TF information
| TF name: | FOXC2 |
| TF family: | Fork_head |
| Ensembl gene ID: | ENSG00000176692 |
| Ensembl protein ID: | ENSP00000326371 |
| Entrez gene ID: | 2303 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of FOXC2 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_069 | Cell line | Brain | SF268 | 0.10687022900763 |
| Sample_02_080 | Cell line | Lung | Calu-3 | 0.18181818181818 |
| Sample_02_179 | Cell line | Urinary bladder | T24 | 0.14942528735632 |
| Sample_02_317 | Cell line | Neuroblastoma | GICAN | 0.10810810810811 |
FOXC2 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
FOXC2 distribution in all CRCs
Genomic distribution of SEs associated with FOXC2
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of FOXC2
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs765735196 | chr16 | 86601494 | 86601494 | G | A | exonic | FOXC2 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr16 | 86602228 | 86602228 | C | T | exonic | FOXC2 | synonymous | ESCA|1|185|0.00541 |
| - | chr16 | 86602427 | 86602427 | T | C | exonic | FOXC2 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr16 | 86602380 | 86602380 | C | G | exonic | FOXC2 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr16 | 86601231 | 86601231 | G | A | exonic | FOXC2 | nonsynonymous | PAAD|1|185|0.00541 |
| rs148657129 | chr16 | 86602438 | 86602438 | G | A | exonic | FOXC2 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,SKCM|1|368|0.00272 |
| - | chr16 | 86601058 | 86601058 | C | T | exonic | FOXC2 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86602418 | 86602418 | C | A | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601995 | 86601995 | C | - | exonic | FOXC2 | frameshift | THCA|1|504|0.00198 |
| rs773050488 | chr16 | 86601133 | 86601133 | C | T | exonic | FOXC2 | synonymous | UCEC|1|248|0.00403 |
| rs778599000 | chr16 | 86602288 | 86602288 | C | T | exonic | FOXC2 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs748779213 | chr16 | 86601025 | 86601025 | G | A | exonic | FOXC2 | synonymous | UCEC|1|248|0.00403 |
| - | chr16 | 86602198 | 86602198 | G | A | exonic | FOXC2 | synonymous | PAAD|1|185|0.00541,PRAD|1|499|0.00200 |
| - | chr16 | 86601138 | 86601138 | C | T | exonic | FOXC2 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr16 | 86601098 | 86601098 | G | A | exonic | FOXC2 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr16 | 86601239 | 86601239 | C | T | exonic | FOXC2 | stopgain | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601261 | 86601261 | C | A | exonic | FOXC2 | nonsynonymous | OV|1|469|0.00213 |
| rs138612549 | chr16 | 86602305 | 86602305 | A | G | exonic | FOXC2 | nonsynonymous | ACC|1|90|0.01111 |
| - | chr16 | 86601490 | 86601490 | C | G | exonic | FOXC2 | synonymous | HNSC|1|512|0.00195 |
| - | chr16 | 86602407 | 86602407 | G | T | exonic | FOXC2 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr16 | 86601209 | 86601209 | G | A | exonic | FOXC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601563 | 86601563 | G | A | exonic | FOXC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr16 | 86601093 | 86601093 | G | T | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601175 | 86601175 | C | G | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| rs773245007 | chr16 | 86602418 | 86602418 | C | T | exonic | FOXC2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 86601001 | 86601001 | C | T | exonic | FOXC2 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 86601502 | 86601502 | C | T | exonic | FOXC2 | synonymous | SKCM|1|368|0.00272 |
| rs764129123 | chr16 | 86601062 | 86601062 | T | C | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86602184 | 86602184 | G | A | exonic | FOXC2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 86601425 | 86601425 | C | A | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601105 | 86601105 | C | G | exonic | FOXC2 | nonsynonymous | BLCA|1|396|0.00253 |
| rs764783770 | chr16 | 86602381 | 86602381 | C | T | exonic | FOXC2 | synonymous | SKCM|1|368|0.00272 |
| - | chr16 | 86601397 | 86601397 | C | A | exonic | FOXC2 | synonymous | HNSC|1|512|0.00195 |
| - | chr16 | 86601503 | 86601503 | C | T | exonic | FOXC2 | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr16 | 86600952 | 86600952 | G | A | exonic | FOXC2 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr16 | 86601010 | 86601010 | T | G | exonic | FOXC2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr16 | 86601069 | 86601069 | G | A | exonic | FOXC2 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr16 | 86601394 | 86601394 | C | A | exonic | FOXC2 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr16 | 86602406 | 86602406 | C | T | exonic | FOXC2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 86602312 | 86602312 | C | T | exonic | FOXC2 | synonymous | LUSC|1|178|0.00562 |
| - | chr16 | 86601202 | 86601202 | C | A | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601457 | 86601457 | C | T | exonic | FOXC2 | synonymous | UCEC|1|248|0.00403 |
| - | chr16 | 86601304 | 86601304 | C | A | exonic | FOXC2 | synonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86602295 | 86602295 | G | A | exonic | FOXC2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr16 | 86601059 | 86601059 | G | A | exonic | FOXC2 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs755617186 | chr16 | 86601967 | 86601967 | C | T | exonic | FOXC2 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601383 | 86601383 | C | A | exonic | FOXC2 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr16 | 86600960 | 86600960 | G | A | exonic | FOXC2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr16 | 86601483 | 86601483 | C | G | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601603 | 86601603 | C | T | exonic | FOXC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601141 | 86601141 | C | A | exonic | FOXC2 | nonsynonymous | PAAD|1|185|0.00541 |
| rs759417459 | chr16 | 86601223 | 86601223 | C | T | exonic | FOXC2 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601350 | 86601350 | G | A | exonic | FOXC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601011 | 86601011 | T | C | exonic | FOXC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601196 | 86601196 | C | A | exonic | FOXC2 | synonymous | ACC|1|90|0.01111 |
| - | chr16 | 86601361 | 86601361 | C | T | exonic | FOXC2 | synonymous | UCEC|1|248|0.00403 |
| - | chr16 | 86602395 | 86602395 | C | A | exonic | FOXC2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr16 | 86602257 | 86602257 | C | G | exonic | FOXC2 | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr16 | 86601587 | 86601587 | G | A | exonic | FOXC2 | nonsynonymous | HNSC|1|512|0.00195,SKCM|2|368|0.00543 |
| - | chr16 | 86602192 | 86602192 | C | G | exonic | FOXC2 | synonymous | LUAD|2|543|0.00368 |
| - | chr16 | 86601500 | 86601500 | C | - | exonic | FOXC2 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 86601557 | 86601557 | G | C | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601305 | 86601305 | C | A | exonic | FOXC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 86601425 | 86601425 | C | T | exonic | FOXC2 | synonymous | BLCA|1|396|0.00253 |
| - | chr16 | 86601480 | 86601480 | G | - | exonic | FOXC2 | frameshift | SKCM|1|368|0.00272 |
| - | chr16 | 86601790 | 86601790 | G | - | exonic | FOXC2 | frameshift | BLCA|1|396|0.00253 |
| rs751774927 | chr16 | 86601504 | 86601504 | C | T | exonic | FOXC2 | nonsynonymous | BLCA|1|396|0.00253,HNSC|1|512|0.00195 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| FOXC2 | Hydrops Fetalis | C13;C15;C16;C20;C23 | Disease or Syndrome | GENOMICS_ENGLAND |
| FOXC2 | Lymphatic Diseases | C15 | Disease or Syndrome | GENOMICS_ENGLAND |
| FOXC2 | Tetralogy of Fallot | C14;C16 | Congenital Abnormality | CTD_human |
| FOXC2 | Congenital musculoskeletal anomalies | C05;C16 | Congenital Abnormality | CTD_human |
| FOXC2 | Congenital diaphragmatic hernia | C16;C23 | Disease or Syndrome | CTD_human |
| FOXC2 | Cardiovascular Abnormalities | C14;C16 | Congenital Abnormality | CTD_human |
| FOXC2 | Lymphedema distichiasis syndrome | C15 | Disease or Syndrome | CTD_human;ORPHANET;UNIPROT |
| FOXC2 | Congenital hernia of foramen of Morgagni | C16;C23 | Congenital Abnormality | CTD_human |
| FOXC2 | Congenital hernia of foramen of Bochdalek | C16;C23 | Congenital Abnormality | CTD_human |
| FOXC2 | Craniofacial Abnormalities | C05;C16 | Congenital Abnormality | CTD_human |
| FOXC2 | Cakut | C12;C13;C16 | Disease or Syndrome | GENOMICS_ENGLAND |
| FOXC2 | Lymphedema-Distichiasis Syndrome with Renal Disease and Diabetes Mellitus | C12;C13;C15;C18;C19 | Disease or Syndrome | UNIPROT |
| FOXC2 | Intellectual Disability | C10;C23;F01;F03 | Mental or Behavioral Dysfunction | GENOMICS_ENGLAND |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_RESPONSE_TO_NITROGEN_COMPOUND | BP | FOXC2 |
| GO_METANEPHROS_DEVELOPMENT | BP | FOXC2 |
| GO_COLLAGEN_FIBRIL_ORGANIZATION | BP | FOXC2 |
| GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_LOCOMOTION | BP | FOXC2 |
| GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY | BP | FOXC2 |
| GO_MORPHOGENESIS_OF_AN_EPITHELIUM | BP | FOXC2 |
| GO_KIDNEY_EPITHELIUM_DEVELOPMENT | BP | FOXC2 |
| GO_MUSCLE_CELL_PROLIFERATION | BP | FOXC2 |
| GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS | BP | FOXC2 |
| GO_PATTERNING_OF_BLOOD_VESSELS | BP | FOXC2 |
| GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT | BP | FOXC2 |
| GO_ARTERY_MORPHOGENESIS | BP | FOXC2 |
| GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT | BP | FOXC2 |
| GO_MESENCHYMAL_CELL_DIFFERENTIATION | BP | FOXC2 |
| GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT | BP | FOXC2 |
| GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER | BP | FOXC2 |
| GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | BP | FOXC2 |
| GO_REGULATION_OF_HEART_MORPHOGENESIS | BP | FOXC2 |
| GO_NEPHRON_EPITHELIUM_DEVELOPMENT | BP | FOXC2 |
| GO_LYMPHANGIOGENESIS | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_CELL_ADHESION | BP | FOXC2 |
| GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS | BP | FOXC2 |
| GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN | BP | FOXC2 |
| GO_GLOMERULUS_DEVELOPMENT | BP | FOXC2 |
| GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS | BP | FOXC2 |
| GO_MUSCLE_ORGAN_MORPHOGENESIS | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN | BP | FOXC2 |
| GO_ORGAN_GROWTH | BP | FOXC2 |
| GO_MESODERM_MORPHOGENESIS | BP | FOXC2 |
| GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY | BP | FOXC2 |
| GO_BLOOD_VESSEL_REMODELING | BP | FOXC2 |
| GO_OSSIFICATION | BP | FOXC2 |
| GO_MESODERMAL_CELL_DIFFERENTIATION | BP | FOXC2 |
| GO_LYMPH_VESSEL_MORPHOGENESIS | BP | FOXC2 |
| GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_WOUND_HEALING | BP | FOXC2 |
| GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT | BP | FOXC2 |
| GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE | BP | FOXC2 |
| GO_STRIATED_MUSCLE_CELL_PROLIFERATION | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS | BP | FOXC2 |
| GO_PARAXIAL_MESODERM_DEVELOPMENT | BP | FOXC2 |
| GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT | BP | FOXC2 |
| GO_HEART_GROWTH | BP | FOXC2 |
| GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY | BP | FOXC2 |
| GO_LYMPH_VESSEL_DEVELOPMENT | BP | FOXC2 |
| GO_REGULATION_OF_SPROUTING_ANGIOGENESIS | BP | FOXC2 |
| GO_NEPHRON_DEVELOPMENT | BP | FOXC2 |
| GO_MESENCHYME_MORPHOGENESIS | BP | FOXC2 |
| GO_SOMITE_DEVELOPMENT | BP | FOXC2 |
| GO_REGULATION_OF_CELL_DEVELOPMENT | BP | FOXC2 |
| GO_MESONEPHROS_DEVELOPMENT | BP | FOXC2 |
| GO_MESODERMAL_CELL_FATE_COMMITMENT | BP | FOXC2 |
| GO_REGIONALIZATION | BP | FOXC2 |
| GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION | BP | FOXC2 |
| GO_NEURAL_CREST_CELL_DIFFERENTIATION | BP | FOXC2 |
| GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS | BP | FOXC2 |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING | MF | FOXC2 |
| GO_CHROMATIN_DNA_BINDING | MF | FOXC2 |