Cancer CRCdb

TF information

TF name:	HOXD1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000128645
Ensembl protein ID:	ENSP00000328598
Entrez gene ID:	3231

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HOXD1 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_114	Cell line	Mammary Gland	CAL51	0.050251256281407

HOXD1 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name

HOXD1 distribution in all CRCs

Genomic distribution of SEs associated with HOXD1

Download

Mutation of HOXD1

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HOXD1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs779498756	chr2	177053568	177053568	C	T	exonic	HOXD1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	177053603	177053603	C	G	exonic	HOXD1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr2	177054803	177054803	C	T	exonic	HOXD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	177054664	177054664	G	C	exonic	HOXD1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr2	177054731	177054731	A	G	exonic	HOXD1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	177054656	177054656	G	A	exonic	HOXD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs751102076	chr2	177054575	177054575	C	T	exonic	HOXD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PAAD\|1\|185\|0.00541
-	chr2	177054173	177054173	C	T	exonic	HOXD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	177054164	177054164	G	T	exonic	HOXD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	177054729	177054729	G	A	exonic	HOXD1	nonsynonymous	BLCA\|1\|396\|0.00253
rs776337326	chr2	177054551	177054551	A	G	exonic	HOXD1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr2	177054165	177054165	G	A	exonic	HOXD1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs544403010	chr2	177054788	177054788	T	C	exonic	HOXD1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	177054177	177054177	G	C	exonic	HOXD1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	177054696	177054696	G	A	exonic	HOXD1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	177054313	177054313	G	A	intronic	HOXD1	unknown	UCEC\|1\|248\|0.00403
-	chr2	177054838	177054838	G	T	exonic	HOXD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	177053983	177053983	G	A	exonic	HOXD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	177054695	177054695	C	T	exonic	HOXD1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	177053759	177053759	C	T	exonic	HOXD1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr2	177054007	177054007	C	T	exonic	HOXD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	177054663	177054663	C	G	exonic	HOXD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	177054137	177054137	G	T	exonic	HOXD1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	177054563	177054563	G	A	exonic	HOXD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	177054653	177054653	C	T	exonic	HOXD1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	177054043	177054043	G	A	exonic	HOXD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	177054576	177054576	G	A	exonic	HOXD1	synonymous	PAAD\|1\|185\|0.00541
-	chr2	177053626	177053626	C	T	exonic	HOXD1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	177053951	177053951	C	T	exonic	HOXD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	177054839	177054839	G	A	exonic	HOXD1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs867601012	chr2	177054866	177054866	C	T	exonic	HOXD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	177054568	177054568	T	-	exonic	HOXD1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	177054752	177054752	A	G	exonic	HOXD1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	177054708	177054708	C	A	exonic	HOXD1	synonymous	UCEC\|1\|248\|0.00403
-	chr2	177054035	177054035	C	T	exonic	HOXD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	177054725	177054725	G	T	exonic	HOXD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	177053883	177053883	G	A	exonic	HOXD1	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	177054765	177054765	C	T	exonic	HOXD1	synonymous	HNSC\|1\|512\|0.00195
-	chr2	177054863	177054863	C	G	exonic	HOXD1	nonsynonymous	LUAD\|1\|543\|0.00184

Disease information of HOXD1

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HOXD1	Colorectal Carcinoma	C04;C06	Neoplastic Process	CTD_human
HOXD1	Colorectal Neoplasms	C04;C06	Neoplastic Process	CTD_human
HOXD1	Hyperalgesia	C10;C23	Sign or Symptom	CTD_human
HOXD1	Pain	C23	Sign or Symptom	CTD_human
HOXD1	Pain, Burning	C23	Sign or Symptom	CTD_human
HOXD1	Ache	C23	Sign or Symptom	CTD_human
HOXD1	Radiating pain	C23	Sign or Symptom	CTD_human
HOXD1	Allodynia	C10;C23	Finding	CTD_human
HOXD1	Pain, Splitting	C23	Sign or Symptom	CTD_human
HOXD1	Pain, Crushing	C23	Sign or Symptom	CTD_human
HOXD1	Hyperalgesia, Primary	C10;C23	Sign or Symptom	CTD_human
HOXD1	Hyperalgesia, Secondary	C10;C23	Sign or Symptom	CTD_human
HOXD1	Tactile Allodynia	C10;C23	Sign or Symptom	CTD_human
HOXD1	Hyperalgesia, Thermal	C10;C23	Sign or Symptom	CTD_human
HOXD1	Pain, Migratory	C23	Sign or Symptom	CTD_human
HOXD1	Suffering, Physical	C23	Sign or Symptom	CTD_human
HOXD1	ovarian neoplasm	C04;C13;C19	Neoplastic Process	CTD_human
HOXD1	Malignant neoplasm of ovary	C04;C13;C19	Neoplastic Process	CTD_human
HOXD1	Colorectal Cancer	C04;C06	Neoplastic Process	CTD_human
HOXD1	Mechanical Allodynia	C10;C23	Sign or Symptom	CTD_human

Pathway associated with HOXD1

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of HOXD1

Download

GO_term_name	GO_term_type	TF_name
GO_SINGLE_FERTILIZATION	BP	HOXD1
GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING	BP	HOXD1
GO_GLAND_MORPHOGENESIS	BP	HOXD1
GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	HOXD1
GO_PROSTATE_GLAND_MORPHOGENESIS	BP	HOXD1
GO_EMBRYONIC_DIGIT_MORPHOGENESIS	BP	HOXD1
GO_HINDLIMB_MORPHOGENESIS	BP	HOXD1
GO_MALE_GENITALIA_DEVELOPMENT	BP	HOXD1
GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM	BP	HOXD1
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	HOXD1
GO_ADULT_BEHAVIOR	BP	HOXD1
GO_SKELETAL_SYSTEM_DEVELOPMENT	BP	HOXD1
GO_FORELIMB_MORPHOGENESIS	BP	HOXD1
GO_ADULT_LOCOMOTORY_BEHAVIOR	BP	HOXD1
GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD	BP	HOXD1
GO_DORSAL_VENTRAL_PATTERN_FORMATION	BP	HOXD1
GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION	BP	HOXD1
GO_VENTRAL_SPINAL_CORD_DEVELOPMENT	BP	HOXD1
GO_DIGESTIVE_SYSTEM_DEVELOPMENT	BP	HOXD1
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	HOXD1
GO_SENSORY_PERCEPTION_OF_PAIN	BP	HOXD1
GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION	BP	HOXD1
GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD	BP	HOXD1
GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION	BP	HOXD1
GO_NEPHRON_EPITHELIUM_DEVELOPMENT	BP	HOXD1
GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	HOXD1
GO_RENAL_TUBULE_DEVELOPMENT	BP	HOXD1
GO_NEURON_FATE_SPECIFICATION	BP	HOXD1
GO_ORGAN_MORPHOGENESIS	BP	HOXD1
GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS	BP	HOXD1
GO_DIGESTIVE_TRACT_MORPHOGENESIS	BP	HOXD1
GO_APPENDAGE_DEVELOPMENT	BP	HOXD1
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	HOXD1
GO_REGULATION_OF_REPRODUCTIVE_PROCESS	BP	HOXD1
GO_TUBE_DEVELOPMENT	BP	HOXD1
GO_NEURON_FATE_COMMITMENT	BP	HOXD1
GO_CELL_FATE_SPECIFICATION	BP	HOXD1
GO_KIDNEY_MORPHOGENESIS	BP	HOXD1
GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS	BP	HOXD1
GO_PROSTATE_GLAND_DEVELOPMENT	BP	HOXD1
GO_NEPHRON_DEVELOPMENT	BP	HOXD1
GO_GENITALIA_DEVELOPMENT	BP	HOXD1
GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE	BP	HOXD1
GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT	BP	HOXD1
GO_AXIS_ELONGATION	BP	HOXD1
GO_MESONEPHROS_DEVELOPMENT	BP	HOXD1
GO_REGIONALIZATION	BP	HOXD1
GO_DEVELOPMENTAL_GROWTH	BP	HOXD1
GO_MALE_SEX_DIFFERENTIATION	BP	HOXD1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	HOXD1

Survival analysis of HOXD1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HOXD1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)