Cancer CRCdb

TF information

TF name:	HIC1
TF family:	ZBTB
Ensembl gene ID:	ENSG00000177374
Ensembl protein ID:	ENSP00000314080, ENSP00000314080, ENSP00000467045, ENSP00000382742, ENSP00000477858
Entrez gene ID:	3090

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HIC1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_069	Cell line	Brain	SF268	0.31297709923664

HIC1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_069	Brain	Cell line	SF268

HIC1 distribution in all CRCs

Genomic distribution of SEs associated with HIC1

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Mutation of HIC1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HIC1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	1961716	1961716	G	A	exonic	HIC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	1961396	1961396	G	A	exonic	HIC1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr17	1959984	1959984	G	A	exonic	HIC1	synonymous	SKCM\|1\|368\|0.00272
-	chr17	1961548	1961548	G	A	exonic	HIC1	nonsynonymous	PRAD\|2\|499\|0.00401,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1960262	1960262	C	T	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961767	1961767	G	A	exonic	HIC1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	1961130	1961130	G	-	exonic	HIC1	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs759913232	chr17	1961553	1961553	G	A	exonic	HIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961875	1961875	T	-	exonic	HIC1	frameshift	SKCM\|1\|368\|0.00272
-	chr17	1961286	1961286	C	T	exonic	HIC1	synonymous	SARC\|1\|247\|0.00405
-	chr17	1960006	1960006	C	T	exonic	HIC1	nonsynonymous	PRAD\|1\|499\|0.00200
rs77393586	chr17	1960974	1960974	C	T	exonic	HIC1	synonymous	ACC\|4\|90\|0.04444
-	chr17	1960076	1960076	T	C	exonic	HIC1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	1961209	1961209	G	T	exonic	HIC1	stopgain	ESCA\|1\|185\|0.00541
-	chr17	1961719	1961719	G	A	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs556577424	chr17	1961160	1961160	G	A	exonic	HIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961656	1961656	C	T	exonic	HIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	1960080	1960080	C	G	exonic	HIC1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	1960406	1960407	GC	-	exonic	HIC1	frameshift	PRAD\|1\|499\|0.00200,SKCM\|1\|368\|0.00272,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	1961106	1961106	C	T	exonic	HIC1	synonymous	LUSC\|1\|178\|0.00562
rs771684583	chr17	1961428	1961428	G	A	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961664	1961664	G	A	exonic	HIC1	synonymous	SKCM\|2\|368\|0.00543
-	chr17	1959996	1959996	G	A	exonic	HIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961606	1961606	T	G	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961239	1961239	G	A	exonic	HIC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs765775523	chr17	1961293	1961293	G	A	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961558	1961558	T	G	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1960258	1960258	G	A	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1960163	1960163	A	C	exonic	HIC1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	1961289	1961289	G	A	exonic	HIC1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1961105	1961105	G	A	exonic	HIC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	1960068	1960068	C	T	exonic	HIC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of HIC1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HIC1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
HIC1	Gastrointestinal Neoplasms	C04;C06	Neoplastic Process	CTD_human
HIC1	Medulloblastoma	C04	Neoplastic Process	CTD_human
HIC1	polyps	C23	Anatomical Abnormality	CTD_human
HIC1	Medullomyoblastoma	C04	Neoplastic Process	CTD_human
HIC1	Miller Dieker syndrome	C10;C16	Disease or Syndrome	ORPHANET
HIC1	Childhood Medulloblastoma	C04	Neoplastic Process	CTD_human
HIC1	Adult Medulloblastoma	C04	Neoplastic Process	CTD_human
HIC1	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
HIC1	Malignant neoplasm of gastrointestinal tract	C04;C06	Neoplastic Process	CTD_human
HIC1	Desmoplastic Medulloblastoma	C04	Neoplastic Process	CTD_human
HIC1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
HIC1	Melanotic medulloblastoma	C04	Neoplastic Process	CTD_human
HIC1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human

Pathway associated with HIC1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000648	E2F transcription factor network	pid	77	897

Go term information of HIC1

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	BP	HIC1
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE	BP	HIC1
GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	BP	HIC1
GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	BP	HIC1
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS	BP	HIC1
GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS	BP	HIC1
GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS	BP	HIC1
GO_CHROMATIN	CC	HIC1

Survival analysis of HIC1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HIC1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)