TF information
| TF name: | SNAI1 |
| TF family: | zf-C2H2 |
| Ensembl gene ID: | ENSG00000124216 |
| Ensembl protein ID: | ENSP00000244050 |
| Entrez gene ID: | 6615 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of SNAI1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_181 | Cell line | Human melanoma | COLO679 | 0.0042666666666667 |
SNAI1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
SNAI1 distribution in all CRCs
Genomic distribution of SEs associated with SNAI1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of SNAI1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs748041292 | chr20 | 48600511 | 48600511 | G | A | exonic | SNAI1 | nonsynonymous | UCEC|1|248|0.00403 |
| rs369225838 | chr20 | 48600455 | 48600455 | C | T | exonic | SNAI1 | synonymous | LUAD|1|543|0.00184 |
| - | chr20 | 48604525 | 48604525 | C | T | exonic | SNAI1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr20 | 48600466 | 48600466 | C | G | exonic | SNAI1 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr20 | 48600635 | 48600635 | T | C | exonic | SNAI1 | synonymous | SARC|1|247|0.00405 |
| - | chr20 | 48604461 | 48604461 | C | T | exonic | SNAI1 | synonymous | LUAD|1|543|0.00184 |
| - | chr20 | 48604577 | 48604577 | C | T | exonic | SNAI1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr20 | 48604457 | 48604457 | G | A | exonic | SNAI1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr20 | 48600840 | 48600840 | G | T | exonic | SNAI1 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr20 | 48600418 | 48600418 | C | T | exonic | SNAI1 | nonsynonymous | LUSC|1|178|0.00562 |
| rs137950928 | chr20 | 48600442 | 48600442 | C | T | exonic | SNAI1 | nonsynonymous | LUSC|1|178|0.00562 |
| rs774280694 | chr20 | 48600619 | 48600619 | C | T | exonic | SNAI1 | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr20 | 48600837 | 48600837 | A | G | exonic | SNAI1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr20 | 48600845 | 48600845 | C | G | exonic | SNAI1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr20 | 48600674 | 48600674 | G | T | exonic | SNAI1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr20 | 48600469 | 48600469 | T | A | exonic | SNAI1 | nonsynonymous | LUSC|1|178|0.00562 |
| rs34261470 | chr20 | 48600475 | 48600475 | C | T | exonic | SNAI1 | nonsynonymous | DLBC|1|48|0.02083 |
| rs758694399 | chr20 | 48600506 | 48600506 | C | T | exonic | SNAI1 | synonymous | SARC|1|247|0.00405 |
| - | chr20 | 48600448 | 48600448 | C | A | exonic | SNAI1 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr20 | 48604460 | 48604460 | C | G | exonic | SNAI1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr20 | 48604479 | 48604479 | C | G | exonic | SNAI1 | synonymous | BRCA|1|982|0.00102 |
| - | chr20 | 48600634 | 48600634 | C | T | exonic | SNAI1 | nonsynonymous | SARC|1|247|0.00405 |
| rs768825298 | chr20 | 48604442 | 48604442 | G | A | exonic | SNAI1 | nonsynonymous | OV|1|469|0.00213 |
| - | chr20 | 48600475 | 48600475 | C | G | exonic | SNAI1 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr20 | 48604490 | 48604490 | C | G | exonic | SNAI1 | stopgain | CESC|1|194|0.00515 |
| - | chr20 | 48600493 | 48600493 | T | C | exonic | SNAI1 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr20 | 48604456 | 48604456 | C | T | exonic | SNAI1 | nonsynonymous | BRCA|2|982|0.00204 |
| - | chr20 | 48604589 | 48604589 | G | A | exonic | SNAI1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs760808201 | chr20 | 48604441 | 48604441 | C | T | exonic | SNAI1 | nonsynonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr20 | 48600620 | 48600620 | C | T | exonic | SNAI1 | synonymous | SKCM|1|368|0.00272 |
| rs754163516 | chr20 | 48600606 | 48600606 | C | T | exonic | SNAI1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr20 | 48600685 | 48600685 | C | T | exonic | SNAI1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr20 | 48604538 | 48604538 | G | C | exonic | SNAI1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr20 | 48604434 | 48604434 | C | A | exonic | SNAI1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr20 | 48604467 | 48604467 | G | A | exonic | SNAI1 | synonymous | ESCA|1|185|0.00541 |
| - | chr20 | 48604411 | 48604411 | G | A | exonic | SNAI1 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr20 | 48600409 | 48600409 | T | C | exonic | SNAI1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr20 | 48600834 | 48600834 | G | A | exonic | SNAI1 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr20 | 48600381 | 48600381 | T | A | exonic | SNAI1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr20 | 48604526 | 48604526 | G | A | exonic | SNAI1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr20 | 48600678 | 48600678 | C | T | exonic | SNAI1 | stopgain | LUAD|2|543|0.00368 |
| rs369673182 | chr20 | 48600819 | 48600819 | G | A | exonic | SNAI1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr20 | 48600754 | 48600754 | G | T | exonic | SNAI1 | nonsynonymous | PRAD|2|499|0.00401 |
| - | chr20 | 48600371 | 48600371 | C | A | exonic | SNAI1 | nonsynonymous | SKCM|1|368|0.00272 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| SNAI1 | Malignant neoplasm of breast | C04;C17 | Neoplastic Process | CTD_human |
| SNAI1 | Neoplastic Cell Transformation | C04;C23 | Neoplastic Process | CTD_human |
| SNAI1 | Cholestasis | C06 | Disease or Syndrome | CTD_human |
| SNAI1 | Malignant neoplasm of stomach | C04;C06 | Neoplastic Process | CTD_human |
| SNAI1 | Neoplasm Invasiveness | C04;C23 | Pathologic Function | CTD_human |
| SNAI1 | Neoplasm Metastasis | C04;C23 | Neoplastic Process | CTD_human |
| SNAI1 | Stomach Neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| SNAI1 | Papillary thyroid carcinoma | C04;C19 | Neoplastic Process | CTD_human |
| SNAI1 | Breast Carcinoma | C04;C17 | Neoplastic Process | CTD_human |
| SNAI1 | Mammary Neoplasms, Human | C04;C17 | Neoplastic Process | CTD_human |
| SNAI1 | Mammary Neoplasms | C04;C17 | Neoplastic Process | CTD_human |
| SNAI1 | Hereditary Diffuse Gastric Cancer | C04;C06 | Neoplastic Process | CTD_human |
| SNAI1 | AMYOTROPHIC LATERAL SCLEROSIS 1 | C10;C18 | Disease or Syndrome | CTD_human |
| SNAI1 | Amyotrophic Lateral Sclerosis, Sporadic | C10;C18 | Disease or Syndrome | CTD_human |
| SNAI1 | Non-medullary thyroid carcinoma | C04;C19 | Neoplastic Process | CTD_human |
| SNAI1 | Familial Nonmedullary Thyroid Cancer | C04;C19 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS | BP | SNAI1 |
| GO_EPIDERMIS_MORPHOGENESIS | BP | SNAI1 |
| GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | BP | SNAI1 |
| GO_ENDOCARDIAL_CUSHION_DEVELOPMENT | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS | BP | SNAI1 |
| GO_POSITIVE_REGULATION_OF_LOCOMOTION | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS | BP | SNAI1 |
| GO_MORPHOGENESIS_OF_AN_EPITHELIUM | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS | BP | SNAI1 |
| GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY | BP | SNAI1 |
| GO_CARTILAGE_MORPHOGENESIS | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE | BP | SNAI1 |
| GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS | BP | SNAI1 |
| GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | BP | SNAI1 |
| GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS | BP | SNAI1 |
| GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR | BP | SNAI1 |
| GO_ENDOCARDIAL_CUSHION_FORMATION | BP | SNAI1 |
| GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT | BP | SNAI1 |
| GO_LEFT_RIGHT_PATTERN_FORMATION | BP | SNAI1 |
| GO_PALATE_DEVELOPMENT | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | SNAI1 |
| GO_MESENCHYMAL_CELL_DIFFERENTIATION | BP | SNAI1 |
| GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | SNAI1 |
| GO_SKIN_EPIDERMIS_DEVELOPMENT | BP | SNAI1 |
| GO_MESODERM_MORPHOGENESIS | BP | SNAI1 |
| GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION | BP | SNAI1 |
| GO_MOLTING_CYCLE | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT | BP | SNAI1 |
| GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT | BP | SNAI1 |
| GO_EPIDERMIS_DEVELOPMENT | BP | SNAI1 |
| GO_OSSIFICATION | BP | SNAI1 |
| GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE | BP | SNAI1 |
| GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS | BP | SNAI1 |
| GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR | BP | SNAI1 |
| GO_REGULATION_OF_STEROID_METABOLIC_PROCESS | BP | SNAI1 |
| GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | BP | SNAI1 |
| GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS | BP | SNAI1 |
| GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT | BP | SNAI1 |
| GO_MESENCHYME_MORPHOGENESIS | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | BP | SNAI1 |
| GO_REGIONALIZATION | BP | SNAI1 |
| GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY | BP | SNAI1 |
| GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR | BP | SNAI1 |
| GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | SNAI1 |
| GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING | MF | SNAI1 |