Cancer CRCdb

TF information

TF name:	HOXD10
TF family:	Homeobox
Ensembl gene ID:	ENSG00000128710
Ensembl protein ID:	ENSP00000249501
Entrez gene ID:	3236

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HOXD10 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.0095923261390887
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.47802197802198
Sample_02_318	Cell line	Neuroblastoma	NB69	0.7421875

HOXD10 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_318	Neuroblastoma	Cell line	NB69

HOXD10 distribution in all CRCs

Genomic distribution of SEs associated with HOXD10

Download

Mutation of HOXD10

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HOXD10

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	176981904	176981904	A	T	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176981597	176981597	T	-	exonic	HOXD10	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	176981722	176981722	T	A	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176982173	176982173	C	T	exonic	HOXD10	synonymous	UCEC\|1\|248\|0.00403
rs148563899	chr2	176982180	176982180	G	T	exonic	HOXD10	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	176982185	176982185	G	A	exonic	HOXD10	synonymous	ESCA\|1\|185\|0.00541
-	chr2	176981647	176981647	C	A	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176983908	176983908	G	T	exonic	HOXD10	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	176983832	176983832	T	C	exonic	HOXD10	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	176983899	176983899	C	A	exonic	HOXD10	synonymous	LUAD\|1\|543\|0.00184
-	chr2	176982029	176982029	G	C	exonic	HOXD10	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	176983792	176983792	T	A	exonic	HOXD10	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	176983681	176983681	G	C	splicing	HOXD10	splicing	BLCA\|1\|396\|0.00253
-	chr2	176982075	176982075	G	T	exonic	HOXD10	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	176982019	176982019	G	C	exonic	HOXD10	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	176982041	176982041	C	A	exonic	HOXD10	synonymous	LUAD\|1\|543\|0.00184
-	chr2	176981715	176981715	G	T	exonic	HOXD10	stopgain	LUSC\|1\|178\|0.00562
-	chr2	176981590	176981590	C	A	exonic	HOXD10	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176983782	176983782	A	-	exonic	HOXD10	frameshift	LUAD\|1\|543\|0.00184
-	chr2	176982188	176982188	G	C	exonic	HOXD10	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	176983919	176983919	A	G	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176981919	176981919	C	T	exonic	HOXD10	nonsynonymous	PRAD\|1\|499\|0.00200,UCEC\|1\|248\|0.00403
-	chr2	176981993	176981993	T	C	exonic	HOXD10	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	176982111	176982111	G	A	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
rs868004054	chr2	176982240	176982240	G	A	exonic	HOXD10	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr2	176983913	176983913	G	C	exonic	HOXD10	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	176982146	176982146	G	A	exonic	HOXD10	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176981985	176981985	G	A	exonic	HOXD10	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176981665	176981665	A	G	exonic	HOXD10	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	176981700	176981700	G	T	exonic	HOXD10	stopgain	LUAD\|1\|543\|0.00184
-	chr2	176983941	176983941	C	A	exonic	HOXD10	synonymous	LUSC\|1\|178\|0.00562
-	chr2	176982051	176982051	C	A	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176983939	176983939	G	A	exonic	HOXD10	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	176982003	176982003	G	A	exonic	HOXD10	nonsynonymous	OV\|1\|469\|0.00213
rs756352793	chr2	176981740	176981740	G	T	exonic	HOXD10	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	176982041	176982041	C	T	exonic	HOXD10	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176981726	176981726	G	A	exonic	HOXD10	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176983684	176983684	G	A	exonic	HOXD10	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
-	chr2	176983853	176983853	C	T	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176981935	176981935	C	T	exonic	HOXD10	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	176983956	176983956	T	G	exonic	HOXD10	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176982035	176982035	C	T	exonic	HOXD10	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
rs373028650	chr2	176983843	176983843	G	A	exonic	HOXD10	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176982006	176982006	C	T	exonic	HOXD10	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr2	176981682	176981682	G	T	exonic	HOXD10	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr2	176982023	176982023	G	A	exonic	HOXD10	synonymous	UCEC\|1\|248\|0.00403
-	chr2	176981808	176981808	G	C	exonic	HOXD10	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	176983951	176983951	T	C	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176981596	176981596	-	T	exonic	HOXD10	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176983686	176983686	A	G	exonic	HOXD10	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr2	176981598	176981599	TT	-	exonic	HOXD10	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	176982209	176982209	G	A	exonic	HOXD10	synonymous	LUAD\|1\|543\|0.00184
-	chr2	176983772	176983772	T	C	exonic	HOXD10	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176982109	176982109	G	A	exonic	HOXD10	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	176981967	176981967	C	T	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176981673	176981673	C	T	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176982052	176982052	A	C	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176981961	176981961	C	T	exonic	HOXD10	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs752887490	chr2	176981648	176981648	C	T	exonic	HOXD10	synonymous	BRCA\|1\|982\|0.00102
-	chr2	176981724	176981724	C	A	exonic	HOXD10	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	176981685	176981685	G	T	exonic	HOXD10	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr2	176981980	176981980	C	T	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176983685	176983685	A	G	exonic	HOXD10	nonsynonymous	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
rs756832722	chr2	176982113	176982113	C	T	exonic	HOXD10	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176982161	176982161	G	T	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176983683	176983683	G	A	exonic	HOXD10	synonymous	SKCM\|1\|368\|0.00272
-	chr2	176981826	176981826	C	G	exonic	HOXD10	nonsynonymous	HNSC\|1\|512\|0.00195
rs766860933	chr2	176982013	176982013	A	G	exonic	HOXD10	nonsynonymous	HNSC\|1\|512\|0.00195
rs761017009	chr2	176981857	176981857	C	T	exonic	HOXD10	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	176981615	176981615	G	T	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	176983859	176983859	G	A	exonic	HOXD10	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr2	176981927	176981927	A	T	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176983939	176983939	G	T	exonic	HOXD10	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	176982219	176982219	G	C	exonic	HOXD10	nonsynonymous	OV\|1\|469\|0.00213
-	chr2	176982218	176982218	C	A	exonic	HOXD10	synonymous	LUAD\|1\|543\|0.00184
-	chr2	176982179	176982179	C	T	exonic	HOXD10	synonymous	TGCT\|1\|155\|0.00645
-	chr2	176982243	176982243	G	C	exonic	HOXD10	nonsynonymous	LUAD\|1\|543\|0.00184
rs779016325	chr2	176982219	176982219	G	A	exonic	HOXD10	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCS\|1\|57\|0.01754
-	chr2	176982108	176982108	C	T	exonic	HOXD10	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|2\|368\|0.00543
rs529467459	chr2	176982280	176982280	C	A	exonic	HOXD10	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	176981956	176981956	A	T	exonic	HOXD10	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs777285981	chr2	176981954	176981954	C	T	exonic	HOXD10	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs374700658	chr2	176981827	176981827	G	A	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176981813	176981813	G	A	exonic	HOXD10	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PAAD\|1\|185\|0.00541
-	chr2	176981694	176981694	A	G	exonic	HOXD10	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	176982186	176982186	G	A	exonic	HOXD10	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	176981721	176981721	C	A	exonic	HOXD10	nonsynonymous	UCEC\|1\|248\|0.00403
rs33913965	chr2	176983923	176983923	G	C	exonic	HOXD10	synonymous	DLBC\|1\|48\|0.02083
-	chr2	176981711	176981711	C	A	exonic	HOXD10	synonymous	LUAD\|1\|543\|0.00184
-	chr2	176983838	176983838	A	C	exonic	HOXD10	nonsynonymous	OV\|1\|469\|0.00213

Disease information of HOXD10

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HOXD10	Rheumatoid Arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
HOXD10	Charcot-Marie-Tooth Disease	C10;C16	Disease or Syndrome	CTD_human;GENOMICS_ENGLAND
HOXD10	Flatfoot	C05;C16	Anatomical Abnormality	CTD_human
HOXD10	Mouth Neoplasms	C04;C07	Neoplastic Process	CTD_human
HOXD10	Talipes Calcaneovalgus	C05;C16	Congenital Abnormality	CTD_human
HOXD10	Malignant neoplasm of mouth	C04;C07	Neoplastic Process	CTD_human
HOXD10	Roussy-Levy Syndrome (disorder)	C10;C16	Disease or Syndrome	CTD_human
HOXD10	Vertical Talus	C05;C16	Congenital Abnormality	CTD_human;UNIPROT
HOXD10	Charcot-Marie-Tooth Disease, Type Ia (disorder)	C10;C16	Disease or Syndrome	CTD_human
HOXD10	Charcot-Marie-Tooth Disease, Type Ib	C10;C16	Disease or Syndrome	CTD_human
HOXD10	Hereditary Motor and Sensory-Neuropathy Type II	C10;C16	Disease or Syndrome	CTD_human
HOXD10	Lower Extremity Deformities, Congenital	C05;C16	Congenital Abnormality	CTD_human
HOXD10	Hereditary Motor and Sensory Neuropathy Type I	C10;C16	Disease or Syndrome	CTD_human
HOXD10	Squamous cell carcinoma of the head and neck	C04	Neoplastic Process	CTD_human
HOXD10	Congenital vertical talus, bilateral		Finding	ORPHANET
HOXD10	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with HOXD10

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of HOXD10

Download

GO_term_name	GO_term_type	TF_name
GO_SINGLE_FERTILIZATION	BP	HOXD10
GO_HINDLIMB_MORPHOGENESIS	BP	HOXD10
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	HOXD10
GO_ADULT_BEHAVIOR	BP	HOXD10
GO_FORELIMB_MORPHOGENESIS	BP	HOXD10
GO_ADULT_LOCOMOTORY_BEHAVIOR	BP	HOXD10
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	HOXD10
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION	BP	HOXD10
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT	BP	HOXD10
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	HOXD10
GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION	BP	HOXD10
GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	HOXD10
GO_NEURON_FATE_SPECIFICATION	BP	HOXD10
GO_APPENDAGE_DEVELOPMENT	BP	HOXD10
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	HOXD10
GO_NEURON_FATE_COMMITMENT	BP	HOXD10
GO_CELL_FATE_SPECIFICATION	BP	HOXD10
GO_REGIONALIZATION	BP	HOXD10

Survival analysis of HOXD10

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HOXD10

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)