Cancer CRCdb

TF information

TF name:	RXRG
TF family:	RXR-like
Ensembl gene ID:	ENSG00000143171
Ensembl protein ID:	ENSP00000482458, ENSP00000352900
Entrez gene ID:	6258

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of RXRG in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_181	Cell line	Human melanoma	COLO679	0.65493333333333

RXRG distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_181	Human melanoma	Cell line	COLO679

RXRG distribution in all CRCs

Genomic distribution of SEs associated with RXRG

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Mutation of RXRG

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RXRG

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	165398198	165398198	G	T	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165370598	165370598	T	C	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165389170	165389170	G	C	exonic	RXRG	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165370562	165370562	C	A	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
rs149401256	chr1	165378824	165378824	G	A	exonic	RXRG	synonymous	LUAD\|1\|543\|0.00184
-	chr1	165380003	165380003	C	A	exonic	RXRG	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	165370516	165370516	G	A	exonic	RXRG	nonsynonymous	PRAD\|1\|499\|0.00200,SARC\|1\|247\|0.00405
-	chr1	165370609	165370609	G	A	exonic	RXRG	nonsynonymous	SKCM\|1\|368\|0.00272
rs568135949	chr1	165378811	165378811	C	T	exonic	RXRG	nonsynonymous	UVM\|1\|80\|0.01250
rs766520723	chr1	165376129	165376129	A	G	exonic	RXRG	synonymous	LUSC\|1\|178\|0.00562
rs149087358	chr1	165370515	165370515	C	T	exonic	RXRG	synonymous	PRAD\|2\|499\|0.00401
-	chr1	165377463	165377463	C	A	splicing	RXRG	splicing	HNSC\|1\|512\|0.00195
-	chr1	165398161	165398161	G	T	exonic	RXRG	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	165380300	165380300	C	A	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
rs371364035	chr1	165380187	165380187	G	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165414102	165414102	T	G	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	165386339	165386339	C	A	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
rs759787868	chr1	165380319	165380319	C	T	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	165370608	165370608	G	A	exonic	RXRG	synonymous	SKCM\|1\|368\|0.00272
-	chr1	165370572	165370572	G	C	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	165386448	165386448	T	C	exonic	RXRG	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165376126	165376126	C	G	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165389141	165389141	T	A	exonic	RXRG	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	165380195	165380195	C	G	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165406414	165406414	A	C	intronic	RXRG	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs754104309	chr1	165380219	165380219	T	C	exonic	RXRG	synonymous	LUAD\|1\|543\|0.00184
-	chr1	165414094	165414094	C	T	exonic	RXRG	nonsynonymous	CHOL\|1\|35\|0.02857
-	chr1	165380321	165380321	G	T	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165406407	165406407	G	T	intronic	RXRG	unknown	UCEC\|1\|248\|0.00403
-	chr1	165378875	165378875	C	A	exonic	RXRG	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165380213	165380213	G	A	exonic	RXRG	synonymous	BRCA\|1\|982\|0.00102,SKCM\|1\|368\|0.00272
-	chr1	165370566	165370566	G	A	exonic	RXRG	synonymous	BRCA\|1\|982\|0.00102
-	chr1	165398110	165398110	G	T	exonic	RXRG	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	165398047	165398047	G	T	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
rs370579158	chr1	165398092	165398092	C	T	exonic	RXRG	nonsynonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165378874	165378874	C	A	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
rs765348774	chr1	165386316	165386316	C	T	exonic	RXRG	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	165398094	165398094	T	G	exonic	RXRG	synonymous	BRCA\|1\|982\|0.00102
-	chr1	165378827	165378827	G	A	exonic	RXRG	synonymous	SKCM\|2\|368\|0.00543
-	chr1	165380257	165380257	T	C	exonic	RXRG	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	165386317	165386317	G	A	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165386426	165386426	G	A	exonic	RXRG	synonymous	ESCA\|1\|185\|0.00541
-	chr1	165398021	165398021	C	G	exonic	RXRG	nonsynonymous	BRCA\|1\|982\|0.00102
rs749399300	chr1	165378892	165378892	G	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165398114	165398114	C	T	exonic	RXRG	nonsynonymous	SKCM\|1\|368\|0.00272
rs771304563	chr1	165380317	165380317	C	G	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165378919	165378919	C	A	exonic	RXRG	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165379970	165379970	G	A	exonic	RXRG	synonymous	SKCM\|1\|368\|0.00272
rs770751855	chr1	165380012	165380012	G	A	exonic	RXRG	synonymous	UCEC\|1\|248\|0.00403
rs761649501	chr1	165378880	165378880	C	T	exonic	RXRG	nonsynonymous	HNSC\|1\|512\|0.00195
rs540851886	chr1	165379995	165379995	C	T	exonic	RXRG	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	165398199	165398199	G	T	exonic	RXRG	synonymous	LUAD\|1\|543\|0.00184
-	chr1	165397991	165397991	G	C	exonic	RXRG	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	165380320	165380320	G	A	exonic	RXRG	stopgain	LUAD\|1\|543\|0.00184
-	chr1	165370612	165370612	C	T	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
rs780970253	chr1	165370563	165370563	G	A	exonic	RXRG	synonymous	SKCM\|1\|368\|0.00272
-	chr1	165398095	165398095	G	C	exonic	RXRG	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	165370517	165370517	G	T	exonic	RXRG	nonsynonymous	LUAD\|2\|543\|0.00368
rs766425704	chr1	165386374	165386374	G	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165386447	165386447	G	T	exonic	RXRG	stopgain	LUSC\|1\|178\|0.00562
-	chr1	165380011	165380011	C	T	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165376069	165376069	C	G	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165398074	165398074	C	A	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165398029	165398029	G	T	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	165370521	165370521	C	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165380292	165380292	C	T	exonic	RXRG	nonsynonymous	LUSC\|1\|178\|0.00562
rs746442876	chr1	165386283	165386283	C	T	exonic	RXRG	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	165398012	165398012	A	T	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	165380004	165380004	C	T	exonic	RXRG	stopgain	HNSC\|1\|512\|0.00195
-	chr1	165386384	165386384	G	C	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
rs751038970	chr1	165378891	165378891	C	T	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	165376092	165376092	G	A	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165378870	165378870	C	A	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
rs748834240	chr1	165370627	165370627	C	T	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	165398117	165398117	T	C	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	165397991	165397991	G	T	exonic	RXRG	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165398014	165398014	G	T	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165386398	165386398	T	C	exonic	RXRG	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	165380222	165380222	C	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165414181	165414181	G	A	UTR5	RXRG	unknown	ESCA\|1\|185\|0.00541
-	chr1	165398042	165398042	G	A	exonic	RXRG	stopgain	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr1	165414106	165414106	T	C	exonic	RXRG	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	165389151	165389151	G	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165386442	165386442	A	G	exonic	RXRG	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	165406395	165406395	T	C	intronic	RXRG	unknown	UCEC\|1\|248\|0.00403
-	chr1	165380234	165380234	A	C	exonic	RXRG	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165398198	165398198	G	A	exonic	RXRG	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	165370528	165370528	A	G	exonic	RXRG	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	165389159	165389159	G	A	exonic	RXRG	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs200646455	chr1	165389155	165389155	C	T	exonic	RXRG	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	165377464	165377464	C	A	exonic	RXRG	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	165380287	165380287	T	G	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165386311	165386311	G	A	exonic	RXRG	stopgain	BRCA\|1\|982\|0.00102
-	chr1	165398200	165398200	G	A	exonic	RXRG	nonsynonymous	HNSC\|2\|512\|0.00391
rs138979533	chr1	165378812	165378812	G	A	exonic	RXRG	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165379964	165379964	C	A	exonic	RXRG	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr1	165398130	165398130	G	A	exonic	RXRG	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165414095	165414095	G	T	exonic	RXRG	synonymous	PRAD\|1\|499\|0.00200
rs757688872	chr1	165378913	165378913	G	A	exonic	RXRG	synonymous	LUAD\|6\|543\|0.01105
-	chr1	165380346	165380346	G	A	exonic	RXRG	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	165398202	165398202	G	T	exonic	RXRG	synonymous	UCEC\|1\|248\|0.00403
-	chr1	165386387	165386387	G	A	exonic	RXRG	synonymous	BRCA\|1\|982\|0.00102
-	chr1	165398112	165398112	A	C	exonic	RXRG	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	165377516	165377516	C	T	exonic	RXRG	synonymous	ESCA\|1\|185\|0.00541
rs150448748	chr1	165397995	165397995	C	T	exonic	RXRG	synonymous	UCEC\|1\|248\|0.00403
-	chr1	165376074	165376074	G	T	exonic	RXRG	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	165386373	165386373	C	T	exonic	RXRG	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	165380290	165380290	C	A	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165376097	165376097	G	A	exonic	RXRG	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	165377466	165377466	G	T	exonic	RXRG	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	165389184	165389184	C	T	exonic	RXRG	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	165397989	165397989	T	A	exonic	RXRG	synonymous	LUAD\|1\|543\|0.00184
-	chr1	165406376	165406376	G	A	intronic	RXRG	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	165398156	165398156	A	C	exonic	RXRG	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	165397965	165397965	G	T	exonic	RXRG	synonymous	LUAD\|1\|543\|0.00184
-	chr1	165386326	165386326	G	A	exonic	RXRG	stopgain	LUSC\|1\|178\|0.00562

Disease information of RXRG

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
RXRG	Myocardial Ischemia	C14	Disease or Syndrome	CTD_human

Pathway associated with RXRG

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000044	a6b1 and a6b4 Integrin signaling	pid	46	383
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0001883	Retinoic acid receptors-mediated signaling	pid	30	235
pathway0001947	RXR and RAR heterodimerization with other nuclear receptor	pid	26	164
pathway0002028	Signaling by Retinoic Acid	reactome	20	78
pathway0002561	PPAR signaling pathway	kegg	67	520
pathway0002628	Adipocytokine signaling pathway	kegg	65	539
pathway0002656	Pathways in cancer	kegg	321	8293
pathway0002663	Thyroid cancer	kegg	25	123
pathway0002669	Small cell lung cancer	kegg	83	807
pathway0002670	Non-small cell lung cancer	kegg	54	623

Go term information of RXRG

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GO_term_name	GO_term_type	TF_name
GO_RESPONSE_TO_STEROID_HORMONE	BP	RXRG
GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND	BP	RXRG
GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	RXRG
GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS	BP	RXRG
GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY	BP	RXRG
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS	BP	RXRG
GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY	BP	RXRG
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	RXRG
GO_TRANSITION_METAL_ION_BINDING	MF	RXRG

Survival analysis of RXRG

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of RXRG

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)