TF information
| TF name: | TFAP4 |
| TF family: | bHLH |
| Ensembl gene ID: | ENSG00000090447 |
| Ensembl protein ID: | ENSP00000459390, ENSP00000204517 |
| Entrez gene ID: | 7023 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of TFAP4 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_01_022 | Cell line | Prostate | C4-2B | 0.16666666666667 |
| Sample_02_007 | Other | Cervical | cervical-cancer_vector | 0.15894039735099 |
| Sample_02_299 | Cell line | Neuroblastoma | CLB-MA | 0.2757793764988 |
| Sample_02_304 | Cell line | Neuroblastoma | N206 | 0.16847826086957 |
| Sample_02_313 | Cell line | Neuroblastoma | SK-N-DZ | 0.21621621621622 |
| Sample_02_355 | Cell line | Colon | HCT15 | 0.25595238095238 |
TFAP4 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
TFAP4 distribution in all CRCs
Genomic distribution of SEs associated with TFAP4
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of TFAP4
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr16 | 4308095 | 4308095 | C | G | exonic | TFAP4 | nonsynonymous | SARC|1|247|0.00405 |
| rs755945532 | chr16 | 4312619 | 4312619 | C | T | exonic | TFAP4 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr16 | 4312327 | 4312327 | G | A | exonic | TFAP4 | stopgain | SKCM|1|368|0.00272 |
| - | chr16 | 4312623 | 4312623 | C | T | exonic | TFAP4 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 4311902 | 4311902 | C | T | exonic | TFAP4 | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr16 | 4312613 | 4312613 | C | T | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403 |
| - | chr16 | 4322744 | 4322744 | C | A | exonic | TFAP4 | stopgain | BRCA|1|982|0.00102 |
| - | chr16 | 4322736 | 4322736 | G | C | exonic | TFAP4 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr16 | 4312668 | 4312668 | G | A | exonic | TFAP4 | nonsynonymous | SARC|1|247|0.00405 |
| - | chr16 | 4311920 | 4311920 | G | A | exonic | TFAP4 | nonsynonymous | BRCA|1|982|0.00102 |
| rs576796776 | chr16 | 4310163 | 4310163 | G | A | exonic | TFAP4 | synonymous | LUAD|1|543|0.00184 |
| - | chr16 | 4310169 | 4310169 | G | A | exonic | TFAP4 | synonymous | SKCM|1|368|0.00272 |
| - | chr16 | 4311932 | 4311932 | G | A | exonic | TFAP4 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 4312419 | 4312419 | G | A | exonic | TFAP4 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr16 | 4308235 | 4308235 | C | T | exonic | TFAP4 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr16 | 4310115 | 4310115 | C | T | exonic | TFAP4 | synonymous | PRAD|1|499|0.00200 |
| - | chr16 | 4312331 | 4312331 | G | A | exonic | TFAP4 | synonymous | LUAD|1|543|0.00184 |
| rs762237536 | chr16 | 4310219 | 4310219 | G | A | exonic | TFAP4 | nonsynonymous | HNSC|1|512|0.00195 |
| rs767084889 | chr16 | 4310225 | 4310225 | T | G | exonic | TFAP4 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr16 | 4308193 | 4308193 | G | A | exonic | TFAP4 | stopgain | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4312652 | 4312652 | C | T | exonic | TFAP4 | nonsynonymous | ESCA|1|185|0.00541,OV|1|469|0.00213,STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr16 | 4312598 | 4312598 | T | C | exonic | TFAP4 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr16 | 4312624 | 4312624 | G | A | exonic | TFAP4 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4311926 | 4311926 | G | A | exonic | TFAP4 | stopgain | ESCA|1|185|0.00541 |
| - | chr16 | 4308077 | 4308077 | C | A | exonic | TFAP4 | synonymous | SARC|1|247|0.00405 |
| - | chr16 | 4308231 | 4308231 | C | A | exonic | TFAP4 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 4308190 | 4308190 | C | A | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4308230 | 4308230 | G | T | exonic | TFAP4 | synonymous | LUAD|1|543|0.00184 |
| - | chr16 | 4311899 | 4311899 | C | T | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4312644 | 4312644 | G | A | exonic | TFAP4 | nonsynonymous | PRAD|1|499|0.00200,STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4322672 | 4322672 | C | A | exonic | TFAP4 | stopgain | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr16 | 4322723 | 4322723 | G | A | exonic | TFAP4 | stopgain | BLCA|1|396|0.00253 |
| - | chr16 | 4311931 | 4311931 | G | A | exonic | TFAP4 | nonsynonymous | SKCM|1|368|0.00272 |
| rs777093673 | chr16 | 4310139 | 4310139 | G | A | exonic | TFAP4 | synonymous | BLCA|1|396|0.00253 |
| - | chr16 | 4308230 | 4308230 | G | A | exonic | TFAP4 | synonymous | LIHC|1|373|0.00268 |
| rs251732 | chr16 | 4310468 | 4310468 | C | G | exonic | TFAP4 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 4310234 | 4310234 | G | A | exonic | TFAP4 | nonsynonymous | BRCA|1|982|0.00102 |
| rs201856455 | chr16 | 4310097 | 4310097 | G | A | exonic | TFAP4 | synonymous | SKCM|2|368|0.00543 |
| - | chr16 | 4310592 | 4310592 | - | G | exonic | TFAP4 | frameshift | PRAD|1|499|0.00200 |
| - | chr16 | 4310529 | 4310529 | T | A | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4311843 | 4311843 | C | G | exonic | TFAP4 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr16 | 4310153 | 4310153 | C | T | exonic | TFAP4 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr16 | 4310142 | 4310142 | C | T | exonic | TFAP4 | synonymous | UCEC|1|248|0.00403 |
| - | chr16 | 4312391 | 4312391 | G | T | exonic | TFAP4 | synonymous | LUSC|1|178|0.00562 |
| - | chr16 | 4310143 | 4310143 | G | T | exonic | TFAP4 | stopgain | LUAD|1|543|0.00184 |
| - | chr16 | 4311805 | 4311805 | G | A | exonic | TFAP4 | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr16 | 4312570 | 4312570 | G | T | exonic | TFAP4 | synonymous | LUAD|1|543|0.00184 |
| - | chr16 | 4310150 | 4310150 | G | A | exonic | TFAP4 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 4322729 | 4322729 | G | A | exonic | TFAP4 | nonsynonymous | SARC|1|247|0.00405 |
| - | chr16 | 4310208 | 4310208 | C | T | exonic | TFAP4 | synonymous | BLCA|1|396|0.00253 |
| - | chr16 | 4310202 | 4310202 | C | A | exonic | TFAP4 | synonymous | ACC|1|90|0.01111 |
| - | chr16 | 4308067 | 4308067 | C | G | exonic | TFAP4 | nonsynonymous | LUAD|1|543|0.00184 |
| rs772135551 | chr16 | 4311934 | 4311934 | G | A | exonic | TFAP4 | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr16 | 4312678 | 4312678 | G | C | exonic | TFAP4 | synonymous | PCPG|1|184|0.00543 |
| - | chr16 | 4312555 | 4312555 | G | A | exonic | TFAP4 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4310532 | 4310532 | A | T | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4308138 | 4308138 | G | A | exonic | TFAP4 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| rs777971498 | chr16 | 4312636 | 4312636 | G | A | exonic | TFAP4 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4322677 | 4322677 | A | G | exonic | TFAP4 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr16 | 4322659 | 4322659 | C | A | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 4312647 | 4312647 | G | A | exonic | TFAP4 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr16 | 4310485 | 4310485 | C | T | exonic | TFAP4 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr16 | 4308199 | 4308199 | G | C | exonic | TFAP4 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY | BP | TFAP4 |
| GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND | BP | TFAP4 |
| GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION | BP | TFAP4 |
| GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_DNA_BINDING | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS | BP | TFAP4 |
| GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST | BP | TFAP4 |
| GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY | BP | TFAP4 |
| GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY | BP | TFAP4 |
| GO_REGULATION_OF_VIRAL_TRANSCRIPTION | BP | TFAP4 |
| GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY | BP | TFAP4 |
| GO_CELLULAR_RESPONSE_TO_KETONE | BP | TFAP4 |
| GO_INTERACTION_WITH_SYMBIONT | BP | TFAP4 |
| GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY | BP | TFAP4 |
| GO_RESPONSE_TO_DEXAMETHASONE | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS | BP | TFAP4 |
| GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION | BP | TFAP4 |
| GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION | BP | TFAP4 |
| GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY | BP | TFAP4 |
| GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX | CC | TFAP4 |
| GO_PROTEIN_HETERODIMERIZATION_ACTIVITY | MF | TFAP4 |
| GO_E_BOX_BINDING | MF | TFAP4 |
| GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY | MF | TFAP4 |