Cancer CRCdb

TF information

TF name:	DLX5
TF family:	Homeobox
Ensembl gene ID:	ENSG00000105880
Ensembl protein ID:	ENSP00000222598, ENSP00000475008
Entrez gene ID:	1749

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of DLX5 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.0096852300242131

DLX5 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

DLX5 distribution in all CRCs

Genomic distribution of SEs associated with DLX5

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Mutation of DLX5

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of DLX5

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs762498461	chr7	96650094	96650094	C	T	exonic	DLX5	nonsynonymous	LIHC\|1\|373\|0.00268
rs753621536	chr7	96653608	96653608	G	A	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96650308	96650308	C	T	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs773641315	chr7	96653581	96653581	C	T	exonic	DLX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr7	96651650	96651650	C	A	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs753811703	chr7	96653899	96653899	G	A	exonic	DLX5	stopgain	BRCA\|2\|982\|0.00204
-	chr7	96650268	96650268	G	A	exonic	DLX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778952255	chr7	96653617	96653617	C	T	exonic	DLX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96650095	96650095	C	A	exonic	DLX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr7	96653816	96653816	A	G	exonic	DLX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr7	96651664	96651664	G	A	exonic	DLX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr7	96650315	96650315	C	T	exonic	DLX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr7	96650227	96650227	G	T	exonic	DLX5	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr7	96653778	96653778	C	-	exonic	DLX5	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96650106	96650106	A	T	exonic	DLX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr7	96653612	96653612	G	A	exonic	DLX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr7	96653686	96653686	C	T	exonic	DLX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96650052	96650052	T	C	exonic	DLX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr7	96651649	96651649	C	A	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96651669	96651669	G	T	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96650323	96650323	C	A	exonic	DLX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr7	96653697	96653697	A	T	exonic	DLX5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr7	96651537	96651537	C	T	exonic	DLX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr7	96651642	96651642	C	A	exonic	DLX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	96650328	96650328	T	G	exonic	DLX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr7	96653687	96653687	G	-	exonic	DLX5	frameshift	LIHC\|1\|373\|0.00268
-	chr7	96651579	96651579	T	C	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96650195	96650195	A	G	exonic	DLX5	synonymous	BRCA\|1\|982\|0.00102
-	chr7	96653771	96653771	C	T	exonic	DLX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96651526	96651526	C	T	exonic	DLX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr7	96651485	96651485	C	T	intronic	DLX5	unknown	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr7	96650194	96650194	G	A	exonic	DLX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr7	96651680	96651680	C	T	exonic	DLX5	synonymous	HNSC\|1\|512\|0.00195
-	chr7	96650324	96650324	G	A	exonic	DLX5	synonymous	HNSC\|1\|512\|0.00195
-	chr7	96650126	96650126	G	T	exonic	DLX5	synonymous	LUSC\|1\|178\|0.00562
-	chr7	96650141	96650141	C	G	exonic	DLX5	nonsynonymous	LUSC\|1\|178\|0.00562
rs61753628	chr7	96653684	96653684	G	A	exonic	DLX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs376488297	chr7	96651541	96651541	C	G	exonic	DLX5	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr7	96651649	96651649	C	T	exonic	DLX5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr7	96650310	96650310	G	-	exonic	DLX5	frameshift	LUAD\|1\|543\|0.00184
-	chr7	96650229	96650229	G	C	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
rs778003408	chr7	96650040	96650040	C	T	UTR3	DLX5	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96650099	96650099	C	T	exonic	DLX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96650202	96650202	G	A	exonic	DLX5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr7	96651538	96651538	G	A	exonic	DLX5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr7	96653656	96653656	C	T	exonic	DLX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96651583	96651583	A	G	exonic	DLX5	synonymous	BRCA\|1\|982\|0.00102
-	chr7	96650149	96650149	C	T	exonic	DLX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	96653798	96653798	G	A	exonic	DLX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr7	96653652	96653652	T	C	exonic	DLX5	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr7	96651523	96651523	C	T	exonic	DLX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96653605	96653605	C	G	exonic	DLX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr7	96650103	96650103	G	T	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96650277	96650277	G	T	exonic	DLX5	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr7	96650245	96650245	C	A	exonic	DLX5	stopgain	BLCA\|1\|396\|0.00253
-	chr7	96653701	96653701	C	T	exonic	DLX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96651486	96651486	G	A	intronic	DLX5	unknown	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr7	96651624	96651624	C	T	exonic	DLX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr7	96650221	96650221	G	A	exonic	DLX5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr7	96650252	96650252	C	T	exonic	DLX5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96650125	96650125	T	C	exonic	DLX5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr7	96653787	96653787	G	A	exonic	DLX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96651595	96651595	G	A	exonic	DLX5	stopgain	LUAD\|2\|543\|0.00368
-	chr7	96651603	96651603	G	C	exonic	DLX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs779599860	chr7	96651519	96651519	G	A	exonic	DLX5	nonsynonymous	SKCM\|1\|368\|0.00272
rs769554704	chr7	96651532	96651532	C	T	exonic	DLX5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96650104	96650104	G	A	exonic	DLX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr7	96650234	96650234	G	C	exonic	DLX5	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr7	96650372	96650372	T	G	exonic	DLX5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96653817	96653817	G	C	exonic	DLX5	nonsynonymous	OV\|1\|469\|0.00213
-	chr7	96653736	96653736	C	G	exonic	DLX5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr7	96653848	96653848	G	A	exonic	DLX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr7	96651559	96651559	G	T	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96654080	96654080	C	A	UTR5	DLX5	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96651668	96651668	G	A	exonic	DLX5	synonymous	SKCM\|1\|368\|0.00272
-	chr7	96651486	96651486	G	C	intronic	DLX5	unknown	HNSC\|1\|512\|0.00195
-	chr7	96653671	96653671	C	T	exonic	DLX5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr7	96653918	96653918	G	T	exonic	DLX5	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr7	96653802	96653802	G	T	exonic	DLX5	nonsynonymous	CHOL\|1\|35\|0.02857,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr7	96651589	96651589	C	A	exonic	DLX5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs61753628	chr7	96653684	96653684	G	C	exonic	DLX5	synonymous	DLBC\|1\|48\|0.02083
-	chr7	96650352	96650352	C	A	exonic	DLX5	nonsynonymous	UCS\|1\|57\|0.01754
-	chr7	96650112	96650112	G	A	exonic	DLX5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr7	96650072	96650072	C	T	exonic	DLX5	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96651605	96651605	A	C	exonic	DLX5	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr7	96651661	96651661	C	G	exonic	DLX5	nonsynonymous	HNSC\|1\|512\|0.00195

Disease information of DLX5

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
DLX5	Bone Diseases, Developmental	C05	Disease or Syndrome	CTD_human
DLX5	Ectrodactyly	C05;C16	Congenital Abnormality	ORPHANET
DLX5	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
DLX5	Split-Hand-Foot Malformation With Sensorineural Hearing Loss	C05;C09;C10;C16;C23	Congenital Abnormality; Disease or Syndrome	CTD_human;ORPHANET;UNIPROT

Pathway associated with DLX5

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002393	Validated transcriptional targets of deltaNp63 isoforms	pid	47	101
pathway0002728	Hs_MECP2_and_Associated_Rett_Syndrome_WP3584_91190	wikipathways	12	14
pathway0002747	Hs_Neural_Crest_Differentiation_WP2064_79263	wikipathways	40	129

Go term information of DLX5

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GO_term_name	GO_term_type	TF_name
GO_BODY_MORPHOGENESIS	BP	DLX5
GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY	BP	DLX5
GO_REPLACEMENT_OSSIFICATION	BP	DLX5
GO_PALATE_DEVELOPMENT	BP	DLX5
GO_NOSE_DEVELOPMENT	BP	DLX5
GO_FACE_DEVELOPMENT	BP	DLX5
GO_OSSIFICATION	BP	DLX5
GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION	BP	DLX5
GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY	BP	DLX5
GO_BONE_MORPHOGENESIS	BP	DLX5
GO_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	DLX5
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS	BP	DLX5
GO_INNER_EAR_MORPHOGENESIS	BP	DLX5
GO_REGULATION_OF_OSSIFICATION	BP	DLX5
GO_HEAD_MORPHOGENESIS	BP	DLX5
GO_HMG_BOX_DOMAIN_BINDING	MF	DLX5

Survival analysis of DLX5

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of DLX5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)