Cancer CRCdb

TF information

TF name:	DEAF1
TF family:	SAND
Ensembl gene ID:	ENSG00000177030
Ensembl protein ID:	ENSP00000371846, ENSP00000431563
Entrez gene ID:	10522

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of DEAF1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_358	Cell line	Colon	LS180	0.03436018957346

DEAF1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

DEAF1 distribution in all CRCs

Genomic distribution of SEs associated with DEAF1

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Mutation of DEAF1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of DEAF1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs773559333	chr11	688398	688398	G	A	exonic	DEAF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	679715	679715	G	T	exonic	DEAF1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr11	686916	686916	C	T	exonic	DEAF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	678763	678763	C	A	exonic	DEAF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	688355	688355	C	A	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs763472641	chr11	680973	680973	C	T	exonic	DEAF1	synonymous	UCEC\|1\|248\|0.00403
-	chr11	688371	688371	C	G	exonic	DEAF1	nonsynonymous	LUSC\|1\|178\|0.00562
rs753858256	chr11	674722	674722	G	A	exonic	DEAF1	synonymous	SKCM\|2\|368\|0.00543
-	chr11	687964	687964	G	A	exonic	DEAF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	687928	687928	T	A	exonic	DEAF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	691516	691516	G	C	exonic	DEAF1	nonsynonymous	HNSC\|1\|512\|0.00195
rs143376874	chr11	691572	691572	C	T	exonic	DEAF1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr11	674755	674755	G	A	exonic	DEAF1	synonymous	SKCM\|1\|368\|0.00272
-	chr11	679783	679783	G	A	exonic	DEAF1	nonsynonymous	SKCM\|1\|368\|0.00272,UVM\|1\|80\|0.01250
rs747584307	chr11	687963	687963	G	A	exonic	DEAF1	synonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs866708744	chr11	674759	674759	G	A	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs777396337	chr11	688343	688343	G	A	exonic	DEAF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	679729	679729	G	A	exonic	DEAF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	654013	654013	C	A	exonic	DEAF1	nonsynonymous	LUSC\|1\|178\|0.00562
rs765924884	chr11	686996	686996	G	A	exonic	DEAF1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	686886	686886	G	A	exonic	DEAF1	nonsynonymous	LUSC\|1\|178\|0.00562,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	687913	687913	G	C	exonic	DEAF1	stopgain	HNSC\|1\|512\|0.00195
-	chr11	678725	678726	TT	-	exonic	DEAF1	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	678769	678769	-	C	exonic	DEAF1	frameshift	BRCA\|2\|982\|0.00204
-	chr11	675164	675165	AA	-	intronic	DEAF1	unknown	OV\|1\|469\|0.00213
-	chr11	688045	688045	G	T	exonic	DEAF1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr11	678761	678761	G	T	exonic	DEAF1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs375262889	chr11	679758	679758	C	T	exonic	DEAF1	synonymous	UCEC\|1\|248\|0.00403
-	chr11	687941	687941	C	A	exonic	DEAF1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr11	674772	674772	G	A	exonic	DEAF1	synonymous	SKCM\|1\|368\|0.00272
rs747111818	chr11	674723	674723	G	A	exonic	DEAF1	nonsynonymous	LUSC\|1\|178\|0.00562,SKCM\|1\|368\|0.00272
-	chr11	688404	688404	C	G	exonic	DEAF1	synonymous	BLCA\|1\|396\|0.00253
rs746106689	chr11	674557	674557	G	A	exonic	DEAF1	synonymous	CHOL\|1\|35\|0.02857
-	chr11	674705	674705	A	G	exonic	DEAF1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr11	688031	688031	C	T	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	680002	680002	-	CCAGGATG	intronic	DEAF1	unknown	SARC\|2\|247\|0.00810
rs371300797	chr11	691531	691531	C	T	exonic	DEAF1	synonymous	UCEC\|1\|248\|0.00403
-	chr11	688009	688009	C	T	exonic	DEAF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	686940	686940	T	C	exonic	DEAF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	678761	678761	G	A	exonic	DEAF1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	681007	681007	G	A	exonic	DEAF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	688032	688032	C	T	exonic	DEAF1	synonymous	SKCM\|1\|368\|0.00272
rs371722695	chr11	688025	688025	C	T	exonic	DEAF1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,SARC\|1\|247\|0.00405
-	chr11	687961	687961	A	G	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	654046	654046	G	A	exonic	DEAF1	synonymous	SKCM\|1\|368\|0.00272
rs368901164	chr11	679753	679753	G	A	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs751558688	chr11	674690	674690	G	A	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	694809	694809	G	C	exonic	DEAF1	nonsynonymous	THCA\|1\|504\|0.00198
-	chr11	687971	687971	C	A	exonic	DEAF1	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr11	686974	686974	G	A	exonic	DEAF1	stopgain	ACC\|1\|90\|0.01111,PRAD\|1\|499\|0.00200
rs142320326	chr11	644595	644595	G	A	exonic	DEAF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	674761	674761	C	A	exonic	DEAF1	synonymous	LUAD\|1\|543\|0.00184
rs765539686	chr11	688337	688337	T	G	exonic	DEAF1	nonsynonymous	BRCA\|1\|982\|0.00102
rs765017164	chr11	644594	644594	C	T	exonic	DEAF1	nonsynonymous	UCEC\|1\|248\|0.00403
rs867499392	chr11	691546	691546	G	A	exonic	DEAF1	synonymous	HNSC\|1\|512\|0.00195
-	chr11	654016	654016	G	A	exonic	DEAF1	synonymous	BRCA\|2\|982\|0.00204
rs776979045	chr11	654033	654033	C	T	exonic	DEAF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	679720	679720	G	A	exonic	DEAF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	688019	688019	C	A	exonic	DEAF1	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr11	678772	678772	G	T	exonic	DEAF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	681025	681025	G	A	exonic	DEAF1	nonsynonymous	UCEC\|1\|248\|0.00403
rs143676584	chr11	676486	676486	C	T	intronic	DEAF1	unknown	OV\|1\|469\|0.00213
-	chr11	688045	688045	G	A	exonic	DEAF1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr11	694963	694988	CCGCCGCCGCCACAGCGGCCGCGGCC	-	exonic	DEAF1	frameshift	LIHC\|1\|373\|0.00268
rs193920740	chr11	654029	654029	C	T	exonic	DEAF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	681026	681026	T	G	exonic	DEAF1	nonsynonymous	UCEC\|1\|248\|0.00403
rs187523180	chr11	674719	674719	C	T	exonic	DEAF1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr11	684948	684948	G	T	exonic	DEAF1	nonsynonymous	ESCA\|1\|185\|0.00541
rs368628431	chr11	674639	674639	G	A	exonic	DEAF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr11	681021	681021	G	T	exonic	DEAF1	synonymous	UCEC\|1\|248\|0.00403
-	chr11	679801	679801	G	A	exonic	DEAF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	679780	679780	C	A	exonic	DEAF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr11	686860	686860	G	A	exonic	DEAF1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	694933	694933	-	G	exonic	DEAF1	frameshift	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125

Disease information of DEAF1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
DEAF1	Mental Depression	F01	Mental or Behavioral Dysfunction	PSYGENET
DEAF1	Depressive disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
DEAF1	Profound Mental Retardation	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
DEAF1	Mental Retardation, Psychosocial	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
DEAF1	Unipolar Depression	F03	Mental or Behavioral Dysfunction	PSYGENET
DEAF1	Smith-Magenis syndrome	C10;C16	Disease or Syndrome	ORPHANET
DEAF1	Mental deficiency	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
DEAF1	Major Depressive Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
DEAF1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human;GENOMICS_ENGLAND
DEAF1	MENTAL RETARDATION, AUTOSOMAL DOMINANT 24		Disease or Syndrome	CTD_human;UNIPROT
DEAF1	DYSKINESIA, SEIZURES, AND INTELLECTUAL DEVELOPMENTAL DISORDER		Disease or Syndrome	CTD_human;ORPHANET

Pathway associated with DEAF1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of DEAF1

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GO_term_name	GO_term_type	TF_name
GO_COGNITION	BP	DEAF1
GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION	BP	DEAF1
GO_ASSOCIATIVE_LEARNING	BP	DEAF1
GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS	BP	DEAF1
GO_FEAR_RESPONSE	BP	DEAF1
GO_VISUAL_BEHAVIOR	BP	DEAF1
GO_NUCLEOLUS	CC	DEAF1

Survival analysis of DEAF1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of DEAF1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)