Cancer CRCdb

TF information

TF name:	SOX8
TF family:	HMG
Ensembl gene ID:	ENSG00000005513
Ensembl protein ID:	ENSP00000293894
Entrez gene ID:	30812

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SOX8 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_250	Tissue	Brain	tumormodel3691	0.6875
Sample_02_413	Tissue	Brain	GBM_2493	0.51648351648352

SOX8 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_250	Brain	Tissue	tumormodel3691

SOX8 distribution in all CRCs

Genomic distribution of SEs associated with SOX8

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Mutation of SOX8

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SOX8

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs375735232	chr16	1035103	1035103	G	A	exonic	SOX8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs764478966	chr16	1034928	1034928	G	A	exonic	SOX8	nonsynonymous	LUSC\|1\|178\|0.00562
rs559279447	chr16	1035280	1035280	G	A	exonic	SOX8	nonsynonymous	PAAD\|1\|185\|0.00541
rs763422761	chr16	1033900	1033900	G	A	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
rs749349882	chr16	1035026	1035026	G	A	exonic	SOX8	synonymous	HNSC\|1\|512\|0.00195
-	chr16	1035307	1035307	A	G	exonic	SOX8	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr16	1034896	1034896	A	C	exonic	SOX8	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs183697287	chr16	1034756	1034756	G	A	exonic	SOX8	synonymous	THCA\|1\|504\|0.00198
-	chr16	1033751	1033751	G	A	exonic	SOX8	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr16	1033836	1033836	G	A	exonic	SOX8	synonymous	SARC\|1\|247\|0.00405
-	chr16	1034993	1034993	G	T	exonic	SOX8	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	1033875	1033875	G	A	exonic	SOX8	synonymous	LIHC\|1\|373\|0.00268
-	chr16	1035161	1035161	C	A	exonic	SOX8	synonymous	LUAD\|1\|543\|0.00184
rs144569380	chr16	1034885	1034885	C	T	exonic	SOX8	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	1034810	1034810	G	T	exonic	SOX8	synonymous	BLCA\|1\|396\|0.00253
rs11542178	chr16	1034954	1034954	T	C	exonic	SOX8	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr16	1034811	1034811	C	A	exonic	SOX8	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr16	1034862	1034862	G	A	exonic	SOX8	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr16	1035259	1035259	-	C	exonic	SOX8	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs755219338	chr16	1034797	1034797	C	T	exonic	SOX8	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr16	1032238	1032238	A	G	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
rs778698678	chr16	1034726	1034726	G	A	exonic	SOX8	synonymous	BLCA\|1\|396\|0.00253
-	chr16	1034924	1034924	C	-	exonic	SOX8	frameshift	LIHC\|1\|373\|0.00268
-	chr16	1034985	1034985	C	A	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	1033810	1033810	T	G	exonic	SOX8	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr16	1035322	1035322	C	A	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	1033873	1033873	G	A	exonic	SOX8	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	1034902	1034902	A	G	exonic	SOX8	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr16	1033887	1033887	C	T	exonic	SOX8	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	1033825	1033825	C	T	exonic	SOX8	nonsynonymous	HNSC\|2\|512\|0.00391,UCS\|1\|57\|0.01754
-	chr16	1034912	1034912	G	T	exonic	SOX8	synonymous	LUSC\|1\|178\|0.00562
-	chr16	1034823	1034823	G	A	exonic	SOX8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	1034859	1034859	G	A	exonic	SOX8	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs755447385	chr16	1033737	1033737	C	T	exonic	SOX8	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr16	1032197	1032197	G	T	exonic	SOX8	nonsynonymous	THYM\|1\|123\|0.00813
-	chr16	1032207	1032207	G	A	exonic	SOX8	synonymous	TGCT\|1\|155\|0.00645
-	chr16	1035195	1035195	G	A	exonic	SOX8	nonsynonymous	BLCA\|1\|396\|0.00253
rs777748762	chr16	1035131	1035131	C	T	exonic	SOX8	synonymous	HNSC\|1\|512\|0.00195
-	chr16	1033796	1033796	A	G	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	1035113	1035113	C	G	exonic	SOX8	synonymous	LUAD\|1\|543\|0.00184
-	chr16	1034901	1034901	G	A	exonic	SOX8	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	1035010	1035010	C	G	exonic	SOX8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	1032189	1032190	CG	-	exonic	SOX8	frameshift	ESCA\|1\|185\|0.00541,HNSC\|1\|512\|0.00195
-	chr16	1033854	1033854	C	A	exonic	SOX8	nonsynonymous	SKCM\|1\|368\|0.00272
rs774515052	chr16	1035032	1035032	C	T	exonic	SOX8	synonymous	PAAD\|1\|185\|0.00541
-	chr16	1035270	1035270	C	T	exonic	SOX8	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr16	1034721	1034721	A	T	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
rs770019584	chr16	1033872	1033872	C	T	exonic	SOX8	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr16	1035178	1035178	G	A	exonic	SOX8	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr16	1033775	1033775	G	A	exonic	SOX8	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr16	1034822	1034822	C	T	exonic	SOX8	synonymous	BLCA\|1\|396\|0.00253
rs755165150	chr16	1034725	1034725	C	T	exonic	SOX8	nonsynonymous	BLCA\|1\|396\|0.00253
rs375129528	chr16	1035326	1035326	C	T	exonic	SOX8	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr16	1034895	1034895	G	A	exonic	SOX8	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr16	1035263	1035263	C	A	exonic	SOX8	synonymous	LUAD\|1\|543\|0.00184

Disease information of SOX8

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SOX8	Peripheral Neuropathy	C10	Disease or Syndrome	CTD_human

Pathway associated with SOX8

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of SOX8

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GO_term_name	GO_term_type	TF_name
GO_METANEPHRIC_NEPHRON_MORPHOGENESIS	BP	SOX8
GO_URETER_DEVELOPMENT	BP	SOX8
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	SOX8
GO_METANEPHROS_DEVELOPMENT	BP	SOX8
GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT	BP	SOX8
GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT	BP	SOX8
GO_SERTOLI_CELL_DEVELOPMENT	BP	SOX8
GO_DEVELOPMENTAL_INDUCTION	BP	SOX8
GO_NEURAL_RETINA_DEVELOPMENT	BP	SOX8
GO_KIDNEY_EPITHELIUM_DEVELOPMENT	BP	SOX8
GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM	BP	SOX8
GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT	BP	SOX8
GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION	BP	SOX8
GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	SOX8
GO_NEURAL_CREST_CELL_MIGRATION	BP	SOX8
GO_REGULATION_OF_KIDNEY_DEVELOPMENT	BP	SOX8
GO_CELL_MATURATION	BP	SOX8
GO_REGULATION_OF_NEURON_DIFFERENTIATION	BP	SOX8
GO_GLIOGENESIS	BP	SOX8
GO_NEPHRON_EPITHELIUM_DEVELOPMENT	BP	SOX8
GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	SOX8
GO_RENAL_TUBULE_DEVELOPMENT	BP	SOX8
GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT	BP	SOX8
GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION	BP	SOX8
GO_ASTROCYTE_DIFFERENTIATION	BP	SOX8
GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION	BP	SOX8
GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	SOX8
GO_METANEPHRIC_NEPHRON_DEVELOPMENT	BP	SOX8
GO_FAT_CELL_DIFFERENTIATION	BP	SOX8
GO_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	SOX8
GO_CELL_FATE_COMMITMENT	BP	SOX8
GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT	BP	SOX8
GO_GLIAL_CELL_FATE_COMMITMENT	BP	SOX8
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	SOX8
GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT	BP	SOX8
GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION	BP	SOX8
GO_SENSORY_ORGAN_DEVELOPMENT	BP	SOX8
GO_SENSORY_ORGAN_MORPHOGENESIS	BP	SOX8
GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION	BP	SOX8
GO_KIDNEY_MORPHOGENESIS	BP	SOX8
GO_OLIGODENDROCYTE_DIFFERENTIATION	BP	SOX8
GO_NEPHRON_TUBULE_FORMATION	BP	SOX8
GO_NEPHRON_DEVELOPMENT	BP	SOX8
GO_REGULATION_OF_GLIOGENESIS	BP	SOX8
GO_SERTOLI_CELL_DIFFERENTIATION	BP	SOX8
GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION	BP	SOX8
GO_ADIPOSE_TISSUE_DEVELOPMENT	BP	SOX8
GO_NEURAL_CREST_CELL_DIFFERENTIATION	BP	SOX8
GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT	BP	SOX8
GO_METANEPHROS_MORPHOGENESIS	BP	SOX8
GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	SOX8
GO_MALE_SEX_DIFFERENTIATION	BP	SOX8
GO_POSITIVE_REGULATION_OF_GLIOGENESIS	BP	SOX8
GO_TRANSCRIPTION_FACTOR_COMPLEX	CC	SOX8
GO_CORE_PROMOTER_BINDING	MF	SOX8
GO_DOUBLE_STRANDED_DNA_BINDING	MF	SOX8
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	SOX8
GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	SOX8

Survival analysis of SOX8

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SOX8

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)