TF information

TF name: TBX20
TF family: T-box
Ensembl gene ID: ENSG00000164532
Ensembl protein ID: ENSP00000386170
Entrez gene ID: 57057
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of TBX20 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_304Cell lineNeuroblastomaN2060.17663043478261
Sample_02_309Cell lineNeuroblastomaSJNB60.99526066350711
Sample_02_313Cell lineNeuroblastomaSK-N-DZ0.93050193050193

TBX20 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_309NeuroblastomaCell lineSJNB6
Sample_02_313NeuroblastomaCell lineSK-N-DZ

TBX20 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with TBX20
Download

Mutation of TBX20
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TBX20

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr73528834035288340TCexonicTBX20nonsynonymous UCEC|1|248|0.00403
-chr73528835335288353GAexonicTBX20nonsynonymous CESC|1|194|0.00515
-chr73528963035289630CGexonicTBX20nonsynonymous ESCA|1|185|0.00541
-chr73524212935242129CTexonicTBX20synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122,LUSC|1|178|0.00562
-chr73524226935242269CTexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73528837335288373GAexonicTBX20nonsynonymous LIHC|1|373|0.00268
-chr73524226235242262ATexonicTBX20nonsynonymous LUAD|1|543|0.00184
rs139984472chr73529316935293169GAexonicTBX20synonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr73528841435288414CTexonicTBX20synonymous SKCM|1|368|0.00272
-chr73524213135242131GAexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73528845135288451CAexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73524211035242110GAexonicTBX20stopgain SKCM|1|368|0.00272
rs768739120chr73524419335244193CTexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73524218435242184GAexonicTBX20nonsynonymous CHOL|1|35|0.02857
-chr73528462435284624GCexonicTBX20synonymous CESC|1|194|0.00515
-chr73527119035271190TCexonicTBX20nonsynonymous UCEC|1|248|0.00403
-chr73528457835284578GTexonicTBX20nonsynonymous ESCA|1|185|0.00541
-chr73524209735242097TCexonicTBX20nonsynonymous SARC|1|247|0.00405
-chr73524232535242325GTexonicTBX20nonsynonymous LUAD|1|543|0.00184
rs747369702chr73528051935280519GAexonicTBX20nonsynonymous THCA|1|504|0.00198
-chr73528961835289618GTexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73529321935293219CAexonicTBX20nonsynonymous SKCM|2|368|0.00543
-chr73524224735242247GAexonicTBX20nonsynonymous PRAD|2|499|0.00401
-chr73528833835288338GAexonicTBX20nonsynonymous UCEC|1|248|0.00403
-chr73528064135280641CTexonicTBX20synonymous SKCM|1|368|0.00272
-chr73528834735288347CTexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73524410635244106CTexonicTBX20nonsynonymous HNSC|1|512|0.00195
-chr73524412635244126TCexonicTBX20nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr73527111835271118CAexonicTBX20nonsynonymous CHOL|1|35|0.02857
-chr73528966035289660CAexonicTBX20stopgain LUSC|1|178|0.00562
-chr73528980935289809AGexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73524207535242075GAexonicTBX20synonymous LUAD|1|543|0.00184
-chr73524216135242161TAexonicTBX20nonsynonymous SKCM|2|368|0.00543
-chr73524419535244195CTsplicingTBX20splicing SKCM|1|368|0.00272
rs372573377chr73524218335242183GAexonicTBX20synonymous SKCM|1|368|0.00272
-chr73528835335288353GCexonicTBX20nonsynonymous BLCA|1|396|0.00253
-chr73528837935288379AGexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73528964935289649GTexonicTBX20synonymous LUAD|1|543|0.00184
-chr73524216335242163CTexonicTBX20nonsynonymous SKCM|2|368|0.00543
-chr73527114635271146CTexonicTBX20nonsynonymous PAAD|1|185|0.00541
-chr73524215635242156GTexonicTBX20synonymous LUSC|1|178|0.00562
-chr73527114735271147GTexonicTBX20synonymous LUAD|1|543|0.00184
rs745523991chr73524212735242127CTexonicTBX20nonsynonymous CESC|1|194|0.00515
-chr73524223835242238AGexonicTBX20nonsynonymous ESCA|1|185|0.00541
-chr73529316635293166CAexonicTBX20synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr73528061135280611CTexonicTBX20synonymous UCEC|1|248|0.00403
-chr73524412235244122TGexonicTBX20nonsynonymous ESCA|1|185|0.00541
-chr73524208235242082CTexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,LIHC|1|373|0.00268
-chr73524207335242073TCexonicTBX20nonsynonymous SKCM|1|368|0.00272
rs138597530chr73528959335289593CAexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73528969435289694CAexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73529317035293170GTexonicTBX20nonsynonymous LUAD|1|543|0.00184
rs112862467chr73528837335288373GCexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73527111935271119TGexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73529313135293131GAexonicTBX20nonsynonymous PAAD|1|185|0.00541
-chr73524222635242226AGexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73527111935271119TCexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73524229435242294GTexonicTBX20synonymous LUAD|1|543|0.00184
-chr73529315735293157CGexonicTBX20synonymous LIHC|1|373|0.00268
-chr73524210335242103CAexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73524408535244085GAexonicTBX20stopgain SKCM|1|368|0.00272
rs113335362chr73524413435244134GAexonicTBX20synonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr73524225435242254GCexonicTBX20nonsynonymous BRCA|1|982|0.00102
-chr73528843435288434GCexonicTBX20nonsynonymous HNSC|1|512|0.00195
-chr73524418835244188AGexonicTBX20synonymous LUSC|1|178|0.00562
-chr73529320635293206GTexonicTBX20nonsynonymous LIHC|1|373|0.00268
-chr73524417835244178GAexonicTBX20synonymous SKCM|1|368|0.00272
-chr73529316735293167GAexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73528832335288323CTexonicTBX20nonsynonymous STAD|2|395|0.00506,STES|2|395|0.00506
-chr73524204735242047CTexonicTBX20nonsynonymous LUSC|1|178|0.00562
rs771888980chr73529312735293127CTexonicTBX20synonymous CESC|1|194|0.00515
-chr73528977135289771GTexonicTBX20nonsynonymous LUSC|1|178|0.00562
-chr73528459135284591GAexonicTBX20synonymous LUSC|1|178|0.00562
-chr73528964635289646TGexonicTBX20nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr73529322535293225AGexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73528960435289604GTexonicTBX20nonsynonymous LUSC|1|178|0.00562
-chr73524204835242048ACexonicTBX20nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr73529317535293175GAexonicTBX20synonymous SKCM|1|368|0.00272
-chr73529313235293132CAexonicTBX20nonsynonymous PRAD|1|499|0.00200
-chr73527112035271120CAexonicTBX20stopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs368803336chr73524218235242182TCexonicTBX20nonsynonymous OV|1|469|0.00213
-chr73528830835288308CTexonicTBX20nonsynonymous LUAD|1|543|0.00184,SKCM|1|368|0.00272
-chr73528964435289644AGexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73529319735293197GCexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73529319235293192GAexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73524412935244129CTexonicTBX20nonsynonymous BRCA|1|982|0.00102,SKCM|1|368|0.00272
rs776684707chr73527118735271187CTexonicTBX20synonymous LUAD|1|543|0.00184
-chr73528960135289601ATexonicTBX20nonsynonymous LUAD|1|543|0.00184
rs375102469chr73529318435293184GAexonicTBX20synonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr73528458835284588GTexonicTBX20synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr73524216235242162CTexonicTBX20synonymous SKCM|1|368|0.00272
rs766895072chr73528463835284638CTexonicTBX20nonsynonymous BLCA|1|396|0.00253,UCEC|1|248|0.00403
-chr73528058535280585GTexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73528060935280609TCexonicTBX20nonsynonymous HNSC|1|512|0.00195
-chr73528835235288352CAexonicTBX20nonsynonymous PRAD|1|499|0.00200
-chr73524410935244109C-exonicTBX20frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73528056635280566CTexonicTBX20synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr73524216835242168CAexonicTBX20nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr73524221135242211CTexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73528050335280503GTexonicTBX20stopgain LUAD|1|543|0.00184
-chr73528965135289651CAexonicTBX20nonsynonymous LUAD|1|543|0.00184
-chr73528964335289643ACexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73528052135280521AGexonicTBX20synonymous SKCM|1|368|0.00272
-chr73528465335284653CAexonicTBX20nonsynonymous PAAD|1|185|0.00541
-chr73528466835284668GAexonicTBX20nonsynonymous SKCM|2|368|0.00543
-chr73529316635293166CTexonicTBX20synonymous PAAD|1|185|0.00541
-chr73528055535280555TCexonicTBX20nonsynonymous HNSC|1|512|0.00195
-chr73524234835242348GCexonicTBX20synonymous HNSC|2|512|0.00391
-chr73524218735242187GTexonicTBX20stopgain HNSC|1|512|0.00195
-chr73528055335280553AGexonicTBX20nonsynonymous SKCM|1|368|0.00272
-chr73528844735288447CTexonicTBX20nonsynonymous UCEC|1|248|0.00403
-chr73528461035284610GTexonicTBX20nonsynonymous BRCA|1|982|0.00102
rs3999940chr73528049035280490CTsplicingTBX20splicing SKCM|1|368|0.00272
-chr73528049035280490CAsplicingTBX20splicing BRCA|1|982|0.00102
-chr73528837435288374GAexonicTBX20nonsynonymous SKCM|1|368|0.00272

Disease information of TBX20
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
TBX20 Ostium secundum atrial septal defect C14;C16 Congenital Abnormality ORPHANET
TBX20 Atrial Septal Defect 4 C14;C16 Congenital Abnormality; Disease or Syndrome CTD_human;UNIPROT
TBX20 Intellectual Disability C10;C23;F01;F03 Mental or Behavioral Dysfunction GENOMICS_ENGLAND

Pathway associated with TBX20
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0002768 Hs_Heart_Development_WP1591_90186 wikipathways 28 78

Go term information of TBX20
GO_term_name GO_term_type TF_name
GO_CARDIAC_CHAMBER_DEVELOPMENT BP TBX20
GO_SPINAL_CORD_DEVELOPMENT BP TBX20
GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS BP TBX20
GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT BP TBX20
GO_FORMATION_OF_PRIMARY_GERM_LAYER BP TBX20
GO_ENDOCARDIAL_CUSHION_DEVELOPMENT BP TBX20
GO_POSITIVE_REGULATION_OF_HEART_GROWTH BP TBX20
GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS BP TBX20
GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS BP TBX20
GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION BP TBX20
GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS BP TBX20
GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT BP TBX20
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD BP TBX20
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION BP TBX20
GO_ENDOCARDIAL_CUSHION_FORMATION BP TBX20
GO_SPECIFICATION_OF_SYMMETRY BP TBX20
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT BP TBX20
GO_LATERAL_MESODERM_DEVELOPMENT BP TBX20
GO_CARDIAC_ATRIUM_DEVELOPMENT BP TBX20
GO_ATRIAL_SEPTUM_DEVELOPMENT BP TBX20
GO_PATTERNING_OF_BLOOD_VESSELS BP TBX20
GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT BP TBX20
GO_ATRIAL_SEPTUM_MORPHOGENESIS BP TBX20
GO_REGULATION_OF_ORGAN_GROWTH BP TBX20
GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY BP TBX20
GO_HEART_MORPHOGENESIS BP TBX20
GO_CARDIAC_VENTRICLE_MORPHOGENESIS BP TBX20
GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET BP TBX20
GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS BP TBX20
GO_HEART_VALVE_FORMATION BP TBX20
GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT BP TBX20
GO_NEURON_MIGRATION BP TBX20
GO_NEUROGENESIS BP TBX20
GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION BP TBX20
GO_PERICARDIUM_DEVELOPMENT BP TBX20
GO_HEART_VALVE_DEVELOPMENT BP TBX20
GO_ENDODERM_FORMATION BP TBX20
GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT BP TBX20
GO_REGULATION_OF_HEART_GROWTH BP TBX20
GO_CARDIAC_CHAMBER_FORMATION BP TBX20
GO_CARDIAC_SEPTUM_MORPHOGENESIS BP TBX20
GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT BP TBX20
GO_MESODERM_DEVELOPMENT BP TBX20
GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT BP TBX20
GO_MESENCHYME_MORPHOGENESIS BP TBX20
GO_EMBRYONIC_ORGAN_DEVELOPMENT BP TBX20
GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH BP TBX20
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING MF TBX20
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING MF TBX20
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING MF TBX20
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING MF TBX20
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY MF TBX20
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY MF TBX20
GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY MF TBX20
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING MF TBX20

Survival analysis of TBX20



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of TBX20