TF information
| TF name: | HOXD11 |
| TF family: | Homeobox |
| Ensembl gene ID: | ENSG00000128713 |
| Ensembl protein ID: | ENSP00000249504 |
| Entrez gene ID: | 3237 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of HOXD11 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_007 | Other | Cervical | cervical-cancer_vector | 0.17218543046358 |
| Sample_02_318 | Cell line | Neuroblastoma | NB69 | 0.7421875 |
HOXD11 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_318 | Neuroblastoma | Cell line | NB69 |
HOXD11 distribution in all CRCs
Genomic distribution of SEs associated with HOXD11
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of HOXD11
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr2 | 176972598 | 176972598 | G | A | exonic | HOXD11 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr2 | 176972316 | 176972316 | G | T | exonic | HOXD11 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr2 | 176973654 | 176973654 | G | T | exonic | HOXD11 | synonymous | SKCM|1|368|0.00272 |
| - | chr2 | 176972311 | 176972312 | CG | - | exonic | HOXD11 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176973778 | 176973778 | C | A | exonic | HOXD11 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr2 | 176973689 | 176973689 | G | A | exonic | HOXD11 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr2 | 176973735 | 176973735 | G | A | exonic | HOXD11 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176972090 | 176972090 | G | A | exonic | HOXD11 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 176972320 | 176972320 | C | A | exonic | HOXD11 | synonymous | LUAD|1|543|0.00184 |
| - | chr2 | 176973687 | 176973687 | C | A | exonic | HOXD11 | synonymous | LUAD|1|543|0.00184 |
| - | chr2 | 176973838 | 176973838 | C | A | exonic | HOXD11 | nonsynonymous | LUAD|3|543|0.00552 |
| - | chr2 | 176973668 | 176973668 | C | A | exonic | HOXD11 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr2 | 176973579 | 176973579 | G | A | intronic | HOXD11 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176973648 | 176973648 | G | A | exonic | HOXD11 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr2 | 176972132 | 176972132 | C | T | exonic | HOXD11 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr2 | 176973637 | 176973637 | - | C | exonic | HOXD11 | frameshift | BRCA|2|982|0.00204,KIPAN|1|799|0.00125,KIRC|1|451|0.00222,LUAD|2|543|0.00368 |
| - | chr2 | 176973611 | 176973611 | C | - | intronic | HOXD11 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176973578 | 176973578 | C | T | intronic | HOXD11 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176972255 | 176972255 | G | A | exonic | HOXD11 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176973665 | 176973665 | G | A | exonic | HOXD11 | nonsynonymous | PCPG|1|184|0.00543 |
| rs539424632 | chr2 | 176973594 | 176973594 | G | T | intronic | HOXD11 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs747734841 | chr2 | 176972185 | 176972185 | C | T | exonic | HOXD11 | synonymous | UCEC|1|248|0.00403 |
| rs139282132 | chr2 | 176973681 | 176973681 | C | T | exonic | HOXD11 | synonymous | UCEC|1|248|0.00403 |
| - | chr2 | 176973703 | 176973703 | G | A | exonic | HOXD11 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 176973740 | 176973740 | G | A | exonic | HOXD11 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs752077506 | chr2 | 176972292 | 176972292 | G | A | exonic | HOXD11 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176974001 | 176974001 | C | T | UTR3 | HOXD11 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 176973688 | 176973688 | C | T | exonic | HOXD11 | nonsynonymous | UCEC|1|248|0.00403 |
| rs760406908 | chr2 | 176972104 | 176972104 | C | T | exonic | HOXD11 | synonymous | DLBC|1|48|0.02083 |
| - | chr2 | 176973754 | 176973754 | C | T | exonic | HOXD11 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 176973786 | 176973786 | A | C | exonic | HOXD11 | nonsynonymous | KIPAN|2|799|0.00250,KIRC|2|451|0.00443 |
| - | chr2 | 176973647 | 176973647 | G | A | exonic | HOXD11 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs755994512 | chr2 | 176973802 | 176973802 | C | T | exonic | HOXD11 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr2 | 176973620 | 176973620 | C | T | intronic | HOXD11 | unknown | STAD|1|395|0.00253,STES|1|395|0.00253 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| HOXD11 | Rheumatoid Arthritis | C05;C17;C20 | Disease or Syndrome | CTD_human |
| HOXD11 | Autistic Disorder | F03 | Mental or Behavioral Dysfunction | CTD_human |
| HOXD11 | Bone Diseases, Developmental | C05 | Disease or Syndrome | CTD_human |
| HOXD11 | Malignant neoplasm of breast | C04;C17 | Neoplastic Process | CTD_human |
| HOXD11 | Male infertility | C12 | Disease or Syndrome | CTD_human |
| HOXD11 | Kidney Diseases | C12;C13 | Disease or Syndrome | CTD_human |
| HOXD11 | Mouth Neoplasms | C04;C07 | Neoplastic Process | CTD_human |
| HOXD11 | Malignant neoplasm of mouth | C04;C07 | Neoplastic Process | CTD_human |
| HOXD11 | Limb Deformities, Congenital | C05;C16 | Congenital Abnormality | CTD_human |
| HOXD11 | Breast Carcinoma | C04;C17 | Neoplastic Process | CTD_human |
| HOXD11 | Subfertility, Male | C12 | Sign or Symptom | CTD_human |
| HOXD11 | Male sterility | C12 | Finding | CTD_human |
| HOXD11 | ovarian neoplasm | C04;C13;C19 | Neoplastic Process | CTD_human |
| HOXD11 | Malignant neoplasm of ovary | C04;C13;C19 | Neoplastic Process | CTD_human |
| HOXD11 | Squamous cell carcinoma of the head and neck | C04 | Neoplastic Process | CTD_human |
| HOXD11 | Mammary Neoplasms, Human | C04;C17 | Neoplastic Process | CTD_human |
| HOXD11 | Mammary Neoplasms | C04;C17 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_DORSAL_VENTRAL_PATTERN_FORMATION | BP | HOXD11 |
| GO_NEPHRON_EPITHELIUM_DEVELOPMENT | BP | HOXD11 |
| GO_RENAL_TUBULE_DEVELOPMENT | BP | HOXD11 |
| GO_ORGAN_MORPHOGENESIS | BP | HOXD11 |
| GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS | BP | HOXD11 |
| GO_KIDNEY_MORPHOGENESIS | BP | HOXD11 |
| GO_NEPHRON_DEVELOPMENT | BP | HOXD11 |
| GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE | BP | HOXD11 |
| GO_MESONEPHROS_DEVELOPMENT | BP | HOXD11 |