Cancer CRCdb

TF information

TF name:	MEF2A
TF family:	SRF
Ensembl gene ID:	ENSG00000068305
Ensembl protein ID:	ENSP00000452989, ENSP00000337202, ENSP00000453478, ENSP00000453095, ENSP00000453441, ENSP00000454023, ENSP00000346389
Entrez gene ID:	4205

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MEF2A in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_236	Cell line	Colon	V206	0.72049689440994
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.825

MEF2A distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_236	Colon	Cell line	V206
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h

MEF2A distribution in all CRCs

Genomic distribution of SEs associated with MEF2A

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Mutation of MEF2A

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MEF2A

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs1135561	chr15	100211575	100211575	C	T	exonic	MEF2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr15	100173355	100173355	A	G	exonic	MEF2A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	100252711	100252712	AG	-	exonic	MEF2A	frameshift	SKCM\|1\|368\|0.00272,THCA\|1\|504\|0.00198
rs753805725	chr15	100211761	100211761	C	T	exonic	MEF2A	nonsynonymous	CHOL\|2\|35\|0.05714,DLBC\|1\|48\|0.02083,LUSC\|1\|178\|0.00562,PAAD\|3\|185\|0.01622,PRAD\|1\|499\|0.00200
-	chr15	100230607	100230607	T	C	exonic	MEF2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	100211585	100211585	G	C	exonic	MEF2A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	100185846	100185846	C	T	exonic	MEF2A	synonymous	BLCA\|1\|396\|0.00253
-	chr15	100185769	100185769	A	T	exonic	MEF2A	nonsynonymous	BRCA\|1\|982\|0.00102
rs199811207	chr15	100252741	100252741	A	C	exonic	MEF2A	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr15	100250958	100250958	T	A	exonic	MEF2A	nonsynonymous	OV\|1\|469\|0.00213
-	chr15	100250869	100250869	C	T	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	100230589	100230589	C	T	exonic	MEF2A	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	100215643	100215643	G	C	exonic	MEF2A	nonsynonymous	BLCA\|1\|396\|0.00253
rs201861701	chr15	100252738	100252738	A	C	exonic	MEF2A	nonsynonymous	BRCA\|1\|982\|0.00102,COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs325380	chr15	100256618	100256618	A	C	UTR3	MEF2A	unknown	BRCA\|1\|982\|0.00102
rs200861006	chr15	100252726	100252726	A	C	exonic	MEF2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	100250918	100250918	G	A	exonic	MEF2A	synonymous	DLBC\|1\|48\|0.02083
-	chr15	100230473	100230473	C	T	exonic	MEF2A	nonsynonymous	CESC\|1\|194\|0.00515
-	chr15	100185917	100185917	A	G	exonic	MEF2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	100185786	100185786	-	T	exonic	MEF2A	frameshift	PAAD\|1\|185\|0.00541
-	chr15	100230480	100230480	T	A	exonic	MEF2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	100211575	100211575	C	A	exonic	MEF2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	100185844	100185844	C	T	exonic	MEF2A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs766481815	chr15	100211754	100211754	C	T	exonic	MEF2A	synonymous	CESC\|1\|194\|0.00515
-	chr15	100211551	100211551	T	A	exonic	MEF2A	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr15	100252908	100252908	C	-	exonic	MEF2A	frameshift	LIHC\|1\|373\|0.00268
-	chr15	100230591	100230591	A	T	exonic	MEF2A	synonymous	LUAD\|1\|543\|0.00184
-	chr15	100247006	100247006	A	G	exonic	MEF2A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	100252747	100252747	C	A	exonic	MEF2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	100252739	100252739	G	-	exonic	MEF2A	frameshift	ESCA\|1\|185\|0.00541
rs748043464	chr15	100250887	100250887	C	T	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	100230446	100230446	G	A	exonic	MEF2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	100185780	100185780	G	T	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766432411	chr15	100246988	100246988	G	A	exonic	MEF2A	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	100211631	100211631	A	T	exonic	MEF2A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	100211641	100211641	T	G	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs201205600	chr15	100211780	100211780	A	G	exonic	MEF2A	nonsynonymous	COADREAD\|1\|489\|0.00204,KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,READ\|1\|122\|0.00820
-	chr15	100230548	100230548	G	T	exonic	MEF2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	100250838	100250838	G	C	splicing	MEF2A	splicing	BRCA\|1\|982\|0.00102
-	chr15	100230590	100230590	G	A	exonic	MEF2A	nonsynonymous	PRAD\|2\|499\|0.00401
rs373219260	chr15	100230604	100230604	C	G	exonic	MEF2A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	100256626	100256626	C	G	UTR3	MEF2A	unknown	SARC\|1\|247\|0.00405
-	chr15	100185846	100185846	C	G	exonic	MEF2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	100250881	100250881	T	C	exonic	MEF2A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	100214726	100214726	A	G	exonic	MEF2A	synonymous	LIHC\|1\|373\|0.00268
-	chr15	100256544	100256544	C	T	UTR3	MEF2A	unknown	CESC\|1\|194\|0.00515
-	chr15	100214776	100214776	C	T	exonic	MEF2A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	100173378	100173378	G	T	exonic	MEF2A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	100250898	100250898	C	T	exonic	MEF2A	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	100211568	100211568	A	G	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	100214806	100214806	C	A	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	100185823	100185823	C	T	exonic	MEF2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	100211576	100211576	G	A	exonic	MEF2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	100211863	100211863	G	A	splicing	MEF2A	splicing	UCEC\|1\|248\|0.00403
-	chr15	100215617	100215617	C	T	exonic	MEF2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs779671375	chr15	100250868	100250868	G	T	exonic	MEF2A	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
-	chr15	100230539	100230539	C	T	exonic	MEF2A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	100214623	100214623	C	G	exonic	MEF2A	stopgain	BLCA\|1\|396\|0.00253
-	chr15	100252723	100252723	A	C	exonic	MEF2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	100211533	100211533	A	T	exonic	MEF2A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	100214790	100214790	C	T	exonic	MEF2A	stopgain	BLCA\|1\|396\|0.00253
-	chr15	100214645	100214645	G	T	exonic	MEF2A	synonymous	TGCT\|1\|155\|0.00645
-	chr15	100252711	100252715	AGCAG	-	exonic	MEF2A	frameshift	ACC\|1\|90\|0.01111,CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
-	chr15	100211647	100211647	C	T	exonic	MEF2A	synonymous	SKCM\|1\|368\|0.00272
rs541112324	chr15	100252748	100252748	G	A	exonic	MEF2A	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,UCEC\|1\|248\|0.00403
-	chr15	100215614	100215614	G	C	exonic	MEF2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	100230497	100230497	G	A	exonic	MEF2A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr15	100250958	100250958	T	C	exonic	MEF2A	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr15	100215612	100215612	T	C	exonic	MEF2A	synonymous	SKCM\|1\|368\|0.00272
-	chr15	100214625	100214625	A	T	exonic	MEF2A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	100214787	100214787	C	T	exonic	MEF2A	nonsynonymous	LUSC\|1\|178\|0.00562,SKCM\|3\|368\|0.00815
-	chr15	100211654	100211654	G	T	exonic	MEF2A	nonsynonymous	PAAD\|1\|185\|0.00541
rs75705863	chr15	100211846	100211846	G	A	exonic	MEF2A	nonsynonymous	TGCT\|3\|155\|0.01935

Disease information of MEF2A

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MEF2A	Psychotic Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
MEF2A	Nonorganic psychosis		Mental or Behavioral Dysfunction	PSYGENET
MEF2A	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1	C14	Disease or Syndrome	CTD_human

Pathway associated with MEF2A

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000393	CDO in myogenesis	reactome	29	200
pathway0000715	ERK/MAPK targets	reactome	17	72
pathway0002044	Signaling mediated by p38-alpha and p38-beta	pid	35	174
pathway0002782	Hs_p38_MAPK_Signaling_Pathway_WP400_72084	wikipathways	28	54

Go term information of MEF2A

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GO_term_name	GO_term_type	TF_name
GO_DENDRITE_DEVELOPMENT	BP	MEF2A
GO_MUSCLE_ORGAN_DEVELOPMENT	BP	MEF2A
GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	MEF2A
GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION	BP	MEF2A
GO_CARDIAC_MYOFIBRIL_ASSEMBLY	BP	MEF2A
GO_REGULATION_OF_HEART_CONTRACTION	BP	MEF2A
GO_NEURON_PROJECTION_DEVELOPMENT	BP	MEF2A
GO_DENDRITE_MORPHOGENESIS	BP	MEF2A
GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION	BP	MEF2A
GO_MYOFIBRIL_ASSEMBLY	BP	MEF2A
GO_HEART_DEVELOPMENT	BP	MEF2A
GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	MEF2A
GO_CELLULAR_RESPONSE_TO_CALCIUM_ION	BP	MEF2A
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	MEF2A
GO_MITOCHONDRIAL_GENOME_MAINTENANCE	BP	MEF2A
GO_MITOCHONDRION_LOCALIZATION	BP	MEF2A
GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT	BP	MEF2A
GO_MITOCHONDRION_DISTRIBUTION	BP	MEF2A
GO_CARDIAC_CONDUCTION	BP	MEF2A
GO_CARDIAC_CELL_DEVELOPMENT	BP	MEF2A
GO_HISTONE_DEACETYLASE_BINDING	MF	MEF2A
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	MEF2A
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	MEF2A
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	MEF2A
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	MEF2A
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	MEF2A
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	MEF2A
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	MEF2A
GO_HISTONE_ACETYLTRANSFERASE_BINDING	MF	MEF2A
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY	MF	MEF2A
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	MEF2A

Survival analysis of MEF2A

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MEF2A

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)