TF information
| TF name: | MAF |
| TF family: | TF_bZIP |
| Ensembl gene ID: | ENSG00000178573 |
| Ensembl protein ID: | ENSP00000327048, ENSP00000377019, ENSP00000455097 |
| Entrez gene ID: | 4094 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of MAF in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_180 | Cell line | Human melanoma | CJM | 0.0234375 |
MAF distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
MAF distribution in all CRCs
Genomic distribution of SEs associated with MAF
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of MAF
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr16 | 79632791 | 79632791 | G | A | exonic | MAF | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 79633671 | 79633671 | G | A | exonic | MAF | synonymous | LUSC|1|178|0.00562 |
| rs759815012 | chr16 | 79633486 | 79633486 | G | A | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79633642 | 79633642 | C | T | exonic | MAF | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 79632975 | 79632975 | G | T | exonic | MAF | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 79632734 | 79632734 | A | G | exonic | MAF | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr16 | 79633490 | 79633490 | C | T | exonic | MAF | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr16 | 79632785 | 79632785 | G | A | exonic | MAF | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr16 | 79633711 | 79633711 | A | T | exonic | MAF | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 79628417 | 79628417 | C | T | exonic | MAF | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr16 | 79633406 | 79633406 | C | T | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79633573 | 79633573 | G | A | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79632883 | 79632883 | C | T | exonic | MAF | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr16 | 79632803 | 79632803 | C | A | exonic | MAF | stopgain | BRCA|1|982|0.00102 |
| - | chr16 | 79632692 | 79632692 | C | T | exonic | MAF | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 79633710 | 79633710 | A | G | exonic | MAF | synonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| rs377735141 | chr16 | 79628410 | 79628410 | C | T | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79633769 | 79633769 | C | G | exonic | MAF | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr16 | 79632907 | 79632907 | T | G | exonic | MAF | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr16 | 79633742 | 79633742 | C | T | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79632802 | 79632803 | TC | - | exonic | MAF | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79633606 | 79633606 | C | T | exonic | MAF | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr16 | 79633527 | 79633527 | G | A | exonic | MAF | synonymous | LUAD|1|543|0.00184 |
| - | chr16 | 79632969 | 79632969 | C | T | exonic | MAF | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 79628399 | 79628399 | C | A | exonic | MAF | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr16 | 79633850 | 79633850 | G | T | UTR5 | MAF | unknown | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr16 | 79633679 | 79633679 | G | A | exonic | MAF | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr16 | 79632895 | 79632895 | G | A | exonic | MAF | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr16 | 79632954 | 79632954 | G | T | exonic | MAF | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr16 | 79633438 | 79633438 | C | T | exonic | MAF | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr16 | 79633675 | 79633675 | A | T | exonic | MAF | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs754156981 | chr16 | 79633485 | 79633485 | C | A | exonic | MAF | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr16 | 79633678 | 79633678 | C | T | exonic | MAF | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr16 | 79633683 | 79633683 | G | A | exonic | MAF | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 79632690 | 79632690 | C | T | exonic | MAF | synonymous | UCEC|1|248|0.00403 |
| - | chr16 | 79632824 | 79632824 | G | A | exonic | MAF | stopgain | BLCA|1|396|0.00253 |
| - | chr16 | 79632723 | 79632723 | G | C | exonic | MAF | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr16 | 79632962 | 79632962 | C | T | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79633553 | 79633553 | C | T | exonic | MAF | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 79632737 | 79632737 | C | T | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr16 | 79632973 | 79632973 | C | T | exonic | MAF | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr16 | 79632703 | 79632703 | G | A | exonic | MAF | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| MAF | Intrahepatic Cholestasis | C06 | Disease or Syndrome | CTD_human |
| MAF | Congenital ocular coloboma (disorder) | C11;C16 | Congenital Abnormality | GENOMICS_ENGLAND |
| MAF | Cataract | C11 | Acquired Abnormality | GENOMICS_ENGLAND |
| MAF | Cataract, congenital, cerulean type 1 | C11 | Congenital Abnormality | ORPHANET |
| MAF | Cataracts, Congenital, with Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, and Mental Retardation | C09;C10;C11;C23;F01;F03 | Disease or Syndrome | CTD_human;UNIPROT |
| MAF | Cataract, Pulverulent | C11;C16 | Disease or Syndrome | ORPHANET |
| MAF | CATARACT, COPPOCK-LIKE | C11 | Disease or Syndrome | ORPHANET |
| MAF | Abnormality of the cornea | Finding | GENOMICS_ENGLAND | |
| MAF | Cataract, Pulverulent, Juvenile-Onset | C11 | Congenital Abnormality | CTD_human;UNIPROT |
| MAF | Cataract microcornea syndrome | C11 | Disease or Syndrome | ORPHANET |
| MAF | Intellectual Disability | C10;C23;F01;F03 | Mental or Behavioral Dysfunction | GENOMICS_ENGLAND |
| MAF | CATARACT 21, MULTIPLE TYPES | Disease or Syndrome | UNIPROT |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000343 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 | 304 |
| pathway0000403 | Ceramide signaling pathway | pid | 49 | 409 |
| pathway0001236 | Kaposi sarcoma-associated herpesvirus | mirtarbase | 13 | 2 |
| pathway0001834 | Regulation of gene expression in beta cells | reactome | 17 | 54 |
| pathway0002246 | TNF receptor signaling pathway | pid | 46 | 428 |
| pathway0002252 | TNFR1-mediated ceramide production | reactome | 6 | 10 |
| pathway0002629 | Type II diabetes mellitus | kegg | 44 | 261 |
| pathway0002631 | Maturity onset diabetes of the young | kegg | 25 | 76 |
| pathway0002801 | Hs_TNF_alpha_Signaling_Pathway_WP231_89895 | wikipathways | 61 | 486 |
| pathway0002841 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 | 137 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_LENS_FIBER_CELL_DIFFERENTIATION | BP | MAF |
| GO_RESPIRATORY_GASEOUS_EXCHANGE | BP | MAF |
| GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION | BP | MAF |
| GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT | BP | MAF |
| GO_AMIDE_TRANSPORT | BP | MAF |
| GO_ADULT_BEHAVIOR | BP | MAF |
| GO_RESPONSE_TO_WOUNDING | BP | MAF |
| GO_PROTEIN_SECRETION | BP | MAF |
| GO_INSULIN_SECRETION | BP | MAF |
| GO_SINGLE_ORGANISM_CELL_ADHESION | BP | MAF |
| GO_SECOND_MESSENGER_MEDIATED_SIGNALING | BP | MAF |
| GO_THYMUS_DEVELOPMENT | BP | MAF |
| GO_IMMUNE_SYSTEM_DEVELOPMENT | BP | MAF |
| GO_HORMONE_TRANSPORT | BP | MAF |
| GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS | BP | MAF |
| GO_PEPTIDE_SECRETION | BP | MAF |
| GO_WOUND_HEALING | BP | MAF |
| GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS | BP | MAF |
| GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION | BP | MAF |
| GO_EMBRYO_DEVELOPMENT | BP | MAF |
| GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION | BP | MAF |
| GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION | BP | MAF |
| GO_REGULATION_OF_HEMOPOIESIS | BP | MAF |
| GO_THYMOCYTE_AGGREGATION | BP | MAF |
| GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER | BP | MAF |
| GO_MUSCLE_STRUCTURE_DEVELOPMENT | BP | MAF |
| GO_SPHINGOLIPID_METABOLIC_PROCESS | BP | MAF |
| GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS | BP | MAF |
| GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS | BP | MAF |
| GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION | BP | MAF |
| GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION | BP | MAF |
| GO_SEGMENTATION | BP | MAF |
| GO_PARTURITION | BP | MAF |
| GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION | BP | MAF |
| GO_EAR_MORPHOGENESIS | BP | MAF |
| GO_SEGMENT_SPECIFICATION | BP | MAF |
| GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION | BP | MAF |
| GO_CERAMIDE_METABOLIC_PROCESS | BP | MAF |
| GO_LEUKOCYTE_CELL_CELL_ADHESION | BP | MAF |
| GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS | BP | MAF |
| GO_CELLULAR_CHEMICAL_HOMEOSTASIS | BP | MAF |
| GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION | BP | MAF |
| GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS | BP | MAF |
| GO_MEMBRANE_LIPID_METABOLIC_PROCESS | BP | MAF |
| GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION | BP | MAF |
| GO_REGULATION_OF_CELLULAR_PH | BP | MAF |
| GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION | BP | MAF |
| GO_T_CELL_DIFFERENTIATION | BP | MAF |
| GO_TISSUE_DEVELOPMENT | BP | MAF |
| GO_LYMPHOCYTE_DIFFERENTIATION | BP | MAF |
| GO_PEPTIDE_TRANSPORT | BP | MAF |
| GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE | BP | MAF |
| GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION | BP | MAF |
| GO_AXON | CC | MAF |
| GO_NEURON_PROJECTION | CC | MAF |
| GO_INHIBITORY_SYNAPSE | CC | MAF |
| GO_TRANSCRIPTION_COFACTOR_BINDING | MF | MAF |
| GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | MF | MAF |
| GO_RNA_POLYMERASE_BINDING | MF | MAF |
| GO_RNA_POLYMERASE_CORE_ENZYME_BINDING | MF | MAF |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING | MF | MAF |
| GO_GABA_RECEPTOR_BINDING | MF | MAF |
| GO_LIPASE_ACTIVATOR_ACTIVITY | MF | MAF |
| GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING | MF | MAF |