Cancer CRCdb

TF information

TF name:	NKX2-2
TF family:	Homeobox
Ensembl gene ID:	ENSG00000125820
Ensembl protein ID:	ENSP00000366347
Entrez gene ID:	4821

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NKX2-2 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.13698630136986

NKX2-2 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name

NKX2-2 distribution in all CRCs

Genomic distribution of SEs associated with NKX2-2

Download

Mutation of NKX2-2

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NKX2-2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr20	21492616	21492616	G	T	exonic	NKX2-2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	21492642	21492642	G	T	exonic	NKX2-2	stopgain	BLCA\|1\|396\|0.00253
-	chr20	21492891	21492891	G	C	exonic	NKX2-2	synonymous	BRCA\|1\|982\|0.00102
-	chr20	21492565	21492565	C	G	exonic	NKX2-2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	21494232	21494232	C	T	exonic	NKX2-2	nonsynonymous	CESC\|1\|194\|0.00515
rs753385322	chr20	21494276	21494276	G	A	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr20	21493117	21493117	C	-	exonic	NKX2-2	frameshift	LUAD\|1\|543\|0.00184
-	chr20	21492260	21492260	C	T	UTR3	NKX2-2	unknown	SARC\|1\|247\|0.00405
-	chr20	21492919	21492919	G	A	exonic	NKX2-2	nonsynonymous	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492922	21492922	G	T	exonic	NKX2-2	stopgain	BLCA\|1\|396\|0.00253
-	chr20	21494122	21494122	C	T	exonic	NKX2-2	synonymous	LUSC\|1\|178\|0.00562
-	chr20	21494205	21494205	C	G	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	21492910	21492910	C	T	exonic	NKX2-2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr20	21494286	21494286	T	C	exonic	NKX2-2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
-	chr20	21492823	21492823	C	T	exonic	NKX2-2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr20	21494266	21494266	G	A	exonic	NKX2-2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	21494259	21494259	C	G	exonic	NKX2-2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr20	21492786	21492786	C	T	exonic	NKX2-2	synonymous	PAAD\|1\|185\|0.00541
-	chr20	21494272	21494272	G	A	exonic	NKX2-2	synonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492752	21492752	C	A	exonic	NKX2-2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr20	21492807	21492807	C	T	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	21493052	21493065	ACTCGTCGGCCGAG	-	exonic	NKX2-2	frameshift	LIHC\|1\|373\|0.00268
-	chr20	21493013	21493013	C	-	exonic	NKX2-2	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr20	21492988	21492988	C	G	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253,HNSC\|1\|512\|0.00195
-	chr20	21492156	21492156	G	A	UTR3	NKX2-2	unknown	SARC\|1\|247\|0.00405
-	chr20	21493005	21493005	G	-	exonic	NKX2-2	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr20	21493043	21493043	T	C	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	21492893	21492893	G	A	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	21492997	21492997	C	T	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	21494152	21494152	G	A	exonic	NKX2-2	synonymous	PAAD\|1\|185\|0.00541
-	chr20	21494055	21494055	A	C	exonic	NKX2-2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	21492991	21492991	C	A	exonic	NKX2-2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	21492953	21492953	C	T	exonic	NKX2-2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr20	21494155	21494155	G	T	exonic	NKX2-2	synonymous	BLCA\|1\|396\|0.00253
rs754196742	chr20	21492756	21492756	G	C	exonic	NKX2-2	synonymous	CESC\|1\|194\|0.00515
-	chr20	21494126	21494126	A	G	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
rs113222063	chr20	21492732	21492732	C	T	exonic	NKX2-2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	21493000	21493000	T	G	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	21492693	21492693	C	T	exonic	NKX2-2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21494277	21494277	A	C	exonic	NKX2-2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr20	21494282	21494282	C	A	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	21492887	21492887	G	A	exonic	NKX2-2	nonsynonymous	CESC\|1\|194\|0.00515,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs553704906	chr20	21492085	21492085	T	A	UTR3	NKX2-2	unknown	ESCA\|1\|185\|0.00541
-	chr20	21494135	21494135	C	T	exonic	NKX2-2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492668	21492668	C	T	exonic	NKX2-2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs145819196	chr20	21492653	21492653	G	A	exonic	NKX2-2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	21494104	21494104	G	T	exonic	NKX2-2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	21492811	21492811	C	A	exonic	NKX2-2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr20	21492579	21492579	G	A	exonic	NKX2-2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	21494067	21494067	C	T	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	21492909	21492909	G	A	exonic	NKX2-2	synonymous	ESCA\|1\|185\|0.00541
-	chr20	21492667	21492667	G	T	exonic	NKX2-2	nonsynonymous	LUSC\|1\|178\|0.00562
rs759316509	chr20	21492725	21492725	C	T	exonic	NKX2-2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	21492814	21492814	T	G	exonic	NKX2-2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr20	21492611	21492611	G	-	exonic	NKX2-2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492824	21492824	G	A	exonic	NKX2-2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	21494163	21494163	C	A	exonic	NKX2-2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	21492978	21492978	G	A	exonic	NKX2-2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	21492969	21492969	C	T	exonic	NKX2-2	synonymous	BRCA\|1\|982\|0.00102,LUAD\|1\|543\|0.00184
-	chr20	21492834	21492834	C	T	exonic	NKX2-2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	21492966	21492966	C	G	exonic	NKX2-2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs372356384	chr20	21494212	21494212	C	T	exonic	NKX2-2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492707	21492707	C	T	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	21492879	21492879	C	T	exonic	NKX2-2	synonymous	PAAD\|1\|185\|0.00541
rs761265871	chr20	21492827	21492827	C	A	exonic	NKX2-2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	21492759	21492759	C	-	exonic	NKX2-2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	21492750	21492750	G	A	exonic	NKX2-2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	21492602	21492602	T	G	exonic	NKX2-2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	21492948	21492948	C	T	exonic	NKX2-2	synonymous	SKCM\|1\|368\|0.00272
-	chr20	21494192	21494192	G	T	exonic	NKX2-2	nonsynonymous	LIHC\|1\|373\|0.00268
rs752776917	chr20	21493012	21493012	-	C	exonic	NKX2-2	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,SKCM\|1\|368\|0.00272
-	chr20	21492699	21492699	G	T	exonic	NKX2-2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr20	21494134	21494134	G	T	exonic	NKX2-2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	21492938	21492938	G	A	exonic	NKX2-2	stopgain	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21493040	21493040	C	T	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	21494245	21494245	G	C	exonic	NKX2-2	synonymous	LUAD\|1\|543\|0.00184
-	chr20	21494243	21494243	T	A	exonic	NKX2-2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr20	21492742	21492742	G	T	exonic	NKX2-2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	21492959	21492959	C	T	exonic	NKX2-2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr20	21493107	21493107	G	A	exonic	NKX2-2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492970	21492970	G	A	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr20	21492584	21492584	G	A	exonic	NKX2-2	stopgain	SKCM\|1\|368\|0.00272
-	chr20	21493048	21493048	G	A	exonic	NKX2-2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr20	21492202	21492202	G	T	UTR3	NKX2-2	unknown	ESCA\|2\|185\|0.01081
rs143227190	chr20	21494072	21494072	C	T	exonic	NKX2-2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr20	21492936	21492936	C	A	exonic	NKX2-2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr20	21494290	21494290	T	C	exonic	NKX2-2	synonymous	BLCA\|1\|396\|0.00253
-	chr20	21494091	21494091	A	G	exonic	NKX2-2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr20	21492735	21492735	G	A	exonic	NKX2-2	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr20	21493106	21493106	C	A	exonic	NKX2-2	nonsynonymous	LUSC\|1\|178\|0.00562
rs115780948	chr20	21494213	21494213	G	A	exonic	NKX2-2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr20	21492574	21492574	T	-	exonic	NKX2-2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr20	21492858	21492858	C	G	exonic	NKX2-2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222

Disease information of NKX2-2

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with NKX2-2

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001834	Regulation of gene expression in beta cells	reactome	17	54
pathway0001836	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	reactome	5	5
pathway0002631	Maturity onset diabetes of the young	kegg	25	76
pathway0002746	Hs_Dopaminergic_Neurogenesis_WP2855_87239	wikipathways	19	37

Go term information of NKX2-2

Download

GO_term_name	GO_term_type	TF_name
GO_SPINAL_CORD_DEVELOPMENT	BP	NKX2-2
GO_EPITHELIAL_CELL_DEVELOPMENT	BP	NKX2-2
GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION	BP	NKX2-2
GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT	BP	NKX2-2
GO_GLIAL_CELL_DEVELOPMENT	BP	NKX2-2
GO_CRANIAL_NERVE_DEVELOPMENT	BP	NKX2-2
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	NKX2-2
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION	BP	NKX2-2
GO_PANCREAS_DEVELOPMENT	BP	NKX2-2
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT	BP	NKX2-2
GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT	BP	NKX2-2
GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION	BP	NKX2-2
GO_REGULATION_OF_NEURON_DIFFERENTIATION	BP	NKX2-2
GO_RESPONSE_TO_KETONE	BP	NKX2-2
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	NKX2-2
GO_OPTIC_NERVE_DEVELOPMENT	BP	NKX2-2
GO_NEURON_FATE_SPECIFICATION	BP	NKX2-2
GO_SPINAL_CORD_PATTERNING	BP	NKX2-2
GO_ASTROCYTE_DIFFERENTIATION	BP	NKX2-2
GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION	BP	NKX2-2
GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION	BP	NKX2-2
GO_RESPONSE_TO_CARBOHYDRATE	BP	NKX2-2
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT	BP	NKX2-2
GO_RESPONSE_TO_PROGESTERONE	BP	NKX2-2
GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION	BP	NKX2-2
GO_CELL_FATE_DETERMINATION	BP	NKX2-2
GO_SMOOTHENED_SIGNALING_PATHWAY	BP	NKX2-2
GO_GLIAL_CELL_FATE_COMMITMENT	BP	NKX2-2
GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION	BP	NKX2-2
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	NKX2-2
GO_OLIGODENDROCYTE_DEVELOPMENT	BP	NKX2-2
GO_NEURON_DIFFERENTIATION	BP	NKX2-2
GO_NEURON_FATE_COMMITMENT	BP	NKX2-2
GO_CELL_FATE_SPECIFICATION	BP	NKX2-2
GO_OLIGODENDROCYTE_DIFFERENTIATION	BP	NKX2-2
GO_EPITHELIAL_CELL_FATE_COMMITMENT	BP	NKX2-2
GO_POSITIVE_REGULATION_OF_GLIOGENESIS	BP	NKX2-2
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION	BP	NKX2-2

Survival analysis of NKX2-2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NKX2-2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)