CR overview
| CR: | EZH2 | |
| Accession: | Q15910 | |
| Protein names: | [Histone H3]-lysine(27) N-trimethyltransferase (EC 2.1.1.356) | |
| Function type: | Histone Modifier | |
| Histone type: | Writer | |
| Methytor type: | Unkown | |
| Aliases: | PRC2;enhancer of zeste 2 polycomb repressive complex 2 subunit;Histone methyltransferases;SET-HMT | |
| PMID: | 26845405 32619406 34115825 32723346 | |
| Disease: | 44 | |
| Go term: | 60 | |
| Pathway: | 6 | |
| Hallmark: | 2 | |
| Super Enhancer: | chr7:148607258-148640073 chr7:148595892-148640084 chr7:148590896-148639893 chr7:148613164-148645468 chr7:148469630-148603144 |
|
| Enhancer: |
chr7:148959450-148961800 chr7:148578620-148580280 chr7:148723360-148725410 chr7:148785240-148787710 chr7:148982590-148984650 chr7:148563910-148565220 chr7:148442380-148444860 chr7:148747160-148747720 chr7:148609830-148612270 chr7:148613190-148614180 chr7:148816420-148818300 chr7:148923500-148925120 chr7:148236680-148238310 chr7:148597920-148598950 chr7:148396120-148398490 chr7:148403060-148404060 chr7:148404620-148405950 chr7:148469050-148471460 chr7:148535820-148536920 chr7:148722210-148722460 chr7:148722970-148723330 chr7:148857340-148859330 chr7:148868970-148869620 chr7:148900980-148901950 chr7:148902590-148903780 chr7:148905300-148907670 chr7:148925790-148927950 chr7:149066540-149068560 chr7:148525970-148526670 chr7:148738390-148739180 chr7:148346800-148348490 chr7:148399700-148400480 chr7:148411490-148411910 chr7:148412210-148412760 chr7:148413000-148415200 chr7:148424410-148425390 chr7:148435230-148437020 chr7:148188680-148190710 chr7:148480980-148481060 chr7:148916880-148918110 chr7:148320690-148321150 chr7:148418820-148420610 chr7:148422240-148422840 chr7:148716530-148718050 chr7:148264410-148265660 chr7:148303860-148305430 chr7:148544890-148546930 chr7:148916180-148916600 chr7:148232170-148233320 |
|
| Promoter: |
chr7:148882321-148886321 |
ChIP-seq based regulatory details of EZH2
| Sample ID | CR | Biosample type | Biosample term name | File accession | Experiment accession | Source |
|---|---|---|---|---|---|---|
| CR_01_0004 | EZH2 | cell line | GM12878 | ENCFF000ARU | ENCSR000ARD | Encode |
| CR_01_0006 | EZH2 | cell line | GM12878 | ENCFF000ASA | ENCSR000ARD | Encode |
| CR_01_0013 | EZH2 | cell line | HeLa-S3 | ENCFF000BBD | ENCSR000ATC | Encode |
| CR_01_0014 | EZH2 | cell line | HeLa-S3 | ENCFF000BBE | ENCSR000ATC | Encode |
| CR_01_0015 | EZH2 | cell line | HepG2 | ENCFF000BEL | ENCSR000ARI | Encode |
| CR_01_0016 | EZH2 | cell line | HepG2 | ENCFF000BEQ | ENCSR000ARI | Encode |
| CR_01_0017 | EZH2 | primary cell | mammary epithelial cell | ENCFF000BHT | ENCSR000ARE | Encode |
| CR_01_0018 | EZH2 | primary cell | mammary epithelial cell | ENCFF000BHU | ENCSR000ARE | Encode |
| CR_01_0019 | EZH2 | primary cell | skeletal muscle myoblast | ENCFF000BKY | ENCSR000ARH | Encode |
| CR_01_0020 | EZH2 | primary cell | skeletal muscle myoblast | ENCFF000BKZ | ENCSR000ARH | Encode |
| CR_01_0023 | EZH2 | in vitro differentiated cells | myotube | ENCFF000BOB | ENCSR000ASZ | Encode |
| CR_01_0024 | EZH2 | in vitro differentiated cells | myotube | ENCFF000BOE | ENCSR000ASZ | Encode |
| CR_01_0025 | EZH2 | primary cell | endothelial cell of umbilical vein | ENCFF000BRJ | ENCSR000ATA | Encode |
| CR_01_0026 | EZH2 | primary cell | endothelial cell of umbilical vein | ENCFF000BRN | ENCSR000ATA | Encode |
| CR_01_0027 | EZH2 | cell line | K562 | ENCFF000BWQ | ENCSR000AQE | Encode |
| CR_01_0028 | EZH2 | cell line | K562 | ENCFF000BWS | ENCSR000AQE | Encode |
| CR_01_0038 | EZH2 | primary cell | astrocyte | ENCFF000CGB | ENCSR000ARR | Encode |
| CR_01_0039 | EZH2 | primary cell | astrocyte | ENCFF000CGE | ENCSR000ARR | Encode |
| CR_01_0042 | EZH2 | primary cell | fibroblast of dermis | ENCFF000CJH | ENCSR000ASE | Encode |
| CR_01_0043 | EZH2 | primary cell | fibroblast of dermis | ENCFF000CJJ | ENCSR000ASE | Encode |
| CR_01_0246 | EZH2 | in vitro differentiated cells | neural cell | ENCFF002AVV | ENCSR511CUH | Encode |
| CR_01_0248 | EZH2 | in vitro differentiated cells | neural cell | ENCFF002AYE | ENCSR511CUH | Encode |
| CR_01_0282 | EZH2 | cell line | PC-3 | ENCFF043VXL | ENCSR218QFN | Encode |
| CR_01_0302 | EZH2 | in vitro differentiated cells | hepatocyte | ENCFF109ECO | ENCSR384LYW | Encode |
| CR_01_0309 | EZH2 | cell line | MM.1S | ENCFF131TJJ | ENCSR703KWN | Encode |
| CR_01_0310 | EZH2 | cell line | SK-N-MC | ENCFF135UCD | ENCSR113GDB | Encode |
| CR_01_0313 | EZH2 | cell line | MM.1S | ENCFF145CLU | ENCSR703KWN | Encode |
| CR_01_0334 | EZH2 | cell line | SK-N-MC | ENCFF202YVD | ENCSR113GDB | Encode |
| CR_01_0353 | EZH2 | cell line | A673 | ENCFF248CVW | ENCSR179SAO | Encode |
| CR_01_0371 | EZH2 | in vitro differentiated cells | hepatocyte | ENCFF273BIC | ENCSR384LYW | Encode |
| CR_01_0447 | EZH2 | cell line | MM.1S | ENCFF499TRH | ENCSR703KWN | Encode |
| CR_01_0519 | EZH2 | cell line | MM.1S | ENCFF684UWO | ENCSR703KWN | Encode |
| CR_01_0528 | EZH2 | cell line | MM.1S | ENCFF702LEK | ENCSR703KWN | Encode |
| CR_01_0586 | EZH2 | cell line | PC-3 | ENCFF837RUP | ENCSR218QFN | Encode |
| CR_01_0672 | EZH2 | primary cell | B cell | ENCFF000ANM | ENCSR000AUZ | Encode |
| CR_01_0673 | EZH2 | primary cell | B cell | ENCFF000ANN | ENCSR000AUZ | Encode |
| CR_01_0676 | EZH2 | cell line | DND-41 | ENCFF000AOQ | ENCSR000ASW | Encode |
| CR_01_0677 | EZH2 | cell line | DND-41 | ENCFF000AOR | ENCSR000ASW | Encode |
| CR_01_0678 | EZH2 | cell line | H1-hESC | ENCFF000AVZ | ENCSR000ASY | Encode |
| CR_01_0679 | EZH2 | cell line | H1-hESC | ENCFF000AWC | ENCSR000ASY | Encode |
| CR_01_0701 | EZH2 | primary cell | keratinocyte | ENCFF000CMR | ENCSR000ARK | Encode |
| CR_01_0702 | EZH2 | primary cell | keratinocyte | ENCFF000CMS | ENCSR000ARK | Encode |
| CR_01_0703 | EZH2 | primary cell | fibroblast of lung | ENCFF000CRA | ENCSR000ARO | Encode |
| CR_01_0704 | EZH2 | primary cell | fibroblast of lung | ENCFF000CRB | ENCSR000ARO | Encode |
| CR_01_0889 | EZH2 | cell line | H1-hESC | ENCFF090FUA | ENCSR000ASY | Encode |
| CR_01_0901 | EZH2 | cell line | OCI-LY1 | ENCFF171CHB | ENCSR520VTO | Encode |
| CR_01_0903 | EZH2 | in vitro differentiated cells | neural progenitor cell | ENCFF190QDZ | ENCSR069DPL | Encode |
| CR_01_0908 | EZH2 | cell line | H1-hESC | ENCFF225ZAL | ENCSR000ASY | Encode |
| CR_01_0915 | EZH2 | cell line | HCT116 | ENCFF254OVT | ENCSR046HGP | Encode |
| CR_01_0924 | EZH2 | cell line | A673 | ENCFF332FPJ | ENCSR179SAO | Encode |
| CR_01_0927 | EZH2 | cell line | OCI-LY1 | ENCFF367CZA | ENCSR520VTO | Encode |
| CR_01_0931 | EZH2 | cell line | OCI-LY1 | ENCFF389MUN | ENCSR520VTO | Encode |
| CR_01_0941 | EZH2 | cell line | A673 | ENCFF452HXG | ENCSR179SAO | Encode |
| CR_01_0943 | EZH2 | cell line | H1-hESC | ENCFF458LKN | ENCSR000ASY | Encode |
| CR_01_0947 | EZH2 | cell line | A673 | ENCFF497MMJ | ENCSR179SAO | Encode |
| CR_01_0951 | EZH2 | cell line | OCI-LY1 | ENCFF512JLH | ENCSR520VTO | Encode |
| CR_01_0980 | EZH2 | cell line | HCT116 | ENCFF758IZH | ENCSR046HGP | Encode |
| CR_01_0994 | EZH2 | in vitro differentiated cells | neural progenitor cell | ENCFF892UWM | ENCSR069DPL | Encode |
| CR_02_0091 | EZH2 | cell line | DU145 | SRR10992885 | GSE135623 | GEO |
| CR_02_0092 | EZH2 | cell line | DU145 | SRR10992886 | GSE135623 | GEO |
| CR_02_0160 | EZH2 | cell line | HCT116 | SRR11968986 | GSE152144 | GEO |
| CR_02_0217 | EZH2 | Tissue | fetal liver | SRR1506959 | GSE59090/GSE59087 | GEO |
| CR_02_0218 | EZH2 | cell line | NCI-H1299 | SRR12327297 | GSE155129 | GEO |
| CR_02_0219 | EZH2 | cell line | NCI-H1299 | SRR12327299 | GSE155129 | GEO |
| CR_02_0220 | EZH2 | cell line | NCI-H1299 | SRR12327301 | GSE155129 | GEO |
| CR_02_0221 | EZH2 | cell line | NCI-H1299 | SRR12327325 | GSE155129 | GEO |
| CR_02_0222 | EZH2 | cell line | NCI-H1299 | SRR12327327 | GSE155129 | GEO |
| CR_02_0223 | EZH2 | cell line | NCI-H1299 | SRR12327329 | GSE155129 | GEO |
| CR_02_0234 | EZH2 | Tissue | fetal liver | SRR1506963 | GSE59090/GSE59087 | GEO |
| CR_02_0235 | EZH2 | Tissue | fetal liver | SRR1506964 | GSE59090/GSE59087 | GEO |
| CR_02_0238 | EZH2 | cell line | IMR32 | SRR13125064 | GSE162057 | GEO |
| CR_02_0245 | EZH2 | GBM Patient Derived Xenograft | GBM Patient Derived Xenograft | SRR13370683 | GSE164352 | GEO |
| CR_02_0246 | EZH2 | GBM Patient Derived Xenograft | GBM Patient Derived Xenograft | SRR13370684 | GSE164352 | GEO |
| CR_02_0265 | EZH2 | cell line | MM.1S | SRR14103006 | GSE169795 | GEO |
| CR_02_0266 | EZH2 | cell line | MM.1S | SRR14103007 | GSE169795 | GEO |
| CR_02_0318 | EZH2 | neural cell | neural cell | SRR14636312 | GSE174862 | GEO |
| CR_02_0319 | EZH2 | neural cell | neural cell | SRR14636313 | GSE174862 | GEO |
| CR_02_0336 | EZH2 | smooth muscle cell | smooth muscle cell | SRR14637366 | GSE175063 | GEO |
| CR_02_0412 | EZH2 | cell line | PC9 | SRR1721587 | GSE64243 | GEO |
| CR_02_0413 | EZH2 | cell line | PC9 | SRR1721589 | GSE64243 | GEO |
| CR_02_0416 | EZH2 | cell line | HCT116 | SRR1737302 | GSE39467 | GEO |
| CR_02_0471 | EZH2 | cell line | PC9 | SRR2532667 | GSE64243 | GEO |
| CR_02_0472 | EZH2 | cell line | PC9 | SRR2532669 | GSE64243 | GEO |
| CR_02_0507 | EZH2 | None | None | SRR3997646 | GSE85169 | GEO |
| CR_02_0508 | EZH2 | None | None | SRR3997647 | GSE85169 | GEO |
| CR_02_0513 | EZH2 | Tissue | Diffuse Intrinsic Pontine Glioma (DIPG) | SRR4014861 | GSE78801 | GEO |
| CR_02_0514 | EZH2 | Tissue | Diffuse Intrinsic Pontine Glioma (DIPG) | SRR4014862 | GSE78801 | GEO |
| CR_02_0521 | EZH2 | Tissue | Diffuse Intrinsic Pontine Glioma (DIPG) | SRR4014883 | GSE78801 | GEO |
| CR_02_0522 | EZH2 | Tissue | Diffuse Intrinsic Pontine Glioma (DIPG) | SRR4014884 | GSE78801 | GEO |
| CR_02_0523 | EZH2 | Tissue | Kelly | SRR4017703 | GSE85430 | GEO |
| CR_02_0524 | EZH2 | cell line | LAN-1 | SRR4017707 | GSE85430 | GEO |
| CR_02_0528 | EZH2 | cell line | RWPE1 | SRR4099190 | GSE86232 | GEO |
| CR_02_0529 | EZH2 | cell line | RWPE1 | SRR4099191 | GSE86232 | GEO |
| CR_02_0530 | EZH2 | cell line | RWPE1 | SRR4099192 | GSE86232 | GEO |
| CR_02_0624 | EZH2 | cell line | LNCaP | SRR524707 | GSE39459 | GEO |
| CR_02_0626 | EZH2 | cell line | HCT116 | SRR524721 | GSE39467 | GEO |
| CR_02_0627 | EZH2 | cell line | MDA-MB-231 LM2 | SRR5282137 | GSE95305 | GEO |
| CR_02_0777 | EZH2 | primary cell | Primary Human Umbilical Vein Endothelial Cells | SRR6511208 | GSE109625 | GEO |
| CR_02_0778 | EZH2 | primary cell | Primary Human Umbilical Vein Endothelial Cells | SRR6511209 | GSE109625 | GEO |
| CR_02_0779 | EZH2 | primary cell | Primary Human Umbilical Vein Endothelial Cells | SRR6511210 | GSE109625 | GEO |
| CR_02_0810 | EZH2 | cell line | OCI-Ly7 cell line | SRR834997 | GSE45982 | GEO |
| CR_02_0811 | EZH2 | cell line | Farage cell line | SRR834998 | GSE45982 | GEO |
| CR_02_0840 | EZH2 | cell line | MRC-iPS-25 | SRR925554 | GSE48518/GSE48515 | GEO |
| CR_02_0842 | EZH2 | cell line | MRC-iPS-25 | SRR925557 | GSE48518/GSE48515 | GEO |
| CR_02_0845 | EZH2 | cell line | AM-iPS-6 | SRR925561 | GSE48518/GSE48516 | GEO |
| CR_02_0848 | EZH2 | cell line | AM-iPS-8 | SRR925565 | GSE48518/GSE48516 | GEO |
| CR_02_0850 | EZH2 | cell line | Edom-iPS-2 | SRR925569 | GSE48518/GSE48516 | GEO |
| CR_02_0851 | EZH2 | cell line | Edom-iPS-2 | SRR925570 | GSE48518/GSE48516 | GEO |
| CR_02_0854 | EZH2 | cell line | MRC-iPS-25 | SRR925576 | GSE48518/GSE48516 | GEO |
| CR_02_0861 | EZH2 | cell line | UtE-iPS-4 | SRR925584 | GSE48518/GSE48516 | GEO |
| CR_02_0863 | EZH2 | cell line | UtE-iPS-6 | SRR925588 | GSE48518/GSE48516 | GEO |
| CR_02_0903 | EZH2 | None | None | SRR7743648 | GSE118954 | GEO |
| CR_02_0904 | EZH2 | None | None | SRR7743649 | GSE118954 | GEO |
| CR_02_0905 | EZH2 | None | None | SRR7743650 | GSE118954 | GEO |
| CR_02_0906 | EZH2 | None | None | SRR7743651 | GSE118954 | GEO |
| CR_02_0907 | EZH2 | None | None | SRR7743652 | GSE118954 | GEO |
| CR_02_0908 | EZH2 | None | None | SRR7743653 | GSE118954 | GEO |
| CR_02_0909 | EZH2 | None | None | SRR7743654 | GSE118954 | GEO |
| CR_02_0910 | EZH2 | None | None | SRR7743655 | GSE118954 | GEO |
| CR_02_0911 | EZH2 | None | None | SRR7743656 | GSE118954 | GEO |
| CR_02_0912 | EZH2 | None | None | SRR7743657 | GSE118954 | GEO |
| CR_02_0998 | EZH2 | neural progenitor cell | neural progenitor cell | SRR8275084 | GSE123199 | GEO |
| CR_02_0999 | EZH2 | neural progenitor cell | neural progenitor cell | SRR8275085 | GSE123199 | GEO |
| CR_02_1001 | EZH2 | cell line | PC-3 | SRR8275096 | GSE123204 | GEO |
| CR_02_1002 | EZH2 | cell line | PC-3 | SRR8275097 | GSE123204 | GEO |
| CR_02_1083 | EZH2 | cell line | MDA-MB-231 | SRR8719699 | GSE128231 | GEO |
| CR_02_1084 | EZH2 | cell line | MDA-MB-231 | SRR8719704 | GSE128231 | GEO |
| CR_02_1103 | EZH2 | cell line | DU145 | SRR9937820 | GSE135623 | GEO |
| CR_02_1178 | EZH2 | cell line | MDA-MB-231 | SRR10012656 | GSE136195/GSE136187 | GEO |
| CR_02_1179 | EZH2 | cell line | MDA-MB-231 | SRR10012657 | GSE136195/GSE136187 | GEO |
| CR_02_1185 | EZH2 | cell line | A549 | SRR10777202 | GSE102599 | GEO |
| CR_02_1186 | EZH2 | cell line | A549 | SRR10777203 | GSE102599 | GEO |
| CR_02_1202 | EZH2 | cell line | Immortalized normal esophageal epithelium | SRR11927928 | GSE151838 | GEO |
| CR_02_1203 | EZH2 | cell line | Esophageal squamous carcinoma | SRR11927929 | GSE151838 | GEO |
| CR_02_1217 | EZH2 | cell line | A375 | SRR13627120 | GSE133834 | GEO |
| CR_02_1218 | EZH2 | cell line | A375 | SRR13627123 | GSE133834 | GEO |
| CR_02_1223 | EZH2 | cell line | H1 hESCs | SRR14005202 | GSE169207/GSE150072 | GEO |
| CR_02_1231 | EZH2 | cell line | H1 hESCs | SRR14005224 | GSE169207/GSE150072 | GEO |
| CR_02_1244 | EZH2 | cell line | GM23248 | SRR14637006 | GSE175004 | GEO |
| CR_02_1245 | EZH2 | cell line | GM23248 | SRR14637007 | GSE175004 | GEO |
| CR_02_1248 | EZH2 | cell line | neural stem cell (NSC) | SRR1582157 | GSE61586 | GEO |
| CR_02_1249 | EZH2 | cell line | SF7761 cell line | SRR1582160 | GSE61586 | GEO |
| CR_02_1261 | EZH2 | cell line | LNCaP cells | SRR4191320 | GSE86532 | GEO |
| CR_02_1322 | EZH2 | cell line | A1847 | SRR5310696 | GSE95645/GSE95643 | GEO |
| CR_02_1323 | EZH2 | cell line | A1847 | SRR5310699 | GSE95645/GSE95643 | GEO |
| CR_02_1324 | EZH2 | cell line | MCF-7 | SRR5833155 | GSE101364 | GEO |
| CR_02_1404 | EZH2 | cell line | T98G | SRR6881723 | GSE112242/GSE112240 | GEO |
| CR_02_1410 | EZH2 | cell line | GM23338 | SRR8275080 | GSE123196 | GEO |
| CR_02_1411 | EZH2 | cell line | HCT116 | SRR8275081 | GSE123197 | GEO |
| CR_02_1412 | EZH2 | cell line | PC-9 | SRR8275145 | GSE123228 | GEO |
| CR_02_1413 | EZH2 | cell line | PC-9 | SRR8275146 | GSE123228 | GEO |
| CR_02_1439 | EZH2 | engrafted primary inv(16) AMLs | engrafted primary inv(16) AMLs | SRR8777082 | GSE128771 | GEO |
| CR_02_1440 | EZH2 | engrafted primary inv(16) AMLs | engrafted primary inv(16) AMLs | SRR8777085 | GSE128771 | GEO |
| CR_02_1459 | EZH2 | cell line | NCI-H1299 | SRR12327298 | GSE155129 | GEO |
| CR_02_1460 | EZH2 | cell line | NCI-H1299 | SRR12327300 | GSE155129 | GEO |
| CR_02_1461 | EZH2 | cell line | NCI-H1299 | SRR12327324 | GSE155129 | GEO |
| CR_02_1462 | EZH2 | cell line | NCI-H1299 | SRR12327326 | GSE155129 | GEO |
| CR_02_1463 | EZH2 | cell line | NCI-H1299 | SRR12327328 | GSE155129 | GEO |
Downstream target genes of EZH2
Upstream regulatory details of EZH2
Protein-protein interaction of EZH2
Annotation of EZH2
TCGA cancer survival map of EZH2
Other information of EZH2