About Enhancer
| Enhancer ID: | E_02_0922 |
| Species: | mouse |
| Position : | chr19:10215891-10216703   |
| Biosample name: | |
| Experiment class : | Low throughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 24204311 |
| Enhancer experiment: | ChIP,Luciferase Reporter Assay,EMSA,qPCR |
| Enhancer experiment description: | Considering the large number of potential Sox binding sites and the low predictive power of their presence, we decided to assess regulatory potential and Sox10-responsiveness of the ECR in luciferase assays.To verify that Sox10 is bound to ECR9 in OL we next performed chromatin immunoprecipitation (ChIP) experiments. Some were clustered so that eight oligonucleotides were sufficient to cover all sites in electrophoretic mobility shift assays (EMSA). |
About Target gene
| Target gene : | Myrf(6030439E18,Gm1804,Gm98,Mrf) |
| Strong evidence: | -- |
| Less strong evidence: | Immunoprecipitation |
| Target gene experiment description: | To address this issue we performed immunoprecipitation experiments with anti-Sox10 antibodies on extracts of the OL-like OLN93 cell line. |
About TF
| TF name : | Sox10(DOM,PCWH,WS2E,WS4,WS4C) |
| TF experiment: | ChIP |
| TF experiment description: | To verify that Sox10 is bound to ECR9 in OL we next performed chromatin immunoprecipitation (ChIP) experiments. |
About Function
| Enhancer function : | -- |
| Enhancer function experiment: | -- |
| Enhancer function experiment description: |
-- |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Sox10 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene