Cancer CRCdb

TF information

TF name:	EOMES
TF family:	T-box
Ensembl gene ID:	ENSG00000163508
Ensembl protein ID:	ENSP00000295743, ENSP00000388620, ENSP00000487112
Entrez gene ID:	8320

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of EOMES in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_395	Cell line	Mammary Gland	BT-549	0.16699300699301

EOMES distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

EOMES distribution in all CRCs

Genomic distribution of SEs associated with EOMES

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Mutation of EOMES

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of EOMES

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	27759290	27759290	G	A	exonic	EOMES	synonymous	HNSC\|1\|512\|0.00195
rs141551851	chr3	27758889	27758889	C	T	exonic	EOMES	nonsynonymous	CESC\|1\|194\|0.00515
-	chr3	27758656	27758656	G	A	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
rs767871834	chr3	27759217	27759217	G	A	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
-	chr3	27760081	27760081	T	C	exonic	EOMES	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	27763641	27763641	C	G	exonic	EOMES	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	27760901	27760901	C	A	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27761702	27761702	-	C	exonic	EOMES	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758565	27758565	G	A	exonic	EOMES	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	27759046	27759046	G	T	exonic	EOMES	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	27763724	27763724	G	T	exonic	EOMES	nonsynonymous	HNSC\|1\|512\|0.00195
rs371656694	chr3	27760315	27760315	C	T	exonic	EOMES	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	27760140	27760140	C	T	splicing	EOMES	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	27758988	27758988	A	C	exonic	EOMES	nonsynonymous	LUAD\|2\|543\|0.00368,UCEC\|1\|248\|0.00403
-	chr3	27761715	27761715	C	T	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27763618	27763618	G	T	exonic	EOMES	synonymous	TGCT\|1\|155\|0.00645
-	chr3	27760377	27760377	A	T	exonic	EOMES	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	27761789	27761789	G	A	exonic	EOMES	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs777301986	chr3	27760113	27760113	G	A	exonic	EOMES	synonymous	LUAD\|1\|543\|0.00184
rs752005397	chr3	27758960	27758960	G	A	exonic	EOMES	synonymous	SKCM\|1\|368\|0.00272
-	chr3	27763289	27763289	T	-	exonic	EOMES	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	27763181	27763181	G	T	exonic	EOMES	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	27760106	27760106	C	T	exonic	EOMES	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	27760935	27760935	A	T	exonic	EOMES	synonymous	PRAD\|1\|499\|0.00200
-	chr3	27761703	27761703	C	-	exonic	EOMES	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr3	27760940	27760940	T	G	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	27758588	27758588	C	A	exonic	EOMES	synonymous	LUAD\|1\|543\|0.00184
-	chr3	27762916	27762916	C	T	exonic	EOMES	synonymous	SKCM\|1\|368\|0.00272
-	chr3	27760930	27760930	G	A	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	27758862	27758862	G	C	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
rs867722017	chr3	27760228	27760228	C	T	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	27761806	27761806	G	A	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
rs773626452	chr3	27761771	27761771	G	T	exonic	EOMES	synonymous	SKCM\|1\|368\|0.00272
-	chr3	27759021	27759021	C	A	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	27758974	27758974	T	A	exonic	EOMES	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	27758689	27758689	G	T	exonic	EOMES	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	27759190	27759190	C	A	exonic	EOMES	stopgain	PAAD\|1\|185\|0.00541
-	chr3	27759023	27759023	G	C	exonic	EOMES	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	27760275	27760275	G	T	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	27761677	27761677	C	T	exonic	EOMES	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr3	27758783	27758783	T	C	exonic	EOMES	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758754	27758754	G	-	exonic	EOMES	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758942	27758942	G	A	exonic	EOMES	synonymous	SKCM\|1\|368\|0.00272
rs772872800	chr3	27759145	27759145	C	T	exonic	EOMES	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr3	27759225	27759225	G	T	exonic	EOMES	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	27760264	27760264	T	G	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	27758893	27758893	C	A	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758621	27758621	C	T	exonic	EOMES	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr3	27760256	27760256	G	T	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27763289	27763289	T	C	exonic	EOMES	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr3	27759037	27759037	T	A	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
rs753570106	chr3	27760902	27760902	G	A	exonic	EOMES	synonymous	UCS\|1\|57\|0.01754
-	chr3	27760901	27760901	C	T	exonic	EOMES	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	27758876	27758876	C	G	exonic	EOMES	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr3	27758785	27758785	C	T	exonic	EOMES	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr3	27758784	27758784	T	C	exonic	EOMES	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr3	27763601	27763601	T	A	exonic	EOMES	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	27763048	27763048	G	A	exonic	EOMES	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758585	27758585	A	C	exonic	EOMES	stopgain	OV\|1\|469\|0.00213
-	chr3	27761750	27761750	G	A	exonic	EOMES	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,ESCA\|1\|185\|0.00541,SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr3	27760303	27760303	T	G	exonic	EOMES	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs761569819	chr3	27761733	27761733	G	A	exonic	EOMES	nonsynonymous	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs201822269	chr3	27759208	27759208	C	T	exonic	EOMES	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr3	27758575	27758575	A	-	exonic	EOMES	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs766572704	chr3	27763429	27763429	T	G	exonic	EOMES	synonymous	LIHC\|1\|373\|0.00268
-	chr3	27763407	27763408	CG	-	exonic	EOMES	frameshift	ESCA\|1\|185\|0.00541,PRAD\|1\|499\|0.00200,THCA\|1\|504\|0.00198
-	chr3	27761814	27761814	C	T	exonic	EOMES	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr3	27763427	27763427	-	GGCGC	exonic	EOMES	frameshift	SARC\|5\|247\|0.02024,THYM\|1\|123\|0.00813
-	chr3	27760974	27760974	T	C	splicing	EOMES	splicing	LUAD\|1\|543\|0.00184
-	chr3	27763020	27763020	C	T	exonic	EOMES	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	27760382	27760382	C	A	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	27758890	27758890	G	A	exonic	EOMES	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758600	27758600	T	C	exonic	EOMES	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs6783101	chr3	27758756	27758756	G	A	exonic	EOMES	synonymous	DLBC\|1\|48\|0.02083
-	chr3	27761801	27761801	G	T	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758815	27758815	C	T	exonic	EOMES	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	27758626	27758626	C	T	exonic	EOMES	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr3	27761814	27761814	C	A	exonic	EOMES	nonsynonymous	BLCA\|1\|396\|0.00253,PRAD\|1\|499\|0.00200
-	chr3	27758884	27758884	A	G	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
rs560560725	chr3	27764052	27764052	C	G	UTR5	EOMES	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs137915789	chr3	27759192	27759192	G	A	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27763405	27763405	-	CG	exonic	EOMES	frameshift	PRAD\|1\|499\|0.00200
-	chr3	27760355	27760355	G	A	exonic	EOMES	synonymous	BLCA\|1\|396\|0.00253
-	chr3	27758906	27758906	C	A	exonic	EOMES	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	27760382	27760382	C	T	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184
rs868242390	chr3	27759018	27759018	G	A	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	27758785	27758785	C	A	exonic	EOMES	stopgain	OV\|1\|469\|0.00213
-	chr3	27763709	27763709	C	T	exonic	EOMES	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	27761760	27761760	T	C	exonic	EOMES	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	27759079	27759079	G	A	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	27758943	27758943	G	A	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27758863	27758863	C	T	exonic	EOMES	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	27758824	27758824	A	C	exonic	EOMES	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs768922132	chr3	27758698	27758698	G	A	exonic	EOMES	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	27759079	27759079	G	T	exonic	EOMES	nonsynonymous	LUAD\|1\|543\|0.00184

Disease information of EOMES

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
EOMES	Anxiety Disorders	F03	Mental or Behavioral Dysfunction	CTD_human
EOMES	Malignant neoplasm of urinary bladder	C04;C12;C13	Neoplastic Process	CTD_human
EOMES	Bladder Neoplasm	C04;C12;C13	Neoplastic Process	CTD_human
EOMES	Malignant neoplasm of breast	C04;C17	Neoplastic Process	UNIPROT
EOMES	Malignant tumor of colon	C04;C06	Neoplastic Process	CTD_human
EOMES	Colonic Neoplasms	C04;C06	Neoplastic Process	CTD_human
EOMES	Anxiety States, Neurotic	F03	Mental or Behavioral Dysfunction	CTD_human
EOMES	Primary microcephaly		Congenital Abnormality	GENOMICS_ENGLAND
EOMES	Autoimmune Diseases of the Nervous System	C10;C20	Disease or Syndrome	CTD_human
EOMES	Immune Disorders, Nervous System	C10;C20	Disease or Syndrome	CTD_human
EOMES	Anxiety neurosis (finding)	F03	Mental or Behavioral Dysfunction	CTD_human
EOMES	Malformations of Cortical Development	C10;C16	Disease or Syndrome	GENOMICS_ENGLAND
EOMES	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with EOMES

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000634	Downstream signaling in na�ve CD8+ T cells	pid	69	708
pathway0001116	IL12-mediated signaling events	pid	62	684
pathway0001702	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	reactome	10	27

Go term information of EOMES

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GO_term_name	GO_term_type	TF_name
GO_ALPHA_BETA_T_CELL_DIFFERENTIATION	BP	EOMES
GO_CELL_ACTIVATION	BP	EOMES
GO_BLASTOCYST_FORMATION	BP	EOMES
GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	EOMES
GO_FOREBRAIN_REGIONALIZATION	BP	EOMES
GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT	BP	EOMES
GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION	BP	EOMES
GO_MESENCHYMAL_CELL_DIFFERENTIATION	BP	EOMES
GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER	BP	EOMES
GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE	BP	EOMES
GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT	BP	EOMES
GO_CEREBRAL_CORTEX_DEVELOPMENT	BP	EOMES
GO_ENDODERMAL_CELL_DIFFERENTIATION	BP	EOMES
GO_INTERFERON_GAMMA_PRODUCTION	BP	EOMES
GO_PALLIUM_DEVELOPMENT	BP	EOMES
GO_CARDIOBLAST_DIFFERENTIATION	BP	EOMES
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	EOMES
GO_BLASTOCYST_DEVELOPMENT	BP	EOMES
GO_MESODERM_MORPHOGENESIS	BP	EOMES
GO_ENDODERM_DEVELOPMENT	BP	EOMES
GO_MAINTENANCE_OF_CELL_NUMBER	BP	EOMES
GO_OLFACTORY_LOBE_DEVELOPMENT	BP	EOMES
GO_CARDIOCYTE_DIFFERENTIATION	BP	EOMES
GO_ENDODERM_FORMATION	BP	EOMES
GO_TROPHECTODERMAL_CELL_DIFFERENTIATION	BP	EOMES
GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION	BP	EOMES
GO_CELL_FATE_SPECIFICATION	BP	EOMES
GO_TELENCEPHALON_REGIONALIZATION	BP	EOMES
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	EOMES
GO_REGIONALIZATION	BP	EOMES
GO_ENDODERMAL_CELL_FATE_COMMITMENT	BP	EOMES
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	EOMES
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	EOMES
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	EOMES

Survival analysis of EOMES

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of EOMES

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)