Cancer CRCdb

TF information

TF name:	POU2F2
TF family:	Pou
Ensembl gene ID:	ENSG00000028277
Ensembl protein ID:	ENSP00000452930, ENSP00000471890, ENSP00000453255, ENSP00000475664, ENSP00000431603, ENSP00000476062, ENSP00000454179, ENSP00000339369, ENSP00000436988, ENSP00000373992, ENSP00000437224
Entrez gene ID:	5452

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of POU2F2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_179	Cell line	Urinary bladder	T24	0.22988505747126
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.52997601918465
Sample_02_318	Cell line	Neuroblastoma	NB69	0.546875

POU2F2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_318	Neuroblastoma	Cell line	NB69

POU2F2 distribution in all CRCs

Genomic distribution of SEs associated with POU2F2

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Mutation of POU2F2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of POU2F2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr19	42603753	42603753	T	G	exonic	POU2F2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr19	42596350	42596350	C	T	exonic	POU2F2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr19	42600283	42600283	T	C	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
rs769204325	chr19	42626525	42626525	C	T	exonic	POU2F2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCEC\|1\|248\|0.00403
rs375042716	chr19	42603760	42603760	C	T	exonic	POU2F2	synonymous	ACC\|1\|90\|0.01111
-	chr19	42599578	42599578	C	T	exonic	POU2F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	42599709	42599709	C	T	exonic	POU2F2	synonymous	BRCA\|2\|982\|0.00204
-	chr19	42600367	42600367	G	A	exonic	POU2F2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr19	42599447	42599447	G	T	exonic	POU2F2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr19	42621423	42621423	C	G	exonic	POU2F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	42596347	42596347	G	C	exonic	POU2F2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs200445754	chr19	42598028	42598028	G	A	exonic	POU2F2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr19	42603707	42603707	G	A	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	42626708	42626708	G	T	exonic	POU2F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	42599544	42599544	C	T	exonic	POU2F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	42596302	42596302	G	-	exonic	POU2F2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	42598045	42598045	G	C	exonic	POU2F2	synonymous	BLCA\|1\|396\|0.00253
-	chr19	42597984	42597984	T	G	exonic	POU2F2	nonsynonymous	PRAD\|1\|499\|0.00200
rs145518520	chr19	42626700	42626700	G	A	exonic	POU2F2	synonymous	LUAD\|1\|543\|0.00184
-	chr19	42603720	42603720	C	A	exonic	POU2F2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr19	42600386	42600386	G	A	exonic	POU2F2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr19	42626663	42626663	C	T	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	42599721	42599721	G	A	exonic	POU2F2	synonymous	BLCA\|1\|396\|0.00253,UCEC\|1\|248\|0.00403
-	chr19	42599443	42599443	G	T	exonic	POU2F2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr19	42600343	42600343	G	A	exonic	POU2F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	42603737	42603737	G	A	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	42599549	42599549	C	T	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272
-	chr19	42599765	42599765	G	A	exonic	POU2F2	nonsynonymous	OV\|1\|469\|0.00213
-	chr19	42600387	42600387	G	A	exonic	POU2F2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr19	42600296	42600296	C	T	exonic	POU2F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	42600329	42600329	G	A	exonic	POU2F2	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr19	42600050	42600050	T	C	exonic	POU2F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	42597998	42597998	C	A	exonic	POU2F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs757334613	chr19	42603703	42603703	C	A	exonic	POU2F2	nonsynonymous	THCA\|1\|504\|0.00198
rs150784596	chr19	42621421	42621421	G	A	exonic	POU2F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	42621504	42621504	G	A	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272
-	chr19	42599726	42599726	G	A	exonic	POU2F2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr19	42600043	42600043	G	A	exonic	POU2F2	synonymous	DLBC\|1\|48\|0.02083
-	chr19	42621499	42621499	C	A	exonic	POU2F2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr19	42599759	42599759	G	A	exonic	POU2F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	42626697	42626697	C	T	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272
-	chr19	42600075	42600075	C	A	exonic	POU2F2	nonsynonymous	LUAD\|1\|543\|0.00184
rs761440487	chr19	42603913	42603913	G	A	exonic	POU2F2	nonsynonymous	UCEC\|1\|248\|0.00403
rs760733530	chr19	42626521	42626521	C	A	exonic	POU2F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	42598031	42598031	C	T	exonic	POU2F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	42626508	42626508	G	C	exonic	POU2F2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr19	42597985	42597985	T	C	exonic	POU2F2	synonymous	PRAD\|1\|499\|0.00200
-	chr19	42599543	42599543	-	GGATCA	exonic	POU2F2	nonframeshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	42636560	42636560	C	A	exonic	POU2F2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr19	42626683	42626683	T	C	exonic	POU2F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	42600287	42600287	C	A	exonic	POU2F2	stopgain	LUAD\|1\|543\|0.00184
rs756999992	chr19	42621519	42621519	C	T	splicing	POU2F2	splicing	LUAD\|1\|543\|0.00184
rs761526279	chr19	42621520	42621520	-	G	splicing	POU2F2	unknown	KIPAN\|9\|799\|0.01126,KIRC\|9\|451\|0.01996,LUAD\|1\|543\|0.00184
-	chr19	42626516	42626516	C	T	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	42599751	42599751	C	G	exonic	POU2F2	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr19	42600325	42600325	G	A	exonic	POU2F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	42599998	42599998	C	T	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272
-	chr19	42596305	42596305	G	A	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	42603967	42603967	G	A	exonic	POU2F2	stopgain	DLBC\|1\|48\|0.02083
-	chr19	42596301	42596301	-	G	exonic	POU2F2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr19	42599555	42599555	C	T	exonic	POU2F2	synonymous	UCEC\|1\|248\|0.00403
-	chr19	42599725	42599725	C	T	exonic	POU2F2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr19	42599758	42599758	C	T	exonic	POU2F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	42600276	42600276	G	T	exonic	POU2F2	synonymous	LUSC\|1\|178\|0.00562
rs369799078	chr19	42599534	42599534	G	A	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272,TGCT\|1\|155\|0.00645
-	chr19	42595605	42595605	A	T	UTR3	POU2F2	unknown	CESC\|1\|194\|0.00515
-	chr19	42598024	42598024	C	T	exonic	POU2F2	synonymous	UCEC\|1\|248\|0.00403
-	chr19	42596307	42596307	T	G	exonic	POU2F2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr19	42636553	42636553	G	A	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
rs756460030	chr19	42600013	42600013	G	A	exonic	POU2F2	synonymous	BLCA\|1\|396\|0.00253,CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
rs752605068	chr19	42599739	42599739	G	T	exonic	POU2F2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr19	42626729	42626729	C	T	splicing	POU2F2	splicing	SARC\|1\|247\|0.00405
-	chr19	42626661	42626661	A	C	splicing	POU2F2	splicing	BRCA\|1\|982\|0.00102
-	chr19	42600042	42600042	C	A	exonic	POU2F2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs185988799	chr19	42596302	42596302	G	A	exonic	POU2F2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr19	42626518	42626518	T	C	exonic	POU2F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	42597981	42597981	C	G	exonic	POU2F2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr19	42600307	42600307	G	A	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr19	42621437	42621437	C	A	exonic	POU2F2	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr19	42600360	42600360	G	C	exonic	POU2F2	synonymous	HNSC\|1\|512\|0.00195
-	chr19	42600030	42600030	T	C	exonic	POU2F2	nonsynonymous	DLBC\|2\|48\|0.04167
-	chr19	42595860	42595860	C	G	intronic	POU2F2	unknown	CESC\|1\|194\|0.00515
-	chr19	42599696	42599696	C	A	splicing	POU2F2	splicing	LUAD\|1\|543\|0.00184
-	chr19	42626335	42626335	C	A	splicing	POU2F2	splicing	UCEC\|1\|248\|0.00403
-	chr19	42600377	42600377	G	A	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272
-	chr19	42599712	42599712	C	A	exonic	POU2F2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr19	42596242	42596242	-	A	exonic	POU2F2	frameshift	ACC\|1\|90\|0.01111
-	chr19	42626317	42626317	G	T	exonic	POU2F2	synonymous	UCEC\|1\|248\|0.00403
-	chr19	42598041	42598041	G	A	exonic	POU2F2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr19	42600336	42600336	G	A	exonic	POU2F2	synonymous	BLCA\|1\|396\|0.00253
-	chr19	42600252	42600252	G	C	exonic	POU2F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	42599776	42599776	C	A	exonic	POU2F2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr19	42600378	42600378	C	T	exonic	POU2F2	synonymous	UCEC\|1\|248\|0.00403
rs757595289	chr19	42596240	42596240	C	A	exonic	POU2F2	nonsynonymous	LUAD\|1\|543\|0.00184
rs535353969	chr19	42599576	42599576	G	A	exonic	POU2F2	synonymous	BRCA\|1\|982\|0.00102
-	chr19	42621408	42621408	T	A	exonic	POU2F2	synonymous	SKCM\|1\|368\|0.00272
-	chr19	42621469	42621469	G	A	exonic	POU2F2	nonsynonymous	SKCM\|1\|368\|0.00272

Disease information of POU2F2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with POU2F2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002393	Validated transcriptional targets of deltaNp63 isoforms	pid	47	101

Go term information of POU2F2

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GO_term_name	GO_term_type	TF_name
GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS	BP	POU2F2
GO_CELL_ACTIVATION	BP	POU2F2
GO_LEUKOCYTE_MEDIATED_IMMUNITY	BP	POU2F2
GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION	BP	POU2F2
GO_B_CELL_DIFFERENTIATION	BP	POU2F2
GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	POU2F2
GO_NCRNA_TRANSCRIPTION	BP	POU2F2
GO_HUMORAL_IMMUNE_RESPONSE	BP	POU2F2
GO_IMMUNOGLOBULIN_PRODUCTION	BP	POU2F2
GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE	BP	POU2F2
GO_MATURE_B_CELL_DIFFERENTIATION	BP	POU2F2
GO_SNRNA_METABOLIC_PROCESS	BP	POU2F2
GO_SEQUENCE_SPECIFIC_DNA_BINDING	MF	POU2F2

Survival analysis of POU2F2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of POU2F2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)