TF information
| TF name: | RUNX3 |
| TF family: | Runt |
| Ensembl gene ID: | ENSG00000020633 |
| Ensembl protein ID: | ENSP00000308051, ENSP00000343477, ENSP00000382800 |
| Entrez gene ID: | 864 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of RUNX3 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_184 | Cell line | Skin | SKMEL30 | 0.57877813504823 |
| Sample_02_406 | Cell line | Mammary Gland | ZR-75-30_parental | 0.014492753623188 |
RUNX3 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_184 | Skin | Cell line | SKMEL30 |
RUNX3 distribution in all CRCs
Genomic distribution of SEs associated with RUNX3
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of RUNX3
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr1 | 25229078 | 25229078 | G | A | exonic | RUNX3 | synonymous | PAAD|1|185|0.00541 |
| - | chr1 | 25245742 | 25245742 | C | T | exonic | RUNX3 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs200276750 | chr1 | 25229116 | 25229116 | C | T | exonic | RUNX3 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr1 | 25233845 | 25233845 | C | A | exonic | RUNX3 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25229102 | 25229102 | G | - | exonic | RUNX3 | frameshift | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr1 | 25229111 | 25229111 | G | A | exonic | RUNX3 | synonymous | LIHC|1|373|0.00268 |
| - | chr1 | 25245743 | 25245743 | G | A | exonic | RUNX3 | nonsynonymous | STAD|3|395|0.00759,STES|3|395|0.00759 |
| rs750722272 | chr1 | 25256138 | 25256138 | G | A | exonic | RUNX3 | synonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25228965 | 25228965 | G | T | exonic | RUNX3 | nonsynonymous | HNSC|2|512|0.00391 |
| - | chr1 | 25228881 | 25228881 | G | A | exonic | RUNX3 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr1 | 25254159 | 25254159 | C | A | exonic | RUNX3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 25256117 | 25256117 | C | A | exonic | RUNX3 | synonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr1 | 25233840 | 25233840 | G | A | exonic | RUNX3 | nonsynonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr1 | 25245810 | 25245810 | A | T | exonic | RUNX3 | synonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25291022 | 25291022 | G | T | exonic | RUNX3 | stopgain | SARC|1|247|0.00405 |
| rs755295660 | chr1 | 25291054 | 25291054 | C | T | exonic | RUNX3 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 25229099 | 25229099 | C | A | exonic | RUNX3 | synonymous | LUSC|1|178|0.00562 |
| rs567207182 | chr1 | 25229150 | 25229150 | C | T | exonic | RUNX3 | synonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355,SARC|1|247|0.00405 |
| - | chr1 | 25228904 | 25228904 | C | A | exonic | RUNX3 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr1 | 25228878 | 25228878 | G | A | exonic | RUNX3 | nonsynonymous | SKCM|1|368|0.00272 |
| rs751887340 | chr1 | 25228982 | 25228982 | G | A | exonic | RUNX3 | synonymous | BRCA|1|982|0.00102 |
| - | chr1 | 25256084 | 25256084 | G | T | exonic | RUNX3 | synonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25245749 | 25245749 | C | T | exonic | RUNX3 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| rs573562275 | chr1 | 25228691 | 25228691 | G | A | exonic | RUNX3 | synonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25228914 | 25228914 | G | A | exonic | RUNX3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25254161 | 25254161 | C | A | exonic | RUNX3 | stopgain | HNSC|1|512|0.00195 |
| - | chr1 | 25228994 | 25228994 | G | C | exonic | RUNX3 | nonsynonymous | LUAD|1|543|0.00184 |
| rs746716793 | chr1 | 25291042 | 25291042 | G | A | exonic | RUNX3 | synonymous | LUAD|4|543|0.00737 |
| rs202015637 | chr1 | 25228963 | 25228963 | T | G | exonic | RUNX3 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 25256280 | 25256281 | CC | - | exonic | RUNX3 | frameshift | THYM|1|123|0.00813 |
| - | chr1 | 25256116 | 25256116 | G | T | exonic | RUNX3 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 25228823 | 25228823 | C | A | exonic | RUNX3 | synonymous | LUAD|1|543|0.00184 |
| rs377188925 | chr1 | 25229099 | 25229099 | C | T | exonic | RUNX3 | synonymous | CHOL|1|35|0.02857 |
| - | chr1 | 25229132 | 25229132 | G | C | exonic | RUNX3 | synonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25254203 | 25254203 | C | T | exonic | RUNX3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs144597350 | chr1 | 25229132 | 25229132 | G | A | exonic | RUNX3 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 25254140 | 25254140 | G | A | exonic | RUNX3 | nonsynonymous | CESC|1|194|0.00515,HNSC|1|512|0.00195 |
| - | chr1 | 25291031 | 25291031 | G | A | exonic | RUNX3 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr1 | 25229066 | 25229066 | G | C | exonic | RUNX3 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25254076 | 25254076 | C | A | exonic | RUNX3 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25256172 | 25256172 | G | T | exonic | RUNX3 | nonsynonymous | HNSC|1|512|0.00195 |
| rs764020894 | chr1 | 25228968 | 25228968 | G | A | exonic | RUNX3 | nonsynonymous | CESC|1|194|0.00515 |
| rs757662116 | chr1 | 25254126 | 25254126 | G | A | exonic | RUNX3 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 25254205 | 25254205 | T | A | exonic | RUNX3 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 25229042 | 25229042 | G | A | exonic | RUNX3 | synonymous | SKCM|1|368|0.00272 |
| rs779977917 | chr1 | 25245750 | 25245750 | G | A | exonic | RUNX3 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs761109803 | chr1 | 25256188 | 25256188 | C | G | exonic | RUNX3 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| rs746125249 | chr1 | 25229113 | 25229113 | G | A | exonic | RUNX3 | nonsynonymous | PRAD|1|499|0.00200 |
| rs749580286 | chr1 | 25228664 | 25228664 | C | T | exonic | RUNX3 | synonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25228682 | 25228682 | G | T | exonic | RUNX3 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr1 | 25228807 | 25228807 | C | A | exonic | RUNX3 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr1 | 25245770 | 25245770 | C | A | exonic | RUNX3 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr1 | 25254076 | 25254076 | C | T | exonic | RUNX3 | nonsynonymous | PAAD|1|185|0.00541 |
| rs202187723 | chr1 | 25229007 | 25229007 | G | A | exonic | RUNX3 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs773791670 | chr1 | 25233874 | 25233874 | C | T | exonic | RUNX3 | synonymous | PRAD|1|499|0.00200 |
| - | chr1 | 25245773 | 25245773 | G | A | exonic | RUNX3 | stopgain | HNSC|1|512|0.00195 |
| - | chr1 | 25254143 | 25254143 | G | A | exonic | RUNX3 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs756828615 | chr1 | 25228901 | 25228901 | G | A | exonic | RUNX3 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 25256086 | 25256086 | C | A | exonic | RUNX3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25228777 | 25228777 | C | T | exonic | RUNX3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25233903 | 25233903 | G | A | exonic | RUNX3 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 25256143 | 25256143 | T | A | exonic | RUNX3 | nonsynonymous | DLBC|1|48|0.02083 |
| rs779004787 | chr1 | 25229012 | 25229012 | C | T | exonic | RUNX3 | synonymous | BLCA|1|396|0.00253,PAAD|1|185|0.00541 |
| - | chr1 | 25254068 | 25254068 | G | T | exonic | RUNX3 | synonymous | PRAD|1|499|0.00200 |
| - | chr1 | 25229017 | 25229017 | C | A | exonic | RUNX3 | nonsynonymous | LUAD|1|543|0.00184 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| RUNX3 | Adenocarcinoma | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Celiac Disease | C06;C18 | Disease or Syndrome | CTD_human |
| RUNX3 | Esophageal Neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| RUNX3 | Glioblastoma | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Leukemia, Myelocytic, Acute | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Lung Neoplasms | C04;C08 | Neoplastic Process | CTD_human |
| RUNX3 | Malignant neoplasm of stomach | C04;C06 | Neoplastic Process | CTD_human |
| RUNX3 | Acute Myeloid Leukemia, M1 | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Pustulosis of Palms and Soles | C17 | Disease or Syndrome | CTD_human |
| RUNX3 | Polycystic Ovary Syndrome | C04;C13;C19 | Disease or Syndrome | CTD_human |
| RUNX3 | Psoriasis | C17 | Disease or Syndrome | CTD_human |
| RUNX3 | Ankylosing spondylitis | C05 | Disease or Syndrome | CTD_human |
| RUNX3 | Stomach Neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| RUNX3 | Adenocarcinoma, Basal Cell | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Adenocarcinoma, Oxyphilic | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Carcinoma, Cribriform | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Carcinoma, Granular Cell | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Adenocarcinoma, Tubular | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Malignant neoplasm of lung | C04;C08 | Neoplastic Process | CTD_human |
| RUNX3 | Giant Cell Glioblastoma | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Malignant neoplasm of esophagus | C04;C06 | Neoplastic Process | CTD_human |
| RUNX3 | Sclerocystic Ovaries | C04;C13;C19 | Disease or Syndrome | CTD_human |
| RUNX3 | Glioblastoma Multiforme | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Hereditary Diffuse Gastric Cancer | C04;C06 | Neoplastic Process | CTD_human |
| RUNX3 | Acute Myeloid Leukemia (AML-M2) | C04 | Neoplastic Process | CTD_human |
| RUNX3 | Liver carcinoma | C04;C06 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0002812 | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 | 60 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_CARTILAGE_DEVELOPMENT | BP | RUNX3 |
| GO_IMMUNE_SYSTEM_PROCESS | BP | RUNX3 |
| GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION | BP | RUNX3 |
| GO_RESPONSE_TO_GROWTH_FACTOR | BP | RUNX3 |
| GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT | BP | RUNX3 |
| GO_NEGATIVE_REGULATION_OF_CELL_CYCLE | BP | RUNX3 |