TF information
| TF name: | SMAD1 |
| TF family: | MH1 |
| Ensembl gene ID: | ENSG00000170365 |
| Ensembl protein ID: | ENSP00000426568, ENSP00000305769, ENSP00000377652, ENSP00000424959, ENSP00000424649, ENSP00000427002, ENSP00000425270 |
| Entrez gene ID: | 4086 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of SMAD1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_314 | Cell line | Neuroblastoma | SK-N-FI | 0.32098765432099 |
SMAD1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
SMAD1 distribution in all CRCs
Genomic distribution of SEs associated with SMAD1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of SMAD1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr4 | 146436069 | 146436069 | G | T | exonic | SMAD1 | stopgain | BLCA|1|396|0.00253 |
| - | chr4 | 146436067 | 146436067 | A | G | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146461145 | 146461145 | G | T | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146463850 | 146463850 | G | A | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146461063 | 146461063 | G | A | exonic | SMAD1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr4 | 146467983 | 146467983 | C | T | exonic | SMAD1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr4 | 146475083 | 146475083 | T | A | exonic | SMAD1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr4 | 146467936 | 146467936 | C | T | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs773218247 | chr4 | 146435948 | 146435948 | G | A | exonic | SMAD1 | synonymous | CESC|1|194|0.00515 |
| - | chr4 | 146435880 | 146435880 | A | - | exonic | SMAD1 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146460985 | 146460985 | A | G | exonic | SMAD1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr4 | 146467907 | 146467907 | C | T | exonic | SMAD1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146463769 | 146463769 | G | C | exonic | SMAD1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr4 | 146467997 | 146467997 | G | C | exonic | SMAD1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr4 | 146479017 | 146479017 | C | T | exonic | SMAD1 | synonymous | LUSC|1|178|0.00562 |
| - | chr4 | 146460988 | 146460988 | G | A | exonic | SMAD1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr4 | 146436166 | 146436166 | G | T | splicing | SMAD1 | splicing | LUSC|1|178|0.00562 |
| - | chr4 | 146475128 | 146475128 | A | G | exonic | SMAD1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr4 | 146479012 | 146479012 | G | T | exonic | SMAD1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr4 | 146463793 | 146463793 | C | T | exonic | SMAD1 | stopgain | BLCA|1|396|0.00253 |
| - | chr4 | 146435868 | 146435868 | G | A | exonic | SMAD1 | nonsynonymous | BLCA|1|396|0.00253 |
| rs373113912 | chr4 | 146435834 | 146435834 | C | T | exonic | SMAD1 | synonymous | UCEC|1|248|0.00403 |
| - | chr4 | 146474982 | 146474982 | - | A | exonic | SMAD1 | frameshift | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr4 | 146468035 | 146468035 | G | A | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146468031 | 146468031 | A | G | exonic | SMAD1 | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr4 | 146436032 | 146436032 | C | T | exonic | SMAD1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr4 | 146475083 | 146475083 | T | - | exonic | SMAD1 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr4 | 146435774 | 146435774 | G | A | exonic | SMAD1 | synonymous | ACC|1|90|0.01111 |
| - | chr4 | 146478948 | 146478948 | G | C | exonic | SMAD1 | nonsynonymous | OV|1|469|0.00213 |
| rs576994811 | chr4 | 146463818 | 146463818 | C | T | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146436151 | 146436151 | G | A | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146461204 | 146461204 | C | T | exonic | SMAD1 | stopgain | SKCM|1|368|0.00272 |
| - | chr4 | 146467854 | 146467854 | G | C | splicing | SMAD1 | splicing | LUAD|1|543|0.00184 |
| rs766290015 | chr4 | 146460987 | 146460987 | C | T | exonic | SMAD1 | synonymous | HNSC|1|512|0.00195 |
| rs752874837 | chr4 | 146463741 | 146463741 | G | A | exonic | SMAD1 | synonymous | UCEC|1|248|0.00403 |
| - | chr4 | 146435885 | 146435885 | A | G | exonic | SMAD1 | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr4 | 146460992 | 146460992 | A | G | exonic | SMAD1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr4 | 146467854 | 146467854 | G | A | splicing | SMAD1 | splicing | HNSC|1|512|0.00195 |
| - | chr4 | 146475180 | 146475180 | G | C | exonic | SMAD1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr4 | 146463845 | 146463845 | G | A | exonic | SMAD1 | nonsynonymous | LUAD|1|543|0.00184,SKCM|1|368|0.00272 |
| rs769453113 | chr4 | 146435831 | 146435831 | G | A | exonic | SMAD1 | synonymous | ESCA|1|185|0.00541 |
| - | chr4 | 146467968 | 146467968 | G | A | exonic | SMAD1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr4 | 146475004 | 146475004 | C | T | exonic | SMAD1 | stopgain | SKCM|1|368|0.00272 |
| rs372397852 | chr4 | 146474973 | 146474973 | C | T | exonic | SMAD1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr4 | 146475175 | 146475175 | C | T | exonic | SMAD1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr4 | 146475084 | 146475084 | T | G | exonic | SMAD1 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr4 | 146479006 | 146479006 | C | G | exonic | SMAD1 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr4 | 146435905 | 146435905 | C | T | exonic | SMAD1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| rs765987226 | chr4 | 146475164 | 146475164 | T | C | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146475147 | 146475147 | C | T | exonic | SMAD1 | synonymous | BRCA|1|982|0.00102 |
| - | chr4 | 146435852 | 146435852 | G | A | exonic | SMAD1 | stopgain | HNSC|2|512|0.00391 |
| - | chr4 | 146467880 | 146467880 | A | G | exonic | SMAD1 | synonymous | BRCA|1|982|0.00102 |
| - | chr4 | 146474941 | 146474941 | C | A | exonic | SMAD1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr4 | 146463737 | 146463737 | A | G | exonic | SMAD1 | nonsynonymous | LUAD|1|543|0.00184 |
| rs747747846 | chr4 | 146463798 | 146463798 | G | A | exonic | SMAD1 | synonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr4 | 146461025 | 146461025 | - | T | exonic | SMAD1 | frameshift | LUAD|1|543|0.00184 |
| - | chr4 | 146468016 | 146468016 | C | T | exonic | SMAD1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs370506404 | chr4 | 146435947 | 146435947 | C | T | exonic | SMAD1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr4 | 146435880 | 146435880 | A | G | exonic | SMAD1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr4 | 146461008 | 146461008 | C | T | exonic | SMAD1 | synonymous | UCEC|1|248|0.00403 |
| - | chr4 | 146436153 | 146436153 | G | T | exonic | SMAD1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr4 | 146460970 | 146460970 | C | G | exonic | SMAD1 | nonsynonymous | HNSC|1|512|0.00195 |
| rs746555376 | chr4 | 146463782 | 146463782 | A | G | exonic | SMAD1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr4 | 146461124 | 146461124 | G | C | exonic | SMAD1 | nonsynonymous | LUSC|1|178|0.00562 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| SMAD1 | Pulmonary arterial hypertension | Disease or Syndrome | GENOMICS_ENGLAND | |
| SMAD1 | Idiopathic pulmonary arterial hypertension | C08 | Disease or Syndrome | GENOMICS_ENGLAND |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000135 | ALK1 signaling events | pid | 26 | 204 |
| pathway0000136 | ALK2 signaling events | pid | 11 | 35 |
| pathway0000317 | BMP receptor signaling | pid | 42 | 280 |
| pathway0000321 | BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 34 | 385 |
| pathway0000323 | BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 13 | 47 |
| pathway0000897 | Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 8 | 27 |
| pathway0000898 | Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 7 | 20 |
| pathway0000994 | Hedgehog | netpath | 39 | 177 |
| pathway0001279 | LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) ) | inoh | 10 | 29 |
| pathway0001452 | Negative regulation of (nuclear import of R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 11 | 26 |
| pathway0001455 | Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) ) | inoh | 21 | 184 |
| pathway0002009 | Signaling by BMP | reactome | 23 | 122 |
| pathway0002218 | TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) ) | inoh | 51 | 970 |
| pathway0002591 | TGF-beta signaling pathway | kegg | 82 | 1017 |
| pathway0002747 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 | 129 |
| pathway0002768 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 | 78 |
| pathway0002770 | Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082 | wikipathways | 6 | 10 |
| pathway0002792 | Hs_G13_Signaling_Pathway_WP524_72112 | wikipathways | 18 | 18 |
| pathway0002826 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 | 175 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION | BP | SMAD1 |
| GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS | BP | SMAD1 |
| GO_REGULATION_OF_CARTILAGE_DEVELOPMENT | BP | SMAD1 |
| GO_TISSUE_MORPHOGENESIS | BP | SMAD1 |
| GO_SKELETAL_SYSTEM_DEVELOPMENT | BP | SMAD1 |
| GO_KIDNEY_EPITHELIUM_DEVELOPMENT | BP | SMAD1 |
| GO_MUSCLE_CELL_PROLIFERATION | BP | SMAD1 |
| GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS | BP | SMAD1 |
| GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER | BP | SMAD1 |
| GO_EMBRYONIC_PATTERN_SPECIFICATION | BP | SMAD1 |
| GO_MIDBRAIN_DEVELOPMENT | BP | SMAD1 |
| GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS | BP | SMAD1 |
| GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND | BP | SMAD1 |
| GO_NCRNA_METABOLIC_PROCESS | BP | SMAD1 |
| GO_ORGAN_GROWTH | BP | SMAD1 |
| GO_GASTRULATION | BP | SMAD1 |
| GO_MESODERM_MORPHOGENESIS | BP | SMAD1 |
| GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT | BP | SMAD1 |
| GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY | BP | SMAD1 |
| GO_MESODERMAL_CELL_DIFFERENTIATION | BP | SMAD1 |
| GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION | BP | SMAD1 |
| GO_POSTTRANSCRIPTIONAL_GENE_SILENCING | BP | SMAD1 |
| GO_CELLULAR_RESPONSE_TO_DSRNA | BP | SMAD1 |
| GO_DSRNA_FRAGMENTATION | BP | SMAD1 |
| GO_CELL_FATE_COMMITMENT | BP | SMAD1 |
| GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS | BP | SMAD1 |
| GO_STRIATED_MUSCLE_CELL_PROLIFERATION | BP | SMAD1 |
| GO_CONNECTIVE_TISSUE_DEVELOPMENT | BP | SMAD1 |
| GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION | BP | SMAD1 |
| GO_RESPONSE_TO_DSRNA | BP | SMAD1 |
| GO_HEART_GROWTH | BP | SMAD1 |
| GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS | BP | SMAD1 |
| GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS | BP | SMAD1 |
| GO_MESONEPHROS_DEVELOPMENT | BP | SMAD1 |
| GO_MESODERMAL_CELL_FATE_COMMITMENT | BP | SMAD1 |
| GO_DEVELOPMENTAL_GROWTH | BP | SMAD1 |
| GO_NUCLEAR_INNER_MEMBRANE | CC | SMAD1 |
| GO_SMAD_BINDING | MF | SMAD1 |
| GO_CORE_PROMOTER_BINDING | MF | SMAD1 |
| GO_I_SMAD_BINDING | MF | SMAD1 |
| GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING | MF | SMAD1 |
| GO_CO_SMAD_BINDING | MF | SMAD1 |
| GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING | MF | SMAD1 |
| GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING | MF | SMAD1 |