Cancer CRCdb

TF information

TF name:	NFKB2
TF family:	RHD
Ensembl gene ID:	ENSG00000077150
Ensembl protein ID:	ENSP00000410256, ENSP00000471586, ENSP00000358983, ENSP00000189444
Entrez gene ID:	4791

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NFKB2 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_237	Cell line	Colon	V389	7.362414872078E-5

NFKB2 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name

NFKB2 distribution in all CRCs

Genomic distribution of SEs associated with NFKB2

Download

Mutation of NFKB2

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFKB2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr10	104160161	104160161	G	T	exonic	NFKB2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	104159847	104159847	C	A	exonic	NFKB2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104159900	104159900	C	T	exonic	NFKB2	synonymous	SKCM\|2\|368\|0.00543
-	chr10	104161814	104161814	G	A	exonic	NFKB2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	104161523	104161523	A	G	exonic	NFKB2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	104160128	104160128	G	A	exonic	NFKB2	nonsynonymous	SKCM\|1\|368\|0.00272
rs757088566	chr10	104160067	104160067	G	A	exonic	NFKB2	synonymous	UCEC\|1\|248\|0.00403
-	chr10	104157287	104157287	C	T	exonic	NFKB2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr10	104160764	104160764	G	A	exonic	NFKB2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr10	104157099	104157099	A	G	exonic	NFKB2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104160129	104160129	G	A	exonic	NFKB2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	104157402	104157402	-	C	exonic	NFKB2	frameshift	LIHC\|1\|373\|0.00268
-	chr10	104157082	104157082	A	G	exonic	NFKB2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	104158032	104158032	C	T	exonic	NFKB2	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr10	104160936	104160936	G	T	splicing	NFKB2	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	104160423	104160423	G	T	exonic	NFKB2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs45580031	chr10	104158555	104158555	G	A	exonic	NFKB2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr10	104157131	104157131	G	T	exonic	NFKB2	nonsynonymous	CHOL\|1\|35\|0.02857
rs200006038	chr10	104161010	104161010	G	A	exonic	NFKB2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104161068	104161068	G	A	exonic	NFKB2	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|2\|543\|0.00368
-	chr10	104160960	104160960	G	A	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	104158163	104158163	C	-	exonic	NFKB2	frameshift	BRCA\|1\|982\|0.00102,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr10	104160250	104160250	T	G	splicing	NFKB2	splicing	BRCA\|1\|982\|0.00102
rs4919633	chr10	104159196	104159196	A	G	exonic	NFKB2	synonymous	ACC\|21\|90\|0.23333
-	chr10	104157399	104157399	C	T	exonic	NFKB2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	104156720	104156720	A	G	exonic	NFKB2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104161522	104161522	G	C	exonic	NFKB2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr10	104157819	104157819	T	A	exonic	NFKB2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr10	104156228	104156228	C	T	exonic	NFKB2	synonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr10	104159907	104159907	G	A	exonic	NFKB2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	104158035	104158035	C	T	exonic	NFKB2	nonsynonymous	HNSC\|1\|512\|0.00195
rs774146275	chr10	104157318	104157318	A	G	exonic	NFKB2	synonymous	BLCA\|1\|396\|0.00253
-	chr10	104159337	104159337	G	A	exonic	NFKB2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr10	104157155	104157155	G	T	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
rs576597585	chr10	104159416	104159416	G	T	exonic	NFKB2	synonymous	ACC\|1\|90\|0.01111
-	chr10	104156498	104156498	G	A	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	104156679	104156679	C	T	exonic	NFKB2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr10	104161253	104161253	C	A	exonic	NFKB2	synonymous	HNSC\|1\|512\|0.00195
-	chr10	104156785	104156785	C	T	exonic	NFKB2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	104157352	104157352	C	T	exonic	NFKB2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr10	104161543	104161543	G	C	exonic	NFKB2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr10	104160083	104160083	T	C	exonic	NFKB2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	104160088	104160088	G	T	exonic	NFKB2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104157429	104157429	C	T	exonic	NFKB2	synonymous	LUAD\|1\|543\|0.00184
rs758282915	chr10	104160987	104160987	C	-	exonic	NFKB2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104157359	104157359	G	A	exonic	NFKB2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104159414	104159414	G	-	exonic	NFKB2	frameshift	SKCM\|1\|368\|0.00272
-	chr10	104159110	104159110	A	G	exonic	NFKB2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr10	104160229	104160229	G	A	exonic	NFKB2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	104160207	104160207	C	T	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
rs762145275	chr10	104156690	104156690	C	T	exonic	NFKB2	synonymous	BRCA\|1\|982\|0.00102,PAAD\|1\|185\|0.00541
rs574309302	chr10	104160708	104160708	G	A	exonic	NFKB2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr10	104159451	104159451	C	T	exonic	NFKB2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr10	104157414	104157414	A	G	exonic	NFKB2	synonymous	BLCA\|1\|396\|0.00253
-	chr10	104156717	104156717	C	T	exonic	NFKB2	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr10	104161038	104161038	C	T	exonic	NFKB2	stopgain	ESCA\|1\|185\|0.00541
-	chr10	104162098	104162098	C	T	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
rs764692852	chr10	104160052	104160052	G	A	exonic	NFKB2	synonymous	UCEC\|1\|248\|0.00403
-	chr10	104161207	104161207	T	-	exonic	NFKB2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104156056	104156056	C	A	exonic	NFKB2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	104160748	104160748	C	T	exonic	NFKB2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	104157797	104157797	C	T	exonic	NFKB2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	104158521	104158521	G	T	exonic	NFKB2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr10	104156724	104156724	C	T	exonic	NFKB2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	104161252	104161252	C	T	exonic	NFKB2	nonsynonymous	LUSC\|1\|178\|0.00562
rs377480135	chr10	104157101	104157101	G	C	exonic	NFKB2	nonsynonymous	BLCA\|1\|396\|0.00253
rs767315544	chr10	104160223	104160223	G	T	exonic	NFKB2	nonsynonymous	ACC\|1\|90\|0.01111,KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	104156492	104156492	G	A	exonic	NFKB2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs367889547	chr10	104161558	104161558	G	A	exonic	NFKB2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	104157342	104157342	G	C	exonic	NFKB2	synonymous	BLCA\|1\|396\|0.00253
-	chr10	104159894	104159894	T	C	exonic	NFKB2	synonymous	UCEC\|1\|248\|0.00403
-	chr10	104154243	104154243	C	T	UTR5	NFKB2	unknown	CESC\|1\|194\|0.00515
-	chr10	104158597	104158597	G	A	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	104159438	104159438	C	T	exonic	NFKB2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr10	104157744	104157744	C	T	exonic	NFKB2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	104157319	104157319	G	T	exonic	NFKB2	stopgain	CHOL\|1\|35\|0.02857,UCEC\|1\|248\|0.00403
-	chr10	104157126	104157126	C	T	exonic	NFKB2	stopgain	HNSC\|1\|512\|0.00195
-	chr10	104158221	104158221	G	A	exonic	NFKB2	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr10	104158208	104158208	C	A	exonic	NFKB2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	104161211	104161211	G	T	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	104157408	104157408	G	A	exonic	NFKB2	synonymous	LUAD\|1\|543\|0.00184
-	chr10	104156244	104156244	C	T	exonic	NFKB2	stopgain	LUAD\|1\|543\|0.00184
-	chr10	104160788	104160788	C	T	exonic	NFKB2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr10	104156557	104156557	C	G	exonic	NFKB2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	104160055	104160055	G	C	exonic	NFKB2	synonymous	BLCA\|1\|396\|0.00253
-	chr10	104161508	104161508	G	C	exonic	NFKB2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	104157369	104157369	C	T	exonic	NFKB2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	104160556	104160556	G	A	exonic	NFKB2	nonsynonymous	LIHC\|1\|373\|0.00268
rs200373995	chr10	104160707	104160707	C	T	exonic	NFKB2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	104156527	104156527	G	A	exonic	NFKB2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr10	104157747	104157747	G	A	exonic	NFKB2	nonsynonymous	LUAD\|1\|543\|0.00184

Disease information of NFKB2

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NFKB2	Common Variable Immunodeficiency	C20	Disease or Syndrome	CTD_human;ORPHANET
NFKB2	Heat Stroke	C26	Injury or Poisoning	CTD_human
NFKB2	Lymphoma, T-Cell, Cutaneous	C04;C15;C20	Neoplastic Process	CTD_human
NFKB2	Granulomatous Slack Skin	C04;C15;C20	Neoplastic Process	CTD_human
NFKB2	Acquired Hypogammaglobulinemia	C20	Disease or Syndrome	CTD_human
NFKB2	Immunoglobulin Deficiency, Late-Onset	C20	Disease or Syndrome	CTD_human
NFKB2	IMMUNODEFICIENCY, COMMON VARIABLE, 10		Disease or Syndrome	UNIPROT

Pathway associated with NFKB2

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000151	Alternative NF-kappaB pathway	pid	6	17
pathway0000552	Dectin-1 mediated noncanonical NF-kB signaling	reactome	61	1526
pathway0000590	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	reactome	13	41
pathway0001089	IkBA variant leads to EDA-ID	reactome	7	23
pathway0001090	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	reactome	8	30
pathway0001182	Interleukin-1 processing	reactome	7	19
pathway0001194	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine	smpdb	37	233
pathway0001195	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine	smpdb	38	237
pathway0001497	NIK-->noncanonical NF-kB signaling	reactome	58	1471
pathway0001908	RIP-mediated NFkB activation via ZBP1	reactome	21	99
pathway0002189	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	reactome	26	173
pathway0002284	TRAF6 mediated NF-kB activation	reactome	24	140
pathway0002355	TSLP	netpath	24	159
pathway0002356	TWEAK	netpath	35	280
pathway0002801	Hs_TNF_alpha_Signaling_Pathway_WP231_89895	wikipathways	61	486

Go term information of NFKB2

Download

GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION	BP	NFKB2
GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING	BP	NFKB2
GO_RESPONSE_TO_EXTERNAL_STIMULUS	BP	NFKB2
GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY	BP	NFKB2
GO_NIK_NF_KAPPAB_SIGNALING	BP	NFKB2
GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN	BP	NFKB2
GO_SPLEEN_DEVELOPMENT	BP	NFKB2
GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION	BP	NFKB2
GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	MF	NFKB2

Survival analysis of NFKB2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NFKB2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)