Cancer CRCdb

TF information

TF name:	OSR2
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000164920
Ensembl protein ID:	ENSP00000429910, ENSP00000430041, ENSP00000430780, ENSP00000402862, ENSP00000430074, ENSP00000414657, ENSP00000297565
Entrez gene ID:	116039

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of OSR2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.70503597122302

OSR2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

OSR2 distribution in all CRCs

Genomic distribution of SEs associated with OSR2

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Mutation of OSR2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of OSR2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr8	99961205	99961205	C	T	exonic	OSR2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr8	99961348	99961348	G	-	exonic	OSR2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961429	99961429	C	T	exonic	OSR2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	99963767	99963767	C	T	exonic	OSR2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	99963816	99963816	C	A	exonic	OSR2	nonsynonymous	UCEC\|1\|248\|0.00403
rs768292533	chr8	99961777	99961777	G	A	exonic	OSR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961222	99961222	G	A	exonic	OSR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs372847306	chr8	99961493	99961493	G	A	exonic	OSR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	99963753	99963753	C	G	exonic	OSR2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr8	99961562	99961562	G	C	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	99961551	99961551	C	A	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961319	99961319	C	G	exonic	OSR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr8	99961358	99961358	A	G	exonic	OSR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961724	99961724	A	G	exonic	OSR2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr8	99962935	99962935	A	T	exonic	OSR2	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	99963880	99963880	G	-	exonic	OSR2	frameshift	BRCA\|1\|982\|0.00102
-	chr8	99961704	99961704	A	C	exonic	OSR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368868923	chr8	99961621	99961621	C	A	exonic	OSR2	synonymous	PAAD\|1\|185\|0.00541
-	chr8	99963021	99963021	C	T	intronic	OSR2	unknown	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
-	chr8	99963751	99963751	C	T	exonic	OSR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr8	99961588	99961588	G	C	exonic	OSR2	synonymous	LUAD\|1\|543\|0.00184
-	chr8	99961684	99961684	G	A	exonic	OSR2	synonymous	SKCM\|2\|368\|0.00543
-	chr8	99961644	99961644	C	A	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
rs778807175	chr8	99961711	99961711	C	T	exonic	OSR2	synonymous	UCEC\|1\|248\|0.00403
-	chr8	99961829	99961829	G	C	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961203	99961203	C	T	exonic	OSR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961349	99961349	G	T	exonic	OSR2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr8	99961627	99961627	C	A	exonic	OSR2	synonymous	BLCA\|1\|396\|0.00253
-	chr8	99961177	99961177	G	C	exonic	OSR2	synonymous	ESCA\|1\|185\|0.00541
-	chr8	99962918	99962918	C	A	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961564	99961564	G	C	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	99961249	99961249	C	T	exonic	OSR2	synonymous	SKCM\|1\|368\|0.00272
-	chr8	99963899	99963899	C	A	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961736	99961736	A	G	exonic	OSR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	99961327	99961327	G	A	exonic	OSR2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	99961401	99961401	-	G	exonic	OSR2	frameshift	BLCA\|1\|396\|0.00253,PAAD\|1\|185\|0.00541
-	chr8	99961562	99961562	G	T	exonic	OSR2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961674	99961674	C	A	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	99961792	99961792	C	G	exonic	OSR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961741	99961741	G	A	exonic	OSR2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	99961384	99961384	C	A	exonic	OSR2	synonymous	LUAD\|1\|543\|0.00184
-	chr8	99961232	99961232	C	A	exonic	OSR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	99961477	99961477	G	T	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	99961116	99961116	G	A	exonic	OSR2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr8	99962900	99962900	G	T	exonic	OSR2	stopgain	ESCA\|1\|185\|0.00541
-	chr8	99963857	99963857	C	A	exonic	OSR2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961691	99961691	G	C	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
rs567369139	chr8	99961558	99961558	G	T	exonic	OSR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
-	chr8	99963924	99963924	T	G	exonic	OSR2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr8	99961333	99961333	G	T	exonic	OSR2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	99962928	99962928	G	A	exonic	OSR2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	99962942	99962942	C	A	exonic	OSR2	nonsynonymous	CESC\|1\|194\|0.00515
rs763852070	chr8	99961213	99961213	G	T	exonic	OSR2	synonymous	ESCA\|1\|185\|0.00541
-	chr8	99961516	99961516	C	G	exonic	OSR2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr8	99963890	99963890	G	C	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961618	99961618	C	T	exonic	OSR2	synonymous	LUAD\|1\|543\|0.00184
-	chr8	99963845	99963845	C	T	exonic	OSR2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr8	99961141	99961141	G	T	exonic	OSR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	99962969	99962969	A	C	exonic	OSR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961765	99961765	G	A	exonic	OSR2	synonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	99961747	99961747	C	A	exonic	OSR2	synonymous	LUSC\|1\|178\|0.00562
-	chr8	99962883	99962883	G	A	splicing	OSR2	splicing	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	99961351	99961351	G	A	exonic	OSR2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr8	99963037	99963037	C	T	intronic	OSR2	unknown	SKCM\|1\|368\|0.00272
-	chr8	99961435	99961435	C	G	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961360	99961360	T	C	exonic	OSR2	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr8	99963089	99963089	G	C	intronic	OSR2	unknown	ESCA\|1\|185\|0.00541
-	chr8	99962949	99962949	G	T	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr8	99961313	99961313	G	A	exonic	OSR2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr8	99961377	99961377	G	C	exonic	OSR2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr8	99961494	99961494	T	A	exonic	OSR2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr8	99961433	99961433	T	G	exonic	OSR2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	99961221	99961221	C	A	exonic	OSR2	nonsynonymous	LUAD\|1\|543\|0.00184
rs769169543	chr8	99961683	99961683	C	T	exonic	OSR2	nonsynonymous	ACC\|1\|90\|0.01111
-	chr8	99961579	99961579	G	C	exonic	OSR2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr8	99963889	99963889	G	A	exonic	OSR2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs765881456	chr8	99961420	99961420	C	T	exonic	OSR2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr8	99961236	99961236	C	T	exonic	OSR2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr8	99962908	99962908	C	T	exonic	OSR2	synonymous	LUAD\|1\|543\|0.00184

Disease information of OSR2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
OSR2	Endometriosis	C13	Disease or Syndrome	CTD_human
OSR2	Endometrioma	C13	Neoplastic Process	CTD_human

Pathway associated with OSR2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000205	Arf1 pathway	pid	28	106
pathway0000366	Cargo concentration in the ER	reactome	33	341
pathway0000491	COPII (Coat Protein 2) Mediated Vesicle Transport	reactome	68	1414
pathway0001193	Intra-Golgi traffic	reactome	44	369
pathway0002456	XBP1(S) activates chaperone genes	reactome	53	101
pathway0002577	SNARE interactions in vesicular transport	kegg	36	220

Go term information of OSR2

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GO_term_name	GO_term_type	TF_name
GO_SINGLE_ORGANISM_MEMBRANE_FUSION	BP	OSR2
GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE	BP	OSR2
GO_METANEPHROS_DEVELOPMENT	BP	OSR2
GO_EMBRYONIC_DIGIT_MORPHOGENESIS	BP	OSR2
GO_HINDLIMB_MORPHOGENESIS	BP	OSR2
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	OSR2
GO_VESICLE_TARGETING	BP	OSR2
GO_FORELIMB_MORPHOGENESIS	BP	OSR2
GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE	BP	OSR2
GO_SINGLE_ORGANISM_MEMBRANE_BUDDING	BP	OSR2
GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN	BP	OSR2
GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT	BP	OSR2
GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT	BP	OSR2
GO_PALATE_DEVELOPMENT	BP	OSR2
GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	OSR2
GO_EMBRYONIC_FORELIMB_MORPHOGENESIS	BP	OSR2
GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	OSR2
GO_PROTEIN_LOCALIZATION_TO_VACUOLE	BP	OSR2
GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	OSR2
GO_MIDDLE_EAR_MORPHOGENESIS	BP	OSR2
GO_APPENDAGE_DEVELOPMENT	BP	OSR2
GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS	BP	OSR2
GO_VESICLE_COATING	BP	OSR2
GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT	BP	OSR2
GO_REGULATION_OF_GASTRULATION	BP	OSR2
GO_GOLGI_TO_VACUOLE_TRANSPORT	BP	OSR2
GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE	BP	OSR2
GO_EYE_DEVELOPMENT	BP	OSR2
GO_BONE_MORPHOGENESIS	BP	OSR2
GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT	BP	OSR2
GO_LOCALIZATION_WITHIN_MEMBRANE	BP	OSR2
GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT	BP	OSR2
GO_MESONEPHROS_DEVELOPMENT	BP	OSR2
GO_REGULATION_OF_OSSIFICATION	BP	OSR2
GO_ER_TO_GOLGI_TRANSPORT_VESICLE	CC	OSR2
GO_LATE_ENDOSOME_MEMBRANE	CC	OSR2
GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE	CC	OSR2
GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK	CC	OSR2
GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT	CC	OSR2
GO_SNAP_RECEPTOR_ACTIVITY	MF	OSR2

Survival analysis of OSR2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of OSR2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)