Cancer CRCdb

TF information

TF name:	IRF8
TF family:	IRF
Ensembl gene ID:	ENSG00000140968
Ensembl protein ID:	ENSP00000455784, ENSP00000456992, ENSP00000455048, ENSP00000268638, ENSP00000458047, ENSP00000455816
Entrez gene ID:	3394

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of IRF8 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_237	Cell line	Colon	V389	0.87373458494386
Sample_02_322	Cell line	Colon	Caco-2	0.26917900403769

IRF8 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_237	Colon	Cell line	V389

IRF8 distribution in all CRCs

Genomic distribution of SEs associated with IRF8

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Mutation of IRF8

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRF8

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr16	85946755	85946755	A	G	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	85936695	85936695	G	T	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	85946829	85946829	G	A	exonic	IRF8	synonymous	UCEC\|1\|248\|0.00403
rs765523642	chr16	85953744	85953744	C	T	exonic	IRF8	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr16	85942776	85942776	A	C	exonic	IRF8	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs150193781	chr16	85936747	85936747	C	T	exonic	IRF8	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	85936730	85936730	C	T	exonic	IRF8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	85945260	85945260	A	G	exonic	IRF8	nonsynonymous	OV\|1\|469\|0.00213
rs532341216	chr16	85946784	85946784	G	T	exonic	IRF8	synonymous	LUAD\|1\|543\|0.00184
rs372510203	chr16	85952285	85952285	C	T	exonic	IRF8	synonymous	SKCM\|1\|368\|0.00272
-	chr16	85954879	85954879	C	-	exonic	IRF8	frameshift	DLBC\|1\|48\|0.02083
rs772557507	chr16	85954818	85954818	G	A	exonic	IRF8	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	85952250	85952250	G	A	exonic	IRF8	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	85942692	85942692	G	A	exonic	IRF8	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr16	85948115	85948115	C	A	exonic	IRF8	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr16	85946800	85946800	A	T	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	85936643	85936643	C	A	exonic	IRF8	synonymous	LUAD\|1\|543\|0.00184
rs769456462	chr16	85946797	85946797	C	T	exonic	IRF8	nonsynonymous	SARC\|1\|247\|0.00405
-	chr16	85946833	85946833	C	T	exonic	IRF8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	85946809	85946809	C	T	exonic	IRF8	nonsynonymous	LUSC\|1\|178\|0.00562
rs770342843	chr16	85952327	85952327	C	T	exonic	IRF8	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs34712374	chr16	85942710	85942710	G	A	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
rs757320154	chr16	85948095	85948095	G	A	exonic	IRF8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	85952322	85952322	G	A	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	85942775	85942775	A	G	exonic	IRF8	synonymous	DLBC\|1\|48\|0.02083
rs535845826	chr16	85952318	85952318	C	T	exonic	IRF8	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	85954882	85954886	CGTCT	-	exonic	IRF8	frameshift	DLBC\|1\|48\|0.02083
-	chr16	85936694	85936694	G	T	exonic	IRF8	stopgain	LUAD\|1\|543\|0.00184
-	chr16	85946793	85946793	C	T	exonic	IRF8	synonymous	LUAD\|1\|543\|0.00184
-	chr16	85942614	85942614	G	T	exonic	IRF8	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs756331900	chr16	85942713	85942713	C	T	exonic	IRF8	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	85954779	85954779	T	A	exonic	IRF8	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr16	85952165	85952165	G	A	exonic	IRF8	synonymous	SKCM\|2\|368\|0.00543
-	chr16	85952378	85952378	C	A	exonic	IRF8	synonymous	CESC\|1\|194\|0.00515
rs397514711	chr16	85942659	85942659	A	G	exonic	IRF8	nonsynonymous	DLBC\|2\|48\|0.04167
-	chr16	85946794	85946794	T	A	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
rs370022572	chr16	85952271	85952271	C	T	exonic	IRF8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	85952307	85952307	C	T	exonic	IRF8	nonsynonymous	SKCM\|1\|368\|0.00272
rs753030994	chr16	85953824	85953824	C	T	exonic	IRF8	synonymous	HNSC\|1\|512\|0.00195
-	chr16	85946782	85946782	C	T	exonic	IRF8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	85954816	85954816	C	T	exonic	IRF8	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	85936654	85936654	A	C	exonic	IRF8	synonymous	PRAD\|2\|499\|0.00401
-	chr16	85936717	85936717	G	T	exonic	IRF8	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	85954813	85954813	C	G	exonic	IRF8	synonymous	BRCA\|1\|982\|0.00102,LUAD\|1\|543\|0.00184
-	chr16	85945192	85945192	A	T	exonic	IRF8	synonymous	LUAD\|1\|543\|0.00184
rs202107230	chr16	85952286	85952286	G	A	exonic	IRF8	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr16	85954880	85954886	ACCGTCT	-	exonic	IRF8	frameshift	DLBC\|1\|48\|0.02083
-	chr16	85946766	85946766	C	G	exonic	IRF8	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	85948116	85948116	G	A	exonic	IRF8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	85945181	85945181	C	A	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	85942616	85942616	G	A	exonic	IRF8	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs781716749	chr16	85952387	85952387	C	T	exonic	IRF8	synonymous	BRCA\|1\|982\|0.00102
-	chr16	85953808	85953808	G	A	exonic	IRF8	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
rs112843240	chr16	85948113	85948113	C	T	exonic	IRF8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs749700728	chr16	85936702	85936702	T	C	exonic	IRF8	synonymous	PRAD\|1\|499\|0.00200
-	chr16	85945236	85945236	G	T	exonic	IRF8	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr16	85936688	85936688	T	C	exonic	IRF8	nonsynonymous	UCEC\|1\|248\|0.00403
rs751576714	chr16	85952190	85952190	G	A	exonic	IRF8	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	85952132	85952132	C	G	exonic	IRF8	synonymous	LUAD\|1\|543\|0.00184
-	chr16	85952177	85952177	C	T	exonic	IRF8	synonymous	SKCM\|1\|368\|0.00272
rs371942842	chr16	85942753	85942753	G	A	exonic	IRF8	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	85954808	85954808	C	T	exonic	IRF8	stopgain	SKCM\|1\|368\|0.00272
-	chr16	85953807	85953807	C	A	exonic	IRF8	nonsynonymous	LUAD\|1\|543\|0.00184
rs146360039	chr16	85946826	85946826	G	A	exonic	IRF8	synonymous	PAAD\|1\|185\|0.00541,PRAD\|2\|499\|0.00401
rs780811704	chr16	85936699	85936699	G	A	exonic	IRF8	synonymous	SKCM\|1\|368\|0.00272
-	chr16	85946795	85946795	G	T	exonic	IRF8	nonsynonymous	HNSC\|2\|512\|0.00391
rs140514602	chr16	85948094	85948094	C	T	exonic	IRF8	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr16	85942746	85942746	G	A	exonic	IRF8	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	85952310	85952310	G	A	exonic	IRF8	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr16	85942758	85942758	G	T	exonic	IRF8	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs540457833	chr16	85948086	85948086	G	A	exonic	IRF8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
rs148203070	chr16	85953803	85953803	C	T	exonic	IRF8	synonymous	SKCM\|1\|368\|0.00272
-	chr16	85946818	85946818	T	C	exonic	IRF8	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	85952071	85952071	G	A	exonic	IRF8	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr16	85952157	85952157	G	A	exonic	IRF8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	85952175	85952175	T	C	exonic	IRF8	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr16	85952173	85952173	G	A	exonic	IRF8	nonsynonymous	HNSC\|1\|512\|0.00195
rs375352812	chr16	85953745	85953745	G	A	exonic	IRF8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs142267779	chr16	85952145	85952145	T	C	exonic	IRF8	nonsynonymous	ACC\|1\|90\|0.01111
-	chr16	85953768	85953768	C	T	exonic	IRF8	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs747312747	chr16	85952180	85952180	G	A	exonic	IRF8	synonymous	BLCA\|1\|396\|0.00253,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr16	85954861	85954861	C	T	exonic	IRF8	synonymous	SKCM\|1\|368\|0.00272
-	chr16	85936784	85936784	T	G	exonic	IRF8	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr16	85936785	85936785	C	A	exonic	IRF8	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr16	85946744	85946744	T	C	exonic	IRF8	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr16	85952247	85952247	C	A	exonic	IRF8	nonsynonymous	LUSC\|1\|178\|0.00562

Disease information of IRF8

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
IRF8	Rheumatoid Arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
IRF8	Malignant neoplasm of breast	C04;C17	Neoplastic Process	UNIPROT
IRF8	Liver Cirrhosis, Experimental	C06	Experimental Model of Disease	CTD_human
IRF8	Multiple Sclerosis	C10;C20	Disease or Syndrome	CTD_human
IRF8	Diffuse Large B-Cell Lymphoma	C04;C15;C20	Neoplastic Process	CGI
IRF8	Multiple Sclerosis, Acute Fulminating	C10;C20	Disease or Syndrome	CTD_human
IRF8	IMMUNODEFICIENCY 32A		Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
IRF8	IMMUNODEFICIENCY 32B		Disease or Syndrome	CTD_human;UNIPROT

Pathway associated with IRF8

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000966	GMCSF-mediated signaling events	pid	38	413
pathway0002391	Validated targets of C-MYC transcriptional repression	pid	63	385
pathway0002815	Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168	wikipathways	10	14

Go term information of IRF8

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GO_term_name	GO_term_type	TF_name
GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST	BP	IRF8
GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	IRF8
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	IRF8
GO_RESPONSE_TO_TYPE_I_INTERFERON	BP	IRF8
GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS	BP	IRF8
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION	BP	IRF8
GO_RESPONSE_TO_PROTOZOAN	BP	IRF8
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	IRF8
GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION	BP	IRF8
GO_RESPONSE_TO_INTERFERON_GAMMA	BP	IRF8
GO_MYELOID_CELL_DIFFERENTIATION	BP	IRF8
GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION	BP	IRF8
GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	IRF8
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	IRF8
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	IRF8

Survival analysis of IRF8

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of IRF8

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)