TF information
| TF name: | POU5F1 |
| TF family: | Pou |
| Ensembl gene ID: | ENSG00000204531 |
| Ensembl protein ID: | ENSP00000484778, ENSP00000389359, ENSP00000425479, ENSP00000475512, ENSP00000475880, ENSP00000259915, ENSP00000425083 |
| Entrez gene ID: | 5460 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of POU5F1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_114 | Cell line | Mammary Gland | CAL51 | 0.38190954773869 |
POU5F1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
POU5F1 distribution in all CRCs
Genomic distribution of SEs associated with POU5F1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of POU5F1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr6 | 31138204 | 31138204 | G | - | exonic | POU5F1 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31133748 | 31133748 | C | T | exonic | POU5F1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr6 | 31133009 | 31133009 | C | G | exonic | POU5F1 | nonsynonymous | OV|1|469|0.00213 |
| - | chr6 | 31132949 | 31132949 | G | A | exonic | POU5F1 | stopgain | ESCA|1|185|0.00541 |
| - | chr6 | 31132571 | 31132571 | T | C | exonic | POU5F1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31138149 | 31138149 | C | - | exonic | POU5F1 | frameshift | LIHC|1|373|0.00268 |
| rs1061118 | chr6 | 31132414 | 31132414 | G | A | exonic | POU5F1 | synonymous | BRCA|1|982|0.00102 |
| rs779696279 | chr6 | 31138094 | 31138094 | C | T | exonic | POU5F1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr6 | 31133443 | 31133443 | C | G | exonic | POU5F1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr6 | 31138066 | 31138066 | G | A | exonic | POU5F1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr6 | 31132983 | 31132983 | C | A | exonic | POU5F1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31138029 | 31138029 | C | T | exonic | POU5F1 | synonymous | BLCA|1|396|0.00253 |
| - | chr6 | 31132579 | 31132580 | TT | - | exonic | POU5F1 | frameshift | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| rs751426340 | chr6 | 31137991 | 31137991 | G | A | splicing | POU5F1 | splicing | UCEC|1|248|0.00403 |
| - | chr6 | 31133004 | 31133004 | G | T | exonic | POU5F1 | nonsynonymous | LAML|1|197|0.00508 |
| rs780177765 | chr6 | 31138323 | 31138323 | C | T | exonic | POU5F1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31138067 | 31138067 | A | G | exonic | POU5F1 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr6 | 31133041 | 31133041 | A | G | exonic | POU5F1 | nonsynonymous | LUAD|2|543|0.00368 |
| - | chr6 | 31138063 | 31138063 | G | C | exonic | POU5F1 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr6 | 31133762 | 31133762 | C | G | exonic | POU5F1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr6 | 31133377 | 31133377 | C | T | exonic | POU5F1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr6 | 31138167 | 31138167 | C | T | exonic | POU5F1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31138068 | 31138068 | G | - | exonic | POU5F1 | frameshift | BRCA|1|982|0.00102 |
| rs1062630 | chr6 | 31138107 | 31138107 | G | A | exonic | POU5F1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31138004 | 31138004 | T | A | exonic | POU5F1 | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr6 | 31138112 | 31138112 | C | T | exonic | POU5F1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr6 | 31133413 | 31133413 | A | G | exonic | POU5F1 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| - | chr6 | 31132543 | 31132543 | T | C | exonic | POU5F1 | synonymous | HNSC|1|512|0.00195 |
| - | chr6 | 31132966 | 31132966 | C | A | exonic | POU5F1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr6 | 31133468 | 31133468 | G | A | exonic | POU5F1 | synonymous | THCA|1|504|0.00198 |
| - | chr6 | 31133802 | 31133802 | T | A | exonic | POU5F1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr6 | 31132537 | 31132537 | T | C | exonic | POU5F1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs1265160 | chr6 | 31138371 | 31138371 | G | A | exonic | POU5F1 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr6 | 31132912 | 31132912 | T | C | exonic | POU5F1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs41257954 | chr6 | 31138310 | 31138310 | C | T | exonic | POU5F1 | nonsynonymous | DLBC|1|48|0.02083 |
| - | chr6 | 31133755 | 31133755 | T | G | exonic | POU5F1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr6 | 31133735 | 31133735 | G | A | exonic | POU5F1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr6 | 31133727 | 31133727 | C | T | exonic | POU5F1 | nonsynonymous | SKCM|1|368|0.00272 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| POU5F1 | Congenital Heart Defects | C14;C16 | Congenital Abnormality | CTD_human |
| POU5F1 | Embryonal Neoplasm | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Neoplasms, Germ Cell and Embryonal | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Germ cell tumor | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Neoplasms, Embryonal and Mixed | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Amphetamine-Related Disorders | C25;F03 | Mental or Behavioral Dysfunction | CTD_human |
| POU5F1 | Amphetamine Addiction | C25;F03 | Mental or Behavioral Dysfunction | CTD_human |
| POU5F1 | Amphetamine Abuse | C25;F03 | Mental or Behavioral Dysfunction | CTD_human |
| POU5F1 | Germ Cell Cancer | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Cancer, Embryonal | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Cancer, Embryonal and Mixed | C04 | Neoplastic Process | CTD_human |
| POU5F1 | Gestational Trophoblastic Neoplasms | C04;C13 | Neoplastic Process | CTD_human |
| POU5F1 | Gestational trophoblastic disease | C04;C13 | Disease or Syndrome | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0001022 | HIF-2-alpha transcription factor network | pid | 34 | 119 |
| pathway0001701 | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | reactome | 13 | 36 |
| pathway0001702 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 | 27 |
| pathway0002301 | Transcriptional regulation of pluripotent stem cells | reactome | 28 | 184 |
| pathway0002740 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 | 260 |
| pathway0002821 | Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_90291 | wikipathways | 12 | 20 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT | BP | POU5F1 |
| GO_DEVELOPMENTAL_INDUCTION | BP | POU5F1 |
| GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS | BP | POU5F1 |
| GO_REGULATION_OF_ORGAN_FORMATION | BP | POU5F1 |
| GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS | BP | POU5F1 |
| GO_REGULATION_OF_CHROMATIN_SILENCING | BP | POU5F1 |
| GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER | BP | POU5F1 |
| GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY | BP | POU5F1 |
| GO_REGULATION_OF_HEART_MORPHOGENESIS | BP | POU5F1 |
| GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE | BP | POU5F1 |
| GO_ENDODERMAL_CELL_DIFFERENTIATION | BP | POU5F1 |
| GO_CARDIAC_CELL_FATE_COMMITMENT | BP | POU5F1 |
| GO_BLASTOCYST_DEVELOPMENT | BP | POU5F1 |
| GO_ORGAN_INDUCTION | BP | POU5F1 |
| GO_ENDODERM_DEVELOPMENT | BP | POU5F1 |
| GO_MAINTENANCE_OF_CELL_NUMBER | BP | POU5F1 |
| GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS | BP | POU5F1 |
| GO_CELL_FATE_DETERMINATION | BP | POU5F1 |
| GO_MRNA_TRANSCRIPTION | BP | POU5F1 |
| GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS | BP | POU5F1 |
| GO_CARDIOCYTE_DIFFERENTIATION | BP | POU5F1 |
| GO_ENDODERM_FORMATION | BP | POU5F1 |
| GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS | BP | POU5F1 |
| GO_REGULATION_OF_CELL_FATE_SPECIFICATION | BP | POU5F1 |
| GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS | BP | POU5F1 |
| GO_CELL_FATE_SPECIFICATION | BP | POU5F1 |
| GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT | BP | POU5F1 |
| GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING | BP | POU5F1 |
| GO_NEGATIVE_REGULATION_OF_GENE_SILENCING | BP | POU5F1 |
| GO_ENDODERMAL_CELL_FATE_COMMITMENT | BP | POU5F1 |
| GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY | BP | POU5F1 |
| GO_REGULATION_OF_CELL_FATE_COMMITMENT | BP | POU5F1 |
| GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | BP | POU5F1 |
| GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | BP | POU5F1 |
| GO_MIRNA_BINDING | MF | POU5F1 |
| GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING | MF | POU5F1 |