Cancer CRCdb

TF information

TF name:	IRF4
TF family:	IRF
Ensembl gene ID:	ENSG00000137265
Ensembl protein ID:	ENSP00000436094, ENSP00000370343
Entrez gene ID:	3662

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of IRF4 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_184	Cell line	Skin	SKMEL30	0.14147909967846
Sample_02_359	Cell line	Colon	Colo741	0.0060240963855422

IRF4 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

IRF4 distribution in all CRCs

Genomic distribution of SEs associated with IRF4

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Mutation of IRF4

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRF4

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	394899	394899	T	C	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
rs200431511	chr6	397164	397164	G	A	exonic	IRF4	synonymous	PRAD\|1\|499\|0.00200,UCEC\|1\|248\|0.00403
-	chr6	398864	398864	C	A	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	401567	401567	G	A	exonic	IRF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	394897	394897	G	T	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	398857	398857	T	C	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	393206	393206	C	G	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	397159	397159	G	T	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	398908	398908	A	G	exonic	IRF4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	398912	398912	C	A	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	393188	393188	C	T	exonic	IRF4	synonymous	UCEC\|1\|248\|0.00403
-	chr6	394831	394831	T	C	exonic	IRF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	401423	401423	G	A	splicing	IRF4	splicing	BRCA\|2\|982\|0.00204
-	chr6	401642	401642	G	A	exonic	IRF4	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	394848	394848	C	T	exonic	IRF4	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs755460615	chr6	395910	395910	C	T	exonic	IRF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs777806353	chr6	401485	401485	C	T	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	405067	405067	G	A	exonic	IRF4	synonymous	OV\|1\|469\|0.00213
-	chr6	401636	401636	G	C	exonic	IRF4	nonsynonymous	BLCA\|1\|396\|0.00253
rs771669183	chr6	401501	401501	C	T	exonic	IRF4	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	407568	407568	A	G	exonic	IRF4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	398832	398832	C	T	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	394886	394886	G	T	exonic	IRF4	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	393159	393159	C	G	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	407546	407546	G	A	exonic	IRF4	nonsynonymous	HNSC\|1\|512\|0.00195,THCA\|1\|504\|0.00198
-	chr6	393302	393302	C	-	exonic	IRF4	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	394868	394868	G	A	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	407582	407582	C	A	exonic	IRF4	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	401488	401488	C	T	exonic	IRF4	synonymous	SKCM\|1\|368\|0.00272
rs769596072	chr6	401482	401482	G	A	exonic	IRF4	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUSC\|1\|178\|0.00562
rs144395675	chr6	398928	398928	G	A	exonic	IRF4	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	397138	397138	G	A	exonic	IRF4	nonsynonymous	BRCA\|1\|982\|0.00102
rs781586995	chr6	397159	397159	G	A	exonic	IRF4	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	401436	401436	A	C	exonic	IRF4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	394896	394896	C	T	exonic	IRF4	nonsynonymous	ESCA\|1\|185\|0.00541
rs780902340	chr6	401621	401621	G	A	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	397234	397234	G	A	exonic	IRF4	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr6	397161	397161	C	-	exonic	IRF4	frameshift	PRAD\|2\|499\|0.00401
-	chr6	394869	394869	G	T	exonic	IRF4	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	407524	407524	T	C	exonic	IRF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	401645	401645	G	A	exonic	IRF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	395968	395968	G	C	intronic	IRF4	unknown	BRCA\|1\|982\|0.00102
-	chr6	405036	405036	A	G	exonic	IRF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	393209	393209	C	T	exonic	IRF4	synonymous	DLBC\|1\|48\|0.02083
rs558061652	chr6	397158	397158	C	T	exonic	IRF4	synonymous	BLCA\|1\|396\|0.00253
rs375133421	chr6	398884	398884	G	A	exonic	IRF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	401609	401609	C	A	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	393222	393222	C	G	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
rs201105575	chr6	401655	401655	C	T	exonic	IRF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	407527	407527	G	A	exonic	IRF4	nonsynonymous	HNSC\|1\|512\|0.00195
rs762541080	chr6	398916	398916	C	T	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	393330	393330	C	A	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	397170	397170	G	T	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	393249	393249	G	A	exonic	IRF4	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	397192	397192	-	A	exonic	IRF4	frameshift	PRAD\|1\|499\|0.00200
-	chr6	401690	401690	G	T	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	393360	393360	C	G	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	395894	395894	C	A	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	398917	398917	G	A	exonic	IRF4	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,PRAD\|1\|499\|0.00200
rs1050973	chr6	401596	401596	G	C	exonic	IRF4	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	393348	393348	G	A	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	401555	401555	C	T	exonic	IRF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	405052	405052	G	A	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	393224	393224	C	T	exonic	IRF4	synonymous	DLBC\|1\|48\|0.02083
-	chr6	394900	394900	G	A	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	401489	401489	C	T	exonic	IRF4	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	393203	393203	G	A	exonic	IRF4	synonymous	LIHC\|1\|373\|0.00268
rs774672138	chr6	401689	401689	C	T	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	393329	393329	G	A	exonic	IRF4	synonymous	DLBC\|1\|48\|0.02083
-	chr6	405053	405053	C	A	exonic	IRF4	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	407593	407593	G	T	exonic	IRF4	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	394877	394877	C	G	exonic	IRF4	synonymous	BLCA\|1\|396\|0.00253
-	chr6	393255	393255	G	T	exonic	IRF4	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	394997	394997	A	G	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	398903	398903	G	T	exonic	IRF4	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	397185	397185	C	-	exonic	IRF4	frameshift	LUAD\|1\|543\|0.00184
rs143640869	chr6	397188	397188	G	A	exonic	IRF4	synonymous	UCEC\|1\|248\|0.00403
-	chr6	394860	394860	G	A	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	393328	393328	A	G	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	407544	407544	C	T	exonic	IRF4	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	401593	401593	G	C	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
rs756602021	chr6	407576	407576	G	A	exonic	IRF4	nonsynonymous	HNSC\|2\|512\|0.00391
rs113364548	chr6	401644	401644	C	T	exonic	IRF4	synonymous	PAAD\|1\|185\|0.00541
-	chr6	394839	394839	G	T	exonic	IRF4	stopgain	UCEC\|1\|248\|0.00403
rs143144957	chr6	397219	397219	G	A	exonic	IRF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	401669	401669	C	T	exonic	IRF4	stopgain	ACC\|1\|90\|0.01111
rs753427028	chr6	397217	397217	G	A	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	393167	393167	C	T	exonic	IRF4	synonymous	ESCA\|1\|185\|0.00541
-	chr6	401457	401457	A	C	exonic	IRF4	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	393256	393256	G	A	exonic	IRF4	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	401567	401567	G	T	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
rs751010198	chr6	398927	398927	C	T	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
rs199596593	chr6	401715	401715	G	A	exonic	IRF4	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	405041	405041	G	A	exonic	IRF4	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	393318	393318	C	T	exonic	IRF4	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	407567	407567	G	A	exonic	IRF4	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	397111	397111	G	C	exonic	IRF4	nonsynonymous	LUAD\|1\|543\|0.00184
rs766676957	chr6	401656	401656	G	A	exonic	IRF4	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of IRF4

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
IRF4	Chronic Lymphocytic Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
IRF4	Adult T-Cell Lymphoma/Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
IRF4	Multiple Myeloma	C04;C14;C15;C20	Neoplastic Process	CTD_human
IRF4	Lymphoma, T-Cell, Cutaneous	C04;C15;C20	Neoplastic Process	CTD_human
IRF4	Granulomatous Slack Skin	C04;C15;C20	Neoplastic Process	CTD_human

Pathway associated with IRF4

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000343	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	pid	50	304
pathway0001127	IL4-mediated signaling events	pid	66	512
pathway0001180	Interferon alpha/beta signaling	reactome	67	378

Go term information of IRF4

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION	BP	IRF4
GO_DENDRITIC_CELL_DIFFERENTIATION	BP	IRF4
GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION	BP	IRF4
GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION	BP	IRF4
GO_POSITIVE_REGULATION_OF_BINDING	BP	IRF4
GO_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	IRF4
GO_RESPONSE_TO_TYPE_I_INTERFERON	BP	IRF4
GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	BP	IRF4
GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION	BP	IRF4
GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS	BP	IRF4
GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS	BP	IRF4
GO_POSITIVE_REGULATION_OF_DNA_BINDING	BP	IRF4
GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	BP	IRF4
GO_PEPTIDYL_LYSINE_MODIFICATION	BP	IRF4
GO_REGULATION_OF_HEMOPOIESIS	BP	IRF4
GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	BP	IRF4
GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM	BP	IRF4
GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS	BP	IRF4
GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE	BP	IRF4
GO_PROTEIN_ACETYLATION	BP	IRF4
GO_MYELOID_LEUKOCYTE_ACTIVATION	BP	IRF4
GO_REGULATION_OF_DNA_BINDING	BP	IRF4
GO_RESPONSE_TO_PROTOZOAN	BP	IRF4
GO_POSITIVE_T_CELL_SELECTION	BP	IRF4
GO_COVALENT_CHROMATIN_MODIFICATION	BP	IRF4
GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	IRF4
GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION	BP	IRF4
GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	BP	IRF4
GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT	BP	IRF4
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION	BP	IRF4
GO_T_CELL_LINEAGE_COMMITMENT	BP	IRF4
GO_RESPONSE_TO_INTERFERON_GAMMA	BP	IRF4
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION	BP	IRF4
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION	BP	IRF4
GO_MYELOID_CELL_DIFFERENTIATION	BP	IRF4
GO_PROTEIN_ACYLATION	BP	IRF4
GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION	BP	IRF4
GO_REGULATION_OF_BINDING	BP	IRF4
GO_HISTONE_H4_ACETYLATION	BP	IRF4
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION	BP	IRF4
GO_PEPTIDYL_LYSINE_METHYLATION	BP	IRF4
GO_HISTONE_H3_ACETYLATION	BP	IRF4
GO_MYELOID_DENDRITIC_CELL_ACTIVATION	BP	IRF4
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS	BP	IRF4
GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION	BP	IRF4
GO_T_CELL_SELECTION	BP	IRF4
GO_NUCLEAR_NUCLEOSOME	CC	IRF4
GO_PROTEIN_DNA_COMPLEX	CC	IRF4
GO_N_METHYLTRANSFERASE_ACTIVITY	MF	IRF4
GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY	MF	IRF4
GO_TRANSCRIPTION_FACTOR_BINDING	MF	IRF4
GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY	MF	IRF4

Survival analysis of IRF4

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of IRF4

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)