Cancer CRCdb

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.272

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRX2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs765950888	chr5	2749523	2749523	C	T	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749791	2749793	GTT	-	exonic	IRX2	nonframeshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749890	2749890	G	A	exonic	IRX2	synonymous	PAAD\|1\|185\|0.00541
-	chr5	2748596	2748596	C	A	exonic	IRX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	2749815	2749815	G	T	exonic	IRX2	synonymous	SKCM\|1\|368\|0.00272
-	chr5	2749798	2749798	C	G	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs747627856	chr5	2749510	2749510	G	A	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2748737	2748737	G	C	exonic	IRX2	stopgain	LUAD\|1\|543\|0.00184
-	chr5	2749119	2749119	C	A	exonic	IRX2	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs149245392	chr5	2749899	2749899	G	T	exonic	IRX2	synonymous	TGCT\|1\|155\|0.00645
-	chr5	2749779	2749779	G	A	exonic	IRX2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,UCEC\|1\|248\|0.00403
-	chr5	2749852	2749852	T	C	exonic	IRX2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr5	2749864	2749864	C	T	exonic	IRX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	2749025	2749025	T	A	exonic	IRX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	2749629	2749629	C	T	exonic	IRX2	synonymous	SKCM\|1\|368\|0.00272
-	chr5	2748643	2748643	T	A	exonic	IRX2	synonymous	LUAD\|1\|543\|0.00184
-	chr5	2749785	2749785	C	T	exonic	IRX2	synonymous	CESC\|1\|194\|0.00515
-	chr5	2749827	2749827	G	A	exonic	IRX2	synonymous	LUAD\|1\|543\|0.00184
-	chr5	2749846	2749846	G	A	exonic	IRX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	2747681	2747681	T	-	exonic	IRX2	frameshift	LUAD\|1\|543\|0.00184
-	chr5	2749032	2749032	C	G	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2747696	2747696	G	A	exonic	IRX2	synonymous	UCEC\|1\|248\|0.00403
-	chr5	2749548	2749548	G	A	exonic	IRX2	synonymous	PAAD\|1\|185\|0.00541
-	chr5	2748676	2748676	G	A	exonic	IRX2	synonymous	LUAD\|1\|543\|0.00184
-	chr5	2748735	2748735	T	G	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2748603	2748603	G	T	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2749884	2749884	C	T	exonic	IRX2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs776996559	chr5	2749615	2749615	G	A	exonic	IRX2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	2749623	2749623	G	C	exonic	IRX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	2747690	2747690	C	A	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2749898	2749898	C	T	exonic	IRX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs749462859	chr5	2749113	2749113	C	T	exonic	IRX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	2748740	2748740	G	A	exonic	IRX2	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr5	2749500	2749500	G	A	exonic	IRX2	synonymous	PRAD\|1\|499\|0.00200
rs750492323	chr5	2748541	2748541	C	T	exonic	IRX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749656	2749656	G	C	exonic	IRX2	nonsynonymous	UCS\|1\|57\|0.01754
-	chr5	2748509	2748509	G	A	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
rs774767226	chr5	2748724	2748724	C	T	exonic	IRX2	synonymous	BLCA\|1\|396\|0.00253
rs768698662	chr5	2749503	2749503	C	T	exonic	IRX2	synonymous	LUAD\|1\|543\|0.00184
rs148326536	chr5	2748634	2748634	C	T	exonic	IRX2	synonymous	SKCM\|1\|368\|0.00272
-	chr5	2751518	2751518	G	T	exonic	IRX2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr5	2748955	2748955	G	A	exonic	IRX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs767081175	chr5	2748586	2748586	A	C	exonic	IRX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2747724	2747724	C	T	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2748714	2748714	A	T	exonic	IRX2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr5	2749643	2749643	G	T	exonic	IRX2	synonymous	LUAD\|1\|543\|0.00184
-	chr5	2749802	2749802	A	T	exonic	IRX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	2749790	2749790	C	G	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749165	2749165	C	T	exonic	IRX2	synonymous	SKCM\|2\|368\|0.00543
-	chr5	2749569	2749569	G	A	exonic	IRX2	synonymous	UCEC\|1\|248\|0.00403
rs756601056	chr5	2749162	2749162	G	A	exonic	IRX2	synonymous	BLCA\|1\|396\|0.00253
rs766887002	chr5	2749021	2749021	C	T	exonic	IRX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs781161297	chr5	2749566	2749566	G	A	exonic	IRX2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	2750599	2750610	CCTCGAGACTCG	-	intronic	IRX2	unknown	-
rs771720742	chr5	2749749	2749749	G	A	exonic	IRX2	synonymous	UCEC\|1\|248\|0.00403
-	chr5	2751510	2751510	G	T	exonic	IRX2	synonymous	TGCT\|1\|155\|0.00645
-	chr5	2748668	2748668	G	A	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749795	2749795	T	C	exonic	IRX2	nonsynonymous	DLBC\|1\|48\|0.02083
rs201409542	chr5	2749791	2749791	G	A	exonic	IRX2	synonymous	UCEC\|1\|248\|0.00403
-	chr5	2749614	2749614	G	T	exonic	IRX2	synonymous	ESCA\|1\|185\|0.00541
rs748509438	chr5	2749842	2749842	G	A	exonic	IRX2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	2748559	2748559	C	T	exonic	IRX2	synonymous	SKCM\|1\|368\|0.00272
-	chr5	2749576	2749576	T	C	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749790	2749790	C	T	exonic	IRX2	nonsynonymous	HNSC\|1\|512\|0.00195
rs780600315	chr5	2749036	2749036	G	A	exonic	IRX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749778	2749778	C	G	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2749065	2749065	C	A	exonic	IRX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	2749625	2749625	T	C	exonic	IRX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	2748519	2748519	C	T	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs751185719	chr5	2747723	2747723	G	A	exonic	IRX2	synonymous	PAAD\|1\|185\|0.00541
-	chr5	2749726	2749726	G	C	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2748564	2748564	C	A	exonic	IRX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	2749765	2749765	A	G	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749825	2749825	G	A	exonic	IRX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	2748624	2748624	C	A	exonic	IRX2	nonsynonymous	THCA\|1\|504\|0.00198
-	chr5	2749024	2749024	G	A	exonic	IRX2	synonymous	PAAD\|1\|185\|0.00541
-	chr5	2748620	2748620	G	A	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2748698	2748698	G	A	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2748963	2748963	G	A	exonic	IRX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	2749671	2749671	C	A	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2749815	2749815	G	A	exonic	IRX2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr5	2748758	2748758	G	A	exonic	IRX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	2749606	2749606	G	T	exonic	IRX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	2749124	2749124	G	A	exonic	IRX2	nonsynonymous	SKCM\|1\|368\|0.00272
rs61748183	chr5	2749539	2749539	G	C	exonic	IRX2	synonymous	DLBC\|1\|48\|0.02083
-	chr5	2749008	2749018	CCTCGTCGTCG	-	exonic	IRX2	frameshift	HNSC\|1\|512\|0.00195
-	chr5	2749835	2749835	C	T	exonic	IRX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PAAD\|1\|185\|0.00541
-	chr5	2749803	2749803	C	T	exonic	IRX2	synonymous	TGCT\|1\|155\|0.00645,UCEC\|1\|248\|0.00403
rs531740600	chr5	2749029	2749029	C	T	exonic	IRX2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	2749632	2749632	C	T	exonic	IRX2	synonymous	SKCM\|1\|368\|0.00272
-	chr5	2748985	2748985	C	T	exonic	IRX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2748989	2748989	G	A	exonic	IRX2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	2749646	2749646	G	A	exonic	IRX2	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
-	chr5	2749530	2749530	C	T	exonic	IRX2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	2749083	2749083	C	T	exonic	IRX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	2749764	2749764	G	A	exonic	IRX2	synonymous	BLCA\|1\|396\|0.00253
-	chr5	2749519	2749519	G	A	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749089	2749089	C	T	exonic	IRX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	2748683	2748683	C	T	exonic	IRX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	2749627	2749627	T	A	exonic	IRX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	2748604	2748604	A	G	exonic	IRX2	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
rs749189949	chr5	2748625	2748625	G	A	exonic	IRX2	synonymous	HNSC\|1\|512\|0.00195,STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr5	2749663	2749663	G	T	exonic	IRX2	nonsynonymous	OV\|1\|469\|0.00213
-	chr5	2749012	2749012	G	A	exonic	IRX2	synonymous	PAAD\|1\|185\|0.00541
-	chr5	2749639	2749639	C	T	exonic	IRX2	nonsynonymous	PAAD\|2\|185\|0.01081,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

TF name:	IRX2
TF family:	Homeobox
Ensembl gene ID:	ENSG00000170561
Ensembl protein ID:	ENSP00000372056, ENSP00000307006
Entrez gene ID:	153572

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
IRX2	Lung diseases	C08	Disease or Syndrome	CTD_human
IRX2	Clear cell sarcoma of kidney		Neoplastic Process	ORPHANET

GO_term_name	GO_term_type	TF_name
GO_LOOP_OF_HENLE_DEVELOPMENT	BP	IRX2
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	IRX2
GO_RENAL_TUBULE_DEVELOPMENT	BP	IRX2
GO_SEGMENTATION	BP	IRX2
GO_METANEPHRIC_NEPHRON_DEVELOPMENT	BP	IRX2
GO_SEGMENT_SPECIFICATION	BP	IRX2
GO_NEPHRON_TUBULE_FORMATION	BP	IRX2

TF information

TCGA somatic mutations and clinical variants of IRX2

Survival analysis of IRX2

Expression of IRX2