Cancer CRCdb

TF information

TF name:	SOX17
TF family:	HMG
Ensembl gene ID:	ENSG00000164736
Ensembl protein ID:	ENSP00000297316
Entrez gene ID:	64321

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SOX17 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_114	Cell line	Mammary Gland	CAL51	0.085427135678392

SOX17 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

SOX17 distribution in all CRCs

Genomic distribution of SEs associated with SOX17

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Mutation of SOX17

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SOX17

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr8	55371645	55371645	C	T	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55370935	55370935	T	C	exonic	SOX17	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	55372409	55372409	C	G	exonic	SOX17	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	55370898	55370898	G	A	exonic	SOX17	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55371633	55371633	C	T	exonic	SOX17	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs201582946	chr8	55372417	55372417	C	T	exonic	SOX17	synonymous	HNSC\|1\|512\|0.00195
-	chr8	55372554	55372554	G	A	exonic	SOX17	synonymous	UCEC\|1\|248\|0.00403
-	chr8	55372418	55372418	G	A	exonic	SOX17	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	55371672	55371672	-	GA	exonic	SOX17	frameshift	CESC\|1\|194\|0.00515
-	chr8	55372532	55372532	T	C	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55370808	55370808	G	T	exonic	SOX17	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr8	55370926	55370926	G	A	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs764648837	chr8	55372202	55372202	G	A	exonic	SOX17	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs768558895	chr8	55370804	55370804	C	T	exonic	SOX17	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	55371765	55371765	-	G	exonic	SOX17	frameshift	UCS\|1\|57\|0.01754
-	chr8	55372386	55372386	A	G	exonic	SOX17	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	55370747	55370747	C	A	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
rs868625307	chr8	55372347	55372347	C	T	exonic	SOX17	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr8	55372342	55372342	C	T	exonic	SOX17	synonymous	PAAD\|1\|185\|0.00541
-	chr8	55372148	55372148	G	T	exonic	SOX17	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr8	55372518	55372518	G	T	exonic	SOX17	nonsynonymous	UCEC\|4\|248\|0.01613
-	chr8	55370910	55370910	C	T	exonic	SOX17	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr8	55372528	55372528	-	T	exonic	SOX17	frameshift	UCEC\|1\|248\|0.00403
-	chr8	55371662	55371662	G	A	exonic	SOX17	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr8	55370848	55370848	G	A	exonic	SOX17	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55372549	55372549	C	T	exonic	SOX17	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55372308	55372308	C	T	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs771488614	chr8	55372486	55372486	C	T	exonic	SOX17	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55372364	55372364	G	T	exonic	SOX17	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs200451706	chr8	55372161	55372161	C	T	exonic	SOX17	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr8	55371726	55371726	C	T	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55372287	55372287	-	C	exonic	SOX17	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55370847	55370847	C	G	exonic	SOX17	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr8	55371727	55371727	G	C	exonic	SOX17	synonymous	LUAD\|1\|543\|0.00184
-	chr8	55370816	55370816	G	A	exonic	SOX17	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr8	55371731	55371731	C	A	exonic	SOX17	synonymous	LUSC\|1\|178\|0.00562
-	chr8	55372456	55372456	T	C	exonic	SOX17	synonymous	LUSC\|1\|178\|0.00562
-	chr8	55370987	55370987	G	A	exonic	SOX17	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	55371807	55371807	C	T	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55372442	55372442	C	T	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	55372534	55372534	C	T	exonic	SOX17	synonymous	BLCA\|1\|396\|0.00253
-	chr8	55371725	55371725	C	G	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	55370985	55370985	C	G	exonic	SOX17	nonsynonymous	CESC\|1\|194\|0.00515,UCEC\|2\|248\|0.00806
-	chr8	55372523	55372523	G	A	exonic	SOX17	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	55372131	55372131	T	G	exonic	SOX17	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr8	55371955	55371955	C	T	exonic	SOX17	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	55372288	55372288	C	-	exonic	SOX17	frameshift	STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr8	55371702	55371702	A	G	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55370970	55370970	C	T	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	55370866	55370866	C	T	exonic	SOX17	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	55372417	55372417	C	A	exonic	SOX17	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	55372529	55372529	T	C	exonic	SOX17	nonsynonymous	SARC\|1\|247\|0.00405
-	chr8	55370918	55370918	G	A	exonic	SOX17	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	55370819	55370819	G	A	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	55370965	55370965	G	A	exonic	SOX17	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	55372039	55372039	G	A	exonic	SOX17	synonymous	SARC\|1\|247\|0.00405
-	chr8	55370930	55370930	T	C	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	55370910	55370910	C	A	exonic	SOX17	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	55372372	55372372	C	A	exonic	SOX17	synonymous	HNSC\|1\|512\|0.00195
-	chr8	55370802	55370802	C	A	exonic	SOX17	stopgain	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	55372394	55372394	G	A	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	55371663	55371663	T	C	exonic	SOX17	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr8	55372474	55372474	C	T	exonic	SOX17	synonymous	SKCM\|1\|368\|0.00272
-	chr8	55371735	55371735	G	A	exonic	SOX17	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	55371723	55371723	G	A	exonic	SOX17	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of SOX17

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SOX17	Colorectal Carcinoma	C04;C06	Neoplastic Process	CTD_human
SOX17	Colorectal Neoplasms	C04;C06	Neoplastic Process	CTD_human
SOX17	Vesico-Ureteral Reflux	C12;C13	Disease or Syndrome	CTD_human;ORPHANET
SOX17	Teratogenesis	C23	Pathologic Function	CTD_human
SOX17	Colorectal Cancer	C04;C06	Neoplastic Process	CTD_human
SOX17	Cakut	C12;C13;C16	Disease or Syndrome	GENOMICS_ENGLAND
SOX17	Pulmonary arterial hypertension		Disease or Syndrome	GENOMICS_ENGLAND
SOX17	VESICOURETERAL REFLUX 3		Disease or Syndrome	UNIPROT
SOX17	Idiopathic pulmonary arterial hypertension	C08	Disease or Syndrome	GENOMICS_ENGLAND
SOX17	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with SOX17

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000549	Deactivation of the beta-catenin transactivating complex	reactome	42	236
pathway0002740	Hs_Endoderm_Differentiation_WP2853_88152	wikipathways	62	260

Go term information of SOX17

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GO_term_name	GO_term_type	TF_name
GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT	BP	SOX17
GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT	BP	SOX17
GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT	BP	SOX17
GO_FORMATION_OF_PRIMARY_GERM_LAYER	BP	SOX17
GO_NEURAL_TUBE_DEVELOPMENT	BP	SOX17
GO_BLASTOCYST_FORMATION	BP	SOX17
GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	SOX17
GO_ENDOCARDIUM_DEVELOPMENT	BP	SOX17
GO_ENDOTHELIAL_CELL_DIFFERENTIATION	BP	SOX17
GO_SPECIFICATION_OF_SYMMETRY	BP	SOX17
GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM	BP	SOX17
GO_ORGAN_FORMATION	BP	SOX17
GO_PROTEIN_DESTABILIZATION	BP	SOX17
GO_REGULATION_OF_MESODERM_DEVELOPMENT	BP	SOX17
GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER	BP	SOX17
GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING	BP	SOX17
GO_HEART_MORPHOGENESIS	BP	SOX17
GO_ENDODERMAL_CELL_DIFFERENTIATION	BP	SOX17
GO_DIGESTIVE_TRACT_MORPHOGENESIS	BP	SOX17
GO_CARDIAC_CELL_FATE_COMMITMENT	BP	SOX17
GO_ENDOTHELIUM_DEVELOPMENT	BP	SOX17
GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION	BP	SOX17
GO_BLASTOCYST_DEVELOPMENT	BP	SOX17
GO_HEART_FORMATION	BP	SOX17
GO_LOCOMOTION	BP	SOX17
GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT	BP	SOX17
GO_REGULATION_OF_GASTRULATION	BP	SOX17
GO_CELL_FATE_DETERMINATION	BP	SOX17
GO_MRNA_TRANSCRIPTION	BP	SOX17
GO_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	SOX17
GO_ENDODERM_FORMATION	BP	SOX17
GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	SOX17
GO_TUBE_MORPHOGENESIS	BP	SOX17
GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT	BP	SOX17
GO_OUTFLOW_TRACT_MORPHOGENESIS	BP	SOX17
GO_REGULATION_OF_CELL_FATE_SPECIFICATION	BP	SOX17
GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT	BP	SOX17
GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION	BP	SOX17
GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS	BP	SOX17
GO_REGULATION_OF_ORGAN_MORPHOGENESIS	BP	SOX17
GO_ENDODERMAL_CELL_FATE_COMMITMENT	BP	SOX17
GO_NEURAL_TUBE_PATTERNING	BP	SOX17
GO_REGULATION_OF_CELL_FATE_COMMITMENT	BP	SOX17
GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SOX17
GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION	BP	SOX17
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX	CC	SOX17
GO_BETA_CATENIN_BINDING	MF	SOX17
GO_PROTEIN_DIMERIZATION_ACTIVITY	MF	SOX17

Survival analysis of SOX17

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SOX17

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)