Cancer CRCdb

TF information

TF name:	SP8
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000164651
Ensembl protein ID:	ENSP00000408792, ENSP00000483588, ENSP00000354482
Entrez gene ID:	221833

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SP8 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_181	Cell line	Human melanoma	COLO679	0.16693333333333
Sample_02_413	Tissue	Brain	GBM_2493	0.52747252747253

SP8 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_413	Brain	Tissue	GBM_2493

SP8 distribution in all CRCs

Genomic distribution of SEs associated with SP8

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Mutation of SP8

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SP8

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr7	20824912	20824912	T	C	exonic	SP8	nonsynonymous	PRAD\|2\|499\|0.00401
rs748563164	chr7	20824871	20824871	C	T	exonic	SP8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20825175	20825175	A	T	exonic	SP8	synonymous	THYM\|1\|123\|0.00813
-	chr7	20824181	20824181	C	T	exonic	SP8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824578	20824578	G	A	exonic	SP8	synonymous	ACC\|1\|90\|0.01111
rs34908430	chr7	20824614	20824614	C	T	exonic	SP8	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr7	20826399	20826399	C	A	exonic	SP8	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr7	20824584	20824584	G	A	exonic	SP8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824432	20824432	C	-	exonic	SP8	frameshift	ESCA\|1\|185\|0.00541
rs201512381	chr7	20825272	20825272	G	A	exonic	SP8	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr7	20824665	20824665	C	-	exonic	SP8	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr7	20825289	20825289	G	A	exonic	SP8	synonymous	HNSC\|1\|512\|0.00195
-	chr7	20825271	20825271	C	A	exonic	SP8	synonymous	LIHC\|1\|373\|0.00268
-	chr7	20824133	20824133	C	T	exonic	SP8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824258	20824258	G	A	exonic	SP8	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs201180283	chr7	20824956	20824956	C	G	exonic	SP8	synonymous	ACC\|1\|90\|0.01111,DLBC\|1\|48\|0.02083,KIPAN\|2\|799\|0.00250,KIRP\|2\|282\|0.00709,LIHC\|1\|373\|0.00268
-	chr7	20825372	20825372	C	A	exonic	SP8	nonsynonymous	LUAD\|1\|543\|0.00184
rs374176171	chr7	20824833	20824833	G	A	exonic	SP8	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	20825258	20825258	C	A	exonic	SP8	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr7	20824045	20824046	CC	-	exonic	SP8	frameshift	ESCA\|1\|185\|0.00541
-	chr7	20825307	20825307	G	T	exonic	SP8	synonymous	UCEC\|1\|248\|0.00403
-	chr7	20824098	20824098	G	A	exonic	SP8	synonymous	ESCA\|1\|185\|0.00541
-	chr7	20824392	20824392	G	T	exonic	SP8	synonymous	ESCA\|1\|185\|0.00541
-	chr7	20824858	20824858	A	-	exonic	SP8	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr7	20824282	20824282	T	C	exonic	SP8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr7	20824953	20824953	G	C	exonic	SP8	synonymous	ACC\|2\|90\|0.02222,DLBC\|1\|48\|0.02083
-	chr7	20824574	20824574	G	A	exonic	SP8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20825187	20825187	C	T	exonic	SP8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20823935	20823935	G	C	exonic	SP8	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr7	20824269	20824269	C	T	exonic	SP8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824781	20824781	C	T	exonic	SP8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824506	20824506	C	T	exonic	SP8	synonymous	ESCA\|1\|185\|0.00541
-	chr7	20824043	20824043	-	CC	exonic	SP8	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	20824767	20824767	G	A	exonic	SP8	synonymous	LUAD\|1\|543\|0.00184
-	chr7	20825340	20825340	C	T	exonic	SP8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824196	20824196	G	A	exonic	SP8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824320	20824320	G	A	exonic	SP8	synonymous	HNSC\|2\|512\|0.00391
-	chr7	20824942	20824943	CC	-	exonic	SP8	frameshift	ACC\|11\|90\|0.12222,HNSC\|2\|512\|0.00391,KICH\|1\|66\|0.01515,KIPAN\|3\|799\|0.00375,KIRC\|2\|451\|0.00443,LUAD\|3\|543\|0.00552,PAAD\|1\|185\|0.00541,PCPG\|2\|184\|0.01087,PRAD\|4\|499\|0.00802,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,THCA\|4\|504\|0.00794
-	chr7	20825329	20825329	G	A	exonic	SP8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr7	20825354	20825354	C	A	exonic	SP8	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	20824970	20824970	C	T	exonic	SP8	nonsynonymous	LIHC\|1\|373\|0.00268,TGCT\|6\|155\|0.03871
-	chr7	20824806	20824806	C	T	exonic	SP8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs145875827	chr7	20825271	20825271	C	T	exonic	SP8	synonymous	DLBC\|1\|48\|0.02083
-	chr7	20824186	20824186	C	T	exonic	SP8	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr7	20824396	20824396	C	T	exonic	SP8	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr7	20824641	20824641	C	T	exonic	SP8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	20824940	20825106	AGCCGCCGCCGCCGCCCCCGCCGCCGCCGCCGCTGCCCCCGGAAACTCCGGGGGCCTGGAAAACAGAGTAGTCGTTGGCGAAGGGCGAGCTGGAGGCGGCGGCTGCGGCGGCGGCGGCGGCGGCTGCGGCGCTGCTGGAGGTGAGGGAGAAGGCGCTGGAGCCAGGC	-	exonic	SP8	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr7	20825373	20825373	G	A	exonic	SP8	synonymous	SKCM\|1\|368\|0.00272
-	chr7	20824321	20824321	C	A	exonic	SP8	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr7	20824901	20824901	A	G	exonic	SP8	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125

Disease information of SP8

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SP8	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
SP8	Psychotic Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
SP8	Nonorganic psychosis		Mental or Behavioral Dysfunction	PSYGENET

Pathway associated with SP8

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000176	AndrogenReceptor	netpath	167	2267
pathway0000196	Apoptosis signaling pathway	panther	104	1308
pathway0000198	Apoptotic cleavage of cellular proteins	reactome	18	40
pathway0000229	ATF-2 transcription factor network	pid	59	451
pathway0000375	CASP8 activity is inhibited	reactome	11	49
pathway0000376	Caspase-mediated cleavage of cytoskeletal proteins	reactome	12	27
pathway0000377	Caspase Cascade in Apoptosis	pid	57	396
pathway0000403	Ceramide signaling pathway	pid	49	409
pathway0000452	CLEC7A/inflammasome pathway	reactome	6	15
pathway0000492	Coregulation of Androgen receptor activity	pid	61	268
pathway0000603	Dimerization of procaspase-8	reactome	11	49
pathway0000629	Downregulation of ERBB2:ERBB3 signaling	reactome	13	59
pathway0000639	Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )	inoh	236	3833
pathway0000695	ErbB2/ErbB3 signaling events	pid	41	404
pathway0000754	FAS (CD95) signaling pathway	pid	36	259
pathway0000755	Fas signaling pathway ( Fas signaling pathway )	inoh	21	108
pathway0000756	FAS signaling pathway	panther	37	148
pathway0000757	FasL/ CD95L signaling	reactome	5	11
pathway0001033	HIV-1 Nef: Negative effector of Fas and TNF-alpha	pid	33	281
pathway0001176	Integrins in angiogenesis	pid	66	791
pathway0001192	Internalization of ErbB1	pid	38	304
pathway0001280	Ligand-dependent caspase activation	reactome	16	71
pathway0001465	Negative regulation of MAPK pathway	reactome	38	287
pathway0001481	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	reactome	12	63
pathway0001503	NOD1/2 Signaling Pathway	reactome	31	245
pathway0001789	RAF-independent MAPK1/3 activation	reactome	13	25
pathway0001822	Regulation by c-FLIP	reactome	11	49
pathway0001832	Regulation of FZD by ubiquitination	reactome	21	80
pathway0001847	Regulation of necroptotic cell death	reactome	7	22
pathway0001851	Regulation of p38-alpha and p38-beta	pid	31	149
pathway0001862	Regulation of TNFR1 signaling	reactome	31	297
pathway0001909	RIPK1-mediated regulated necrosis	reactome	16	92
pathway0002246	TNF receptor signaling pathway	pid	46	428
pathway0002249	TNFalpha	netpath	274	5236
pathway0002251	TNFR1-induced proapoptotic signaling	reactome	13	64
pathway0002253	TNFR1 signaling pathway ( TNFR1 signaling pathway )	inoh	15	66
pathway0002289	TRAIL signaling	reactome	7	22
pathway0002290	TRAIL signaling pathway	pid	25	157
pathway0002333	TRIF-mediated programmed cell death	reactome	10	44
pathway0002356	TWEAK	netpath	35	280
pathway0002575	p53 signaling pathway	kegg	66	297
pathway0002584	Apoptosis	kegg	88	932
pathway0002602	Toll-like receptor signaling pathway	kegg	100	1158
pathway0002603	NOD-like receptor signaling pathway	kegg	60	456
pathway0002604	RIG-I-like receptor signaling pathway	kegg	71	471
pathway0002639	Alzheimers disease	kegg	167	1805
pathway0002642	Huntingtons disease	kegg	182	1941
pathway0002650	Chagas disease	kegg	103	1158
pathway0002652	Toxoplasmosis	kegg	131	1443
pathway0002679	Viral myocarditis	kegg	66	239
pathway0002689	Hs_Cytokines_and_Inflammatory_Response_WP530_79331	wikipathways	21	53
pathway0002694	Hs_DNA_Damage_Response_WP707_82937	wikipathways	28	166
pathway0002695	Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694	wikipathways	28	154
pathway0002714	Hs_Nucleotide-binding_Oligomerization_Domain_(NOD)_pathway_WP1433_86035	wikipathways	37	143
pathway0002731	Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941	wikipathways	122	1333
pathway0002734	Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293	wikipathways	71	522
pathway0002738	Hs_Alzheimers_Disease_WP2059_87372	wikipathways	24	65
pathway0002751	Hs_Integrated_Cancer_Pathway_WP1971_82939	wikipathways	33	206
pathway0002762	Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910	wikipathways	27	164
pathway0002769	Hs_Apoptosis_Modulation_by_HSP70_WP384_67054	wikipathways	10	20
pathway0002779	Hs_Allograft_Rejection_WP2328_90020	wikipathways	12	18
pathway0002793	Hs_Integrin-mediated_Cell_Adhesion_WP185_88160	wikipathways	38	69
pathway0002794	Hs_Nanomaterial_induced_apoptosis_WP2507_89231	wikipathways	8	22
pathway0002795	Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172	wikipathways	47	253
pathway0002796	Hs_Toll-like_Receptor_Signaling_Pathway_WP75_83867	wikipathways	17	68
pathway0002801	Hs_TNF_alpha_Signaling_Pathway_WP231_89895	wikipathways	61	486

Go term information of SP8

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GO_term_name	GO_term_type	TF_name
GO_MITOTIC_CYTOKINESIS	BP	SP8
GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY	BP	SP8
GO_LABYRINTHINE_LAYER_DEVELOPMENT	BP	SP8
GO_RESPONSE_TO_COLD	BP	SP8
GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS	BP	SP8
GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY	BP	SP8
GO_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	SP8
GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_DORSAL_VENTRAL_PATTERN_FORMATION	BP	SP8
GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION	BP	SP8
GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	BP	SP8
GO_ERBB2_SIGNALING_PATHWAY	BP	SP8
GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS	BP	SP8
GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION	BP	SP8
GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	BP	SP8
GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT	BP	SP8
GO_PROTEIN_OLIGOMERIZATION	BP	SP8
GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY	BP	SP8
GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS	BP	SP8
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	SP8
GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION	BP	SP8
GO_REGULATION_OF_HEMOPOIESIS	BP	SP8
GO_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_ERBB_SIGNALING_PATHWAY	BP	SP8
GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY	BP	SP8
GO_REGULATION_OF_NECROTIC_CELL_DEATH	BP	SP8
GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY	BP	SP8
GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS	BP	SP8
GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION	BP	SP8
GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	BP	SP8
GO_RESPONSE_TO_LIPID	BP	SP8
GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_NATURAL_KILLER_CELL_ACTIVATION	BP	SP8
GO_REGULATION_OF_PROTEIN_LOCALIZATION	BP	SP8
GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY	BP	SP8
GO_PROTEIN_K48_LINKED_DEUBIQUITINATION	BP	SP8
GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING	BP	SP8
GO_RESPONSE_TO_TEMPERATURE_STIMULUS	BP	SP8
GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS	BP	SP8
GO_CELL_CYCLE	BP	SP8
GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS	BP	SP8
GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY	BP	SP8
GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_MACROPHAGE_DIFFERENTIATION	BP	SP8
GO_INTERACTION_WITH_SYMBIONT	BP	SP8
GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY	BP	SP8
GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	BP	SP8
GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	SP8
GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION	BP	SP8
GO_PROTEIN_K63_LINKED_DEUBIQUITINATION	BP	SP8
GO_MYELOID_CELL_DIFFERENTIATION	BP	SP8
GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SP8
GO_REGULATION_OF_MEMBRANE_PERMEABILITY	BP	SP8
GO_EXECUTION_PHASE_OF_APOPTOSIS	BP	SP8
GO_RESPONSE_TO_COBALT_ION	BP	SP8
GO_INACTIVATION_OF_MAPK_ACTIVITY	BP	SP8
GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS	BP	SP8
GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS	BP	SP8
GO_ZYMOGEN_ACTIVATION	BP	SP8
GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	SP8
GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS	BP	SP8
GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION	BP	SP8
GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY	BP	SP8
GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY	BP	SP8
GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS	BP	SP8
GO_PROTEIN_HETEROOLIGOMERIZATION	BP	SP8
GO_CYTOSOLIC_PART	CC	SP8
GO_NUCLEAR_BODY	CC	SP8
GO_PML_BODY	CC	SP8
GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE	CC	SP8
GO_MIDBODY	CC	SP8
GO_MITOCHONDRIAL_ENVELOPE	CC	SP8
GO_PEPTIDASE_REGULATOR_ACTIVITY	MF	SP8
GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY	MF	SP8
GO_PEPTIDASE_ACTIVATOR_ACTIVITY	MF	SP8
GO_SH3_DOMAIN_BINDING	MF	SP8
GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY	MF	SP8
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	MF	SP8
GO_SCAFFOLD_PROTEIN_BINDING	MF	SP8
GO_SUMO_BINDING	MF	SP8
GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY	MF	SP8
GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP8
GO_DEATH_RECEPTOR_BINDING	MF	SP8
GO_MAP_KINASE_PHOSPHATASE_ACTIVITY	MF	SP8
GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING	MF	SP8
GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING	MF	SP8
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP8
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP8

Survival analysis of SP8

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SP8

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)