TF information

TF name: HOXB13
TF family: Homeobox
Ensembl gene ID: ENSG00000159184
Ensembl protein ID: ENSP00000290295
Entrez gene ID: 10481
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of HOXB13 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_068Cell lineProstate: derived from metastatic site: vertebral metastasisVCaP0.36986301369863
Sample_02_168Cell lineProstateLNCaP0.53231939163498

HOXB13 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

HOXB13 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with HOXB13
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Mutation of HOXB13
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HOXB13

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr174680437946804379CAexonicHOXB13nonsynonymous LUAD|1|543|0.00184
-chr174680419146804191CTexonicHOXB13synonymous LUAD|1|543|0.00184
rs372121677chr174680427746804277CTexonicHOXB13nonsynonymous HNSC|1|512|0.00195
-chr174680578046805780GTexonicHOXB13nonsynonymous ESCA|1|185|0.00541
-chr174680588446805884CTexonicHOXB13synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr174680560146805601CGexonicHOXB13nonsynonymous BLCA|1|396|0.00253
-chr174680572946805729GAexonicHOXB13nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680551946805519AGexonicHOXB13nonsynonymous PRAD|1|499|0.00200
-chr174680566646805666AGexonicHOXB13nonsynonymous PRAD|1|499|0.00200
-chr174680551546805515AGexonicHOXB13synonymous BLCA|1|396|0.00253
-chr174680580246805802CTexonicHOXB13nonsynonymous SKCM|1|368|0.00272
-chr174680570546805705CGexonicHOXB13nonsynonymous BLCA|1|396|0.00253
-chr174680438446804384GTexonicHOXB13nonsynonymous LUAD|1|543|0.00184
-chr174680542246805422CTexonicHOXB13stopgain BRCA|1|982|0.00102
-chr174680434246804342GAexonicHOXB13nonsynonymous BRCA|1|982|0.00102
-chr174680436746804367GAexonicHOXB13nonsynonymous UCEC|1|248|0.00403
-chr174680544246805442ACexonicHOXB13nonsynonymous PRAD|1|499|0.00200
rs759838136chr174680423546804235GAexonicHOXB13nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680436646804366CTexonicHOXB13nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr174680434346804343GAexonicHOXB13nonsynonymous SKCM|1|368|0.00272
-chr174680434946804349GAexonicHOXB13nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs368505949chr174680589346805893CTexonicHOXB13synonymous SKCM|2|368|0.00543
-chr174680434546804345ATexonicHOXB13nonsynonymous LUAD|1|543|0.00184
-chr174680565346805653GTexonicHOXB13synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680539146805391TCexonicHOXB13nonsynonymous BRCA|1|982|0.00102
rs768311961chr174680563246805632CTexonicHOXB13synonymous HNSC|1|512|0.00195
-chr174680536346805363GAexonicHOXB13nonsynonymous UCEC|1|248|0.00403
-chr174680588746805887CTexonicHOXB13synonymous SKCM|1|368|0.00272
-chr174680433546804335GAexonicHOXB13synonymous LUAD|1|543|0.00184
-chr174680435646804356GAexonicHOXB13synonymous LUAD|1|543|0.00184
-chr174680560446805604CTexonicHOXB13nonsynonymous SKCM|2|368|0.00543
-chr174680552146805521GTexonicHOXB13nonsynonymous LUSC|1|178|0.00562
-chr174680544446805444GTexonicHOXB13nonsynonymous LIHC|1|373|0.00268
rs138213197chr174680570546805705CTexonicHOXB13nonsynonymous SKCM|2|368|0.00543
-chr174680430746804307CTexonicHOXB13nonsynonymous SKCM|1|368|0.00272
-chr174680539946805399CTexonicHOXB13nonsynonymous SKCM|1|368|0.00272
rs770620686chr174680578046805780GAexonicHOXB13nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
rs750244360chr174680426846804268GAexonicHOXB13nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403
-chr174680556746805567TGexonicHOXB13nonsynonymous HNSC|1|512|0.00195
-chr174680588446805884C-exonicHOXB13frameshift ACC|1|90|0.01111,STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680424646804246CTexonicHOXB13nonsynonymous UCEC|1|248|0.00403
-chr174680570046805700CTexonicHOXB13nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680540846805408CAexonicHOXB13nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr174680546746805467CTexonicHOXB13synonymous LIHC|1|373|0.00268
-chr174680430846804308CTexonicHOXB13synonymous SKCM|1|368|0.00272
-chr174680553846805538TCexonicHOXB13nonsynonymous UCEC|1|248|0.00403
rs763590684chr174680535446805354CAsplicingHOXB13splicing LUAD|1|543|0.00184
-chr174680582546805825GTexonicHOXB13nonsynonymous UCEC|1|248|0.00403
-chr174680573446805734GAexonicHOXB13synonymous SKCM|1|368|0.00272
-chr174680424046804240GCexonicHOXB13nonsynonymous LUAD|1|543|0.00184
-chr174680587146805871CTexonicHOXB13nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr174680434146804341CTexonicHOXB13synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680566546805665CTexonicHOXB13synonymous BLCA|1|396|0.00253
-chr174680573746805737CAexonicHOXB13synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr174680437946804379CTexonicHOXB13nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr174680435546804355TCexonicHOXB13nonsynonymous PRAD|1|499|0.00200

Disease information of HOXB13
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
HOXB13 Malignant neoplasm of breast C04;C17 Neoplastic Process CTD_human
HOXB13 melanoma C04 Neoplastic Process CTD_human
HOXB13 Neoplasm Invasiveness C04;C23 Pathologic Function CTD_human
HOXB13 Prostatic Neoplasms C04;C12 Neoplastic Process CTD_human
HOXB13 Malignant neoplasm of prostate C04;C12 Neoplastic Process CTD_human;UNIPROT
HOXB13 Breast Carcinoma C04;C17 Neoplastic Process CTD_human
HOXB13 Mammary Neoplasms, Human C04;C17 Neoplastic Process CTD_human
HOXB13 Mammary Neoplasms C04;C17 Neoplastic Process CTD_human
HOXB13 Prostate cancer, familial C04;C12 Neoplastic Process CTD_human;GENOMICS_ENGLAND;ORPHANET

Pathway associated with HOXB13
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001825 Regulation of Androgen receptor activity pid 54 338

Go term information of HOXB13
GO_term_name GO_term_type TF_name
GO_PROSTATE_GLAND_MORPHOGENESIS BP HOXB13
GO_EPITHELIAL_CELL_DEVELOPMENT BP HOXB13
GO_RESPONSE_TO_TESTOSTERONE BP HOXB13
GO_CELL_MATURATION BP HOXB13
GO_RESPONSE_TO_KETONE BP HOXB13
GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT BP HOXB13
GO_PROSTATE_GLAND_DEVELOPMENT BP HOXB13
GO_REPRODUCTION BP HOXB13
GO_ANGIOGENESIS BP HOXB13
GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT BP HOXB13
GO_EPITHELIAL_CELL_MATURATION BP HOXB13

Survival analysis of HOXB13



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of HOXB13