Cancer CRCdb

TF information

TF name:	NEUROD1
TF family:	bHLH
Ensembl gene ID:	ENSG00000162992
Ensembl protein ID:	ENSP00000295108
Entrez gene ID:	4760

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NEUROD1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.29411764705882
Sample_02_302	Cell line	Neuroblastoma	IMR32	0.17857142857143
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.08256880733945

NEUROD1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

NEUROD1 distribution in all CRCs

Genomic distribution of SEs associated with NEUROD1

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Mutation of NEUROD1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NEUROD1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	182542564	182542564	G	A	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	182542935	182542935	G	T	exonic	NEUROD1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	182542619	182542619	G	C	exonic	NEUROD1	synonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr2	182543375	182543375	T	C	exonic	NEUROD1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	182542723	182542723	G	T	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
rs773337298	chr2	182543437	182543437	C	A	exonic	NEUROD1	nonsynonymous	DLBC\|1\|48\|0.02083,LUSC\|1\|178\|0.00562
-	chr2	182543116	182543116	G	T	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	182542954	182542954	C	T	exonic	NEUROD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543081	182543081	A	T	exonic	NEUROD1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	182543242	182543242	C	G	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	182542615	182542615	G	A	exonic	NEUROD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195
-	chr2	182542604	182542604	G	A	exonic	NEUROD1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	182543136	182543136	C	A	exonic	NEUROD1	nonsynonymous	LUAD\|2\|543\|0.00368
rs780843075	chr2	182542721	182542721	C	T	exonic	NEUROD1	synonymous	CHOL\|1\|35\|0.02857,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543335	182543335	C	T	exonic	NEUROD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs375774931	chr2	182543231	182543231	C	T	exonic	NEUROD1	synonymous	CESC\|1\|194\|0.00515,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182542923	182542923	-	G	exonic	NEUROD1	frameshift	OV\|1\|469\|0.00213
-	chr2	182542933	182542933	-	G	exonic	NEUROD1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182543214	182543214	C	T	exonic	NEUROD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	182543465	182543465	G	A	exonic	NEUROD1	synonymous	ESCA\|1\|185\|0.00541
-	chr2	182543250	182543250	C	T	exonic	NEUROD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182542971	182542971	T	-	exonic	NEUROD1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543445	182543445	G	A	exonic	NEUROD1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	182543230	182543230	C	A	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
rs774325551	chr2	182542533	182542533	G	A	exonic	NEUROD1	nonsynonymous	PRAD\|1\|499\|0.00200
rs773755753	chr2	182543494	182543494	C	T	exonic	NEUROD1	nonsynonymous	HNSC\|1\|512\|0.00195,UCEC\|1\|248\|0.00403
rs752873809	chr2	182542579	182542579	C	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
rs770828405	chr2	182542874	182542874	A	G	exonic	NEUROD1	synonymous	LUSC\|1\|178\|0.00562
-	chr2	182543515	182543515	C	G	exonic	NEUROD1	nonsynonymous	BLCA\|1\|396\|0.00253
rs769839183	chr2	182542656	182542656	-	C	exonic	NEUROD1	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	182543473	182543473	T	A	exonic	NEUROD1	stopgain	OV\|1\|469\|0.00213
-	chr2	182543460	182543460	A	C	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	182543486	182543486	G	A	exonic	NEUROD1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	182542705	182542705	T	C	exonic	NEUROD1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	182542879	182542879	A	G	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	182543516	182543516	G	A	exonic	NEUROD1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	182542972	182542972	G	-	exonic	NEUROD1	frameshift	ESCA\|1\|185\|0.00541
-	chr2	182543576	182543576	C	T	exonic	NEUROD1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543443	182543443	C	T	exonic	NEUROD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182543371	182543371	C	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
rs188971339	chr2	182543540	182543540	G	T	exonic	NEUROD1	synonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543039	182543039	C	T	exonic	NEUROD1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	182543549	182543549	C	T	exonic	NEUROD1	synonymous	HNSC\|1\|512\|0.00195
-	chr2	182542961	182542961	C	T	exonic	NEUROD1	synonymous	PRAD\|1\|499\|0.00200
-	chr2	182542525	182542525	G	A	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
rs372600079	chr2	182543084	182543084	G	A	exonic	NEUROD1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	182543276	182543276	C	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	182542763	182542763	C	T	exonic	NEUROD1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182543011	182543011	G	A	exonic	NEUROD1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	182542901	182542901	C	T	exonic	NEUROD1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182543404	182543404	C	T	exonic	NEUROD1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,SKCM\|1\|368\|0.00272
-	chr2	182542607	182542607	C	A	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	182543321	182543321	C	T	exonic	NEUROD1	synonymous	BRCA\|1\|982\|0.00102
-	chr2	182543324	182543324	C	A	exonic	NEUROD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	182543231	182543231	C	A	exonic	NEUROD1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	182543262	182543262	C	A	exonic	NEUROD1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	182543103	182543103	C	T	exonic	NEUROD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	182543374	182543374	C	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	182543523	182543523	C	T	exonic	NEUROD1	stopgain	SKCM\|1\|368\|0.00272
rs538415264	chr2	182543033	182543033	C	T	exonic	NEUROD1	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182542664	182542664	C	T	exonic	NEUROD1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182542546	182542546	C	A	exonic	NEUROD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	182543157	182543157	C	T	exonic	NEUROD1	nonsynonymous	PAAD\|1\|185\|0.00541,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	182543278	182543278	T	G	exonic	NEUROD1	nonsynonymous	HNSC\|1\|512\|0.00195
rs756392502	chr2	182543116	182543116	G	A	exonic	NEUROD1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	182543447	182543447	G	A	exonic	NEUROD1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr2	182542570	182542570	A	-	exonic	NEUROD1	frameshift	BLCA\|1\|396\|0.00253
-	chr2	182543237	182543237	C	T	exonic	NEUROD1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	182543471	182543471	C	A	exonic	NEUROD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182543472	182543472	T	C	exonic	NEUROD1	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
rs763092306	chr2	182543260	182543260	C	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
rs387906384	chr2	182542971	182542971	-	G	exonic	NEUROD1	frameshift	BRCA\|1\|982\|0.00102,KIPAN\|15\|799\|0.01877,KIRC\|15\|451\|0.03326,LUAD\|15\|543\|0.02762,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs116321775	chr2	182543459	182543459	G	A	exonic	NEUROD1	synonymous	UCS\|1\|57\|0.01754
-	chr2	182543313	182543313	G	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	182542871	182542871	G	A	exonic	NEUROD1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	182543486	182543486	G	C	exonic	NEUROD1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	182543334	182543334	C	T	exonic	NEUROD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543337	182543337	C	T	exonic	NEUROD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs759568651	chr2	182542962	182542962	G	A	exonic	NEUROD1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	182543431	182543431	G	A	exonic	NEUROD1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	182542847	182542847	G	A	exonic	NEUROD1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs375030401	chr2	182543034	182543034	G	A	exonic	NEUROD1	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr2	182543450	182543450	C	A	exonic	NEUROD1	nonsynonymous	UCEC\|1\|248\|0.00403
rs746977592	chr2	182543225	182543225	T	C	exonic	NEUROD1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	182543356	182543356	C	T	exonic	NEUROD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	182543346	182543346	G	A	exonic	NEUROD1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	182542645	182542645	C	T	exonic	NEUROD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182542991	182542991	C	T	exonic	NEUROD1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	182543323	182543323	T	G	exonic	NEUROD1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	182542874	182542885	ATGGGAGCTGTC	-	exonic	NEUROD1	nonframeshift	LIHC\|1\|373\|0.00268
-	chr2	182543157	182543157	C	A	exonic	NEUROD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	182542884	182542884	T	C	exonic	NEUROD1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	182542799	182542799	A	T	exonic	NEUROD1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	182542519	182542519	A	G	exonic	NEUROD1	stoploss	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	182543167	182543167	C	G	exonic	NEUROD1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	182543295	182543295	C	T	exonic	NEUROD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	182543416	182543416	C	G	exonic	NEUROD1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	182543042	182543042	G	A	exonic	NEUROD1	synonymous	BRCA\|1\|982\|0.00102
rs184871420	chr2	182542610	182542610	G	A	exonic	NEUROD1	synonymous	HNSC\|1\|512\|0.00195
rs147793698	chr2	182543331	182543331	G	A	exonic	NEUROD1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr2	182543168	182543168	G	A	exonic	NEUROD1	synonymous	SARC\|1\|247\|0.00405,SKCM\|1\|368\|0.00272
rs748334227	chr2	182542944	182542944	G	A	exonic	NEUROD1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	182542881	182542881	C	T	exonic	NEUROD1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	182542979	182542979	C	A	exonic	NEUROD1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	182543449	182543449	T	C	exonic	NEUROD1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	182543118	182543118	A	G	exonic	NEUROD1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	182543049	182543051	GTG	-	exonic	NEUROD1	nonframeshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	182543312	182543312	A	T	exonic	NEUROD1	synonymous	LUSC\|1\|178\|0.00562

Disease information of NEUROD1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NEUROD1	Alloxan Diabetes	C18;C19	Experimental Model of Disease	CTD_human
NEUROD1	Diabetes Mellitus, Experimental	C18;C19	Experimental Model of Disease	CTD_human
NEUROD1	Diabetes Mellitus, Non-Insulin-Dependent	C18;C19	Disease or Syndrome	CTD_human;UNIPROT
NEUROD1	nervous system disorder	C10	Disease or Syndrome	CTD_human
NEUROD1	Streptozotocin Diabetes	C18;C19	Experimental Model of Disease	CTD_human
NEUROD1	Maturity onset diabetes mellitus in young	C18;C19	Disease or Syndrome	ORPHANET
NEUROD1	INSULIN RESISTANCE, SUSCEPTIBILITY TO		Finding	UNIPROT
NEUROD1	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 6 (disorder)	C18;C19	Disease or Syndrome	CTD_human;UNIPROT
NEUROD1	DIABETES MELLITUS, TYPE 2, PROTECTION AGAINST		Finding	UNIPROT

Pathway associated with NEUROD1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001834	Regulation of gene expression in beta cells	reactome	17	54
pathway0001836	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	reactome	5	5
pathway0002631	Maturity onset diabetes of the young	kegg	25	76
pathway0002746	Hs_Dopaminergic_Neurogenesis_WP2855_87239	wikipathways	19	37

Go term information of NEUROD1

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GO_term_name	GO_term_type	TF_name
GO_DENTATE_GYRUS_DEVELOPMENT	BP	NEUROD1
GO_EPITHELIUM_DEVELOPMENT	BP	NEUROD1
GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS	BP	NEUROD1
GO_METENCEPHALON_DEVELOPMENT	BP	NEUROD1
GO_INSULIN_SECRETION	BP	NEUROD1
GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS	BP	NEUROD1
GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT	BP	NEUROD1
GO_PEPTIDE_SECRETION	BP	NEUROD1
GO_POSITIVE_REGULATION_OF_DNA_BINDING	BP	NEUROD1
GO_EAR_DEVELOPMENT	BP	NEUROD1
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS	BP	NEUROD1
GO_HIPPOCAMPUS_DEVELOPMENT	BP	NEUROD1
GO_EMBRYONIC_ORGAN_MORPHOGENESIS	BP	NEUROD1
GO_ENDOCRINE_PANCREAS_DEVELOPMENT	BP	NEUROD1
GO_RESPONSE_TO_CARBOHYDRATE	BP	NEUROD1
GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS	BP	NEUROD1
GO_CELLULAR_GLUCOSE_HOMEOSTASIS	BP	NEUROD1
GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION	BP	NEUROD1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING	BP	NEUROD1
GO_REGULATION_OF_CELL_CYCLE_ARREST	BP	NEUROD1
GO_NEGATIVE_REGULATION_OF_STAT_CASCADE	BP	NEUROD1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	NEUROD1
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	NEUROD1
GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION	BP	NEUROD1
GO_PATTERN_SPECIFICATION_PROCESS	BP	NEUROD1
GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING	BP	NEUROD1
GO_EPITHELIAL_CELL_FATE_COMMITMENT	BP	NEUROD1
GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION	BP	NEUROD1
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION	BP	NEUROD1
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX	CC	NEUROD1
GO_E_BOX_BINDING	MF	NEUROD1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	NEUROD1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	NEUROD1
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	NEUROD1
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	NEUROD1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	NEUROD1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY	MF	NEUROD1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	NEUROD1

Survival analysis of NEUROD1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NEUROD1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)