TF information

TF name: NR6A1
TF family: GCNF-like
Ensembl gene ID: ENSG00000148200
Ensembl protein ID: ENSP00000420587, ENSP00000341135, ENSP00000362686, ENSP00000413701, ENSP00000420267
Entrez gene ID: 2649
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of NR6A1 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_268Cell lineKidneyA-4980.040059073287798
Sample_02_310Cell lineNeuroblastomaSJNB80.10615989515072

NR6A1 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name

NR6A1 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with NR6A1
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Mutation of NR6A1
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR6A1

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr9127300495127300495CGexonicNR6A1nonsynonymous LUAD|1|543|0.00184
-chr9127316621127316621CTexonicNR6A1nonsynonymous SKCM|1|368|0.00272
rs767988049chr9127287138127287138TGexonicNR6A1nonsynonymous HNSC|1|512|0.00195
-chr9127298239127298239GTexonicNR6A1nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr9127302395127302395GAexonicNR6A1synonymous SKCM|1|368|0.00272
-chr9127300526127300526GAexonicNR6A1synonymous SKCM|2|368|0.00543
-chr9127289083127289083CTexonicNR6A1nonsynonymous BLCA|1|396|0.00253
-chr9127302411127302411GAexonicNR6A1nonsynonymous ESCA|1|185|0.00541
-chr9127289093127289093TCexonicNR6A1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,SKCM|1|368|0.00272
-chr9127316690127316690TAexonicNR6A1nonsynonymous SARC|1|247|0.00405
-chr9127316735127316735CTexonicNR6A1nonsynonymous PRAD|1|499|0.00200
-chr9127316757127316757CAexonicNR6A1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr9127289121127289121GAexonicNR6A1nonsynonymous SKCM|1|368|0.00272
-chr9127289154127289154TCexonicNR6A1nonsynonymous UCEC|1|248|0.00403
-chr9127289130127289130GTexonicNR6A1nonsynonymous ESCA|1|185|0.00541
-chr9127316820127316820GAexonicNR6A1stopgain PAAD|1|185|0.00541
-chr9127316717127316717CAexonicNR6A1nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr9127300525127300525GAexonicNR6A1stopgain LUAD|3|543|0.00552
-chr9127316748127316748CAexonicNR6A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9127495614127495614CTexonicNR6A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9127298251127298251GAexonicNR6A1synonymous SKCM|1|368|0.00272
-chr9127495601127495601AGexonicNR6A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9127285049127285049CAexonicNR6A1stopgain BRCA|3|982|0.00305
-chr9127316774127316774CAexonicNR6A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9127289143127289143GAexonicNR6A1synonymous HNSC|1|512|0.00195
-chr9127300382127300382CGexonicNR6A1nonsynonymous CESC|1|194|0.00515
-chr9127302467127302467CAsplicingNR6A1splicing UCEC|1|248|0.00403,UCS|1|57|0.01754
rs530534854chr9127298174127298174GAexonicNR6A1synonymous SKCM|1|368|0.00272
-chr9127289100127289100CAexonicNR6A1stopgain BLCA|1|396|0.00253
-chr9127289057127289057CTsplicingNR6A1splicing KIPAN|2|799|0.00250,KIRC|2|451|0.00443
-chr9127285047127285047CTexonicNR6A1synonymous BLCA|1|396|0.00253
-chr9127316734127316734C-exonicNR6A1frameshift HNSC|1|512|0.00195
rs780379141chr9127300415127300415GAexonicNR6A1synonymous UCS|1|57|0.01754
-chr9127298227127298227TCexonicNR6A1nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr9127298312127298312GTexonicNR6A1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs771035345chr9127316795127316795CTexonicNR6A1nonsynonymous BRCA|1|982|0.00102
rs538806855chr9127302449127302449GAexonicNR6A1synonymous COADREAD|1|489|0.00204,READ|1|122|0.00820,UCEC|2|248|0.00806
-chr9127298359127298359CTexonicNR6A1nonsynonymous SKCM|1|368|0.00272
-chr9127287012127287012GAexonicNR6A1stopgain CESC|1|194|0.00515
-chr9127306128127306128CAexonicNR6A1stopgain PAAD|1|185|0.00541,UCEC|1|248|0.00403
rs776287206chr9127302372127302372GCexonicNR6A1nonsynonymous LUAD|1|543|0.00184
-chr9127298175127298175GAexonicNR6A1nonsynonymous SKCM|1|368|0.00272
-chr9127298262127298262T-exonicNR6A1frameshift KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr9127316631127316631GAexonicNR6A1nonsynonymous SKCM|1|368|0.00272
-chr9127316808127316808TAexonicNR6A1nonsynonymous OV|1|469|0.00213
-chr9127302413127302413CTexonicNR6A1synonymous SKCM|2|368|0.00543
rs760817530chr9127302448127302448CTexonicNR6A1nonsynonymous BRCA|1|982|0.00102,UCEC|1|248|0.00403
-chr9127300562127300562CTexonicNR6A1synonymous SKCM|1|368|0.00272
-chr9127287104127287104CTexonicNR6A1nonsynonymous UCEC|1|248|0.00403
-chr9127316626127316626CGexonicNR6A1nonsynonymous BRCA|1|982|0.00102
-chr9127316765127316765GAexonicNR6A1nonsynonymous SKCM|1|368|0.00272
-chr9127298392127298392CAexonicNR6A1stopgain OV|1|469|0.00213
-chr9127316675127316675CTexonicNR6A1nonsynonymous BRCA|1|982|0.00102
-chr9127284984127284984TCexonicNR6A1stoploss LIHC|1|373|0.00268
-chr9127298343127298343TCexonicNR6A1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr9127289153127289153AGexonicNR6A1nonsynonymous PRAD|1|499|0.00200
-chr9127298387127298387TCexonicNR6A1synonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs202064939chr9127289152127289152GAexonicNR6A1synonymous STAD|1|395|0.00253,STES|1|395|0.00253,UCEC|1|248|0.00403

Disease information of NR6A1
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source

Pathway associated with NR6A1
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0001534 Nuclear Receptor transcription pathway reactome 51 284
pathway0001701 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation reactome 13 36

Go term information of NR6A1
GO_term_name GO_term_type TF_name
GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY BP NR6A1
GO_HORMONE_MEDIATED_SIGNALING_PATHWAY BP NR6A1
GO_TRANSCRIPTION_FACTOR_COMPLEX CC NR6A1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING MF NR6A1
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF NR6A1
GO_STEROID_HORMONE_RECEPTOR_ACTIVITY MF NR6A1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF NR6A1

Survival analysis of NR6A1



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of NR6A1