Cancer CRCdb

TF information

TF name:	ELK3
TF family:	ETS
Ensembl gene ID:	ENSG00000111145
Ensembl protein ID:	ENSP00000447857, ENSP00000446806, ENSP00000228741, ENSP00000449430
Entrez gene ID:	2004

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ELK3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_164	Cell line	Lung	H2087_Parental	0.13333333333333
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.017241379310345
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.011111111111111
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.040540540540541
Sample_02_323	Cell line	Colon	RKO	0.1

ELK3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

ELK3 distribution in all CRCs

Genomic distribution of SEs associated with ELK3

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Mutation of ELK3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ELK3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr12	96641384	96641384	A	-	exonic	ELK3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	96640822	96640822	C	T	exonic	ELK3	synonymous	UCEC\|1\|248\|0.00403
-	chr12	96640864	96640864	C	T	exonic	ELK3	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	96653588	96653588	C	A	exonic	ELK3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	96641178	96641178	C	G	exonic	ELK3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr12	96641176	96641176	C	G	exonic	ELK3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr12	96617510	96617510	T	C	exonic	ELK3	nonsynonymous	LIHC\|1\|373\|0.00268
rs138151504	chr12	96617428	96617428	G	A	exonic	ELK3	synonymous	UCEC\|1\|248\|0.00403
-	chr12	96641034	96641034	C	A	exonic	ELK3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	96640771	96640771	C	T	exonic	ELK3	synonymous	SKCM\|1\|368\|0.00272
-	chr12	96660949	96660949	G	T	exonic	ELK3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	96617494	96617494	-	A	exonic	ELK3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	96640943	96640943	T	C	exonic	ELK3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	96617557	96617557	C	T	intronic	ELK3	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs555376474	chr12	96641215	96641215	C	T	exonic	ELK3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	96641401	96641401	G	T	exonic	ELK3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	96640956	96640956	A	T	exonic	ELK3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	96641458	96641458	C	T	exonic	ELK3	synonymous	BRCA\|1\|982\|0.00102
-	chr12	96617393	96617393	G	A	exonic	ELK3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	96640795	96640795	T	C	exonic	ELK3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	96653537	96653537	G	A	exonic	ELK3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	96640767	96640767	C	A	exonic	ELK3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr12	96617358	96617358	T	C	exonic	ELK3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs767528787	chr12	96640867	96640867	C	T	exonic	ELK3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs769175197	chr12	96641028	96641028	-	C	exonic	ELK3	frameshift	BRCA\|1\|982\|0.00102,COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,HNSC\|2\|512\|0.00391,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013
rs118124881	chr12	96641121	96641121	C	T	exonic	ELK3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	96617349	96617349	A	T	exonic	ELK3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs776694424	chr12	96641260	96641260	A	C	exonic	ELK3	synonymous	HNSC\|1\|512\|0.00195
-	chr12	96653545	96653545	C	A	exonic	ELK3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	96640929	96640929	C	G	exonic	ELK3	stopgain	BLCA\|1\|396\|0.00253
rs369779294	chr12	96641080	96641080	C	T	exonic	ELK3	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr12	96640911	96640911	G	A	exonic	ELK3	nonsynonymous	UCEC\|1\|248\|0.00403
rs115218295	chr12	96641344	96641344	G	A	exonic	ELK3	synonymous	DLBC\|1\|48\|0.02083
rs780839884	chr12	96641143	96641143	C	T	exonic	ELK3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs751599496	chr12	96641453	96641453	G	A	exonic	ELK3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	96640793	96640793	C	G	exonic	ELK3	nonsynonymous	OV\|1\|469\|0.00213
rs747750273	chr12	96640905	96640905	C	T	exonic	ELK3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	96617374	96617374	C	T	exonic	ELK3	synonymous	SKCM\|1\|368\|0.00272
-	chr12	96640976	96640976	G	A	exonic	ELK3	nonsynonymous	HNSC\|1\|512\|0.00195
rs200818787	chr12	96640801	96640801	G	A	exonic	ELK3	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs199857700	chr12	96641322	96641322	T	G	exonic	ELK3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs143649233	chr12	96653599	96653599	G	A	exonic	ELK3	nonsynonymous	HNSC\|1\|512\|0.00195
rs200446514	chr12	96641300	96641300	G	C	exonic	ELK3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	96617398	96617398	G	A	exonic	ELK3	synonymous	LUSC\|1\|178\|0.00562
-	chr12	96641179	96641179	C	A	exonic	ELK3	synonymous	SKCM\|1\|368\|0.00272
rs766374190	chr12	96641452	96641452	C	T	exonic	ELK3	synonymous	DLBC\|1\|48\|0.02083
-	chr12	96661219	96661219	A	G	UTR3	ELK3	unknown	ESCA\|1\|185\|0.00541
rs770276677	chr12	96640852	96640852	G	A	exonic	ELK3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs765199394	chr12	96641092	96641092	C	T	exonic	ELK3	synonymous	PRAD\|1\|499\|0.00200
rs140155479	chr12	96641161	96641161	C	T	exonic	ELK3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	96640914	96640914	A	C	exonic	ELK3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs201595118	chr12	96641122	96641122	G	A	exonic	ELK3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs758120639	chr12	96653534	96653534	C	T	exonic	ELK3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|4\|543\|0.00737
-	chr12	96617528	96617528	G	A	exonic	ELK3	nonsynonymous	HNSC\|1\|512\|0.00195
rs142048091	chr12	96641197	96641197	C	T	exonic	ELK3	synonymous	PAAD\|1\|185\|0.00541
-	chr12	96641178	96641178	C	T	exonic	ELK3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	96641019	96641019	C	T	exonic	ELK3	nonsynonymous	ESCA\|1\|185\|0.00541
rs202181482	chr12	96640892	96640892	G	A	exonic	ELK3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs759686205	chr12	96640916	96640916	G	A	exonic	ELK3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	96641039	96641039	G	T	exonic	ELK3	stopgain	LIHC\|1\|373\|0.00268

Disease information of ELK3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ELK3	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
ELK3	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
ELK3	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
ELK3	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human

Pathway associated with ELK3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000702	ERK cascade ( FGF8 signaling (Mouse) )	inoh	17	71
pathway0000703	ERK cascade ( FGF8 signaling (Xenopus) )	inoh	17	71
pathway0000781	FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) )	inoh	20	66
pathway0000782	FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) )	inoh	18	53
pathway0001078	ID	netpath	38	213
pathway0001191	Interleukin signaling pathway	panther	86	1548

Go term information of ELK3

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GO_term_name	GO_term_type	TF_name
GO_RESPONSE_TO_WOUNDING	BP	ELK3
GO_WOUND_HEALING	BP	ELK3
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	ELK3
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	ELK3

Survival analysis of ELK3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ELK3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)