Cancer CRCdb

TF information

TF name:	LEF1
TF family:	HMG
Ensembl gene ID:	ENSG00000138795
Ensembl protein ID:	ENSP00000369284, ENSP00000406176, ENSP00000422840, ENSP00000265165
Entrez gene ID:	51176

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of LEF1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_180	Cell line	Human melanoma	CJM	0.625
Sample_02_183	Cell line	Skin	SKMEL2	0.41025641025641
Sample_02_357	Cell line	Colon	Colo320	1

LEF1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_357	Colon	Cell line	Colo320

LEF1 distribution in all CRCs

Genomic distribution of SEs associated with LEF1

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Mutation of LEF1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of LEF1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr4	108999412	108999412	T	A	exonic	LEF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	109088724	109088724	C	A	exonic	LEF1	nonsynonymous	HNSC\|1\|512\|0.00195
rs146861754	chr4	109000748	109000748	C	T	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PRAD\|1\|499\|0.00200,UCEC\|1\|248\|0.00403
-	chr4	109000723	109000723	C	T	exonic	LEF1	nonsynonymous	LIHC\|1\|373\|0.00268
rs773984067	chr4	109086341	109086341	C	T	intronic	LEF1	unknown	ESCA\|1\|185\|0.00541
-	chr4	109084737	109084737	G	A	exonic	LEF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	108999459	108999459	A	G	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs760096679	chr4	108999527	108999527	T	C	exonic	LEF1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr4	109088716	109088716	G	C	exonic	LEF1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr4	109002806	109002806	G	C	exonic	LEF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	109004590	109004590	T	G	exonic	LEF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr4	109000667	109000667	C	G	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
rs567997105	chr4	109086398	109086398	C	T	intronic	LEF1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs372117953	chr4	108969352	108969352	-	A	UTR3	LEF1	unknown	ESCA\|1\|185\|0.00541
-	chr4	108999528	108999528	G	A	exonic	LEF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	109088813	109088813	G	T	exonic	LEF1	synonymous	UCEC\|1\|248\|0.00403
-	chr4	108999454	108999454	C	T	exonic	LEF1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr4	109088923	109088923	T	C	exonic	LEF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	109084747	109084747	G	-	exonic	LEF1	frameshift	UCEC\|1\|248\|0.00403
-	chr4	109002742	109002742	C	T	exonic	LEF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	109086281	109086281	G	A	exonic	LEF1	synonymous	CHOL\|1\|35\|0.02857
rs375238109	chr4	108999439	108999439	C	T	exonic	LEF1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr4	109004570	109004570	G	A	exonic	LEF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	109000705	109000705	A	G	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs368602047	chr4	109084772	109084772	G	A	exonic	LEF1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr4	109000672	109000672	T	C	exonic	LEF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	109088901	109088901	C	T	exonic	LEF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	109084820	109084820	G	T	exonic	LEF1	synonymous	LUAD\|2\|543\|0.00368
-	chr4	109084775	109084775	A	C	exonic	LEF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr4	109086392	109086392	T	C	intronic	LEF1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	109084820	109084820	G	A	exonic	LEF1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr4	109088757	109088757	G	A	exonic	LEF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	108969924	108969924	T	C	intronic	LEF1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	109004522	109004522	G	C	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	108991910	108991910	C	A	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	108985529	108985529	C	A	exonic	LEF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	108969862	108969862	G	T	exonic	LEF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	108999479	108999479	G	A	exonic	LEF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	109088884	109088884	C	-	exonic	LEF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PAAD\|2\|185\|0.01081
-	chr4	109002741	109002741	C	A	splicing	LEF1	splicing	LUAD\|1\|543\|0.00184
-	chr4	109088792	109088792	G	C	exonic	LEF1	synonymous	SKCM\|1\|368\|0.00272
-	chr4	108991878	108991878	G	A	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs199515145	chr4	109010379	109010379	G	A	exonic	LEF1	nonsynonymous	PAAD\|1\|185\|0.00541
rs769759622	chr4	109084728	109084728	C	T	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
rs758817161	chr4	108991888	108991888	A	G	exonic	LEF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	109084842	109084842	C	G	exonic	LEF1	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr4	109088756	109088756	G	-	exonic	LEF1	frameshift	THCA\|1\|504\|0.00198
-	chr4	109086252	109086252	C	A	splicing	LEF1	splicing	OV\|1\|469\|0.00213
-	chr4	108994134	108994158	GGCTCACCGCAGCCTCGAACTCCTG	-	intronic	LEF1	unknown	-
-	chr4	108991841	108991841	C	A	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	108999451	108999451	T	G	exonic	LEF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	109088767	109088767	T	C	exonic	LEF1	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr4	108999544	108999544	-	GT	intronic	LEF1	unknown	UCEC\|1\|248\|0.00403
rs574172621	chr4	109000650	109000650	G	A	exonic	LEF1	synonymous	LUAD\|1\|543\|0.00184
-	chr4	109084785	109084785	G	C	exonic	LEF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	109088797	109088797	G	A	exonic	LEF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	109088746	109088746	C	G	exonic	LEF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	109002824	109002824	G	A	exonic	LEF1	stopgain	UCEC\|1\|248\|0.00403
-	chr4	108985490	108985490	A	G	splicing	LEF1	splicing	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr4	109086290	109086290	C	G	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	108999468	108999468	A	G	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	109000667	109000667	C	T	exonic	LEF1	nonsynonymous	CESC\|1\|194\|0.00515,LUAD\|1\|543\|0.00184
-	chr4	109004529	109004529	G	A	exonic	LEF1	synonymous	BLCA\|1\|396\|0.00253
-	chr4	109004508	109004508	T	C	intronic	LEF1	unknown	ESCA\|2\|185\|0.01081
-	chr4	108999498	108999498	T	-	exonic	LEF1	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr4	109084858	109084858	C	T	splicing	LEF1	splicing	LIHC\|1\|373\|0.00268
-	chr4	108999470	108999470	G	A	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	108969898	108969898	C	A	exonic	LEF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	108985491	108985500	CCTGATGCAG	-	exonic	LEF1	nonframeshift	HNSC\|1\|512\|0.00195
-	chr4	109002741	109002741	C	T	splicing	LEF1	splicing	SKCM\|1\|368\|0.00272
-	chr4	109084776	109084776	T	C	exonic	LEF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	108985506	108985506	T	A	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
rs374147712	chr4	109086329	109086329	T	C	intronic	LEF1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs761818179	chr4	109002749	109002749	T	C	exonic	LEF1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr4	109086270	109086270	C	T	exonic	LEF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	109088742	109088742	G	C	exonic	LEF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	109088893	109088893	C	T	exonic	LEF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	109087430	109087430	C	A	exonic	LEF1	stopgain	UCEC\|1\|248\|0.00403
-	chr4	109088908	109088908	C	T	exonic	LEF1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr4	109010376	109010376	A	G	exonic	LEF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778363288	chr4	109088804	109088804	C	A	exonic	LEF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	109000758	109000758	A	G	exonic	LEF1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189

Disease information of LEF1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
LEF1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
LEF1	Malignant tumor of colon	C04;C06	Neoplastic Process	CTD_human
LEF1	Colonic Neoplasms	C04;C06	Neoplastic Process	CTD_human
LEF1	Chronic Lymphocytic Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
LEF1	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
LEF1	Neoplasm Metastasis	C04;C23	Neoplastic Process	CTD_human
LEF1	Sebaceous Gland Neoplasms	C04;C17	Neoplastic Process	CTD_human
LEF1	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
LEF1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
LEF1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
LEF1	Colorectal Cancer	C04;C06	Neoplastic Process	UNIPROT

Pathway associated with LEF1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000154	Alzheimer disease-presenilin pathway	panther	98	834
pathway0000309	Binding of TCF/LEF:CTNNB1 to target gene promoters	reactome	7	20
pathway0000340	Ca2+ pathway	reactome	62	742
pathway0000355	Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	56	519
pathway0000356	Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )	inoh	56	519
pathway0000357	Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	56	519
pathway0000358	Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )	inoh	56	519
pathway0000359	Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	56	519
pathway0000549	Deactivation of the beta-catenin transactivating complex	reactome	42	236
pathway0001170	Integrin-linked kinase signaling	pid	46	234
pathway0001315	Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )	inoh	49	453
pathway0001517	Notch	netpath	76	661
pathway0001848	Regulation of nuclear beta catenin signaling and target gene transcription	pid	80	611
pathway0001876	Repression of WNT target genes	reactome	14	68
pathway0002046	Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	47	421
pathway0002047	Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram )	inoh	47	421
pathway0002048	Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	47	421
pathway0002049	Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram )	inoh	47	421
pathway0002050	Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	47	421
pathway0002051	Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram )	inoh	47	421
pathway0002052	Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	19	46
pathway0002053	Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	8	26
pathway0002054	Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram )	inoh	8	26
pathway0002055	Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	8	26
pathway0002056	Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram )	inoh	8	26
pathway0002057	Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	8	26
pathway0002058	Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram )	inoh	8	26
pathway0002587	Wnt signaling pathway	kegg	135	1586
pathway0002597	Adherens junction	kegg	70	644
pathway0002627	Melanogenesis	kegg	100	1225
pathway0002657	Colorectal cancer	kegg	63	642
pathway0002660	Endometrial cancer	kegg	52	567
pathway0002662	Prostate cancer	kegg	85	1261
pathway0002668	Acute myeloid leukemia	kegg	53	562
pathway0002677	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	kegg	71	760
pathway0002724	Hs_Wnt_Signaling_Pathway_Netpath_WP363_78571	wikipathways	28	133
pathway0002826	Hs_Mesodermal_Commitment_Pathway_WP2857_87780	wikipathways	47	175

Go term information of LEF1

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION	BP	LEF1
GO_LEUKOCYTE_ACTIVATION	BP	LEF1
GO_DENTATE_GYRUS_DEVELOPMENT	BP	LEF1
GO_LABYRINTHINE_LAYER_DEVELOPMENT	BP	LEF1
GO_NEURONAL_STEM_CELL_DIVISION	BP	LEF1
GO_HINDBRAIN_DEVELOPMENT	BP	LEF1
GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION	BP	LEF1
GO_BODY_MORPHOGENESIS	BP	LEF1
GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION	BP	LEF1
GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH	BP	LEF1
GO_CELL_CHEMOTAXIS	BP	LEF1
GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	LEF1
GO_RESPONSE_TO_INTERLEUKIN_4	BP	LEF1
GO_FORMATION_OF_PRIMARY_GERM_LAYER	BP	LEF1
GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND	BP	LEF1
GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION	BP	LEF1
GO_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	LEF1
GO_B_CELL_PROLIFERATION	BP	LEF1
GO_OSTEOBLAST_DIFFERENTIATION	BP	LEF1
GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS	BP	LEF1
GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM	BP	LEF1
GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS	BP	LEF1
GO_REGULATION_OF_RECEPTOR_BINDING	BP	LEF1
GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY	BP	LEF1
GO_TONGUE_DEVELOPMENT	BP	LEF1
GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	LEF1
GO_STEM_CELL_PROLIFERATION	BP	LEF1
GO_FOREBRAIN_GENERATION_OF_NEURONS	BP	LEF1
GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4	BP	LEF1
GO_SOMATIC_CELL_DNA_RECOMBINATION	BP	LEF1
GO_PIGMENTATION	BP	LEF1
GO_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	LEF1
GO_NEGATIVE_REGULATION_OF_DNA_BINDING	BP	LEF1
GO_HYPOTHALAMUS_DEVELOPMENT	BP	LEF1
GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	LEF1
GO_STEM_CELL_DIVISION	BP	LEF1
GO_EMBRYONIC_PLACENTA_DEVELOPMENT	BP	LEF1
GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	LEF1
GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING	BP	LEF1
GO_ANATOMICAL_STRUCTURE_REGRESSION	BP	LEF1
GO_NEURAL_CREST_CELL_MIGRATION	BP	LEF1
GO_PATTERNING_OF_BLOOD_VESSELS	BP	LEF1
GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION	BP	LEF1
GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	BP	LEF1
GO_SPROUTING_ANGIOGENESIS	BP	LEF1
GO_LYMPHOCYTE_ACTIVATION	BP	LEF1
GO_LEUKOCYTE_PROLIFERATION	BP	LEF1
GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE	BP	LEF1
GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE	BP	LEF1
GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY	BP	LEF1
GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION	BP	LEF1
GO_HIPPOCAMPUS_DEVELOPMENT	BP	LEF1
GO_PROTEIN_ACETYLATION	BP	LEF1
GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	LEF1
GO_SEGMENTATION	BP	LEF1
GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS	BP	LEF1
GO_MESODERM_MORPHOGENESIS	BP	LEF1
GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION	BP	LEF1
GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	LEF1
GO_TRACHEA_DEVELOPMENT	BP	LEF1
GO_NEUROGENESIS	BP	LEF1
GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT	BP	LEF1
GO_VASCULATURE_DEVELOPMENT	BP	LEF1
GO_RESPONSE_TO_BMP	BP	LEF1
GO_ALPHA_BETA_T_CELL_ACTIVATION	BP	LEF1
GO_DEVELOPMENTAL_PIGMENTATION	BP	LEF1
GO_GRANULOCYTE_DIFFERENTIATION	BP	LEF1
GO_LEUKOCYTE_CELL_CELL_ADHESION	BP	LEF1
GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION	BP	LEF1
GO_SOMATIC_STEM_CELL_DIVISION	BP	LEF1
GO_MUSCLE_FIBER_DEVELOPMENT	BP	LEF1
GO_UROGENITAL_SYSTEM_DEVELOPMENT	BP	LEF1
GO_INTERACTION_WITH_SYMBIONT	BP	LEF1
GO_CELL_MIGRATION_IN_HINDBRAIN	BP	LEF1
GO_MESENCHYME_DEVELOPMENT	BP	LEF1
GO_RESPONSE_TO_LITHIUM_ION	BP	LEF1
GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS	BP	LEF1
GO_PARAXIAL_MESODERM_DEVELOPMENT	BP	LEF1
GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION	BP	LEF1
GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	LEF1
GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS	BP	LEF1
GO_GLIAL_CELL_DIFFERENTIATION	BP	LEF1
GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT	BP	LEF1
GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY	BP	LEF1
GO_CELL_DEVELOPMENT	BP	LEF1
GO_MESENCHYME_MORPHOGENESIS	BP	LEF1
GO_HISTONE_H4_ACETYLATION	BP	LEF1
GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS	BP	LEF1
GO_NEUROBLAST_PROLIFERATION	BP	LEF1
GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE	BP	LEF1
GO_HISTONE_H3_ACETYLATION	BP	LEF1
GO_T_CELL_DIFFERENTIATION	BP	LEF1
GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING	BP	LEF1
GO_EMBRYONIC_PLACENTA_MORPHOGENESIS	BP	LEF1
GO_BIOLOGICAL_ADHESION	BP	LEF1
GO_LYMPHOCYTE_DIFFERENTIATION	BP	LEF1
GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	LEF1
GO_V_D_J_RECOMBINATION	BP	LEF1
GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	LEF1
GO_ODONTOGENESIS	BP	LEF1
GO_HEAD_MORPHOGENESIS	BP	LEF1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX	CC	LEF1
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX	CC	LEF1
GO_BETA_CATENIN_BINDING	MF	LEF1
GO_PEPTIDASE_REGULATOR_ACTIVITY	MF	LEF1
GO_DNA_BINDING_BENDING	MF	LEF1
GO_ENHANCER_BINDING	MF	LEF1
GO_ESTROGEN_RECEPTOR_BINDING	MF	LEF1
GO_C2H2_ZINC_FINGER_DOMAIN_BINDING	MF	LEF1
GO_HISTONE_DEACETYLASE_BINDING	MF	LEF1
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY	MF	LEF1
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	LEF1
GO_STEROID_HORMONE_RECEPTOR_BINDING	MF	LEF1
GO_PROTEIN_DOMAIN_SPECIFIC_BINDING	MF	LEF1
GO_GAMMA_CATENIN_BINDING	MF	LEF1
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY	MF	LEF1
GO_ARMADILLO_REPEAT_DOMAIN_BINDING	MF	LEF1
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	LEF1

Survival analysis of LEF1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of LEF1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)