Cancer CRCdb

TF information

TF name:	FOXO1
TF family:	Fork_head
Ensembl gene ID:	ENSG00000150907
Ensembl protein ID:	ENSP00000368880
Entrez gene ID:	2308

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of FOXO1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_114	Cell line	Mammary Gland	CAL51	0.07035175879397
Sample_02_181	Cell line	Human melanoma	COLO679	0.288
Sample_02_204	Cell line	Stomach	IM95	0.68181818181818

FOXO1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_204	Stomach	Cell line	IM95

FOXO1 distribution in all CRCs

Genomic distribution of SEs associated with FOXO1

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Mutation of FOXO1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOXO1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr13	41134632	41134632	C	T	exonic	FOXO1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr13	41134849	41134849	T	C	exonic	FOXO1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41134548	41134548	G	A	exonic	FOXO1	synonymous	SKCM\|1\|368\|0.00272
rs374399783	chr13	41134890	41134890	G	A	exonic	FOXO1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs754690688	chr13	41239792	41239792	G	A	exonic	FOXO1	synonymous	LIHC\|1\|373\|0.00268
-	chr13	41134954	41134954	C	T	exonic	FOXO1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506,UCEC\|2\|248\|0.00806
-	chr13	41134033	41134033	G	A	exonic	FOXO1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr13	41134410	41134410	C	T	exonic	FOXO1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41134356	41134356	A	T	exonic	FOXO1	stopgain	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr13	41134803	41134803	T	C	exonic	FOXO1	synonymous	LIHC\|1\|373\|0.00268
-	chr13	41133971	41133971	T	C	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41134681	41134681	C	T	exonic	FOXO1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr13	41133857	41133857	C	T	exonic	FOXO1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr13	41134738	41134738	G	T	exonic	FOXO1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41134865	41134865	C	T	exonic	FOXO1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr13	41133797	41133797	C	T	exonic	FOXO1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41134248	41134248	T	C	exonic	FOXO1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41133723	41133723	C	T	exonic	FOXO1	synonymous	SKCM\|1\|368\|0.00272
-	chr13	41239736	41239736	C	T	exonic	FOXO1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr13	41239759	41239759	G	C	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs199932286	chr13	41134072	41134072	G	A	exonic	FOXO1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41134077	41134078	CA	-	exonic	FOXO1	frameshift	UCEC\|1\|248\|0.00403
-	chr13	41239788	41239788	C	T	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41134759	41134759	G	T	exonic	FOXO1	stopgain	OV\|1\|469\|0.00213
rs772929365	chr13	41134405	41134405	G	A	exonic	FOXO1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41134955	41134955	G	A	exonic	FOXO1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41134699	41134699	C	A	exonic	FOXO1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41134273	41134273	A	G	exonic	FOXO1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr13	41134523	41134523	C	T	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41134652	41134652	C	G	exonic	FOXO1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr13	41134988	41134988	G	A	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41134546	41134546	C	T	exonic	FOXO1	nonsynonymous	ESCA\|2\|185\|0.01081
-	chr13	41239864	41239864	G	C	exonic	FOXO1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr13	41134508	41134508	G	T	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
rs768488321	chr13	41133803	41133803	G	A	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41240299	41240299	C	A	exonic	FOXO1	synonymous	DLBC\|1\|48\|0.02083
-	chr13	41134875	41134875	C	A	exonic	FOXO1	nonsynonymous	LUAD\|1\|543\|0.00184
rs751994432	chr13	41133865	41133865	C	T	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41134135	41134135	A	G	exonic	FOXO1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41134062	41134062	A	G	exonic	FOXO1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs139436481	chr13	41134629	41134629	G	A	exonic	FOXO1	synonymous	DLBC\|1\|48\|0.02083
rs555035704	chr13	41134254	41134254	C	T	exonic	FOXO1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr13	41134917	41134917	C	A	exonic	FOXO1	nonsynonymous	LUAD\|1\|543\|0.00184
rs149675484	chr13	41133979	41133979	G	A	exonic	FOXO1	nonsynonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr13	41134688	41134688	G	A	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
rs199728685	chr13	41134828	41134828	C	T	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41133687	41133687	T	C	exonic	FOXO1	synonymous	BLCA\|1\|396\|0.00253
rs760747458	chr13	41134687	41134687	C	T	exonic	FOXO1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr13	41134750	41134750	G	T	exonic	FOXO1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr13	41134661	41134661	T	C	exonic	FOXO1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41134083	41134083	T	G	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41134033	41134033	G	T	exonic	FOXO1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41239723	41239723	C	G	exonic	FOXO1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	41134158	41134158	C	T	exonic	FOXO1	synonymous	SKCM\|1\|368\|0.00272
rs768433269	chr13	41133681	41133681	T	C	exonic	FOXO1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41134359	41134359	T	-	exonic	FOXO1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41134987	41134987	C	T	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41134406	41134406	C	T	exonic	FOXO1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41134348	41134348	C	A	exonic	FOXO1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr13	41134638	41134638	G	A	exonic	FOXO1	synonymous	SKCM\|1\|368\|0.00272
-	chr13	41134162	41134162	C	T	exonic	FOXO1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr13	41134284	41134284	A	C	exonic	FOXO1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr13	41240285	41240285	G	C	exonic	FOXO1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr13	41134854	41134854	G	A	exonic	FOXO1	synonymous	LUAD\|1\|543\|0.00184
-	chr13	41134046	41134046	C	A	exonic	FOXO1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr13	41134387	41134387	A	G	exonic	FOXO1	nonsynonymous	BLCA\|2\|396\|0.00505
rs377728010	chr13	41134792	41134792	G	A	exonic	FOXO1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs752627269	chr13	41134524	41134524	G	A	exonic	FOXO1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs768903432	chr13	41134157	41134157	C	T	exonic	FOXO1	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of FOXO1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
FOXO1	Pulmonary Hypertension	C08	Pathologic Function	CTD_human
FOXO1	Keratoconus	C11	Disease or Syndrome	CTD_human
FOXO1	Leukemia, Myelocytic, Acute	C04	Neoplastic Process	CTD_human
FOXO1	Acute Myeloid Leukemia, M1	C04	Neoplastic Process	CTD_human
FOXO1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
FOXO1	Diffuse Large B-Cell Lymphoma	C04;C15;C20	Neoplastic Process	CGI
FOXO1	Alveolar rhabdomyosarcoma	C04	Neoplastic Process	CTD_human;ORPHANET
FOXO1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
FOXO1	Acute Myeloid Leukemia (AML-M2)	C04	Neoplastic Process	CTD_human

Pathway associated with FOXO1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000118	AKT phosphorylates targets in the nucleus	reactome	9	27
pathway0000178	Angiopoietin receptor Tie2-mediated signaling	pid	50	441
pathway0000443	Class I PI3K signaling events mediated by Akt	pid	35	293
pathway0000479	Constitutive Signaling by AKT1 E17K in Cancer	reactome	25	137
pathway0000513	CXCR4-mediated signaling events	pid	87	1183
pathway0000827	FoxO family signaling	pid	50	426
pathway0000842	FSH	netpath	44	301
pathway0001112	IL-7	netpath	28	203
pathway0001126	IL3	netpath	84	1284
pathway0001131	IL6-mediated signaling events	pid	48	426
pathway0001132	IL6	netpath	85	1335
pathway0001167	Insulin/IGF pathway-protein kinase B signaling cascade	panther	22	94
pathway0001264	Leptin	netpath	98	1355
pathway0001322	MAPK6/MAPK4 signaling	reactome	90	1485
pathway0001460	Negative regulation of gene expression ( Insulin receptor signaling (D. melanogaster) )	inoh	7	22
pathway0001461	Negative regulation of gene expression ( Insulin receptor signaling (Mammal) )	inoh	7	22
pathway0001655	PI3 kinase pathway	panther	38	374
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0001834	Regulation of gene expression in beta cells	reactome	17	54
pathway0001849	Regulation of nuclear SMAD2/3 signaling	pid	82	1072
pathway0002035	Signaling events mediated by HDAC Class III	pid	41	421
pathway0002690	Hs_ErbB_Signaling_Pathway_WP673_91869	wikipathways	37	312
pathway0002723	Hs_Angiopoietin_Like_Protein_8_Regulatory_Pathway_WP3915_90629	wikipathways	9	11
pathway0002743	Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000	wikipathways	153	1949
pathway0002763	Hs_Rac1-Pak1-p38-MMP-2_pathway_WP3303_87628	wikipathways	32	197
pathway0002773	Hs_Energy_Metabolism_WP1541_91584	wikipathways	13	34
pathway0002808	Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581	wikipathways	9	16
pathway0002855	Hs_NAD_metabolism,_sirtuins_and_aging_WP3630_88178	wikipathways	8	17
pathway0002862	Hs_AGE-RAGE_pathway_WP2324_89798	wikipathways	27	130
pathway0002875	Hs_Follicle_Stimulating_Hormone_(FSH)_signaling_pathway_WP2035_86080	wikipathways	20	71

Go term information of FOXO1

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_AUTOPHAGY	BP	FOXO1
GO_CHEMICAL_HOMEOSTASIS	BP	FOXO1
GO_REGULATION_OF_MAPK_CASCADE	BP	FOXO1
GO_RESPONSE_TO_COLD	BP	FOXO1
GO_RESPONSE_TO_ACID_CHEMICAL	BP	FOXO1
GO_RESPONSE_TO_PEPTIDE	BP	FOXO1
GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	FOXO1
GO_TOOTH_MINERALIZATION	BP	FOXO1
GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS	BP	FOXO1
GO_REGULATION_OF_ENERGY_HOMEOSTASIS	BP	FOXO1
GO_PANCREAS_DEVELOPMENT	BP	FOXO1
GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE	BP	FOXO1
GO_ENAMEL_MINERALIZATION	BP	FOXO1
GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS	BP	FOXO1
GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS	BP	FOXO1
GO_RESPONSE_TO_INSULIN	BP	FOXO1
GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS	BP	FOXO1
GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS	BP	FOXO1
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	FOXO1
GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS	BP	FOXO1
GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS	BP	FOXO1
GO_VASCULATURE_DEVELOPMENT	BP	FOXO1
GO_AMELOGENESIS	BP	FOXO1
GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS	BP	FOXO1
GO_CELLULAR_GLUCOSE_HOMEOSTASIS	BP	FOXO1
GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE	BP	FOXO1
GO_CARBOHYDRATE_HOMEOSTASIS	BP	FOXO1
GO_CELLULAR_RESPONSE_TO_KETONE	BP	FOXO1
GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE	BP	FOXO1
GO_BIOMINERAL_TISSUE_DEVELOPMENT	BP	FOXO1
GO_RESPONSE_TO_DEXAMETHASONE	BP	FOXO1
GO_PROTEIN_ACYLATION	BP	FOXO1
GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES	BP	FOXO1
GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	FOXO1
GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS	BP	FOXO1
GO_RESPONSE_TO_OXIDATIVE_STRESS	BP	FOXO1
GO_TEMPERATURE_HOMEOSTASIS	BP	FOXO1
GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS	BP	FOXO1
GO_RESPONSE_TO_STARVATION	BP	FOXO1
GO_REGULATION_OF_GLUCONEOGENESIS	BP	FOXO1
GO_ODONTOGENESIS	BP	FOXO1
GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS	BP	FOXO1
GO_RESPONSE_TO_NITRIC_OXIDE	BP	FOXO1
GO_BETA_CATENIN_BINDING	MF	FOXO1
GO_TRANSCRIPTION_COFACTOR_BINDING	MF	FOXO1
GO_TRANSCRIPTION_COACTIVATOR_BINDING	MF	FOXO1
GO_PROTEIN_PHOSPHATASE_2A_BINDING	MF	FOXO1

Survival analysis of FOXO1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of FOXO1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)