Cancer CRCdb

TF information

TF name:	ZIC1
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000152977
Ensembl protein ID:	ENSP00000419664, ENSP00000282928
Entrez gene ID:	7545

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ZIC1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_250	Tissue	Brain	tumormodel3691	0.375
Sample_02_413	Tissue	Brain	GBM_2493	0.66483516483516

ZIC1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_413	Brain	Tissue	GBM_2493

ZIC1 distribution in all CRCs

Genomic distribution of SEs associated with ZIC1

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Mutation of ZIC1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ZIC1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	147128096	147128096	C	T	exonic	ZIC1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	147128271	147128271	G	A	exonic	ZIC1	synonymous	LUSC\|1\|178\|0.00562
rs150105356	chr3	147128622	147128622	G	A	exonic	ZIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs767388870	chr3	147131179	147131179	G	A	exonic	ZIC1	synonymous	PAAD\|1\|185\|0.00541
-	chr3	147128502	147128502	C	T	exonic	ZIC1	synonymous	UCEC\|1\|248\|0.00403
-	chr3	147130465	147130465	G	T	exonic	ZIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147128781	147128781	C	T	exonic	ZIC1	synonymous	BLCA\|1\|396\|0.00253
-	chr3	147128729	147128729	C	T	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128206	147128206	C	G	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147127985	147127985	C	-	exonic	ZIC1	frameshift	HNSC\|1\|512\|0.00195
-	chr3	147131172	147131172	C	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147131157	147131157	C	T	exonic	ZIC1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr3	147128145	147128145	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128353	147128353	G	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128064	147128064	G	C	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
-	chr3	147128303	147128303	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128672	147128672	T	C	exonic	ZIC1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	147128439	147128439	G	A	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147128661	147128661	G	T	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147130463	147130463	A	G	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147130393	147130393	G	A	exonic	ZIC1	synonymous	UCEC\|1\|248\|0.00403
rs545219481	chr3	147131323	147131323	C	G	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147130402	147130402	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128649	147128649	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128258	147128258	T	C	exonic	ZIC1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr3	147131311	147131311	T	A	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147128051	147128051	C	A	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147130364	147130364	G	A	exonic	ZIC1	nonsynonymous	CESC\|1\|194\|0.00515,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PRAD\|1\|499\|0.00200
-	chr3	147131162	147131162	G	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128281	147128281	T	A	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147128847	147128847	C	G	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147128643	147128643	C	A	exonic	ZIC1	synonymous	LUSC\|1\|178\|0.00562
-	chr3	147128402	147128402	C	T	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128521	147128521	C	A	exonic	ZIC1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr3	147128058	147128058	G	A	exonic	ZIC1	synonymous	THCA\|2\|504\|0.00397
-	chr3	147128234	147128234	C	T	exonic	ZIC1	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr3	147130409	147130409	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128309	147128309	C	-	exonic	ZIC1	frameshift	LUAD\|2\|543\|0.00368
-	chr3	147128212	147128212	C	A	exonic	ZIC1	synonymous	LUSC\|1\|178\|0.00562
-	chr3	147128091	147128091	C	T	exonic	ZIC1	synonymous	LUSC\|1\|178\|0.00562
-	chr3	147128288	147128288	G	A	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128846	147128846	C	G	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
-	chr3	147128057	147128057	C	A	exonic	ZIC1	stopgain	PRAD\|1\|499\|0.00200
-	chr3	147128543	147128543	G	A	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253,PAAD\|1\|185\|0.00541
-	chr3	147128734	147128734	G	A	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128490	147128490	C	G	exonic	ZIC1	stopgain	LUSC\|1\|178\|0.00562
-	chr3	147128283	147128283	C	T	exonic	ZIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147131190	147131190	C	T	exonic	ZIC1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	147128116	147128116	G	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128660	147128660	C	T	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128206	147128206	C	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147130352	147130352	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128732	147128732	G	A	exonic	ZIC1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	147128856	147128856	A	C	exonic	ZIC1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	147128840	147128840	C	T	exonic	ZIC1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr3	147128060	147128060	A	G	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
rs373965585	chr3	147131304	147131304	C	T	exonic	ZIC1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	147130413	147130413	G	C	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128279	147128279	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128637	147128637	C	T	exonic	ZIC1	synonymous	LIHC\|1\|373\|0.00268
-	chr3	147131271	147131271	C	T	exonic	ZIC1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	147128425	147128425	G	A	exonic	ZIC1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	147130449	147130449	C	T	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs527947592	chr3	147128418	147128418	G	A	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195
rs867511370	chr3	147130455	147130455	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128819	147128819	C	A	exonic	ZIC1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	147128499	147128499	G	T	exonic	ZIC1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs138004710	chr3	147128227	147128227	G	A	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147131305	147131305	G	A	exonic	ZIC1	synonymous	PAAD\|1\|185\|0.00541
-	chr3	147128524	147128524	G	T	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253,LUAD\|1\|543\|0.00184
-	chr3	147128517	147128517	G	A	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195,PAAD\|1\|185\|0.00541
-	chr3	147128637	147128637	C	G	exonic	ZIC1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	147131171	147131171	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147130382	147130382	C	T	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128760	147128760	C	T	exonic	ZIC1	synonymous	CESC\|1\|194\|0.00515
-	chr3	147127995	147127995	C	A	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128284	147128284	G	T	exonic	ZIC1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr3	147130344	147130344	G	C	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147128057	147128057	C	T	exonic	ZIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147128727	147128727	T	G	exonic	ZIC1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	147130368	147130368	G	A	exonic	ZIC1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs564229372	chr3	147131305	147131305	G	T	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195
-	chr3	147127991	147127991	G	A	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147128676	147128676	G	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147130317	147130317	T	G	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128132	147128132	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147131191	147131191	T	C	exonic	ZIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147128015	147128015	C	T	exonic	ZIC1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	147131143	147131143	C	A	exonic	ZIC1	synonymous	UCEC\|1\|248\|0.00403
-	chr3	147131324	147131324	G	A	exonic	ZIC1	nonsynonymous	SKCM\|1\|368\|0.00272
rs763182380	chr3	147128235	147128235	G	A	exonic	ZIC1	synonymous	PRAD\|1\|499\|0.00200
-	chr3	147128137	147128137	C	A	exonic	ZIC1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr3	147130434	147130434	A	G	exonic	ZIC1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	147127967	147127967	A	T	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147128660	147128660	C	A	exonic	ZIC1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	147128034	147128034	C	T	exonic	ZIC1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr3	147128515	147128515	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147130366	147130366	C	A	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147128883	147128883	T	C	splicing	ZIC1	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147127973	147127973	C	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128529	147128529	C	T	exonic	ZIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
-	chr3	147130385	147130385	G	C	exonic	ZIC1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	147131139	147131139	A	C	splicing	ZIC1	splicing	LUAD\|1\|543\|0.00184
-	chr3	147130324	147130324	C	A	exonic	ZIC1	stopgain	LUSC\|1\|178\|0.00562
-	chr3	147128259	147128259	C	G	exonic	ZIC1	synonymous	CESC\|1\|194\|0.00515
-	chr3	147128093	147128093	C	T	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147131292	147131292	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147131186	147131186	A	G	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128370	147128370	C	G	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128284	147128284	G	A	exonic	ZIC1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	147128226	147128226	C	T	exonic	ZIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs764570223	chr3	147128485	147128485	G	A	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs369830340	chr3	147128304	147128304	G	A	exonic	ZIC1	synonymous	BLCA\|1\|396\|0.00253
-	chr3	147128311	147128311	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs577417327	chr3	147128108	147128108	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147131209	147131209	G	A	exonic	ZIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147130318	147130318	C	T	exonic	ZIC1	synonymous	SKCM\|1\|368\|0.00272
-	chr3	147128862	147128862	C	G	exonic	ZIC1	nonsynonymous	BRCA\|1\|982\|0.00102
rs770353879	chr3	147131158	147131158	G	T	exonic	ZIC1	synonymous	BLCA\|1\|396\|0.00253
-	chr3	147128031	147128031	G	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
rs753755493	chr3	147128703	147128703	T	C	exonic	ZIC1	synonymous	OV\|1\|469\|0.00213
rs758948864	chr3	147131245	147131245	G	T	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195
-	chr3	147131198	147131198	G	A	exonic	ZIC1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	147128282	147128282	T	A	exonic	ZIC1	nonsynonymous	LUAD\|2\|543\|0.00368
rs769657730	chr3	147128442	147128442	G	T	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147128840	147128840	C	G	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
rs147993210	chr3	147130438	147130438	G	T	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147128612	147128612	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128793	147128793	C	A	exonic	ZIC1	synonymous	BLCA\|1\|396\|0.00253
-	chr3	147128224	147128224	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128596	147128596	G	A	exonic	ZIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	147128322	147128322	C	G	exonic	ZIC1	synonymous	BLCA\|1\|396\|0.00253
-	chr3	147128843	147128843	G	C	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128023	147128023	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147127954	147127954	G	A	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253,HNSC\|1\|512\|0.00195
-	chr3	147128162	147128162	C	T	exonic	ZIC1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	147128870	147128870	G	T	exonic	ZIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147128391	147128391	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
rs368298985	chr3	147131266	147131266	C	A	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195
-	chr3	147128190	147128190	G	A	exonic	ZIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147128839	147128839	G	-	exonic	ZIC1	frameshift	LUAD\|1\|543\|0.00184
-	chr3	147128086	147128086	G	A	exonic	ZIC1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr3	147128873	147128873	C	T	exonic	ZIC1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	147127911	147127911	C	T	exonic	ZIC1	synonymous	BLCA\|1\|396\|0.00253
-	chr3	147128468	147128468	C	A	exonic	ZIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147130340	147130340	G	T	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147131168	147131168	C	T	exonic	ZIC1	stopgain	HNSC\|1\|512\|0.00195
-	chr3	147128842	147128842	C	T	exonic	ZIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs781380196	chr3	147128169	147128169	C	T	exonic	ZIC1	synonymous	LUSC\|1\|178\|0.00562
rs756393471	chr3	147127956	147127956	G	A	exonic	ZIC1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr3	147128526	147128526	C	A	exonic	ZIC1	synonymous	LUAD\|1\|543\|0.00184
-	chr3	147128364	147128364	G	A	exonic	ZIC1	synonymous	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128793	147128793	C	T	exonic	ZIC1	synonymous	PAAD\|1\|185\|0.00541,PRAD\|1\|499\|0.00200
-	chr3	147128763	147128763	A	G	exonic	ZIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128808	147128808	C	T	exonic	ZIC1	synonymous	DLBC\|1\|48\|0.02083
-	chr3	147131226	147131226	C	T	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128361	147128361	G	A	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195
-	chr3	147128745	147128745	C	A	exonic	ZIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128383	147128383	C	A	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128441	147128441	T	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128513	147128526	CCGCGCATCACGGC	-	exonic	ZIC1	frameshift	LIHC\|1\|373\|0.00268
-	chr3	147128677	147128677	C	A	exonic	ZIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	147128662	147128662	C	A	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128794	147128794	G	T	exonic	ZIC1	stopgain	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr3	147130396	147130396	C	A	exonic	ZIC1	nonsynonymous	LUAD\|2\|543\|0.00368
rs756221956	chr3	147130418	147130418	A	G	exonic	ZIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	147128456	147128456	C	T	exonic	ZIC1	nonsynonymous	BRCA\|1\|982\|0.00102,COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	147127937	147127937	G	T	exonic	ZIC1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr3	147128158	147128158	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr3	147131190	147131190	C	G	exonic	ZIC1	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	147128194	147128194	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147130363	147130363	C	G	exonic	ZIC1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	147128382	147128382	G	A	exonic	ZIC1	synonymous	SKCM\|1\|368\|0.00272
-	chr3	147128811	147128811	C	T	exonic	ZIC1	synonymous	SKCM\|1\|368\|0.00272
-	chr3	147131289	147131289	C	G	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128470	147128470	G	T	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
rs759778746	chr3	147128475	147128475	G	A	exonic	ZIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr3	147127972	147127972	G	A	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147131197	147131197	C	T	exonic	ZIC1	synonymous	PRAD\|1\|499\|0.00200
rs752213758	chr3	147128534	147128534	C	A	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128850	147128850	G	C	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147130454	147130454	C	T	exonic	ZIC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	147128165	147128165	A	C	exonic	ZIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	147128288	147128288	G	C	exonic	ZIC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	147128358	147128358	C	T	exonic	ZIC1	synonymous	HNSC\|1\|512\|0.00195
-	chr3	147128795	147128795	A	G	exonic	ZIC1	nonsynonymous	ESCA\|1\|185\|0.00541

Disease information of ZIC1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ZIC1	Craniosynostosis	C05;C16	Disease or Syndrome	CTD_human;GENOMICS_ENGLAND
ZIC1	Acrocephaly	C05;C16	Congenital Abnormality	CTD_human;ORPHANET
ZIC1	Brachycephaly	C05;C16	Congenital Abnormality	CTD_human;ORPHANET
ZIC1	Plagiocephaly	C05;C16	Congenital Abnormality	ORPHANET
ZIC1	Scaphycephaly	C05;C16	Congenital Abnormality	CTD_human
ZIC1	Trigonocephaly	C05;C16	Congenital Abnormality	CTD_human
ZIC1	Synostotic Posterior Plagiocephaly	C05;C16	Disease or Syndrome	CTD_human
ZIC1	Metopic synostosis	C05;C16	Congenital Abnormality	CTD_human
ZIC1	Synostotic Anterior Plagiocephaly	C05;C16	Congenital Abnormality; Disease or Syndrome	CTD_human
ZIC1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
ZIC1	CRANIOSYNOSTOSIS 6		Disease or Syndrome	UNIPROT

Pathway associated with ZIC1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002747	Hs_Neural_Crest_Differentiation_WP2064_79263	wikipathways	40	129

Go term information of ZIC1

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GO_term_name	GO_term_type	TF_name
GO_SPINAL_CORD_DEVELOPMENT	BP	ZIC1
GO_SINGLE_ORGANISM_BEHAVIOR	BP	ZIC1
GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT	BP	ZIC1
GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT	BP	ZIC1
GO_EAR_MORPHOGENESIS	BP	ZIC1
GO_WALKING_BEHAVIOR	BP	ZIC1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	ZIC1
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	ZIC1

Survival analysis of ZIC1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ZIC1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)