6	99283859	99283859	G	C	exonic	POU3F2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	99283806	99283806	C	T	exonic	POU3F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	99283974	99283974	G	T	exonic	POU3F2	stopgain	UCEC\|1\|248\|0.00403
-	chr6	99283803	99283803	G	A	exonic	POU3F2	nonsynonymous	SKCM\|1\|368\|0.00272
rs763454533	chr6	99282812	99282812	C	T	exonic	POU3F2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	99283412	99283412	G	T	exonic	POU3F2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	99283327	99283327	C	A	exonic	POU3F2	nonsynonymous	LUSC\|1\|178\|0.00562
rs761254912	chr6	99284000	99284000	G	T	exonic	POU3F2	synonymous	LUSC\|1\|178\|0.00562
-	chr6	99283767	99283767	G	T	exonic	POU3F2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	99282950	99282951	CG	-	exonic	POU3F2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	99283841	99283841	C	T	exonic	POU3F2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of POU3F2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
POU3F2	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET

Pathway associated with POU3F2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of POU3F2

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GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION	BP	POU3F2
GO_PITUITARY_GLAND_DEVELOPMENT	BP	POU3F2
GO_CELL_PROLIFERATION_IN_FOREBRAIN	BP	POU3F2
GO_FOREBRAIN_DEVELOPMENT	BP	POU3F2
GO_FOREBRAIN_CELL_MIGRATION	BP	POU3F2
GO_HYPOTHALAMUS_DEVELOPMENT	BP	POU3F2
GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	POU3F2
GO_CEREBRAL_CORTEX_DEVELOPMENT	BP	POU3F2
GO_ENSHEATHMENT_OF_NEURONS	BP	POU3F2
GO_PALLIUM_DEVELOPMENT	BP	POU3F2
GO_ASTROCYTE_DIFFERENTIATION	BP	POU3F2
GO_EPIDERMIS_DEVELOPMENT	BP	POU3F2
GO_POSITIVE_REGULATION_OF_GROWTH	BP	POU3F2
GO_DIENCEPHALON_DEVELOPMENT	BP	POU3F2
GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT	BP	POU3F2
GO_SCHWANN_CELL_DEVELOPMENT	BP	POU3F2
GO_SCHWANN_CELL_DIFFERENTIATION	BP	POU3F2
GO_CEREBRAL_CORTEX_CELL_MIGRATION	BP	POU3F2
GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION	BP	POU3F2
GO_TELENCEPHALON_DEVELOPMENT	BP	POU3F2
GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	POU3F2
GO_LIMBIC_SYSTEM_DEVELOPMENT	BP	POU3F2
GO_REGULATION_OF_CELL_PROLIFERATION	BP	POU3F2
GO_ASTROCYTE_DEVELOPMENT	BP	POU3F2
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	POU3F2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	POU3F2
GO_IDENTICAL_PROTEIN_BINDING	MF	POU3F2
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	POU3F2

Survival analysis of POU3F2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of POU3F2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)