TF information

TF name: GLIS3
TF family: zf-C2H2
Ensembl gene ID: ENSG00000107249
Ensembl protein ID: ENSP00000371398, ENSP00000325494
Entrez gene ID: 169792
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of GLIS3 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_114Cell lineMammary GlandCAL510.1105527638191
Sample_02_166Cell lineMammary GlandHCC1954_Parental0.26
Sample_02_204Cell lineStomachIM950.13636363636364
Sample_02_268Cell lineKidneyA-4980.52870592578918

GLIS3 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

GLIS3 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with GLIS3
Download

Mutation of GLIS3
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of GLIS3

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr941178264117828CGG-exonicGLIS3nonframeshift LUAD|1|543|0.00184
-chr938293393829339CTexonicGLIS3nonsynonymous LUAD|1|543|0.00184
rs376905545chr941186514118651GAexonicGLIS3nonsynonymous HNSC|1|512|0.00195
-chr941186004118600GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941183924118392CTexonicGLIS3synonymous SKCM|1|368|0.00272
-chr938293683829368CTexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs75462592chr941182624118262CAexonicGLIS3nonsynonymous DLBC|1|48|0.02083
-chr938561613856161GAexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr938794293879429CTexonicGLIS3synonymous LUAD|1|543|0.00184
rs201142941chr942862854286285CTexonicGLIS3synonymous UCEC|1|248|0.00403
-chr938561763856176GTexonicGLIS3nonsynonymous UCEC|1|248|0.00403
-chr938560403856040AGexonicGLIS3synonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr941259164125916GAexonicGLIS3synonymous UCEC|1|248|0.00403
-chr941257714125771TCexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr941184074118407GTexonicGLIS3nonsynonymous HNSC|1|512|0.00195
-chr941185814118581CAexonicGLIS3nonsynonymous UCS|1|57|0.01754
-chr938294443829444GCexonicGLIS3nonsynonymous PAAD|1|185|0.00541
-chr938282873828287GCexonicGLIS3synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr942862134286213CAexonicGLIS3nonsynonymous UCEC|1|248|0.00403
-chr942861224286122GAexonicGLIS3stopgain SKCM|1|368|0.00272
-chr941181104118110TGexonicGLIS3synonymous THCA|1|504|0.00198
rs777119496chr938282813828281GAexonicGLIS3synonymous PRAD|1|499|0.00200
-chr941178264117826CTexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr939323613932361T-exonicGLIS3frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr938987963898796CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs775044065chr941181414118141GAexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr939370843937084TGexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs143229220chr941188484118848CTexonicGLIS3synonymous SKCM|1|368|0.00272
rs758753292chr939370583937058GAexonicGLIS3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr938560413856041GAexonicGLIS3nonsynonymous UVM|1|80|0.01250
rs755318788chr941181484118148GAexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs764619575chr942862074286207GAexonicGLIS3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr938293943829394CAexonicGLIS3stopgain CESC|1|194|0.00515
-chr941185304118530GAexonicGLIS3synonymous SKCM|1|368|0.00272
rs199976011chr942860004286000GAintronicGLIS3unknown GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr941181434118143G-exonicGLIS3frameshift STAD|2|395|0.00506,STES|2|395|0.00506
-chr938561033856103CTexonicGLIS3synonymous HNSC|1|512|0.00195
-chr939710933971113TAGATCGAAGGAAGGAAGGAA-intronicGLIS3unknown -
-chr941185524118552GCexonicGLIS3nonsynonymous SARC|1|247|0.00405
-chr941183784118378CTexonicGLIS3nonsynonymous PAAD|1|185|0.00541
-chr939371643937164GAexonicGLIS3nonsynonymous HNSC|2|512|0.00391
-chr941181344118134CTexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr939371243937124TAexonicGLIS3synonymous LUAD|1|543|0.00184
-chr941181464118146GTexonicGLIS3synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr941185634118563CAexonicGLIS3nonsynonymous ESCA|1|185|0.00541
-chr939323963932396CTexonicGLIS3synonymous SKCM|1|368|0.00272
-chr941182904118290TCexonicGLIS3synonymous BLCA|1|396|0.00253
-chr938987963898796CGexonicGLIS3nonsynonymous BLCA|1|396|0.00253
rs748493859chr941186184118618CTexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr941258594125859CTexonicGLIS3nonsynonymous BLCA|1|396|0.00253,SKCM|1|368|0.00272
rs770212930chr941185044118504GAexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr941179224117922CTexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs753764072chr941185814118581CGexonicGLIS3nonsynonymous BLCA|1|396|0.00253
-chr941185924118592CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs759183029chr941178604117860CTexonicGLIS3nonsynonymous HNSC|1|512|0.00195
-chr941180134118013CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs752036990chr941179634117963GAexonicGLIS3synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
rs774124083chr941181844118184GAexonicGLIS3nonsynonymous LIHC|1|373|0.00268
-chr939371523937152TAexonicGLIS3nonsynonymous HNSC|1|512|0.00195
rs368943263chr941185414118541CTexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr938294443829444GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs749999750chr938283913828391TCexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs76094493chr938283793828379GAexonicGLIS3nonsynonymous LAML|1|197|0.00508
-chr941186254118625TAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr942860574286057A-exonicGLIS3frameshift PAAD|1|185|0.00541
-chr939371353937135GAexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr938987983898798GTexonicGLIS3nonsynonymous LUSC|1|178|0.00562
-chr941181054118105GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr939371603937160CAexonicGLIS3nonsynonymous LUAD|1|543|0.00184
rs759160830chr938294493829449GAexonicGLIS3synonymous UCEC|1|248|0.00403
-chr938293913829391CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941179034117903GAexonicGLIS3synonymous BRCA|1|982|0.00102
rs200702915chr939710943971113AGATCGAAGGAAGGAAGGAA-intronicGLIS3unknown -
-chr941179074117907AGexonicGLIS3nonsynonymous HNSC|1|512|0.00195
-chr941184134118413GAexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr941178924117892CTexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr939328893932889-AintronicGLIS3unknown ESCA|1|185|0.00541
-chr938794313879431CGexonicGLIS3nonsynonymous HNSC|1|512|0.00195
rs181328309chr941177694117769GAexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr938795323879532GTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr939371833937183CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs371355667chr941179454117945GAexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs562740663chr941180074118007CTexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
rs201556131chr938987843898784CTexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr938293183829318C-exonicGLIS3frameshift LUSC|1|178|0.00562
-chr938561513856151GTexonicGLIS3synonymous ESCA|1|185|0.00541
-chr939324213932421GAexonicGLIS3nonsynonymous LUAD|1|543|0.00184
rs6415788chr941181114118111GTexonicGLIS3nonsynonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr941258794125879CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941187394118739CAexonicGLIS3nonsynonymous LUAD|1|543|0.00184
-chr938279203827920GAUTR3GLIS3unknown CESC|1|194|0.00515
-chr941186824118682ATexonicGLIS3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr938283353828335GAexonicGLIS3synonymous BLCA|2|396|0.00505
-chr938560993856099GCexonicGLIS3nonsynonymous OV|1|469|0.00213
-chr942863714286371CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941188704118870GAexonicGLIS3nonsynonymous UCEC|1|248|0.00403
-chr942861164286116CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs765858803chr942862404286240CTexonicGLIS3nonsynonymous UCEC|1|248|0.00403
-chr941185124118512CTexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr939371693937169GAexonicGLIS3synonymous SKCM|1|368|0.00272
rs772874731chr938293513829351TCexonicGLIS3nonsynonymous PAAD|1|185|0.00541
-chr938986933898693GAexonicGLIS3nonsynonymous CESC|1|194|0.00515
-chr942863904286390CAexonicGLIS3synonymous BLCA|1|396|0.00253
-chr941179864117986CAexonicGLIS3nonsynonymous LUAD|1|543|0.00184
-chr938561753856175ACexonicGLIS3synonymous BRCA|1|982|0.00102
rs537966660chr938561443856144GAexonicGLIS3nonsynonymous PRAD|1|499|0.00200
rs771158269chr938283733828373CTexonicGLIS3nonsynonymous CESC|1|194|0.00515
rs750080742chr938987853898785GAexonicGLIS3synonymous UCEC|1|248|0.00403
-chr938795453879545C-exonicGLIS3frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr938794363879436CTexonicGLIS3nonsynonymous BLCA|1|396|0.00253
-chr942861554286155GAexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr939323663932366CAexonicGLIS3nonsynonymous BLCA|1|396|0.00253
-chr939324283932428TCexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr941179164117916AGexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs200195201chr942861934286193CTexonicGLIS3nonsynonymous CHOL|1|35|0.02857
-chr939370293937029GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr938987913898791GAexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr941258794125879CAexonicGLIS3nonsynonymous BLCA|1|396|0.00253
rs759784205chr941258414125841GAexonicGLIS3synonymous BLCA|1|396|0.00253
rs200950499chr942863924286392GAexonicGLIS3nonsynonymous HNSC|1|512|0.00195
-chr942863474286347GAexonicGLIS3nonsynonymous BRCA|1|982|0.00102
rs146067479chr941187814118781CAexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs187615896chr938561223856122GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs756792178chr941178614117861GAexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr941180804118080CTexonicGLIS3synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189,STAD|1|395|0.00253,STES|1|395|0.00253
-chr942996614299661CAUTR5GLIS3unknown BRCA|1|982|0.00102
-chr938293793829379GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941180244118024GAexonicGLIS3nonsynonymous LIHC|1|373|0.00268
-chr942995974299597GAUTR5GLIS3unknown CESC|1|194|0.00515
-chr942860604286060AGexonicGLIS3synonymous CHOL|1|35|0.02857
-chr938294493829449GTexonicGLIS3synonymous TGCT|1|155|0.00645
-chr939371263937126TCexonicGLIS3nonsynonymous THCA|1|504|0.00198
-chr941258364125836GTexonicGLIS3stopgain CESC|1|194|0.00515
-chr941258154125815GCexonicGLIS3nonsynonymous CESC|1|194|0.00515
-chr941187174118717ATexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs757118860chr942862864286286GAexonicGLIS3nonsynonymous SKCM|3|368|0.00815
rs748922836chr939370953937095GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr942862484286248GTexonicGLIS3nonsynonymous DLBC|1|48|0.02083
-chr941181874118187CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr938294113829411CGexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr939324093932409CTexonicGLIS3nonsynonymous CESC|1|194|0.00515
-chr942860074286007T-intronicGLIS3unknown ESCA|1|185|0.00541
-chr941178784117878AGexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr941178644117864CTexonicGLIS3stopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr942862524286252GAexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs777777838chr938560693856069GAexonicGLIS3synonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
rs748645578chr941181024118102G-exonicGLIS3frameshift CHOL|1|35|0.02857
-chr941178964117896GAexonicGLIS3stopgain UCEC|1|248|0.00403
rs780172059chr938293993829399GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272,UCEC|1|248|0.00403
-chr938560093856009CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs751461025chr938294573829457GAexonicGLIS3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr938293193829319CAexonicGLIS3nonsynonymous LUAD|1|543|0.00184
-chr941178004117800CAexonicGLIS3nonsynonymous UCEC|1|248|0.00403
-chr938294383829438CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941178214117821TCexonicGLIS3nonsynonymous HNSC|2|512|0.00391
rs768657630chr942862064286206CTexonicGLIS3nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr941186174118617CTexonicGLIS3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs371790247chr942861384286138CTexonicGLIS3synonymous PAAD|1|185|0.00541
-chr938294713829471TGexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs774796300chr941179934117993GAexonicGLIS3synonymous LUSC|1|178|0.00562
-chr938794903879490CTexonicGLIS3nonsynonymous ESCA|1|185|0.00541
-chr938794293879429CGexonicGLIS3nonsynonymous HNSC|1|512|0.00195
-chr941184434118443CTexonicGLIS3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs745952942chr941185504118550CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr938283383828338GAexonicGLIS3synonymous SARC|1|247|0.00405
-chr938283063828306GAexonicGLIS3nonsynonymous SKCM|1|368|0.00272
rs757448015chr941185894118589GAexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr941188654118865CGexonicGLIS3nonsynonymous BLCA|1|396|0.00253
rs201431173chr941185094118509CTexonicGLIS3synonymous PAAD|1|185|0.00541
-chr941184624118462GTexonicGLIS3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs202217571chr938794413879441GAexonicGLIS3synonymous UCEC|1|248|0.00403
rs770293029chr941185514118551GAexonicGLIS3synonymous SARC|1|247|0.00405
-chr939324333932433CTexonicGLIS3nonsynonymous UCEC|1|248|0.00403
-chr938561103856110CTexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941184684118468GAexonicGLIS3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs765789414chr941178994117899CTexonicGLIS3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr941184814118481CGexonicGLIS3nonsynonymous SKCM|1|368|0.00272
-chr941257724125772CAexonicGLIS3nonsynonymous UVM|1|80|0.01250
-chr941178034117803TAexonicGLIS3stopgain OV|1|469|0.00213
-chr941181834118183CTexonicGLIS3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
rs759183029chr941178604117860CGexonicGLIS3nonsynonymous LIHC|1|373|0.00268
-chr938283863828386GTexonicGLIS3synonymous UCEC|1|248|0.00403
-chr941181164118116CAexonicGLIS3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204

Disease information of GLIS3
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
GLIS3 Congenital Hypothyroidism C05;C16;C19 Disease or Syndrome GENOMICS_ENGLAND
GLIS3 Diabetes Mellitus, Insulin-Dependent C18;C19;C20 Disease or Syndrome CTD_human
GLIS3 Diabetes Mellitus, Non-Insulin-Dependent C18;C19 Disease or Syndrome CTD_human
GLIS3 Angle Closure Glaucoma C11 Disease or Syndrome CTD_human
GLIS3 Diabetes, Autoimmune C18;C19;C20 Disease or Syndrome CTD_human
GLIS3 Brittle diabetes C18;C19;C20 Disease or Syndrome CTD_human
GLIS3 Thyroid Agenesis C16;C19 Congenital Abnormality GENOMICS_ENGLAND
GLIS3 Diabetes Mellitus, Neonatal, with Congenital Hypothyroidism C05;C16;C18;C19 Disease or Syndrome CTD_human;ORPHANET
GLIS3 Intellectual Disability C10;C23;F01;F03 Mental or Behavioral Dysfunction GENOMICS_ENGLAND
GLIS3 Diabetes Mellitus, Ketosis-Prone C18;C19;C20 Disease or Syndrome CTD_human

Pathway associated with GLIS3
pathway_ID pathway_name pathway_source gene_number edge_number

Go term information of GLIS3
GO_term_name GO_term_type TF_name

Survival analysis of GLIS3



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of GLIS3