1. TF detail

TF information

TF name: MAX
TF family: bHLH
Ensembl gene ID: ENSG00000125952
Ensembl protein ID: ENSP00000452197, ENSP00000452378, ENSP00000342482, ENSP00000378104, ENSP00000480127, ENSP00000451907, ENSP00000351175, ENSP00000450818, ENSP00000452286, ENSP00000284165, ENSP00000246163, ENSP00000351490
Entrez gene ID: 4149
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:
Frequency of MAX in all biosamples
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Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_046Cell lineMammary GlandMCF-70.8
Sample_02_096Cell lineMammary GlandZR-75-1_10.96739130434783
Sample_02_115Cell lineMammary GlandMCF-71
Sample_02_168Cell lineProstateLNCaP0.14828897338403
Sample_02_195Cell lineStomachOCUM11
Sample_02_196Cell lineStomachNCC590.14285714285714
Sample_02_219Cell lineMammary GlandMDA-MB-2310.44117647058824
Sample_02_236Cell lineColonV2060.50931677018634
Sample_02_242Cell lineColonV4810.49403960776774
MAX distribution in samples’ most representative CRC
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Sample ID Tissue type Biosample type Biosample name
Sample_01_046Mammary GlandCell lineMCF-7
Sample_02_096Mammary GlandCell lineZR-75-1_1
Sample_02_115Mammary GlandCell lineMCF-7
Sample_02_195StomachCell lineOCUM1
Sample_02_196StomachCell lineNCC59
Sample_02_236ColonCell lineV206
Sample_02_242ColonCell lineV481
MAX distribution in all CRCs
Biosample type
Biosample name
Sample ID
Genomic distribution of SEs associated with MAX
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Mutation of MAX
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Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MAX

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr146555099465550994CTexonicMAXsynonymous LUAD|1|543|0.00184
-chr146556051465560514TCexonicMAXnonsynonymous UCEC|4|248|0.01613
-chr146554472765544727C-exonicMAXframeshift KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr146554338365543383TGsplicingMAXsplicing UCEC|1|248|0.00403
-chr146554463365544633TGexonicMAXnonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr146554409065544090GAUTR3MAXunknown SKCM|2|368|0.00543
-chr146554468265544682GAexonicMAXstopgain LUAD|1|543|0.00184
-chr146555098165550981GAexonicMAXnonsynonymous SKCM|2|368|0.00543
-chr146556049565560495T-exonicMAXframeshift KIPAN|1|799|0.00125,KIRC|1|451|0.00222
rs866762160chr146556045865560458GAexonicMAXnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,PAAD|1|185|0.00541
-chr146554475665544756TCsplicingMAXsplicing KIPAN|4|799|0.00501,KIRC|4|451|0.00887
rs781393600chr146555092065550920TCexonicMAXnonsynonymous PRAD|1|499|0.00200
rs776978293chr146554337865543378CTexonicMAXnonsynonymous UCEC|1|248|0.00403
-chr146547293065472930GTexonicMAXnonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
rs537719104chr146554461565544615GAintronicMAXunknown SKCM|1|368|0.00272
-chr146556833765568337TCintronicMAXunknown UCEC|1|248|0.00403
rs777274451chr146554471365544713GAexonicMAXsynonymous LUAD|1|543|0.00184
rs762084527chr146554337965543379GAexonicMAXnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr146556904265569042CAexonicMAXnonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr146556045665560456CAexonicMAXsynonymous LUAD|1|543|0.00184
-chr146554471265544712GAexonicMAXstopgain LUAD|1|543|0.00184
-chr146554413165544131CGexonicMAXstoploss CESC|1|194|0.00515
-chr146554319965543199TAexonicMAXnonsynonymous LUAD|1|543|0.00184
-chr146554474765544747CTexonicMAXnonsynonymous GBMLGG|3|820|0.00366,LAML|1|197|0.00508,LGG|3|530|0.00566,STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|2|248|0.00806
-chr146556903365569033CTexonicMAXnonsynonymous UCEC|1|248|0.00403
rs769051095chr146554336365543363GAexonicMAXnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr146554333665543336TCexonicMAXnonsynonymous ESCA|1|185|0.00541
-chr146556904565569045CTexonicMAXnonsynonymous BRCA|1|982|0.00102
-chr146554332265543322CTexonicMAXnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr146554465365544653CGexonicMAXnonsynonymous HNSC|1|512|0.00195
-chr146556046065560460AGexonicMAXnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,LUAD|1|543|0.00184
-chr146556830265568302GTintronicMAXunknown UCEC|1|248|0.00403
-chr146554457465544574ACintronicMAXunknown COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr146554331165543311GTexonicMAXsynonymous CESC|1|194|0.00515
-chr146554474765544748CG-exonicMAXframeshift LUAD|1|543|0.00184
-chr146554457965544579GAintronicMAXunknown UCEC|1|248|0.00403
-chr146556047665560476CAexonicMAXnonsynonymous BRCA|1|982|0.00102
-chr146556905565569055CAexonicMAXnonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr146556905065569050TAexonicMAXnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr146554463165544631CTexonicMAXnonsynonymous LUAD|1|543|0.00184
-chr146554333065543330GAexonicMAXnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr146556050365560503CTexonicMAXnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr146554330665543306GAexonicMAXnonsynonymous LUAD|1|543|0.00184
-chr146556049365560493CAexonicMAXnonsynonymous LUAD|2|543|0.00368
Disease information of MAX
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TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
MAX Malignant Neoplasms C04 Neoplastic Process CGI
MAX Malignant neoplasm of endometrium Neoplastic Process CGI
MAX Nephroblastoma C04;C12;C13;C16 Neoplastic Process CTD_human
MAX Pheochromocytoma C04 Neoplastic Process CGI;CTD_human;UNIPROT
MAX Benign neoplasm of adrenal gland Neoplastic Process CLINGEN
MAX Benign neoplasm of aortic body and other paraganglia Neoplastic Process CLINGEN
MAX Carcinoma, Neuroendocrine C04 Neoplastic Process GENOMICS_ENGLAND
MAX Malignant Adrenal Medulla Neoplasm Neoplastic Process CLINGEN
MAX Carcinoma in situ of endometrium Neoplastic Process CGI
MAX Malignant neoplasm of aortic body and other paraganglia Neoplastic Process CLINGEN
MAX Endometrial Carcinoma C04;C13 Neoplastic Process CGI
MAX Colon Carcinoma Neoplastic Process CGI
MAX Pheochromocytoma, Extra-Adrenal C04 Neoplastic Process CTD_human
MAX Bilateral Wilms Tumor C04;C12;C13;C16 Disease or Syndrome CTD_human
MAX PHEOCHROMOCYTOMA, SUSCEPTIBILITY TO Finding UNIPROT
Pathway associated with MAX
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pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000336 C-MYC pathway pid 25 112
pathway0000515 Cyclin A:Cdk2-associated events at S phase entry reactome 15 73
pathway0000518 Cyclin E associated events during G1/S transition reactome 14 63
pathway0001560 Oxidative stress response panther 23 125
pathway0001849 Regulation of nuclear SMAD2/3 signaling pid 82 1072
pathway0001861 Regulation of Telomerase pid 70 708
pathway0002390 Validated targets of C-MYC transcriptional activation pid 80 573
pathway0002391 Validated targets of C-MYC transcriptional repression pid 63 385
pathway0002757 Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 wikipathways 27 108
Go term information of MAX
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GO_term_name GO_term_type TF_name
GO_RESPONSE_TO_AXON_INJURY BP MAX
GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND BP MAX
GO_NEURON_APOPTOTIC_PROCESS BP MAX
GO_CELLULAR_RESPONSE_TO_PEPTIDE BP MAX
GO_NEURON_DEATH BP MAX
GO_PML_BODY CC MAX
GO_MLL1_2_COMPLEX CC MAX
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC MF MAX

Survival analysis of MAX


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of MAX

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)