TF information
| TF name: | RORA |
| TF family: | THR-like |
| Ensembl gene ID: | ENSG00000069667 |
| Ensembl protein ID: | ENSP00000402971, ENSP00000453322, ENSP00000261523, ENSP00000335087, ENSP00000309753 |
| Entrez gene ID: | 6095 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of RORA in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_296 | Cell line | Neuroblastoma | CLB-BER-Lud | 0.10022953328233 |
RORA distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
RORA distribution in all CRCs
Genomic distribution of SEs associated with RORA
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of RORA
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs140905032 | chr15 | 60803593 | 60803593 | C | T | exonic | RORA | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr15 | 60803787 | 60803787 | C | G | exonic | RORA | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr15 | 60803641 | 60803641 | T | C | exonic | RORA | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr15 | 60919479 | 60919479 | C | A | exonic | RORA | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60919554 | 60919554 | C | T | exonic | RORA | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr15 | 60795746 | 60795746 | G | T | exonic | RORA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr15 | 61521357 | 61521357 | C | - | exonic | RORA | frameshift | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr15 | 60803793 | 60803793 | T | - | exonic | RORA | frameshift | LIHC|1|373|0.00268 |
| - | chr15 | 60970881 | 60970881 | G | C | exonic | RORA | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr15 | 60803577 | 60803577 | A | G | exonic | RORA | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr15 | 60849084 | 60849084 | T | C | exonic | RORA | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr15 | 60795042 | 60795042 | C | T | exonic | RORA | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr15 | 60789759 | 60789759 | C | A | exonic | RORA | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| rs769229417 | chr15 | 60806833 | 60806833 | C | T | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| rs372625965 | chr15 | 60919495 | 60919495 | G | A | exonic | RORA | stopgain | SKCM|1|368|0.00272 |
| - | chr15 | 60803785 | 60803785 | C | - | exonic | RORA | frameshift | ACC|1|90|0.01111 |
| - | chr15 | 60789691 | 60789691 | G | C | exonic | RORA | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr15 | 60907193 | 60907193 | G | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60795025 | 60795025 | C | T | exonic | RORA | nonsynonymous | BLCA|1|396|0.00253 |
| rs201818123 | chr15 | 60907184 | 60907184 | T | C | exonic | RORA | synonymous | HNSC|1|512|0.00195 |
| - | chr15 | 60795017 | 60795017 | C | A | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60792113 | 60792113 | C | T | exonic | RORA | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60803545 | 60803545 | G | T | exonic | RORA | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60849111 | 60849111 | T | A | exonic | RORA | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr15 | 60907219 | 60907219 | T | C | exonic | RORA | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr15 | 60803461 | 60803461 | C | A | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60919521 | 60919521 | G | A | exonic | RORA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,LUSC|1|178|0.00562 |
| - | chr15 | 60803529 | 60803529 | A | G | exonic | RORA | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr15 | 60806925 | 60806925 | G | A | exonic | RORA | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60907114 | 60907114 | G | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60803666 | 60803666 | C | T | exonic | RORA | synonymous | CESC|1|194|0.00515 |
| - | chr15 | 60970879 | 60970879 | G | C | exonic | RORA | stopgain | LUAD|1|543|0.00184 |
| - | chr15 | 60806883 | 60806883 | C | T | exonic | RORA | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60803546 | 60803546 | A | G | exonic | RORA | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr15 | 60793217 | 60793217 | G | A | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60919446 | 60919446 | C | T | exonic | RORA | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr15 | 60803653 | 60803653 | C | T | exonic | RORA | nonsynonymous | CESC|1|194|0.00515 |
| rs758295613 | chr15 | 60803736 | 60803736 | C | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60907121 | 60907121 | G | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| rs188796486 | chr15 | 60970873 | 60970873 | G | A | exonic | RORA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr15 | 60795017 | 60795017 | C | G | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60803809 | 60803809 | C | A | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60806916 | 60806916 | G | A | exonic | RORA | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60806947 | 60806947 | T | C | exonic | RORA | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr15 | 60907124 | 60907124 | G | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| rs572542837 | chr15 | 60919494 | 60919494 | C | T | exonic | RORA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs775864488 | chr15 | 60850430 | 60850430 | G | A | exonic | RORA | synonymous | UCEC|1|248|0.00403 |
| rs745753959 | chr15 | 60919532 | 60919532 | C | A | exonic | RORA | nonsynonymous | OV|1|469|0.00213 |
| - | chr15 | 61159052 | 61159052 | - | TCGATCTG | intronic | RORA | unknown | - |
| - | chr15 | 60824052 | 60824052 | T | A | splicing | RORA | splicing | LIHC|1|373|0.00268 |
| rs779480778 | chr15 | 60907162 | 60907162 | C | T | exonic | RORA | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr15 | 60849093 | 60849093 | G | A | exonic | RORA | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr15 | 60789700 | 60789700 | T | G | exonic | RORA | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr15 | 60789779 | 60789779 | G | A | exonic | RORA | stopgain | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr15 | 60789818 | 60789818 | A | C | exonic | RORA | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr15 | 61521385 | 61521385 | G | A | exonic | RORA | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs750243770 | chr15 | 60803735 | 60803735 | G | A | exonic | RORA | synonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60792104 | 60792104 | C | A | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60803744 | 60803744 | C | T | exonic | RORA | synonymous | UCEC|1|248|0.00403 |
| - | chr15 | 61468389 | 61468389 | A | G | intronic | RORA | unknown | CESC|1|194|0.00515 |
| - | chr15 | 60907165 | 60907165 | C | T | exonic | RORA | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr15 | 60795032 | 60795032 | A | C | exonic | RORA | synonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60907095 | 60907095 | T | C | exonic | RORA | nonsynonymous | LIHC|1|373|0.00268 |
| rs199818399 | chr15 | 60797800 | 60797800 | C | T | exonic | RORA | synonymous | ACC|1|90|0.01111 |
| - | chr15 | 60849056 | 60849056 | C | T | exonic | RORA | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr15 | 60795042 | 60795042 | C | G | exonic | RORA | nonsynonymous | BLCA|2|396|0.00505 |
| - | chr15 | 60806849 | 60806849 | T | A | exonic | RORA | nonsynonymous | KIPAN|2|799|0.00250,KIRC|2|451|0.00443 |
| - | chr15 | 60789757 | 60789757 | G | A | exonic | RORA | nonsynonymous | PRAD|1|499|0.00200 |
| rs776035356 | chr15 | 60792196 | 60792196 | T | C | exonic | RORA | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60919563 | 60919563 | C | T | exonic | RORA | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr15 | 60789729 | 60789729 | C | T | exonic | RORA | synonymous | BLCA|1|396|0.00253 |
| - | chr15 | 60907165 | 60907165 | C | A | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60970880 | 60970880 | A | T | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60806923 | 60806923 | T | A | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr15 | 60806938 | 60806938 | G | A | exonic | RORA | stopgain | SKCM|1|368|0.00272 |
| - | chr15 | 60797807 | 60797807 | G | A | exonic | RORA | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr15 | 60919479 | 60919479 | C | G | exonic | RORA | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr15 | 60849113 | 60849113 | C | T | exonic | RORA | synonymous | TGCT|1|155|0.00645 |
| - | chr15 | 60919533 | 60919533 | T | C | exonic | RORA | nonsynonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr15 | 60792166 | 60792166 | T | - | exonic | RORA | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 61521304 | 61521304 | C | T | exonic | RORA | synonymous | DLBC|1|48|0.02083 |
| - | chr15 | 60806876 | 60806876 | A | G | exonic | RORA | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs143671650 | chr15 | 60803789 | 60803789 | C | T | exonic | RORA | synonymous | BLCA|1|396|0.00253 |
| - | chr15 | 60907207 | 60907207 | G | A | exonic | RORA | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs201013771 | chr15 | 60907141 | 60907141 | T | C | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60794985 | 60794985 | G | A | exonic | RORA | nonsynonymous | HNSC|1|512|0.00195 |
| rs780107705 | chr15 | 60970872 | 60970872 | C | T | exonic | RORA | synonymous | SKCM|3|368|0.00815 |
| rs202109768 | chr15 | 60803702 | 60803702 | C | T | exonic | RORA | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr15 | 60919560 | 60919560 | - | C | exonic | RORA | frameshift | LUAD|1|543|0.00184 |
| rs770351742 | chr15 | 60803725 | 60803725 | G | C | exonic | RORA | nonsynonymous | LUAD|1|543|0.00184 |
| rs200655240 | chr15 | 60803596 | 60803596 | C | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| rs199986254 | chr15 | 60919520 | 60919520 | C | T | exonic | RORA | synonymous | PRAD|1|499|0.00200 |
| - | chr15 | 60793161 | 60793161 | C | T | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr15 | 60792129 | 60792129 | G | T | exonic | RORA | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr15 | 60806817 | 60806817 | T | C | exonic | RORA | nonsynonymous | UCEC|1|248|0.00403 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| RORA | Autistic Disorder | F03 | Mental or Behavioral Dysfunction | CTD_human |
| RORA | Bipolar Disorder | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| RORA | Mental Depression | F01 | Mental or Behavioral Dysfunction | PSYGENET |
| RORA | Depressive disorder | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| RORA | Malignant neoplasm of stomach | C04;C06 | Neoplastic Process | CTD_human |
| RORA | Stomach Neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| RORA | Seasonal Affective Disorder | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| RORA | Hereditary Diffuse Gastric Cancer | C04;C06 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000316 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 | 282 |
| pathway0000430 | Circadian Clock | reactome | 49 | 389 |
| pathway0001534 | Nuclear Receptor transcription pathway | reactome | 51 | 284 |
| pathway0001940 | RORA activates gene expression | reactome | 27 | 204 |
| pathway0002700 | Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946 | wikipathways | 15 | 18 |
| pathway0002789 | Hs_Complement_and_Coagulation_Cascades_WP558_90196 | wikipathways | 21 | 30 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_ACYLGLYCEROL_HOMEOSTASIS | BP | RORA |
| GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION | BP | RORA |
| GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS | BP | RORA |
| GO_NITRIC_OXIDE_METABOLIC_PROCESS | BP | RORA |
| GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION | BP | RORA |
| GO_CGMP_METABOLIC_PROCESS | BP | RORA |
| GO_ALPHA_BETA_T_CELL_DIFFERENTIATION | BP | RORA |
| GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION | BP | RORA |
| GO_REGULATION_OF_MACROPHAGE_ACTIVATION | BP | RORA |
| GO_REGULATION_OF_DEFENSE_RESPONSE | BP | RORA |
| GO_HOMEOSTATIC_PROCESS | BP | RORA |
| GO_CEREBELLAR_CORTEX_MORPHOGENESIS | BP | RORA |
| GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS | BP | RORA |
| GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION | BP | RORA |
| GO_LEUKOCYTE_DIFFERENTIATION | BP | RORA |
| GO_LIPID_HOMEOSTASIS | BP | RORA |
| GO_REGULATION_OF_CIRCADIAN_RHYTHM | BP | RORA |
| GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS | BP | RORA |
| GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION | BP | RORA |
| GO_CEREBELLAR_CORTEX_DEVELOPMENT | BP | RORA |
| GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE | BP | RORA |
| GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS | BP | RORA |
| GO_RESPONSE_TO_STEROL | BP | RORA |
| GO_CELL_PROLIFERATION | BP | RORA |
| GO_RESPONSE_TO_HORMONE | BP | RORA |
| GO_CELL_DIFFERENTIATION_IN_HINDBRAIN | BP | RORA |
| GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM | BP | RORA |
| GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE | BP | RORA |
| GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION | BP | RORA |
| GO_CELLULAR_RESPONSE_TO_STEROL | BP | RORA |
| GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING | BP | RORA |
| GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION | BP | RORA |
| GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS | BP | RORA |
| GO_CELL_FATE_COMMITMENT | BP | RORA |
| GO_HINDBRAIN_MORPHOGENESIS | BP | RORA |
| GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY | BP | RORA |
| GO_CELLULAR_RESPONSE_TO_ALCOHOL | BP | RORA |
| GO_REGULATION_OF_STEROID_METABOLIC_PROCESS | BP | RORA |
| GO_REGULATION_OF_INFLAMMATORY_RESPONSE | BP | RORA |
| GO_CEREBELLAR_CORTEX_FORMATION | BP | RORA |
| GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT | BP | RORA |
| GO_RESPONSE_TO_CYTOKINE | BP | RORA |
| GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS | BP | RORA |
| GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS | BP | RORA |
| GO_MUSCLE_CELL_DIFFERENTIATION | BP | RORA |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING | BP | RORA |
| GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION | BP | RORA |
| GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT | BP | RORA |
| GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION | BP | RORA |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS | BP | RORA |
| GO_CORE_PROMOTER_BINDING | MF | RORA |
| GO_STEROID_BINDING | MF | RORA |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING | MF | RORA |
| GO_STEROID_HORMONE_RECEPTOR_ACTIVITY | MF | RORA |
| GO_TRANSCRIPTION_COFACTOR_BINDING | MF | RORA |
| GO_DOUBLE_STRANDED_DNA_BINDING | MF | RORA |
| GO_TRANSCRIPTION_COACTIVATOR_BINDING | MF | RORA |
| GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING | MF | RORA |