TF information

TF name: SOX6
TF family: HMG
Ensembl gene ID: ENSG00000110693
Ensembl protein ID: ENSP00000324948, ENSP00000433233, ENSP00000379644, ENSP00000432134, ENSP00000434455
Entrez gene ID: 55553
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of SOX6 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_359Cell lineColonColo7410.20481927710843

SOX6 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

SOX6 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with SOX6
Download

Mutation of SOX6
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SOX6

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr111599453015994530GTexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111611918316119184GC-exonicSOX6frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr111601067416010674CTexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111607128816071288CTexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111607738916077389GAexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111636260516362605GTexonicSOX6nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr111599460115994601GAexonicSOX6synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111607729816077298CTexonicSOX6synonymous SKCM|1|368|0.00272
-chr111607141016071410AGexonicSOX6synonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr111611921716119217GTexonicSOX6nonsynonymous LUAD|1|543|0.00184
rs373068695chr111606817416068174CTexonicSOX6synonymous TGCT|1|155|0.00645
-chr111600784716007847GAexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111620546216205462GCexonicSOX6nonsynonymous BRCA|1|982|0.00102
rs759362106chr111601067316010673GAexonicSOX6synonymous UCEC|1|248|0.00403
-chr111603651916036519GAexonicSOX6synonymous SKCM|1|368|0.00272
-chr111611917716119177CTexonicSOX6nonsynonymous LUAD|1|543|0.00184
rs369713124chr111606811416068114GAexonicSOX6synonymous THYM|1|123|0.00813
-chr111600784316007843GAexonicSOX6nonsynonymous LUSC|1|178|0.00562,SKCM|1|368|0.00272
-chr111633998616339986-CintronicSOX6unknown STAD|1|395|0.00253,STES|1|395|0.00253
-chr111607131816071318CTexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111607134316071343GAexonicSOX6nonsynonymous SKCM|1|368|0.00272
-chr111625616316256163CGexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111613336916133369G-exonicSOX6frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253
-chr111603656516036565TAexonicSOX6nonsynonymous LUSC|1|178|0.00562
-chr111634010316340103TAexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111599437415994374TGexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111611919616119196CAexonicSOX6nonsynonymous SARC|1|247|0.00405
-chr111634007016340070GAexonicSOX6nonsynonymous SKCM|1|368|0.00272
-chr111625621816256218CAsplicingSOX6splicing ACC|1|90|0.01111
-chr111607732016077320GTexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111611760616117606ACexonicSOX6nonsynonymous SKCM|1|368|0.00272
rs376018780chr111634016016340160GAexonicSOX6stopgain GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr111599452715994527CAexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111634005816340058GAexonicSOX6nonsynonymous SKCM|1|368|0.00272
-chr111606818216068182GCexonicSOX6nonsynonymous BRCA|1|982|0.00102
-chr111599459815994598ACexonicSOX6synonymous LUSC|1|178|0.00562
-chr111607144716071447CGexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111599465515994655TCexonicSOX6synonymous HNSC|1|512|0.00195
-chr111607141316071413CTexonicSOX6synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs148323217chr111603658616036586CTexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111620846716208467CAexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111600788616007886CTexonicSOX6nonsynonymous HNSC|1|512|0.00195
-chr111600790316007903AGexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111603658116036581CGexonicSOX6nonsynonymous CESC|1|194|0.00515
-chr111599452315994523GAexonicSOX6synonymous SKCM|1|368|0.00272
rs774770291chr111634011116340111CTexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111607135116071351CAexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111600792716007927GTexonicSOX6nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr111607129416071294CTexonicSOX6stopgain SKCM|1|368|0.00272
-chr111599456715994567TCexonicSOX6nonsynonymous OV|1|469|0.00213
-chr111601076816010768CTexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111606821816068218GCexonicSOX6nonsynonymous LUAD|1|543|0.00184
rs747244986chr111633995516339955A-intronicSOX6unknown STAD|2|395|0.00506,STES|2|395|0.00506
-chr111601067516010675GAexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,KIPAN|1|799|0.00125,KIRC|1|451|0.00222,OV|1|469|0.00213
-chr111606820016068200TCexonicSOX6nonsynonymous PAAD|1|185|0.00541
-chr111607148416071484CGexonicSOX6nonsynonymous HNSC|1|512|0.00195
-chr111613345016133450GAexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111634015816340158TGexonicSOX6synonymous OV|1|469|0.00213
-chr111620547816205478AGexonicSOX6nonsynonymous LIHC|1|373|0.00268
-chr111611547016115539CATACTAGGAAAGTTTGGGAAACCCATCTTTTAAACAAGGTCGATCTTTTCTAACCAGAGTCCACATGAG-intronicSOX6unknown -
-chr111600785616007856GAexonicSOX6stopgain UCEC|1|248|0.00403
-chr111603652016036520ACexonicSOX6nonsynonymous SKCM|1|368|0.00272
rs747791112chr111634007216340072CTexonicSOX6nonsynonymous LUSC|1|178|0.00562
-chr111620841316208413CTexonicSOX6synonymous LUAD|1|543|0.00184
-chr111620840616208407CA-exonicSOX6frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr111599439015994390CAexonicSOX6stopgain BLCA|1|396|0.00253
rs773497953chr111636274016362740CTexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111607743716077437GAexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111599465515994655TAexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111611922216119222GAexonicSOX6nonsynonymous SKCM|1|368|0.00272
-chr111634001716340017CAexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs563514211chr111607144716071447CTexonicSOX6nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
rs772358464chr111611922116119221GAexonicSOX6synonymous SKCM|1|368|0.00272
rs34820506chr111633991816339918-TintronicSOX6unknown STAD|1|395|0.00253,STES|1|395|0.00253
-chr111620835416208354TCexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111601066816010668CTexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111620834516208345CAexonicSOX6nonsynonymous CHOL|1|35|0.02857
rs766953577chr111607743616077436GAexonicSOX6synonymous PAAD|1|185|0.00541
-chr111607144316071443GCexonicSOX6synonymous HNSC|1|512|0.00195
-chr111600781716007817GAexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|2|489|0.00409,READ|1|122|0.00820
rs552585211chr111600785116007851CTexonicSOX6synonymous BLCA|1|396|0.00253
-chr111601077516010775TGexonicSOX6synonymous LUAD|2|543|0.00368
-chr111601054316010543CAexonicSOX6stopgain LUSC|1|178|0.00562
-chr111601059316010593ATexonicSOX6nonsynonymous HNSC|1|512|0.00195
rs763877978chr111607732816077328CGexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111603657616036576ACexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111607132016071320CTexonicSOX6synonymous SKCM|1|368|0.00272
-chr111601069816010698TGexonicSOX6nonsynonymous SKCM|1|368|0.00272
rs769385306chr111634007316340073GAexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,PRAD|1|499|0.00200,UCS|1|57|0.01754
-chr111606808116068081CGexonicSOX6synonymous LUSC|1|178|0.00562
-chr111607126516071265CTexonicSOX6nonsynonymous SKCM|1|368|0.00272
-chr111647687016476877TCGACTTG-intronicSOX6unknown -
-chr111600782716007827GAexonicSOX6synonymous PRAD|1|499|0.00200
-chr111599458215994582GTexonicSOX6nonsynonymous ACC|1|90|0.01111
-chr111633992016339922TTT-intronicSOX6unknown ESCA|1|185|0.00541,STAD|1|395|0.00253,STES|1|395|0.00253
-chr111634012516340125TGexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111607133516071335GAexonicSOX6synonymous SKCM|1|368|0.00272
-chr111606821216068212-AexonicSOX6frameshift BRCA|1|982|0.00102
-chr111607128916071289-AexonicSOX6stopgain SKCM|1|368|0.00272
-chr111601076416010764AGexonicSOX6nonsynonymous UCEC|1|248|0.00403
rs148119560chr111634015916340159CTexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111613339816133398AGexonicSOX6synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr111600792516007925AGexonicSOX6nonsynonymous PAAD|1|185|0.00541
-chr111603648816036488CGexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111600791016007910CTexonicSOX6nonsynonymous BRCA|1|982|0.00102
-chr111607146316071463GTexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111611915316119153AGsplicingSOX6splicing STAD|1|395|0.00253,STES|1|395|0.00253
rs774229287chr111607738216077382TCexonicSOX6synonymous LIHC|1|373|0.00268
-chr111620842516208425CAexonicSOX6nonsynonymous LUAD|2|543|0.00368
-chr111634002616340026CAexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111599462915994629CAexonicSOX6nonsynonymous LUAD|4|543|0.00737
-chr111634015716340157TAexonicSOX6nonsynonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr111634016416340164GAexonicSOX6synonymous SKCM|1|368|0.00272
-chr111606817216068172CTexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111634015816340158TCexonicSOX6synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111607744416077444GTexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111620847616208476T-exonicSOX6frameshift LIHC|1|373|0.00268
-chr111607137816071378GAexonicSOX6nonsynonymous SKCM|1|368|0.00272
-chr111607144316071443GTexonicSOX6synonymous PRAD|1|499|0.00200
-chr111606814416068144CAexonicSOX6nonsynonymous OV|1|469|0.00213
-chr111599464015994640TAexonicSOX6synonymous LIHC|1|373|0.00268
-chr111600794116007941GCexonicSOX6nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111599456515994565TCexonicSOX6synonymous COAD|2|367|0.00545,COADREAD|2|489|0.00409
-chr111607730416077304TCexonicSOX6synonymous HNSC|1|512|0.00195
-chr111599449315994493CAexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111636269216362692GTexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111611763916117639-TexonicSOX6frameshift LUAD|1|543|0.00184
-chr111607127216071272CAexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111606821316068213A-exonicSOX6frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111611766216117662CTexonicSOX6synonymous PRAD|1|499|0.00200
rs763382219chr111599457715994577CTexonicSOX6synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr111607146716071467CAexonicSOX6nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111625614316256143GTexonicSOX6nonsynonymous UCEC|1|248|0.00403
-chr111599445215994452CAexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111613336816133368-GexonicSOX6frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111599463115994631TAexonicSOX6synonymous LUAD|1|543|0.00184
rs375479510chr111601057716010577GAexonicSOX6synonymous PRAD|1|499|0.00200
rs778593289chr111611921816119218TCexonicSOX6synonymous CESC|1|194|0.00515
rs780693524chr111600776116007761GTexonicSOX6nonsynonymous UCEC|1|248|0.00403
rs745532158chr111611922016119220CTexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111599442615994426CAexonicSOX6nonsynonymous SKCM|1|368|0.00272
rs765364888chr111606808516068085CAexonicSOX6nonsynonymous LUAD|1|543|0.00184
rs141152204chr111620837416208374CTexonicSOX6synonymous HNSC|1|512|0.00195
-chr111620837016208370GTexonicSOX6nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr111607743616077436GTexonicSOX6synonymous ESCA|1|185|0.00541
-chr111606811616068116CTexonicSOX6nonsynonymous BRCA|1|982|0.00102
-chr111601061016010610-TexonicSOX6frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr111642422616424226CAUTR5SOX6unknown LUAD|1|543|0.00184
-chr111600784616007846CTexonicSOX6nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122,STAD|1|395|0.00253,STES|1|395|0.00253
-chr111607140216071402TCexonicSOX6nonsynonymous ESCA|1|185|0.00541
-chr111603650416036504CTexonicSOX6synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr111607131316071313CAexonicSOX6stopgain COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr111636269016362690TGexonicSOX6nonsynonymous BLCA|1|396|0.00253
-chr111601060216010602CTexonicSOX6nonsynonymous LUAD|1|543|0.00184
-chr111611923516119235CTsplicingSOX6splicing SKCM|1|368|0.00272
-chr111607735816077358CAexonicSOX6synonymous LUAD|1|543|0.00184
-chr111600796616007966CTexonicSOX6nonsynonymous BRCA|1|982|0.00102
-chr111620834416208344GAexonicSOX6synonymous STAD|1|395|0.00253,STES|1|395|0.00253

Disease information of SOX6
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
SOX6 Schizophrenia F03 Mental or Behavioral Dysfunction PSYGENET

Pathway associated with SOX6
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000549 Deactivation of the beta-catenin transactivating complex reactome 42 236
pathway0002725 Hs_Endochondral_Ossification_WP474_87977 wikipathways 43 117

Go term information of SOX6
GO_term_name GO_term_type TF_name
GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING BP SOX6
GO_MUSCLE_ORGAN_DEVELOPMENT BP SOX6
GO_MYELOID_CELL_HOMEOSTASIS BP SOX6
GO_MYELOID_CELL_DEVELOPMENT BP SOX6
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT BP SOX6
GO_ERYTHROCYTE_HOMEOSTASIS BP SOX6
GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA BP SOX6
GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION BP SOX6
GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION BP SOX6
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION BP SOX6
GO_ASTROCYTE_DIFFERENTIATION BP SOX6
GO_HEART_DEVELOPMENT BP SOX6
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT BP SOX6
GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT BP SOX6
GO_GLIAL_CELL_FATE_COMMITMENT BP SOX6
GO_OLIGODENDROCYTE_DIFFERENTIATION BP SOX6
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION BP SOX6
GO_ERYTHROCYTE_DEVELOPMENT BP SOX6
GO_POST_EMBRYONIC_DEVELOPMENT BP SOX6

Survival analysis of SOX6



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of SOX6