Cancer CRCdb

TF information

TF name:	HLX
TF family:	Homeobox
Ensembl gene ID:	ENSG00000136630
Ensembl protein ID:	ENSP00000408248, ENSP00000355870
Entrez gene ID:	3142

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HLX in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.0052424639580603
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.012987012987013
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.016483516483516

HLX distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

HLX distribution in all CRCs

Genomic distribution of SEs associated with HLX

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Mutation of HLX

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HLX

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	221054616	221054616	G	A	exonic	HLX	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,HNSC\|1\|512\|0.00195
-	chr1	221053336	221053336	T	C	exonic	HLX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	221054582	221054582	C	G	exonic	HLX	synonymous	BRCA\|1\|982\|0.00102
-	chr1	221057717	221057717	G	A	exonic	HLX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr1	221053711	221053711	G	A	exonic	HLX	nonsynonymous	UCEC\|1\|248\|0.00403
rs769686717	chr1	221057963	221057963	G	A	exonic	HLX	nonsynonymous	ACC\|1\|90\|0.01111
-	chr1	221055517	221055517	G	A	exonic	HLX	nonsynonymous	THCA\|1\|504\|0.00198
-	chr1	221055525	221055525	G	A	exonic	HLX	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr1	221054597	221054597	C	G	exonic	HLX	synonymous	THYM\|1\|123\|0.00813
-	chr1	221057991	221057991	C	G	exonic	HLX	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	221053618	221053618	C	T	exonic	HLX	nonsynonymous	PCPG\|2\|184\|0.01087
rs760568441	chr1	221057812	221057812	C	T	exonic	HLX	synonymous	BLCA\|1\|396\|0.00253
-	chr1	221053221	221053221	C	T	exonic	HLX	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	221057551	221057551	C	T	exonic	HLX	synonymous	SKCM\|1\|368\|0.00272
-	chr1	221053526	221053526	G	A	exonic	HLX	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	221057975	221057975	G	C	exonic	HLX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	221057695	221057695	C	T	exonic	HLX	synonymous	UCEC\|1\|248\|0.00403
-	chr1	221054587	221054587	G	T	exonic	HLX	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	221053501	221053501	C	T	exonic	HLX	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	221055559	221055559	C	T	exonic	HLX	nonsynonymous	UCEC\|1\|248\|0.00403
rs182881175	chr1	221053499	221053499	G	A	exonic	HLX	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr1	221055680	221055680	C	T	exonic	HLX	nonsynonymous	BRCA\|2\|982\|0.00204,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221055655	221055655	C	A	exonic	HLX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221053550	221053550	C	T	exonic	HLX	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221055540	221055540	G	A	exonic	HLX	synonymous	UCEC\|1\|248\|0.00403
rs757694055	chr1	221053271	221053271	G	T	exonic	HLX	synonymous	LUAD\|1\|543\|0.00184
rs759024964	chr1	221055663	221055663	G	A	exonic	HLX	synonymous	LUSC\|1\|178\|0.00562
-	chr1	221055508	221055508	C	T	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	221057867	221057867	G	-	exonic	HLX	frameshift	BRCA\|1\|982\|0.00102
-	chr1	221053253	221053253	G	T	exonic	HLX	synonymous	OV\|1\|469\|0.00213
-	chr1	221053723	221053723	A	G	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221053229	221053229	C	T	exonic	HLX	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221057831	221057831	G	A	exonic	HLX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	221057467	221057467	G	A	intronic	HLX	unknown	UCEC\|1\|248\|0.00403
-	chr1	221054559	221054559	G	T	exonic	HLX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221058024	221058024	A	T	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221053787	221053787	G	C	exonic	HLX	synonymous	BLCA\|1\|396\|0.00253
-	chr1	221057749	221057749	C	T	exonic	HLX	synonymous	UCEC\|1\|248\|0.00403
-	chr1	221057727	221057727	C	T	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	221055546	221055546	G	A	exonic	HLX	synonymous	ESCA\|1\|185\|0.00541
-	chr1	221053601	221053601	-	AGCAACAGCCGCCG	exonic	HLX	frameshift	LIHC\|1\|373\|0.00268
-	chr1	221055497	221055497	C	T	intronic	HLX	unknown	CESC\|1\|194\|0.00515
-	chr1	221057860	221057861	CG	-	exonic	HLX	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221054609	221054609	G	T	exonic	HLX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs371016648	chr1	221057775	221057775	G	A	exonic	HLX	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	221057861	221057861	G	A	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,TGCT\|1\|155\|0.00645,THCA\|1\|504\|0.00198
-	chr1	221053223	221053223	C	A	exonic	HLX	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs775163055	chr1	221055673	221055673	G	T	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
rs754490132	chr1	221057685	221057685	G	A	exonic	HLX	nonsynonymous	PRAD\|1\|499\|0.00200,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	221053614	221053614	C	T	exonic	HLX	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	221055545	221055545	C	T	exonic	HLX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs776580614	chr1	221057870	221057870	G	A	exonic	HLX	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	221053721	221053721	C	T	exonic	HLX	synonymous	BLCA\|2\|396\|0.00505
-	chr1	221057701	221057701	T	G	exonic	HLX	synonymous	LUAD\|1\|543\|0.00184
-	chr1	221055574	221055574	G	T	exonic	HLX	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr1	221057558	221057558	C	A	exonic	HLX	synonymous	LUAD\|1\|543\|0.00184
-	chr1	221053402	221053402	C	T	exonic	HLX	nonsynonymous	CESC\|1\|194\|0.00515,LUSC\|1\|178\|0.00562
-	chr1	221055659	221055659	T	C	exonic	HLX	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	221057864	221057864	G	A	exonic	HLX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	221053583	221053583	G	A	exonic	HLX	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221055563	221055563	C	T	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221054585	221054585	A	C	exonic	HLX	synonymous	BRCA\|1\|982\|0.00102
-	chr1	221057858	221057858	A	G	exonic	HLX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221057537	221057537	G	A	exonic	HLX	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	221057561	221057561	C	T	exonic	HLX	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	221054636	221054636	C	G	exonic	HLX	nonsynonymous	TGCT\|2\|155\|0.01290
-	chr1	221055671	221055671	T	C	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
rs752408913	chr1	221053337	221053337	C	T	exonic	HLX	synonymous	BLCA\|1\|396\|0.00253
-	chr1	221057702	221057702	G	A	exonic	HLX	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	221057957	221057957	G	A	exonic	HLX	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	221054568	221054568	G	A	exonic	HLX	nonsynonymous	UCEC\|1\|248\|0.00403
rs751088009	chr1	221054599	221054599	C	T	exonic	HLX	nonsynonymous	BLCA\|1\|396\|0.00253,HNSC\|1\|512\|0.00195
-	chr1	221055534	221055534	C	A	exonic	HLX	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221057824	221057824	C	T	exonic	HLX	synonymous	LUAD\|1\|543\|0.00184
-	chr1	221054565	221054565	C	T	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	221053615	221053615	C	T	exonic	HLX	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	221055560	221055560	G	A	exonic	HLX	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	221057636	221057636	G	T	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221057616	221057616	A	G	exonic	HLX	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	221054701	221054701	A	G	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221053746	221053746	T	C	exonic	HLX	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	221057792	221057792	A	G	exonic	HLX	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	221057562	221057562	G	A	exonic	HLX	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	221054566	221054566	C	T	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	221057895	221057895	C	T	exonic	HLX	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	221057925	221057925	C	T	exonic	HLX	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	221053383	221053383	G	T	exonic	HLX	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	221057751	221057751	C	T	exonic	HLX	nonsynonymous	PAAD\|1\|185\|0.00541
rs778657232	chr1	221053716	221053716	G	T	exonic	HLX	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	221053600	221053600	-	CAGCAACAGCCGCC	exonic	HLX	frameshift	ACC\|1\|90\|0.01111
-	chr1	221053252	221053252	C	A	exonic	HLX	stopgain	LUSC\|1\|178\|0.00562
-	chr1	221057631	221057631	C	T	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	221057767	221057767	G	A	exonic	HLX	synonymous	PAAD\|1\|185\|0.00541
-	chr1	221054601	221054601	-	C	exonic	HLX	frameshift	TGCT\|1\|155\|0.00645
rs199775753	chr1	221054556	221054556	G	A	exonic	HLX	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	221054679	221054679	A	C	exonic	HLX	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr1	221054644	221054644	C	T	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221058014	221058014	G	A	exonic	HLX	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	221053273	221053273	C	T	exonic	HLX	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	221057728	221057728	C	T	exonic	HLX	synonymous	SKCM\|1\|368\|0.00272
-	chr1	221054572	221054572	G	T	exonic	HLX	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	221057723	221057723	G	T	exonic	HLX	stopgain	LUAD\|1\|543\|0.00184
-	chr1	221057573	221057573	C	T	exonic	HLX	nonsynonymous	DLBC\|1\|48\|0.02083,UCEC\|1\|248\|0.00403

Disease information of HLX

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with HLX

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001116	IL12-mediated signaling events	pid	62	684
pathway0002688	Hs_TYROBP_Causal_Network_WP3945_90843	wikipathways	54	71

Go term information of HLX

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GO_term_name	GO_term_type	TF_name
GO_MUSCLE_TISSUE_DEVELOPMENT	BP	HLX
GO_REGULATION_OF_DEVELOPMENTAL_GROWTH	BP	HLX
GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE	BP	HLX
GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION	BP	HLX
GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION	BP	HLX
GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION	BP	HLX
GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS	BP	HLX
GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	HLX
GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE	BP	HLX
GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	HLX
GO_REGULATION_OF_HEMOPOIESIS	BP	HLX
GO_REGULATION_OF_ORGAN_GROWTH	BP	HLX
GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT	BP	HLX
GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE	BP	HLX
GO_DIGESTIVE_TRACT_MORPHOGENESIS	BP	HLX
GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	BP	HLX
GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	HLX
GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION	BP	HLX
GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	BP	HLX
GO_REGULATION_OF_T_CELL_DIFFERENTIATION	BP	HLX
GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION	BP	HLX
GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION	BP	HLX
GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT	BP	HLX
GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION	BP	HLX
GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	BP	HLX
GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION	BP	HLX
GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION	BP	HLX
GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT	BP	HLX
GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION	BP	HLX
GO_TUBE_MORPHOGENESIS	BP	HLX
GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	HLX
GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	HLX
GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE	BP	HLX
GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	BP	HLX
GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE	BP	HLX
GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS	BP	HLX
GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH	BP	HLX
GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	HLX
GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION	BP	HLX

Survival analysis of HLX

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HLX

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)